Clinical trials: Inflammatory Bowel Disease 1
Inflammatory Bowel Diseases, Crohn Disease
A Novel Remote Patient and Medication Monitoring Solution to Improve Adherence and PerSiStence With IBD Therapy
The investigators hypothesize that use of a remote monitoring digital health system that supports medication taking and monitoring of symptoms will improve adherence, clinical outcomes, and decrease healthcare utilization…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- ASSIST (NCT05316584)
- Testing
- Remote monitoring
- Where
- 5 sites in United States
- Volunteers
- 123 people
- Sponsor
- University of Maryland, Baltimore
Supplementation, Bone Health
The Effect of Vitamin K Supplementation on Bone Health in Adult Crohn's Disease Patients
To assess the impact of a 12 month vitamin K supplementation intervention on bone health in adult Crohn's disease patients
- Conditions
- Supplementation, Bone Health, Crohn's Disease
- Trial name
- NCT01235325
- Testing
- phylloquinone (vitamin K1)
- Where
- Ireland
- Volunteers
- 70 people
- Sponsor
- University College Cork
Crohn Disease, Ulcerative Colitis
A Study of the Real-world Use of an Adalimumab Biosimilar and Evaluation of Nutritional Status on the Therapeutic Response
The aim of the study is to describe the real-world profile of patients treated with adalimumab FK in gastroenterology, dermatology or rheumatology in order to evaluate in this population the predictive factors of therapeutic…
- Conditions
- Crohn Disease, Ulcerative Colitis, Psoriasis, Ankylosing Spondylitis
- Trial name
- OPALE (NCT05051943)
- Where
- France
- Volunteers
- 754 people
- Sponsor
- Fresenius Kabi
Bowel Sounds, Intestinal Inflammation
Bowel Sounds Analysis in Paediatric Inflammatory Bowel Disease: Relationship With wPCDAI
The precise and noninvasive evaluation of disease activity among patients with Crohn's disease is not easy, especially for children. It deals with clinical, biological, histological and radiological parameters.
- Conditions
- Bowel Sounds, Intestinal Inflammation, Crohn Disease
- Trial name
- SONO-MICI (NCT05955963)
- Testing
- Abdominal auscultation
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Crohn's Ileocolitis
Safety Study of P28GST Treatment in Crohn's Disease Patients
This multicenter phase 2 clinical trial is designed to assess safety of P28GST (protein 28 Kd glutathion S Transferrase), aiming to control inflammation in moderate Crohn's Disease (CD), before or after intestinal resection…
- Trial name
- ACROHNEM (NCT02281916)
- Testing
- P28GST
- Where
- 5 sites in France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Lille
Colitis, Ulcerative, Crohn's Disease
OTIS Vedolizumab Pregnancy Exposure Registry
The purpose of this study is to assess the prevalence of major structural birth defects in infants of female participants with ulcerative colitis (UC) or Crohn's disease (CD) exposed to vedolizumab during pregnancy, compared to…
- Trial name
- NCT02678052
- Testing
- Vedolizumab, Other Biological Agent
- Where
- United States
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- Takeda
GVHD,Acute, Ulcerative Colitis
Analysis of Intestinal Defensin Expression in Acute GVHD
This study has the aim to analyze intestinal expression of endogenous antimicrobial peptides in patients with acute GVHD. The expression will be compared to intestinal expression of defensins in patients with colitis and patients…
- Conditions
- GVHD,Acute, Ulcerative Colitis, Morbus Crohn
- Trial name
- NCT04522843
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University of Freiburg
Crohn Disease
Value of Pharmacokinetic Assays in the Prediction of Induction and Maintenance Therapeutic Response in Crohn's Disease
Vedolizumab (VDZ) is a monoclonal antibody which has shown its efficacy in Crohn's disease by inducing and maintaining clinical response/remission.
- Trial name
- VEDO-PREDIRESP (NCT02768532)
- Testing
- Vedolizumab
- Where
- 5 sites in France
- Volunteers
- 47 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Crohn Disease
Effect of the Exclusive Enteral Nutrition Combined With Azathioprine for Remission of Crohn's Diseases After Surgery
for some patients with Crohn's diseases undergoing surgery，whether exclusive enteral nutrition(EEN) could delay the disease relapse needs exploration.The trial will study whether the efficacy of postoperative EEN could help…
- Trial name
- NCT04160325
- Testing
- postoperative 3-month exclusive enteral nutrition, azathioprine, normal diet
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Zhu Weiming
Inflammatory Bowel Diseases (IBD)
BCMA-CD19 cCAR T for the Treatment of Refractory Inflammatory Bowel Disease (IBD)
This is a Phase I, IIa, Single-Arm, interventional, open label, treatment study to evaluate the safety and tolerability of ICG318 CAR-T (BCMA-CD19-IL-15/IL15sushi cCAR T cells) in patients with relapsed and/or refractory…
- Trial name
- NCT07544160
- Testing
- ICG318, BCMA-CD19-IL-15/IL-15 sushi Compound CAR T
- Where
- China
- Volunteers
- 18 people
- Sponsor
- iCell Gene Therapeutics
Crohn Disease, Perianal Crohn Disease
A Prospective Longitudinal Study of Fecal Microbiome and Calprotectin to Predict Response to Biological Therapy in Patients With CD
Crohn's disease (CD) is a chronic relapsing-remitting systemic inflammatory disease, affecting any part of the gastrointestinal tract.
