Clinical trials: Inflammatory Bowel Disease (IBD)
Inflammatory Bowel Diseases, Ulcerative Colitis
Inflammatory Bowel Disease Tracker (IBD Tracker)
Inflammatory Bowel Diseases are incurable, life-long conditions that significantly impact a patient's quality of life. Crohn's Disease and ulcerative colitis are the most prevalent inflammatory bowel diseases in the United…
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- IBDTr (NCT03953794)
- Testing
- Fitbit Charge 3
- Sponsor
- Massachusetts General Hospital
Crohn Disease (CD)
AI-Assisted MRE for Intestinal Fibrosis in Crohn's Disease
Intestinal fibrotic strictures represent a severe complication of Crohn's disease (CD), affecting over half of the patients. Despite the continuous emergence of novel medications, effective treatment options remain scarce.
- Trial name
- NCT06858553
- Where
- 5 sites in China
- Volunteers
- 234 people
- Sponsor
- Minhu Chen
Crohn Disease
Stress in Crohn's Disease
There is little information on how Crohn's disease progresses in between a patient's clinic visits and how stress impacts symptom change including flare-ups.
- Trial name
- NCT04809194
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 195 people
- Sponsor
- 4YouandMe
Crohn´s Disease, Ulcerative Colitis
Endoscopy for Assessment of Mucosal Healing in IBD
Inflammatory bowel disease (IBD) encompasses two major forms of chronic intestinal disorders, Crohn's disease and ulcerative colitis (UC).
- Trial name
- NCT01417702
- Testing
- High-definition white light endoscopy and i-Scan
- Where
- Germany
- Volunteers
- 232 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Crohn's Disease
PBMC (Peripheral Blood Mononuclear Cells) /Lymphocyte SPECT (Single Photon Emission Computerized Tomography) Imaging in Crohn's Disease
Using scintigraphic imaging including planar scintigraphy and SPECT, this study will evaluate the utility of two different ex vivo 99mTc-HMPAO labelled mononuclear cell populations in order to select the optimal methodology…
- Trial name
- NCT01051622
- Testing
- Labeling Ceretec
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Crohn's Disease, Ulcerative Colitis
Cannabidiol for Inflammatory Bowel Disease
There are many anecdotal reports about improvement of Inflammatory bowel diseases (IBD) with cannabis smoking. The most effective anti inflammatory compound known today is cannabidiol.
- Trial name
- NCT01037322
- Testing
- cannabidiol
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Meir Medical Center
Inflammatory Bowel Diseases
The Role of Peripheral and Tissue Chitinase 3-like 1 Protein Levels as a Bio-marker in IBD
The digestive system may be involved in various pathologic conditions, with different inflammatory, metaplastic and neoplastic aspects.
- Trial name
- NCT03154905
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Crohn Disease, Ulcerative Colitis
Loss of Response of Adalimumab Biosimilar vs Adalimumab Original, in Inflammatory Bowel Disease.
Loss of response of the Adalimumab biosimilar compared with the original drug.
- Trial name
- ADA-SWITCH (NCT04131322)
- Testing
- Amgevita 40Mg Solution for Injection, HUMIRA 40Mg Solution for Injection
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Crohn's Disease
Early Surgery Versus Conservative Treatment in Patients With Ileocaecal Crohn's Disease
This study compares the efficacy of early surgical with medical treatment in patients with ileocaecal uncomplicated Crohn's disease.
- Trial name
- ESPRIT (NCT02716454)
- Testing
- Ileocaecal resection
- Where
- 12 sites in Czechia
- Volunteers
- 200 people
- Sponsor
- Ondrej Ryska
Inflammatory Bowel Disease (IBD), Cognitive Behavior Therapy
The Impact of Culture in Cognitive Behavior Therapy (CBT) for Patients With Inflammatory Bowel Disease
Introduction Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is a chronic condition that affects the gastrointestinal tract and has a significant impact on patients' quality of life (QoL)…
- Trial name
- NCT06713694
- Testing
- cognitive-behavioral therapy, Wait first, then cognitive-behavioral therapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Wang Zhen
Crohn Disease
Therapeutic Optimization Study Based on MR Enterocolonography in Patients With Crohn's Disease
This randomized, controlled study aims to evaluate the impact of therapeutic intervention (step up) for the patients who are clinical remission with Magnetic Resonance Enterocolonography (MREC) active.
