Clinical trials: Inflammatory Bowel Disease (IBD)
Inflammatory Bowel Diseases
Use of Mesenchymal Stem Cells in Inflammatory Bowel Disease
Scientists hypothesize that directly or parentally injecting Mesenchymal stem cells (MSCs) to affected areas will have a positive impact through reducing or abolishing intestinal inflammation in part via inhibition of neutrophil…
- Trial name
- NCT03299413
- Testing
- Wharton Jelly Mesenchymal stem cells
- Where
- Jordan
- Volunteers
- 20 people
- Sponsor
- Hanan Jafar
Rheumatologic Disorder, Inflammatory Bowel Diseases
Flu Vaccine Response in Patients on Biologic Therapies
This proposed study will assess the immunogenicity, safety, and clinical efficacy of an influenza vaccine booster dose strategy in patients with autoimmune diseases who are receiving immunosuppressive therapies.
- Conditions
- Rheumatologic Disorder, Inflammatory Bowel Diseases, Immune Complex Diseases
- Trial name
- NCT03277703
- Testing
- Influenza vaccine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stony Brook University
Inflammatory Bowel Disease (IBD), Medication Compliance
Telehealth Monitoring in Inflammatory Bowel Disease: Effects on Medication Compliance, Self-Efficacy, and Quality of Life
This randomized controlled trial aims to evaluate the effect of nurse-led telehealth monitoring on medication adherence, self-efficacy, and quality of life in individuals with inflammatory bowel disease (IBD).
- Conditions
- Inflammatory Bowel Disease (IBD), Medication Compliance, Quality of Life, Telehealth Monitoring
- Trial name
- NCT06971627
- Testing
- Nurse-led Telehealth Monitoring Program, No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul University - Cerrahpasa
Oral Health in Children With Inflammatory Bowel Disease
Oral Health in Children With Inflammatory Bowel Disease
In adults with inflammatory bowel disease (IBD), a higher prevalence of dental caries and periodontal disease has been reported compared with healthy control subjects, but similar data on children are missing in the literature.We…
- Trial name
- NCT05538923
- Testing
- No intervention was given to the patients
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Marmara University
Crohn Disease, Vitamin D Deficiency
Effects of Supplementation of Vitamin D in Patients With Crohn's Disease
Thus, the aim of the current study is to assess the influence of vitamin D deficiency and, consequently, of serum calcium deficiency in the body composition, muscular activity, bone mineral density, fatigue, and exercise…
- Conditions
- Crohn Disease, Vitamin D Deficiency, Fatigue, Sarcopenia
- Trial name
- NCT02704624
- Testing
- Vitamin D
- Where
- Brazil
- Volunteers
- 110 people
- Sponsor
- Federal University of Juiz de Fora
Healthy Subjects
Phase I Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of OSE-127 in Healthy Subjects
This study is a first-in-human phase I randomised, double-blind, placebo-controlled, evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Single (IV and SC) and Multiple (IV only)…
- Trial name
- NCT03980080
- Testing
- OSE-127
- Where
- Belgium
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- OSE Immunotherapeutics
Inflammatory Bowel Diseases
A Prospective Study of the Effect of Modified Colonoscopy Bowel Preparation Program on Intestinal Cleaning, Examination and Disease in Patients With Inflammatory Bowel Disease
The purpose of this study is to investigate the effect of modified colonoscopy bowel preparation method compared with traditional method on bowel cleansing effect, colonoscopy examination effect and clinical condition of…
- Trial name
- NCT05485103
- Testing
- Polyethylene Glycols
- Where
- 9 sites in China
- Volunteers
- 144 people
- Sponsor
- Peking Union Medical College Hospital
Colonoscopy: Bowel Preparation, IBD - Inflammatory Bowel Disease
Pre-Packaged Low-Residue Diet Assisting Bowel Preparation in Patients With Inflammatory Bowel Disease
The primary objectives of this study are as follows: 1.To evaluate the efficacy of Maifu Changqing® Complete Nutritional Formula Powder in bowel preparation for colonoscopy among inflammatory bowel disease (IBD) patients;2.To…
- Trial name
- NCT07165470
- Testing
- pre-packaged low-residue diet for bowel preparation
- Where
- 2 sites in China
- Volunteers
- 500 people
- Sponsor
- Changhai Hospital
Crohn Disease, Ulcerative Colitis
Digital Nutrition Therapy for Patients With IBD
Background: Alberta's Center of Excellence for Nutrition in Digestive Diseases (Ascend) is dedicated to generating new discoveries regarding the link between nutrition and digestive diseases and mobilizing existing research to…
- Trial name
- LYFEMD (NCT04653259)
- Testing
- LYFE MD app
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University of Calgary
Crohn Disease
Post-Marketing Surveillance for Crohn's Disease Participants Treated With Stelara (Ustekinumab)
The purpose of post-marketing surveillance (PMS) is to assess the safety and effectiveness of ustekinumab (Stelara) for Crohn's disease participants under real world clinical practice.
