Clinical trials: Inflammatory Bowel Disease 1
Inflammatory Bowel Disease
Inflammatory Bowel Disease (IBD) and Covid-19 Infection
Most of the inflammatory bowel disease (IBD: Crohn's disease and ulcerative colitis) in a tertiary expert Centre are on immunosuppressive and/or biological therapy.
- Trial name
- MICI-Covid-19 (NCT04492267)
- Where
- France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Strasbourg, France
Colonic Diseases, Rectal Diseases
Random Comparison of LigaSure and Disposable Staples for Laparoscopic Surgery
The purpose of this research is to compare two different standard of care surgical methods for the following large bowel (colon) procedures: laparoscopic right colectomy, total colectomy, and left colectomy.
- Trial name
- NCT00487409
- Testing
- Bipolar electrosurgical generator and instruments, Disposable stapling instruments
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University Hospitals Cleveland Medical Center
Inflammatory Bowel Disease, Uterine Cervical Dysplasia
Immune Response to the Human Papillomavirus Vaccine in Young Women With Inflammatory Bowel Disease
The Gardasil vaccine, a vaccine targeted towards the human papillomavirus (HPV), has been shown to prevent the transmission of several strains of HPV in young women.
- Trial name
- NCT01034358
- Testing
- Human Papillomavirus Vaccine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
Fibrostenotic Crohn´s Disease
A Study to Test Whether Spesolimab Helps People With Crohn's Disease Who Have Symptoms of Bowel Obstruction
This study is open to adults, between 18 and 75 years of age, who have narrowings in the small bowel (strictures) due to Crohn's disease. Strictures can lead to bowel obstruction (blockage).
- Trial name
- NCT05013385
- Testing
- Spesolimab
- Where
- 4 sites in United States, Canada and 2 more
- Volunteers
- 5 people
- Sponsor
- Boehringer Ingelheim
Crohn's Disease, IBD
Precision Crohn's Disease Management Utilizing Predictive Protein Panels (ENvISION)
Crohn's disease and ulcerative colitis affect about 1.6 to 3 million people in the United States with many of those being young children and adolescents.
- Trial name
- ENvISION (NCT04131504)
- Testing
- Infliximab, Adalimumab
- Where
- 4 sites in United States
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Inflammatory Bowel Diseases
IBDoc® Canadian User Performance Evaluation
The objective of the IBDoc® user performance evaluation is to demonstrate the ease-of-use of the IBDoc® calprotectin home test to allow patients with inflammatory bowel disease (IBD) to independently and correctly determine…
- Trial name
- NCT03408249
- Testing
- IBDoc calprotectin test, questionnaire
- Where
- 3 sites in Canada
- Volunteers
- 61 people
- Sponsor
- Bühlmann Laboratories AG
Psoriasis, Pregnancy
Stelara and Tremfya Pregnancy Exposure Registry OTIS Autoimmune Diseases in Pregnancy Project
The purpose of the OTIS Autoimmune Diseases in Pregnancy Study is to monitor planned and unplanned pregnancies exposed to certain medications, to evaluate the possible teratogenic effect of these medications and to follow live…
- Conditions
- Psoriasis, Pregnancy, Psoriatic Arthritis, Crohn Disease
- Trial name
- NCT02103361
- Testing
- Ustekinumab, Guselkumab
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of California, San Diego
Perianal Fistula, Crohn Disease
Treatment of Perianal Disease Using Adipose-derived Stem Cells
This study will compare healing and surgical outcomes in patients with chronic perianal disease treated with Adipose-derived Stem Cells (ASCs) to outcomes in patients treated in traditional surgical techniques without ASCs.
- Trial name
- NCT03913572
- Testing
- Injection of adipose-derived stem cells into perianal fistula
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of California, San Diego
Inflammatory Bowel Diseases, Crohn Disease
Effect of Incentive Integrated E-IBD Chronic Disease Management Model on the Quality of Life in IBD Patients
This study aims to prospectively explore the effect of incentive-integrated E-IBD (electronic inflammatory bowel disease) chronic disease management model on the improvement of IBD quality of life, and provide a more effective…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT05719766
- Testing
- education ,psycological support and social support
- Where
- 4 sites in China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Crohn Disease, Inflammatory Bowel Diseases
Study of ExoFlo for the Treatment of Medically Refractory Crohn's Disease
Protocol Summary Title: A Phase I study of ExoFlo, an ex vivo culture-expanded adult allogeneic bone marrow mesenchymal stem cell derived extracellular vesicle isolate product, for the treatment of medically refractory Crohn's…
- Trial name
- NCT05130983
- Testing
- ExoFlo
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Direct Biologics, LLC
Cytomegalovirus Infections, Inflammatory Bowel Diseases
MICI-CMV:Valganciclovir in Recurrent Bouts of Cryptogenic Inflammatory Bowel Diseases With an Infection by Cytomegalovirus
The main objective of this study is to demonstrate the relevance of Valganciclovir on recurrent bouts of cryptogenic inflammatory bowel diseases with infection by cytomegalovirus (CMV).
