Clinical trials: Inflammatory Bowel Disease (IBD)
Ulcerative Colitis, Unspecified
Mesalazine With Hydrocortisone Sodium Succinate Enema for 4-Week Treatment in Patients With Ulcerative Colitis
The research aims to evaluate the efficacy and safety of that mesalazine with hydrocortisone sodium succinate for the induction of clinical remission during a 4-week double-blind treatment period in active UC (define as total…
- Trial name
- NCT03110198
- Testing
- Mesalazine, hydrocortisone sodium succinate, Mesalazine with hydrocortisone sodium succinate
- Where
- China
- Volunteers
- 528 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Crohn Disease
Value of Pharmacokinetic Assays in the Prediction of Induction and Maintenance Therapeutic Response in Crohn's Disease
Vedolizumab (VDZ) is a monoclonal antibody which has shown its efficacy in Crohn's disease by inducing and maintaining clinical response/remission.
- Trial name
- VEDO-PREDIRESP (NCT02768532)
- Testing
- Vedolizumab
- Where
- 5 sites in France
- Volunteers
- 47 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Inflammatory Bowel Diseases
Repurposing Fenofibrate in Modulating AMPK/NLRP3 Inflammasome in Patients With Ulcerative Colitis
Fibrates, specific pharmacological agonists of PPARα, have been widely used to treat hypercholesterolemia and hypertriglyceridemia.
- Trial name
- NCT05781698
- Testing
- Mesalamine, Fenofibrate
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Ulcerative Colitis
Xeljanz Special Investigation for Long-term Use in UC Patients
Secondary data collection study: safety and effectiveness of Xeljanz in UC patients under Japanese medical practice
- Trial name
- NCT03643211
- Where
- Japan
- Volunteers
- 2,016 people
- Sponsor
- Pfizer
Crohn Disease
Effect of the Exclusive Enteral Nutrition Combined With Azathioprine for Remission of Crohn's Diseases After Surgery
for some patients with Crohn's diseases undergoing surgery，whether exclusive enteral nutrition(EEN) could delay the disease relapse needs exploration.The trial will study whether the efficacy of postoperative EEN could help…
- Trial name
- NCT04160325
- Testing
- postoperative 3-month exclusive enteral nutrition, azathioprine, normal diet
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Zhu Weiming
Ulcerative Colitis
Early Intestinal Ultrasound in Predicting Treatment Response to Filgotinib in Ulcerative Colitis
Objective disease assessment in inflammatory bowel diseases at the time of treatment initiation and during follow-up has become gold standard.
- Trial name
- STEER (NCT05653791)
- Testing
- Intestinal ultrasound
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Inflammatory Bowel Diseases (IBD)
BCMA-CD19 cCAR T for the Treatment of Refractory Inflammatory Bowel Disease (IBD)
This is a Phase I, IIa, Single-Arm, interventional, open label, treatment study to evaluate the safety and tolerability of ICG318 CAR-T (BCMA-CD19-IL-15/IL15sushi cCAR T cells) in patients with relapsed and/or refractory…
- Trial name
- NCT07544160
- Testing
- ICG318, BCMA-CD19-IL-15/IL-15 sushi Compound CAR T
- Where
- China
- Volunteers
- 18 people
- Sponsor
- iCell Gene Therapeutics
Ulcerative Colitis
A Study of MDX-1100 in Subjects With Active Ulcerative Colitis
The purpose of this study is to determine the safety and tolerability of the MDX-1100 regimen in subjects with active Ulcerative colitis(UC) and determine the response rate at day 57 in patients administered MDX-1100.
- Trial name
- MDX1100-06 (NCT00656890)
- Testing
- sterile saline for injection, MDX-1100
- Where
- 44 sites in United States, Canada and 6 more
- Volunteers
- 110 people
- Sponsor
- Bristol-Myers Squibb
Inflammatory Bowel Disease, Hepatobiliary Disease
Risk of Methicillin-resistant S.Aureus (MRSA) Infections in MRSA Carrier Under Introduction of Rapid MRSA Screening
This study was designed to evaluate the effect of a targeted preoperative Methicillin-resistant Staphylococcus aureus (MRSA) detection by polymerase chain reaction (PCR) on either endogenous or exogenous postoperative MRSA…
- Conditions
- Inflammatory Bowel Disease, Hepatobiliary Disease, Pancreas Disease
- Trial name
- NCT01918813
- Testing
- vancomycin, mupirocin ointment
- Where
- Japan
- Volunteers
- 662 people
- Sponsor
- Chikara Tashiro
Inflammatory Bowel Disease (IBD), Colonoscopy
Visualization of the Colon Through Use of the Magnetic Flexible Endoscope (MFE) in Participants With Inflammatory Bowel Disease (IBD)
In this study, the investigators will test the ability of the Magnetic Flexible Endoscope (MFE) to travel through the colon of people with Inflammatory Bowel Disease (IBD).