- Trial name
- STELARA CD PMS (NCT03942120)
- Testing
- Ustekinumab
- Where
- 43 sites in South Korea
- Volunteers
- 685 people
- Sponsor
- Janssen Korea, Ltd., Korea
Crohn Disease (CD)
Impact of Ultra-Processed Food Reduction on Remission Duration in Pediatric Crohn's Disease
Crohn's disease is a chronic inflammatory bowel disease. This study will investigate whether reducing the intake of ultra-processed foods through regular consultations with a registered dietitian can help children and adolescents…
- Trial name
- Up4-CD (NCT07884045)
- Testing
- Ultra-Processed Food Reduction Counseling, Standard Dietary Counseling
- Where
- 2 sites in Czechia
- Volunteers
- 124 people
- Sponsor
- University Hospital, Motol
Inflammatory Bowel Disease
Telomere Repair Gene Mutation in Inflammatory Bowel Disease
This study will evaluate and compare the genes of the telomere repair complex in healthy control subjects, patients with blood diseases, and patients with inflammatory bowel disease to identify what, if any, changes are…
- Trial name
- NCT00353639
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Crohn's Fistula
Darvadstrocel for Crohn's Fistula in the Realworld
Background Perianal fistula may affect 15-50% of patients with Crohn's disease (CD). Treatment is complex, requiring a multidisciplinary approach.
- Trial name
- NCT05742100
- Testing
- Darvadstrocel
- Where
- Spain
- Volunteers
- 73 people
- Sponsor
- Dolores Herreros Marcos
Inflammatory Bowel Diseases
The Fecal Microbiota Transplantation Registry
The human intestinal microbiota is composed of complex community of 10*13 to 10*14 commensal microorganisms[1]. Human intestine provides a nutrient-rich habitat for intestinal microorganism which allows a diverse ecosystem to…
- Trial name
- NCT03787771
- Where
- Hong Kong
- Volunteers
- 3,000 people
- Sponsor
- Chinese University of Hong Kong
Inflammatory Bowel Diseases, Crohn Disease
Fertility and Pregnancy After Surgery IBD Audit
Crohn's disease and Ulcerative colitis are chronic disease that are usually diagnosed at young age. The diseases and the associated treatment can impact on patient's sexual function, fertility, pregnancy, and delivery.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Fertility Disorders
- Trial name
- Fertile-IBD (NCT04663971)
- Testing
- Any surgery, Any medical treatment
- Where
- 4 sites in Italy
- Volunteers
- 500 people
- Sponsor
- University of Campania Luigi Vanvitelli
Ulcerative Colitis
PillCam Colon Capsule Endoscopy for Ulcerative Colitis
Pillcam colon capsule (PCC) endoscopy is a novel strategy tool to inspect colon mucosa. The aim of the present study is to evaluate if PCC endoscopy is able to precisely investigate patients with ulcerative colitis and reach high…
- Trial name
- NCT01467609
- Volunteers
- 20 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Ulcerative Colitis
Tofacitinib Versus Cyclosporine for Steroid Refractory Acute Severe Ulcerative Colitis
This randomised trial plans to compare oral tofacitinib with intravenous cyclosporine in patients with acute severe ulcerative colitis who have failed to respond to intravenous steroids
- Trial name
- TOCASU (NCT05112263)
- Testing
- Tofacitinib, Cyclosporine
- Volunteers
- 96 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
CROHN'S DISEASE
Hematopoietic Stem Cell Support in Patients With Severe Crohn's Disease
This disease is believed to be caused by immune cells (called lymphocytes) attacking tissue. Risk of death is highest in people with active acute disease.
- Trial name
- NCT00278577
- Testing
- Immune Ablation and Hematopoietic Stem Cell Support
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Richard Burt, MD
Ulcerative Colitis (UC), Crohn Disease (CD)
INSIGHT-IBD Pragmatic Study
The goal of this study is to evaluate the real-world effectiveness of treatments for inflammatory bowel disease (IBD) within routine clinical practice.
- Trial name
- NCT07686757
- Testing
- Mirikizumab, Anti-TNF agents, anti-integrin antibodies
- Where
- 13 sites in United States
- Volunteers
- 400 people
- Sponsor
- Specialty Networks Research.
Crohn Disease (CD), Crohn Disease of Ileum
Laparoscopic Right Hemicolectomy for Crohn's Disease of the Terminal Ileum Utilizing the Mesenteric Excision and Exclusion
This study is designed for patients requiring surgery for Crohn's disease of the terminal ileum. A combination of laparoscopic segmental right colectomy with extended mesenteric excision and the Kono-s anastomosis will be…
- Conditions
- Crohn Disease (CD), Crohn Disease of Ileum, Kono S Anastomosis, Extended Mesenteric Excision
- Trial name
- NCT07231601
- Testing
- Mesenteric excision and exclusion
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tzaneio General Hospital
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