Clinical trials: Inflammatory Bowel Diseases (IBD)
Inflammatory Bowel Disease, Crohn Disease
Prevalence and Clinical Course of Chronic Hep B Infection in IBD and Rheumatologic Disease
This study aims to determine the prevalence of HBV infection in patients with IBD and rheumatologic disease, and to assess the impact of immunosuppressive therapy on viral load and clinical course of IBD patients.
- Conditions
- Inflammatory Bowel Disease, Crohn Disease, Ulcerative Colitis, Rheumatic Diseases
- Trial name
- NCT02128503
- Testing
- HBV DNA level monitoring
- Where
- Hong Kong
- Volunteers
- 430 people
- Sponsor
- Chinese University of Hong Kong
Inflamatory Bowel Disease, Crohn Disease (CD)
Comparison of the Efficacy of Different Biologic Agents in Preventing Postoperative Endoscopic Recurrence of Crohn's Disease
This retrospective cohort study aims to compare the efficacy of different biologics in preventing postoperative endoscopic recurrence in Crohn's disease (CD).
- Trial name
- NCT07694674
- Testing
- Infliximab, Adalimumab, Vedolizumab
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Shanghai 10th People's Hospital
Crohn's Disease
Extension Study to Assess Long Term Safety in Children and Adolescents With Crohn's Disease Receiving Certolizumab Pegol
The purpose of this study is to evaluate the long-term safety and tolerability of certolizumab pegol (CZP) treatment in children and adolescents with moderately to severely active Crohn's disease.
- Trial name
- NCT01190410
- Testing
- certolizumab pegol
- Where
- 10 sites in United States, Australia and 1 more
- Volunteers
- 16 people
- Sponsor
- UCB Pharma
Inflammatory Bowel Disease (Crohn&Amp;#39;s Disease and Ulcerative Colitis), Fecal Microbiota Transplantation
Efficacy and Mechanism of FMT in the Treatment of Inflammatory Bowel Disease: an Open-label Randomized Controlled Study
This study enrolled 94 patients with UC or CD. Two groups received either 8-week intestinal bacterial transplant capsule therapy or biological therapy, respectively.
- Trial name
- NCT07149441
- Testing
- Fecal microbiota transplantation, infliximab
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Shanghai 10th People's Hospital
Colonoscopy
Chromoendoscopy in Inflammatory Bowel Disease
Patients with longstanding ulcerative colitis (inflammatory bowel disease, IBD) have increased risk of developing colorectal cancer (CRC) when compared with that of the general population.
- Trial name
- NCT03250780
- Testing
- indigo-carmine 0.2% using a spray catheter, 0.03% using a foot pump
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Ulcerative Colitis, Chromoendoscopy
The Clinical Value of Chromoendoscopy as Surveillance Strategy for Dysplasia Detection in Ulcerative Colitis
A recent multicentre randomised controlled trial compared autofluorescence imaging (AFI) with CE for dysplasia detection in colonoscopy surveillance of patients with longstanding UC (FIND-UC).
- Trial name
- NCT03824418
- Testing
- Surveillance colonoscopy with chromoendoscopy
- Where
- Netherlands
- Volunteers
- 210 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Crohn's Disease
Behavioral Therapy for Crohn's Disease
People living with Crohn's disease (CD) experience psychological and emotional symptoms, in addition to known chronic and disabling physical symptoms, which prevent them from living their life to the fullest (flourishing).
- Trial name
- NCT06512597
- Testing
- Primary Intervention for Combination Therapy - IBD Coping Strategies Program, Time and Attention Control - IBD Support Program
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Crohn's Disease
Capsule & Omics for pRedicting Exacerbation of Crohn's Disease
The research group have previously evaluated the benefit of serial consecutive capsule endoscopy as monitoring tool for Crohn's disease in remission, demonstrating its superior accuracy for disclosing inflammation and for…
- Trial name
- CORE-CD (NCT06362174)
- Where
- Israel
- Volunteers
- 62 people
- Sponsor
- Sheba Medical Center
Ulcerative Colitis
Efficacy & Safety in Moderately Active Refractory Ulcerative Colitis Patients
This study is designed as a proof of concept of KRP203 for induction of remission in ulcerative colitis (UC). The purpose of this study is to evaluate clinical benefit of KRP203 in subjects with moderately active refractory…
- Trial name
- NCT01375179
- Testing
- KRP203
- Where
- 14 sites in Belgium, Germany and 4 more
- Volunteers
- 27 people
- Sponsor
- Novartis Pharmaceuticals
Crohn's Disease
Preventing Postoperative Relapse in Crohn's Disease Patients at Risk: Azathioprine Versus Mesalazine
This study aims to compare azathioprine versus mesalazine tablets for the prevention of clinical relapse in postoperative Crohn's disease (CD) patients with moderate or severe endoscopic recurrence.
