Clinical trials: Inflammatory Bowel Disease 1
Crohn's Disease
Comparison of Vedolizumab Treatment to Adalimumab Dose Intensification in Crohn's Disease Patients With Loss of Response or Biomarker Activity to Adalimumab on First Line With Therapeutic Drug Concentration.
A substantial fraction of IBD patients with an initial response to infliximab or adalimumab later experience re-emerging active disease despite ongoing anti-Tumour Necrosis Factor (TNF) agents maintenance therapy.
- Trial name
- VEDIAN (NCT06180382)
- Testing
- Adalimumab, Vedolizumab
- Where
- 12 sites in France
- Volunteers
- 220 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Crohn Disease
Effects of Acupuncture on Abdominal Pain-related Intestinal Flora in Patients With Crohn's Disease
Crohn's disease is an intestinal inflammatory disease, causing abdominal pain, diarrhea and other symptoms. The intestinal flora disorder is closely related to the occurrence and development of Crohn's disease.
- Trial name
- NCT06375382
- Testing
- acupuncture
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Crohn's Disease, Ulcerative Colitis
A Multicenter, Prospective, Long-term, Observational Registry of Pediatric Patients With Inflammatory Bowel Disease
The purpose of this study is to evaluate the long-term safety and clinical status of pediatric patients with Inflammatory Bowel Disease (IBD).
- Conditions
- Crohn's Disease, Ulcerative Colitis, Indeterminate Colitis, Inflammatory Bowel Diseases
- Trial name
- DEVELOP (NCT00606346)
- Testing
- Anti TNF therapy including infliximab, No Biologics
- Where
- 62 sites in United States, Canada
- Volunteers
- 4,970 people
- Sponsor
- Janssen Biotech, Inc.
Colitis, Ulcerative, Crohn's Disease
A Study of Long-term Effects of Vedolizumab Subcutaneous in Adults With Ulcerative Colitis and Crohn's Disease
The main aim of the study is to check for long-term side effects of Vedolizumab Subcutaneous (also known as Vedolizumab SC) in people with ulcerative colitis (UC) and Crohn's disease (CD).
- Trial name
- NCT02620046
- Testing
- Vedolizumab SC
- Where
- 301 sites in United States, Argentina and 31 more
- Volunteers
- 746 people
- Sponsor
- Takeda
Crohn's Disease
Adalimumab Trough Concentrations in Crohn's Disease: A Pilot Pharmacokinetic Study
Observational pharmacokinetics study of adalimumab in patients with active refractory Crohn's disease who are naïve to TNF antagonist therapy.
- Trial name
- NCT02450513
- Testing
- Adalimumab
- Where
- 2 sites in Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Crohn's Disease
Evaluation of a PillCam Colon Bowel Preparation Regimen in Crohn's Disease Patients
The proposed study is designed to evaluate Pillcam regimen in Crohn's disease patients, using the PillCam Colon system.
- Trial name
- RD-207 (NCT01576120)
- Testing
- bowel prep regimen first boost 6 oz. and second boost 3 oz., bowel prep regimen first boost 3 oz. and second boost 6 oz.
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Medtronic - MITG
Inflammatory Bowel Disease, Crohn Disease
Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease
The investigators will be evaluating bone marrow composition via magnetic resonance imaging in newly diagnosed adolescents with Crohn disease (CD) compared to healthy, matched controls.
- Trial name
- NCT04508088
- Testing
- Coronal T1 weighted spin echo images, Spin-lattice relaxation (T1), Magnetic resonance spectroscopy
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Crohn's Disease
A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease
Study participants will be screened during the platform study and randomly assigned to receive mirikizumab or another intervention.
- Trial name
- AMAY (NCT05509777)
- Testing
- Mirikizumab
- Where
- 81 sites in United States, Austria and 14 more
- Volunteers
- 90 people
- Sponsor
- Eli Lilly and Company
Ulcerative Colitis
Study for Safety and Tolerability of TOP1288 Administered Orally in Healthy Subjects
This study evaluates the safety and tolerability of TOP1288 oral single ascending and multiple doses in healthy subjects.
- Trial name
- NCT03071081
- Testing
- TOP1288
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Topivert Pharma Ltd
Serological C Reactive Protein or Erythrocyte Sedimentation Rate
a Single-center Registered Clinical Research of Chinese Patients With Moderate to Severe Crohn's Disease
Many studies reveal that infliximab (IFX, an immunoglobulin gamma-1 antibody)can response well to Crohn's Disease(CD) patients who are intolerant of corticosteroids and immunosuppressant,or steroids-dependent .More over,A complex…
- Trial name
- NCT02088944
- Testing
- Infliximab
- Volunteers
- 142 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Crohn's Disease
Assessment of Small Bowel Healing in Crohn's Disease Patients Treated With Cimzia Using Wireless Capsule Endoscopy
Wireless Capsule Endoscopy has been the most reliable diagnostic standard for small bowel Crohn's disease. Endoscopic healing is an important endpoint to measure response to treatment.
