Clinical trials: Inflammatory Bowel Disease 1
Crohn's Disease
Study to Assess Efficacy and Safety of Cx601, Adult Allogeneic Expanded Adipose-derived Stem Cells (eASC) for the Treatment of Complex Perianal Fistula(s) in Participants With Crohn's Disease (CD)
The purpose of this study is to evaluate the combined remission of complex perianal fistulas, defined as the clinical assessment at Week 24 of closure of all treated external openings that were draining at baseline despite gentle…
- Trial name
- ADMIRE-CD-II (NCT03279081)
- Testing
- Cx601
- Where
- 159 sites in United States, Belgium and 13 more
- Volunteers
- 568 people
- Sponsor
- Tigenix S.A.U.
Crohn Disease
Efficacy (Induction of Response/Remission) and Safety Study in Patients With Moderate to Severe Crohn's Disease
The purpose of this study is to evaluate if Leukine can induce clinical response or remission in patients with Crohn's disease.
- Trial name
- NCT00295165
- Testing
- Sargramostim (Leukine)
- Where
- 111 sites in United States, Australia and 9 more
- Volunteers
- 33 people
- Sponsor
- Genzyme, a Sanofi Company
Crohn Disease
Specific Dietary Pattern for Crohn's Disease Patients Following Surgery
Over the past 10 years, there are a large number of dietary treatments related to the CD, such as specific carbohydrate diet, low Fermentable Oligo-, Di-, Mono-saccharides And Polyols (FODMAP) diet, and allergen-free foods.
- Trial name
- NCT05502965
- Testing
- dietary pattern, EEN
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Crohn's Disease, Active
Partial Enteral Nutrition as Therapeutic Augmentation of Advanced Pharmacological Therapy in Patients With Active Crohn's Disease
This is a multicenter non-randomized prospective open label trial of partial enteral nutrition (PEN) among patients with active Crohn's disease (CD) starting standard of care advanced therapy.
- Trial name
- PANDORA (NCT07356232)
- Testing
- Partial enteral nutrition - orally consumed formula
- Where
- 5 sites in United States
- Volunteers
- 80 people
- Sponsor
- James Lewis
Crohn Disease
Effectiveness of Vedolizumab in CD Patients Naïve to Anti-TNF
Anti-cytokine antibodies, such as Infliximab (an anti TNF alfa chimeric antibody) and Adalimumab (an anti TNF alfa humanize antibody), have been developed and used in clinical practice for the treatment of patients with Crohn…
- Trial name
- NCT02820493
- Testing
- vedolizumab
- Sponsor
- Universita degli Studi di Genova
Crohn's Disease, Ulcerative Colitis
A Study Evaluating the Impact of an Educational Program (EDU-MICI) on Patients With Inflammatory Bowel Disease
This study has the objective to demonstrate that an education program could have a significant impact on Inflammatory Bowel Disease (IBD) patient's skills with regards to their disease.
- Trial name
- ECIPE (NCT02550158)
- Testing
- Educational program EDU-MICI
- Where
- 18 sites in France
- Volunteers
- 263 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
CD - Crohn's Disease
Comparison of the Therapeutic Effects of Balloon Assisted Enteroscopy Assisted Narrow Incision and Balloon Dilation in the Treatment of Crohn's Disease Small Intestinal Stenosis
This study is designed as a controlled trial to evaluate the efficacy of balloon-assisted enteroscopy-guided radial incision therapy for the treatment of stricturing small bowel Crohn's disease.
- Trial name
- CD stenosis (NCT07409376)
- Testing
- stricture incision, balloon dilation, No Interventions
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ulcerative Colitis, Crohn's Disease
Vedolizumab IV in Pediatric Participants With Ulcerative Colitis (UC) or Crohn's Disease (CD)
The purpose of this study is to evaluate vedolizumab pharmacokinetics (PK), safety and tolerability in pediatric participants with moderately to severely active UC or CD.
- Trial name
- NCT03138655
- Testing
- Vedolizumab
- Where
- 88 sites in United States, Belgium and 9 more
- Volunteers
- 89 people
- Sponsor
- Takeda
Crohn's Disease
Observational Study Evaluating the Effectiveness of Drug Concentration to Predict the Recapture of Response in Crohn's Disease Patients With Loss of Response ( PRADA )
This is a multi-center study that explores the relationship between recapture of response with escalation to weekly adalimumab and trough adalimumab concentration before escalation in patients experiencing lack of response (LOR).
- Trial name
- PRADA (NCT02896985)
- Where
- 24 sites in Canada
- Volunteers
- 98 people
- Sponsor
- AbbVie
Crohn's Disease
Real-World Study of IL-23 Inhibitors in Active Crohn's Disease
The goal of this observational study is to learn about the effectiveness and safety of IL-23 inhibitors in adults with active Crohn's disease in real-world clinical practice.
- Trial name
- NCT07545317
- Testing
- IL-23 inhibitor, TNF inhibitors
- Where
- China
- Volunteers
- 665 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Inflammatory Bowel Diseases, Dysplasia Colon
OPtical Diagnosis Training to Improve Dysplasia Characterisation in IBD
People with inflammatory bowel diseases (IBD) can be at higher risk of developing abnormal areas in their bowel. These abnormal areas can be due to active inflammation, healed inflammation, polyps or pre-cancerous changes…
- Conditions
- Inflammatory Bowel Diseases, Dysplasia Colon, Dysplasia, Crohn Disease-Associated, Polyp of Colon
- Trial name
- OPTIC-IBD (NCT04924543)
- Testing
- Online self-learning training module, Refresher training
- Where
- 5 sites in Canada, Italy and 1 more
- Volunteers
- 182 people
- Sponsor
- University of Birmingham
Moderately to Severely Active Crohn's Disease, Crohn Disease
VECTORS - A Study to Evaluate Transmural Healing as a Treatment Target in Crohn's Disease
Transmural healing (TMH) is recognized as a potentially important measure of Crohn's disease (CD) activity but not a formal target. Observational studies suggest that TMH may be associated with better long-term outcomes.
