Clinical trials: Inflammatory Bowel Disease (IBD)
Inflammatory Bowel Diseases
Oral Versus Intravenous Iron in IBD Patients With Anti-inflammatory Therapy.
Rationale: Iron deficiency anemia is the most common systemic manifestation of Inflammatory Bowel Diseases (IBD)-Crohn's disease and ulcerative colitis.
- Trial name
- OVI-IBD (NCT05581420)
- Testing
- Ferrous fumarate, MonoFer
- Where
- Netherlands
- Volunteers
- 152 people
- Sponsor
- Leiden University Medical Center
Colitis, Ulcerative
To Evaluate Efficacy and Long-term Safety of Ozanimod in Japanese Subjects With Moderately to Severely Active Ulcerative Colitis
Japanese patients with moderate or severe active ulcerative colitis as a subject when ozanimod 0.46 mg or 0.92 mg is orally administered is evaluated about dose response, efficacy and safety with placebo as a control.
- Trial name
- NCT03915769
- Testing
- Ozanimod
- Where
- 67 sites in Japan
- Volunteers
- 198 people
- Sponsor
- Celgene
Intestinal Failure, Inflammatory Bowel Diseases
Changing the Future of Intestinal Failure in Intestinal Chronic Inflammation (INT-FAIL)
This is an interventional, prospective, no profit study that will be performed at CEMAD, from FONDAZIONE POLICLINICO GEMELLI IRCCS, Rome (UO1) and U.O.C.
- Conditions
- Intestinal Failure, Inflammatory Bowel Diseases, Crohn Disease
- Trial name
- INT-FAIL (NCT06777251)
- Testing
- analysis of predictive factors of IF in patients with Crohn's disease through the characterization of "multiomics" parameters
- Where
- Italy
- Volunteers
- 254 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
IBS, Ulcerative Colitis, Active
Visceral Sensitivity in IBD (Irritable Bowel Disease) and IBS (Irritable Bowel Syndrome)
Aim: More insight in pathogenesis of IBS and IBD. Samples are collected in context of an European research project.
- Conditions
- IBS, Ulcerative Colitis, Active, Ulcerative Colitis, Remission (3a: With IBS Symptoms, 3b: Without IBS Symptoms), Healthy Controls
- Trial name
- NCT02421705
- Testing
- Sample collection
- Where
- Belgium
- Volunteers
- 99,999,999 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Crohn Disease, Ulcerative Colitis
OptiMized REsistaNt Starch in Inflammatory Bowel Disease: The MEND Trial
The purpose of the study is to determine if a plant-based resistant starch that is optimized for the individual will target the underlying cause of inflammatory bowel disease and restore a "healthier" gut microbiome in pediatric…
- Conditions
- Crohn Disease, Ulcerative Colitis, Inflammatory Bowel Diseases
- Trial name
- NCT04520594
- Testing
- Resistant Starch
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Children's Hospital of Eastern Ontario
Ulcerative Colitis
HF2 Therapy in the Treatment of Active Ulcerative Colitis
This is a phase I-II study with the herbal formulation (HF2) for treatment of active ulcerative colitis This will be a two-stage study: Stage 1 will comprise an open label single arm exploratory study of 10 active ulcerative…
- Trial name
- NCT03720002
- Testing
- HF2
- Where
- 2 sites in Greece, Israel
- Volunteers
- 52 people
- Sponsor
- Sheba Medical Center
Ulcerative Colitis
A Study to Learn About the Safety, Effects and Pharmacokinetics of Study Medication (PF-07054894) for the Treatment of Ulcerative Colitis
This is a study to learn if the experimental medicine (called PF-07054894) is safe, effective, and how it is processed in adult people with ulcers in the colon.
- Trial name
- NCT05549323
- Testing
- PF-07054894
- Where
- 17 sites in United States, Germany and 1 more
- Volunteers
- 44 people
- Sponsor
- Pfizer
Crohn Disease, Fistula
An Open Label, Prospective, One Arm, Feasibility, Study for The Use of Halevy Kit for the Treatment of Perianal Fistulas in Patients With Crohn's Disease
Today, there is no available equipment specifically designed for the procedure of instillation of fibrin glue for the repair of perianal fistulae.
- Trial name
- NCT00653094
- Testing
- Halevy kit
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- ResQ Medical Ltd
Crohn's Disease
The Effect of Adalimumab on the Bone Microstructure in Crohn's Disease (CD) Patients
The investigators will study the effect of Adalimumab on the bone microstructure. Trial with medicinal product
- Trial name
- NCT01012570
- Testing
- Application of Adalimumab
- Where
- Switzerland
- Volunteers
- 34 people
- Sponsor
- Gerhard Rogler
Inflammatory Bowel Disease
A Randomized, Double-Blind, Placebo-Controlled, Ascending Single Dose Study of E6007 in Healthy Subjects
The purpose of this study is to evaluate the safety and tolerability of single oral ascending doses of E6007 in healthy subjects.