- Trial name
- NCT01053559
- Testing
- certolizumab pegol
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Shafran Gastroenterology Center
Crohns Disease
Comparative Effectiveness of MR Enterography
The purpose of this study is to determine the efficacy of ultrasound imaging compared to MRE (Magnetic Resonance Enterography) a form of magnetic resonance imaging (MRI) in accurately diagnosing and following Small Bowel Crohn…
- Trial name
- NCT01593462
- Testing
- MRE (magnetic resonance enterography), The Ultrasound scan, (UEI) Ultrasound Elastography Imaging with ARFI (acoustic radiation force impulse), Study Questionnaires
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan
Inflammatory Bowel Diseases, Crohn Disease
Implementing a Multimodal RCT Intervention to Improve the Transition of Patients With Crohn's Disease From Pediatric to Adult Care
Background: Transition in care is defined as the "purposeful and planned movement of adolescents and young adults with a chronic medical condition from pediatric to adult-oriented healthcare systems/care providers." Currently…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Adolescent Development
- Trial name
- NCT05221281
- Testing
- Multimodal intervention consisting of four core components, Standard of care
- Where
- 3 sites in Canada
- Volunteers
- 90 people
- Sponsor
- The Hospital for Sick Children
Crohn Disease
A Study to Assess Whether Etrolizumab is a Safe and Efficacious Treatment for Participants With Moderately to Severely Active Crohn's Disease
This is a multicenter, Phase 3, double-blind, placebo-controlled study evaluating the efficacy, safety, and tolerability of etrolizumab compared with placebo during induction and maintenance treatment of moderately to severely…
- Trial name
- BERGAMOT (NCT02394028)
- Testing
- Etrolizumab
- Where
- 327 sites in United States, Argentina and 31 more
- Volunteers
- 1,035 people
- Sponsor
- Hoffmann-La Roche
Crohn's Disease, Malnutrition
Assessment of Nutritional Status of Patients With Crohn's Disease
Good nutritional status of patients with Crohn's disease (CD) is associated with better outcome of the disease and better health-related quality of life.
- Conditions
- Crohn's Disease, Malnutrition, Overweight and Obesity, Sarcopenia
- Trial name
- NCT03871634
- Where
- Greece
- Volunteers
- 250 people
- Sponsor
- Harokopio University
Ulcerative Colitis, Crohn Disease
HMPL004-6599 Phase I Dose-escalating Study
To assess the safety and tolerability of single and multiple doses of HMPL004-6599 in healthy male volunteers
- Trial name
- NCT03597971
- Testing
- HMPL004-6599
- Where
- Australia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Nutrition Science Partners Limited
Ulcerative Colitis, Crohn's Colitis
RCT: HDWL vs Virtual Chromoendoscopy in the Detection of Intraepithelial Neoplasia in Longstanding Colitis
Colitis is inflammation of the large bowel and it is often caused by conditions known as ulcerative colitis and Crohn's disease.
- Trial name
- VIRTUOSO (NCT02822352)
- Testing
- Chromoendoscopy
- Where
- United Kingdom
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Crohn Disease
Effect of Prebiotic FOS on Intestinal Abundance of Faecalibacterium Prausnitzii in Patients With Crohn´s Disease
FOS improve gut colonization by Faecalibacterium prausnitzii in patients with Crohn's disease
- Trial name
- NCT02539849
- Testing
- FOS, Adalimumab
- Where
- 5 sites in Spain
- Volunteers
- 38 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
CD
Crohn's Disease Endoscopic REmission Definition in an Objective Way
The CDEIS (Crohn's disease endoscopic index of severity) and its derivative, SES-CD (single endoscopic score for Crohn's disease) were constructed to evaluate the endoscopic severity of Crohn's disease (CD).
- Trial name
- CREDO1 (NCT03498625)
- Testing
- Colonoscopy
- Where
- 2 sites in Belgium, France
- Volunteers
- 240 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Crohn Disease, Colitis, Ulcerative
A Study of Continued Use of Guselkumab in Participants With Crohn's Disease and Ulcerative Colitis in Real World Setting
The purpose of this study is to find out how long a participant keeps taking guselkumab or continues with their treatment plan without stopping (treatment persistence) in participants with moderate to severe Crohn's disease (CD)…
- Trial name
- GusTaCon (NCT07746765)
- Volunteers
- 35 people
- Sponsor
- Janssen Sciences Ireland UC
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