- Conditions
- Moderately to Severely Active Crohn's Disease, Crohn Disease, Disease Crohn
- Trial name
- VECTORS (NCT06257706)
- Testing
- Vedolizumab
- Where
- 69 sites in United States, Australia and 11 more
- Volunteers
- 304 people
- Sponsor
- Alimentiv Inc.
Crohn's Disease
Prospective Evaluation of a Scoring System in Patients Newly Diagnosed With Crohn's Disease
The purpose of this study is to prospectively evaluate a scoring system to predict a mild course of disease in patients newly diagnosed with Crohn's disease.
- Trial name
- PROGNOS (NCT02193048)
- Testing
- This study will evaluate a new clinical scoring system in patients receiving routine treatment
- Where
- Germany
- Volunteers
- 216 people
- Sponsor
- Ferring Pharmaceuticals
Inflammatory Bowel Diseases, Colon Dysplasia
High Definition Colonoscopy (HDC) vs. Dye Spraying Chromo-colonoscopy (DSC) in Screening Patients With Long-standing Inflammatory Bowel Disease (IBD)
Inflammatory Bowel Disease (IBD) involving the colon is a known risk for colon cancer. There are two standards-of-care colonoscopy techniques used for screening all patients who suffer from IBD for more than eight years.
- Conditions
- Inflammatory Bowel Diseases, Colon Dysplasia, Ulcerative Colitis, Crohn Colitis
- Trial name
- NCT04191655
- Testing
- High Definition Colonoscopy, Dye Spraying Chromocolonoscopy
- Where
- 2 sites in United States
- Volunteers
- 211 people
- Sponsor
- Beth Israel Deaconess Medical Center
Ulcerative Colitis (UC), IBD (Inflammatory Bowel Disease)
Ex Vivo Comparison Of Combination Versus Single Therapeutic Pathway Inhibition In Human Intestinal Mucosa From Patients With Inflammatory Bowel Disease
The purpose of this study is to evaluate whether simultaneously targeting three inflammatory pathways (TL1A, IL-23, and α4β7) produces a stronger anti-inflammatory effect in intestinal tissue from patients with Inflammatory Bowel…
- Conditions
- Ulcerative Colitis (UC), IBD (Inflammatory Bowel Disease), Crohn Disease (CD)
- Trial name
- NCT07824726
- Testing
- Collection of 8 additional intestinal mucosal biopsies during standard-of-care endoscopy for subsequent ex vivo testing, Collection of an additional 2 mL blood sample
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- PhoenixLAB srls
Crohn Disease
An Innovative Treatment for Fistula-in-ano in Crohn Disease : Local Micro Reinjection of Autologous Fat and SVF
Crohn's disease is a chronic inflammation of all or part of the digestive tract, " from the mouth to the anus ". . Cell therapy is a new and promising approach for the treatment of inflammatory disease including Crohn's disease…
- Trial name
- NCT02520843
- Testing
- stromal vascular fraction (SVF)
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Inflammatory Bowel Diseases (IBD), Crohn's Disease (CD)
Fecal Microbiota Transplantation in Pediatric Patients
A disturbance in the diversity of gut bacterial composition could be linked to several immune mediated diseases including inflammatory bowel diseases (IBD).
- Conditions
- Inflammatory Bowel Diseases (IBD), Crohn's Disease (CD), Ulcerative Colitis (UC)
- Trial name
- FMT (NCT02108821)
- Testing
- Fecal Microbiota Transplantation (FMT)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Inflammatory Bowel Disease (IBD), Inflammatory Bowel Disease (Crohn&Amp;#39;s Disease and Ulcerative Colitis)
Pilot Study Assessing the Feasibility and Impact of a Remote Adapted Physical Activity Program on Quality of Life in Patients With Inflammatory Bowel Disease (IBD)
Inflammatory Bowel Disease (IBD) is a chronic relapsing condition that affects the gastrointestinal tract and is increasingly diagnosed in adolescents and young adults.
- Trial name
- APIMICI (NCT07191106)
- Testing
- adapted physical activity
- Where
- 2 sites in France
- Volunteers
- 72 people
- Sponsor
- Raincy Montfermeil Hospital Group
Crohn's Disease
An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease
This is a multinational, multicenter, randomized, double-blind, placebo-controlled, Phase 3 induction study, comprised of 3 sub-studies, to evaluate the efficacy and safety of duvakitug in participants with moderately to severely…
- Trial name
- STARSCAPE-1 (NCT07184931)
- Testing
- Duvakitug
- Where
- 461 sites in United States, Argentina and 34 more
- Volunteers
- 980 people
- Sponsor
- Sanofi
Crohn Disease
CNI-1493 for Treatment of Moderate to Severe Crohn's Disease
The purpose of this study is to determine whether CNI-1493 is safe and effective in the treatment of moderate to severe Crohn's Disease.
- Trial name
- CD02 (NCT00038766)
- Testing
- semapimod
- Where
- 13 sites in United States
- Volunteers
- 33 people
- Sponsor
- Ferring Pharmaceuticals
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