- Trial name
- NCT02332356
- Testing
- azathioprine or adalimumab and infliximab
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Tokyo Medical and Dental University
Inflammatory Bowel Diseases, Ulcerative Colitis
Fecal Microbiota Transplant (FMT) in Pediatric Active Ulcerative Colitis and Pediatric Active Crohn's Colitis
The primary aims of this phase I/II, randomized, placebo controlled study are the assessment of safety and tolerability of universal donor FMT compared to placebo in pediatric and young adult subjects (ages 5 years through 30…
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT02330653
- Testing
- Fecal Microbiota Transplant (FMT)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stacy A. Kahn
Ulcerative Colitis, Crohn's Disease
VEST: The UK Vedolizumab Real Life Experience Study in Inflammatory Bowel Disease
Vedolizumab has been approved for the treatment of both ulcerative colitis and Crohn's disease. The aim of this study is to capture the early real life UK experience of vedolizumab including the outcomes of treatment, describing…
- Trial name
- VEST (NCT03257345)
- Where
- 22 sites in United Kingdom
- Volunteers
- 360 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Ulcerative Colitis
Open Label Study to Assess Safety, PK and Explore Efficacy of OPRX-106 in Patients With Active Mild to Moderate Ulcerative Colitis
This is a proof of concept, randomized, open label, 2-arm study of OPRX-106 in subjects with active mild to moderate ulcerative colitis.
- Trial name
- NCT02768974
- Testing
- OPRX-106
- Where
- 7 sites in Israel
- Volunteers
- 20 people
- Sponsor
- Protalix
Ulcerative Colitis
In Vivo Molecular Imaging Predicts Therapeutic Response in Ulcerative Colitis
Molecular imaging with infliximab antibody with FITC has the potential to predict therapeutic responses to infliximab antibody and can be used for personalized medicine in ulcerative colitis.
- Trial name
- NCT02852850
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shandong University
COVID-19
Assessment of the Response to the Complete Vaccination Guidelines Against Sars-cov2
Prospective observational single-center study in which the impact of anti-TNF biological treatment on the humoral response after complete vaccination against SARS-COV2 in patients with inflammatory bowel disease is analyzed.
- Trial name
- COVID-19 (NCT05153850)
- Where
- Spain
- Volunteers
- 243 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Inflammatory Bowel Diseases, Child
Nutritional Status in Children With IBD
Malnutrition and growth retardation are major extraintestinal presentations of inflammatory bowel disease (IBD) in childhood and are especially prevalent among those with Crohn's disease.
- Trial name
- NCT04457518
- Where
- Turkey (Türkiye)
- Volunteers
- 824 people
- Sponsor
- Ankara University
Ulcerative Colitis (UC)
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of ONO-6414 Administered Orally in Healthy Adult Participants and Patients With Active Ulcerative Colitis
A study to investigate the safety, tolerability, and pharmacokinetics (PK) of ONO-6414 orally in healthy adult participants and in patients with active ulcerative colitis (UC).
- Trial name
- NCT07749768
- Testing
- ONO-6414
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Ulcerative Colitis and Crohn's Disease
Entyvio (Vedolizumab) Long Term Safety Study
The purpose of this study is to assess the long-term safety of vedolizumab versus other biologic agents in participants with Ulcerative Colitis (UC) or Crohn's Disease (CD).
- Trial name
- Entyvio PASS (NCT02674308)
- Testing
- Vedolizumab, Other Biologic Agents
- Where
- 287 sites in United States, Austria and 19 more
- Volunteers
- 5,302 people
- Sponsor
- Takeda
Crohn's Disease
Transmural Healing and Disease-Modifying Effect of Guselkumab in Crohn's Disease Patients
The purpose of this study is to evaluate the efficacy of guselkumab in healing of all layers of the digestive tract (transmural healing) with the help of a score called Magnetic Resonance Index of Activity (MaRIA) based on a scan…
- Trial name
- REASON (NCT06408935)
- Testing
- Guselkumab
- Where
- 84 sites in United States, Australia and 12 more
- Volunteers
- 120 people
- Sponsor
- Janssen-Cilag Ltd.
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