- Trial name
- NCT03994224
- Where
- Hong Kong
- Volunteers
- 13 people
- Sponsor
- Chinese University of Hong Kong
Crohn Disease
Non-invasive Vagus Nerve Stimulation in the Treatment of Crohn's Disease - A Pilot Study
To assess the safety and efficacy of transcutaneous vagal stimulation in adult patients with active Crohn's disease.
- Trial name
- VNS (NCT05165108)
- Testing
- Vagal Nerve Stimulator
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Indiana University
Crohn Disease (CD)
WAter Preparation in Crohn's Disease's Imagery
The goal of this clinical trial is to compare distension quality and patient experience of water and polyethylene glycol preparation as oral contrast media in Magnetic Resonance Enterography (MRE) in patients with Crohn's…
- Trial name
- WAM (NCT06690632)
- Testing
- water preparation, polyethylene glycol preparation
- Where
- France
- Volunteers
- 194 people
- Sponsor
- University Hospital, Toulouse
Crohn's Disease, Upadacitinib
IUS Predicts Upadacitinib Efficacy in Patients With Moderate to Severe Crohn's Disease：a Prospective Study
Crohn's disease (CD) is a chronic nonspecific inflammatory disease of the intestinal tract whose etiology is not yet fully understood, and can present with serious complications such as intestinal obstruction, perforation…
- Conditions
- Crohn's Disease, Upadacitinib, Intestinal Ultrasound, Predictors
- Trial name
- NCT06573944
- Where
- China
- Volunteers
- 34 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Inflammatory Bowel Diseases, Crohn Disease
Social Determinants of Health, Medication Use, and Quality of Life in Inflammatory Bowel Disease
Optimizing health related-quality of life (HRQoL) for patients with inflammatory bowel disease (IBD), who often experience a relapsing disease course, is an essential component of care.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT06266663
- Testing
- Survey
- Where
- 2 sites in United States
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Crohn's Disease
Effectiveness and Safety in Patients With Crohn´s Disease in Clinical Routine
The purpose of this study was intended to evaluate the long-term safety and effectiveness of adalimumab in participants with Crohn's disease (CD) who are treated as recommended in the product label.
- Trial name
- NCT01083680
- Volunteers
- 4,107 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Crohn's Disease
Imuran Dosing in Crohn's Disease Study
This study will compare two different dosing methods of azathioprine (IMURAN) in participants with Crohn's disease who are currently taking steroids (e.g. prednisone or budesonide)or who have just started steroids.
- Trial name
- NCT00113503
- Testing
- Azathioprine weight-based dose, Azathioprine individualised dose
- Where
- 15 sites in United States, Canada
- Volunteers
- 50 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Intestinal Disorder, Inflammatory Bowel Diseases
Effect of Acupuncture on Mild to Moderate Active Crohn's Disease
To observe the clinical effect of acupuncture on Crohn's disease (CD) and its influence on brain function activity and the TRY-KYN metabolism level, and to screen the brain image markers of acupuncture on CD
- Conditions
- Intestinal Disorder, Inflammatory Bowel Diseases, Crohn Disease
- Trial name
- NCT04187820
- Testing
- acupuncture
- Where
- 2 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Crohn's Disease
STA-5326 in Crohn's Disease Patients
The purpose of this study is to determine the safety and tolerability of STA-5326 given once daily or twice daily to Crohn's Disease patients with moderate disease.
- Trial name
- NCT00088062
- Testing
- STA-5326
- Where
- 18 sites in United States
- Volunteers
- 48 people
- Sponsor
- Synta Pharmaceuticals Corp.
Crohn Disease, Ano Fistula
Study of the 12-month Efficacy of Stem Cell Injection in Crohn's Disease With Complex Ano-perineal Fistula
Ano-perineal (or ano-rectal) fistulas are a frequent and major complication of Crohn's disease. Indeed, they indicate a greater severity of the disease. In addition, they have a major impact on the quality of life of patients.
- Trial name
- ECESMAC (NCT05177003)
- Where
- 2 sites in France
- Volunteers
- 27 people
- Sponsor
- Fondation Hôpital Saint-Joseph