- Trial name
- NCT06989424
- Testing
- Magnetic Flexible Endoscope (MFE)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Vanderbilt University Medical Center
Crohn Disease, Perianal Crohn Disease
A Prospective Longitudinal Study of Fecal Microbiome and Calprotectin to Predict Response to Biological Therapy in Patients With CD
Crohn's disease (CD) is a chronic relapsing-remitting systemic inflammatory disease, affecting any part of the gastrointestinal tract.
- Trial name
- NCT03994224
- Where
- Hong Kong
- Volunteers
- 13 people
- Sponsor
- Chinese University of Hong Kong
Crohn Disease
Non-invasive Vagus Nerve Stimulation in the Treatment of Crohn's Disease - A Pilot Study
To assess the safety and efficacy of transcutaneous vagal stimulation in adult patients with active Crohn's disease.
- Trial name
- VNS (NCT05165108)
- Testing
- Vagal Nerve Stimulator
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Indiana University
Ulcerative Colitis, IBD
Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Ulcerative Colitis
The present study (D5272C00001/Legacy #3151-201-008) aims to evaluate the efficacy and safety of brazikumab in patients with moderately to severely active UC and will include assessments of clinical responses as demonstrated by…
- Trial name
- Expedition (NCT03616821)
- Testing
- Brazikumab
- Where
- 125 sites in United States, Canada and 17 more
- Volunteers
- 242 people
- Sponsor
- AstraZeneca
Crohn Disease (CD)
WAter Preparation in Crohn's Disease's Imagery
The goal of this clinical trial is to compare distension quality and patient experience of water and polyethylene glycol preparation as oral contrast media in Magnetic Resonance Enterography (MRE) in patients with Crohn's…
- Trial name
- WAM (NCT06690632)
- Testing
- water preparation, polyethylene glycol preparation
- Where
- France
- Volunteers
- 194 people
- Sponsor
- University Hospital, Toulouse
Colorectal Cancer
Changes in Stem Cells of the Colon in Response to Increased Risk of Colorectal Cancer
Colorectal cancer is a common disease worldwide. Increasing evidence is demonstrating that colorectal cancers arise from 'cancer stem cells.' Stem cells in the colon reside at the bottom of thousands of microscopic crypts…
- Trial name
- NCT01075893
- Where
- 2 sites in United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Ulcerative Colitis (UC)
Validation of the Reliability and Validity of the New Endoscopic Scoring System for Ulcerative Colitis (CAT-DESIRE Score) and Verification of Its Clinical Practicability
Ulcerative Colitis (UC) is a chronic, non-specific intestinal inflammatory disease of unknown cause, featuring abdominal pain, diarrhea, and bloody stools.
- Trial name
- NCT07608198
- Where
- 9 sites in China
- Volunteers
- 235 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Crohn's Disease, Upadacitinib
IUS Predicts Upadacitinib Efficacy in Patients With Moderate to Severe Crohn's Disease：a Prospective Study
Crohn's disease (CD) is a chronic nonspecific inflammatory disease of the intestinal tract whose etiology is not yet fully understood, and can present with serious complications such as intestinal obstruction, perforation…
- Conditions
- Crohn's Disease, Upadacitinib, Intestinal Ultrasound, Predictors
- Trial name
- NCT06573944
- Where
- China
- Volunteers
- 34 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Inflammatory Bowel Diseases, Crohn Disease
Social Determinants of Health, Medication Use, and Quality of Life in Inflammatory Bowel Disease
Optimizing health related-quality of life (HRQoL) for patients with inflammatory bowel disease (IBD), who often experience a relapsing disease course, is an essential component of care.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT06266663
- Testing
- Survey
- Where
- 2 sites in United States
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Ulcerative Colitis
Study of the Safety and Tolerability of ALTH12 Versus Mesalamine Enema in Subjects With Left-Sided Ulcerative Colitis
This Phase I study will be a closely monitored trial of a small number of subjects to establish, preliminarily, the tolerability and safety of two ALTH12 enema formulations: ALTH12-1:4 and ALTH12-2:4.
- Trial name
- NCT01020708
- Testing
- mesalamine, ALTH12-1:4, ALTH12-2:4
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Altheus Therapeutics, Inc.
Periodontal Diseases, IBD
Periodontal Therapy on the Gut Microbiome of Inflammatory Bowel Disease
Periodontitis and inflammatory bowel disease have been associated by meta-epidemiologic evidence, although their mechanistic connection needs to be further explored.
- Conditions
- Periodontal Diseases, IBD, Dysbiosis, Inflammation
- Trial name
- NCT04790825
- Testing
- Full mouth scaling and root planing (FMSRP)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Turin, Italy
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