- Trial name
- NCT00237653
- Testing
- Valganciclovir
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Crohn Disease, Colitis, Ulcerative
Home basEd faecaL calProtectin Measurements Predicting Adalimumab Induction Destiny
Recently a smartphone application IBDoc® was developed to enable patients to measure faecal calprotectin at home in an easy way.
- Trial name
- HELP-AID (NCT02634060)
- Testing
- Home Based Fecal Calprotectin
- Where
- Belgium
- Volunteers
- 140 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Crohn Disease, Ulcerative Colitis
Clinical Study of Targeting CD7 CAR-T Cells in the Treatment of Autoimmune Diseases
A Clinical Study on the Safety and Effectiveness of Targeting CD7 Chimeric Antigen Receptor T Cells in the Treatment of Autoimmune Diseases
- Conditions
- Crohn Disease, Ulcerative Colitis, Dermatomyositis, Still Disease
- Trial name
- NCT05239702
- Testing
- CD7 CAR T-cells
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Zhejiang University
Chronic Pancreatitis, Inflammatory Bowel Diseases
Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study
This is a prospective, descriptive, observational research study designed to observe and document the clinical practice by domain experts, and how the knowledge of new findings that are published in the medical literature affect…
- Conditions
- Chronic Pancreatitis, Inflammatory Bowel Diseases, Hepatitis, NASH - Nonalcoholic Steatohepatitis
- Trial name
- GREAT1 (NCT04306939)
- Testing
- venipuncture, Questionnaires, Additional Sample Collections
- Where
- United States
- Volunteers
- 120,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Crohn Disease, Inflammatory Bowel Diseases
Investigation of VAP-1 Expression and Tissue Blood Flow by PET-MRI in Patients With Crohn's Disease
This is an observational, single center, imaging study. The CD patients with active disease will be assessed by [68Ga]Ga-DOTA-Siglec-9 and [15O]H2O PET/MRE.
- Conditions
- Crohn Disease, Inflammatory Bowel Diseases, Crohn Disease of Small Intestine, Crohn Colitis
- Trial name
- VAP-PET (NCT06555042)
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Turku University Hospital
Crohn's Disease (CD), Ulcerative Colitis (UC)
Supplementation of Vitamin D3 in Patients With Inflammatory Bowel Diseases and Hypovitaminosis D
This study aims to evaluate the effect of vitamin D3 supplementation on disease activity and quality of life in IBD patients deficient in vitamin D, and also help determine the optimal dose of vitamin D3 for them.
- Trial name
- NCT01877577
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Crohn Disease in Remission, Crohn Disease
Lengthening Adalimumab Dosing Interval in Quiescent Crohn's Disease Patients
Crohn's disease is a chronic inflammatory bowel disease. This disease can be treated with, among other things, biologicals such as adalimumab.
- Trial name
- LADI (NCT03172377)
- Testing
- Lengthening adalimumab dosing interval
- Where
- 22 sites in Netherlands
- Volunteers
- 174 people
- Sponsor
- Radboud University Medical Center
Crohn Disease (CD)
R-3750 in Patients With Crohn's Disease
This is a multicenter, randomized, double-blind, placebo-controlled study evaluating the safety, tolerability, clinical activity, and pharmacodynamic effects of R-3750 in adults with active Crohn's disease.
- Trial name
- NCT07791888
- Testing
- R-3750
- Volunteers
- 40 people
- Sponsor
- Rise Therapeutics LLC
Inflammatory Bowel Diseases, Quality of Life
Effect of Probiotic Administration on Patients With Inflammatory Bowel Disease
The study is a single-center, randomized, single-blinded, controlled trial conducted at ZHUMC's endoscopy unit. It aims to assess the short-term effects of probiotic administration on disease course, quality of life, and…
- Conditions
- Inflammatory Bowel Diseases, Quality of Life, Food Intolerance, Flare Up
- Trial name
- NCT06392061
- Testing
- Trilac
- Where
- Lebanon
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lebanese University
Inflammatory Bowel Diseases
Correlation Between RISANKIZUMAB's Trough Levels, Clinical and Biological Remission in Moderate to Severe Crohn's Disease: a Retrospective Multicentric Study
The goal of this observational study is to determine if, as with other therapeutics such as anti-TNF, trough levels of Risankizumab are correlated with clinical and biological remission in patients with moderate to severe Crohn's…
- Trial name
- RISE-CD (NCT06589895)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
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