- Trial name
- NCT01221818
- Testing
- E6007
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
IBD - Inflammatory Bowel Disease
Investigating Chinese Herbal Medicine for Modulating Gut Microbiota in Treating Inflammatory Bowel Disease: Molecular Mechanisms and Clinical Study
The goal of this exploratory, single-arm intervention study is to evaluate whether Banxia Xiexin Decoction (BXD) can prevent colitis by modulating gut microbiota composition and regulating immune responses, including IgA…
- Trial name
- NCT07035613
- Testing
- BXD treatment
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Ulcerative Colitis
Serum Lactate and Ulcerative Colitis
Patients presenting with severe symptoms of ulcerative colitis (UC) require hospital admission for urgent assessment and therapy.
- Trial name
- NCT05876494
- Testing
- serum lactate
- Where
- Egypt
- Volunteers
- 137 people
- Sponsor
- Assiut University
Crohn Disease, Intestinal Tuberculosis
Validation of Scoring Systems for Differentiating Intestinal Tuberculosis from Crohn's Disease
Differentiating CD from intestinal tuberculosis (ITB) is difficult due to the low sensitivities of currently available diagnostic tests.
- Conditions
- Crohn Disease, Intestinal Tuberculosis, Differential Diagnosis
- Trial name
- NCT06629194
- Testing
- interferon gamma releasing assay (IGRA)
- Where
- 2 sites in Thailand
- Volunteers
- 84 people
- Sponsor
- Mahidol University
Ulcerative Colitis (UC)
A Study to Assess Adverse Events and Change in Disease Condition of Mesalamine Capsules in Children Aged 5 to 17 Years With Ulcerative Colitis
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) characterized by diffuse, continuous inflammation of the colon.
- Trial name
- NCT05316220
- Testing
- Mesalamine
- Where
- 10 sites in United States, Puerto Rico
- Sponsor
- AbbVie
IBD
Biofeedback in Pediatric Inflammatory Bowel Disease
This prospective, randomized, longitudinal, controlled project will occur in two phases. Phase 1 is the pre-diagnosis data collection for treatment-naïve participants who are referred for a diagnostic endoscopy/colonoscopy due to…
- Trial name
- NCT04269720
- Testing
- Biofeedback
- Sponsor
- Ross Maltz
Ulcerative Colitis
An Observational Prospective Long-term Exposure Registry of Adult Patients With Moderate-to-Severe Ulcerative Colitis
The purpose of this study is to describe the long-term safety risks in adult participants with moderate-to-severe ulcerative colitis who are treated with Simponi.
- Trial name
- OPAL (NCT02808780)
- Where
- 63 sites in United States, Austria and 7 more
- Volunteers
- 535 people
- Sponsor
- Janssen Biotech, Inc.
Crohn's Disease, Inflammatory Bowel Disease
A Comparison of Ultrasound Guided Transversus Abdominis Plane Nerve Block Techniques
Postoperative pain can pose significant challenges in the postoperative recovery of patients undergoing major colorectal surgery. Traditionally, opioids have played an important role in treating postoperative pain.
- Conditions
- Crohn's Disease, Inflammatory Bowel Disease, Postoperative Pain
- Trial name
- NCT02538679
- Testing
- US TAP Bupivacaine/Epinephrine, Lap TAP Bupivacaine/Epinephrine
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Ulcerative Colitis
The Effects of Moxibustion on Ulcerative Colitis
To investigate the mechanism and effects of moxibustion on patients with ulcerative colitis.
- Trial name
- NCT02931162
- Testing
- Herb-partitioned moxibustion
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Crohn Disease
Telephone-based Motivational Interviewing for Smoking Cessation in Crohn's Disease Patients
Quitting smoking unequivocally improves the course of Crohn's disease (EC), and therefore, it should be one of the main therapeutic targets in the treatment of this disease.
- Trial name
- NCT04225403
- Testing
- Telephone-based motivational interviewing for smoking cessation
- Volunteers
- 144 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Crohn's Disease
Efficacy Study of Targeted, Local Delivery of Drugs to Treat Crohn's Disease
The study is being undertaken to evaluate whether delayed-release medications, designed to begin to open in the lower intestinal tract, the main site of Crohn's Disease, are more effective than standard systemically delivered…
- Trial name
- NCT00287170
- Testing
- Delayed Release 6MP or Calcitriol vs. Purinethol
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Teva GTC
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