- Trial name
- NCT00946946
- Testing
- Azathioprine, Mesalazine
- Where
- 2 sites in Austria, Germany
- Volunteers
- 78 people
- Sponsor
- Dr. Falk Pharma GmbH
Crohn Disease (CD)
Evaluation of the Acceptability and Therapeutic Maintenance After Substitution of Ustekinumab With a Biosimilar
In a population of adult patients followed for Crohn's disease, who had previously agreed to replace Stelara® with a biosimilar of ustekinumab (Uzpruvo®) and were followed over a period of 12 months under usual medical practice…
- Trial name
- NCT07077681
- Where
- 11 sites in France
- Volunteers
- 246 people
- Sponsor
- EG Labo
Ulcerative Colitis
A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis
Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine).
- Trial name
- MIGHTY (NCT07071519)
- Testing
- Risankizumab
- Where
- 73 sites in United States, Belgium and 14 more
- Volunteers
- 120 people
- Sponsor
- AbbVie
Crohn's Disease
Vitamin D Supplementation in Adult Crohn's Disease
The purpose of this study is to determine whether vitamin D supplementation is effective in the prevention of relapse in Crohn's disease.
- Trial name
- VITD-CD (NCT01369667)
- Testing
- Vitamin D3
- Where
- Ireland
- Volunteers
- 117 people
- Sponsor
- University of Dublin, Trinity College
Ulcerative Colitis
Identification of Biomarkers of Janus Kinase Inhibitor Therapy in Patients With Ulcerative Colitis
This study aims to provide new mechanistic insights into the molecular determinants of response or nonresponse to Janus Kinase inhibitor therapy and the biological heterogeneity that exists in Ulcerative Colitis.
- Trial name
- PROPHETIC (NCT04576000)
- Testing
- Janus Kinase Inhibitor
- Where
- Netherlands
- Volunteers
- 3 people
- Sponsor
- Alimentiv Inc.
Ulcerative Colitis
Safety and Efficacy of Microbial Ecosystem Therapeutic-2 (MET-2) in Patients With Ulcerative Colitis (UC)
To define the parameters for dose-dependent engraftment of MET-2 commensal bacteria for the treatment of mild to moderate ulcerative colitis
- Trial name
- NCT03832400
- Testing
- MET-2
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- NuBiyota
Idiopathic Chronic Inflammatory Bowel Disease
Inflammatory Bowel Disease Registry in Daegu-Gyeongbuk
The purpose of this study is to investigate the incidence and natural course of inflammatory bowel disease in the southeastern area of Korea.
- Trial name
- EPICODE (NCT02193464)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Kyungpook National University Hospital
Crohn Disease, Colitis, Ulcerative
A Study to Evaluate Disease Control, Treatment Patterns, Burden of Disease and Quality of Life in Participants With Moderate to Severe Inflammatory Bowel Disease (IBD)
The purpose of this study is to evaluate the percentage of moderate to severe IBD participants with active disease at Day 1.
- Conditions
- Crohn Disease, Colitis, Ulcerative, Inflammatory Bowel Disease
- Trial name
- RISE AR (NCT03488030)
- Where
- 7 sites in Argentina
- Volunteers
- 246 people
- Sponsor
- Takeda
Breast Cancer, Colo-rectal Cancer
The French E3N Prospective Cohort Study
The French E3N cohort was initiated in 1990 to investigate the risk factors associated with cancer and other major non-communicable diseases in women.
- Conditions
- Breast Cancer, Colo-rectal Cancer, Parkinson Disease, Asthma
- Trial name
- E3N (NCT03285230)
- Where
- France
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Colitis Ulcerative
A Study to Investigate the Efficacy and Safety of Dupilumab Therapy Compared With Placebo in Participants Aged ≥18 Years With Moderately to Severely Active Ulcerative Colitis With an Eosinophilic Phenotype (LIBERTY-UC SUCCEED (Study in UC for Clinical Efficacy Evaluation of Dupilumab))
The protocol of this Phase 2 clinical trial consists of a double-blind, placebo-controlled, parallel-group, multicenter study to evaluate the efficacy and safety of dupilumab in participants with moderately to severely active…
- Trial name
- NCT05731128
- Testing
- Dupilumab
- Where
- 77 sites in United States, Argentina and 9 more
- Volunteers
- 68 people
- Sponsor
- Sanofi
Alopecia Areata, Alopecia Totalis
The Epidemiology, Management and Comorbidities in Alopecia Areata in Czech Republic
The study series consists of three studies with the aim to assess the incidence, prevalence, risk factors, comorbidities and management of patients with alopecia areata in Czech Republic based on the patients and registry of a…
- Conditions
- Alopecia Areata, Alopecia Totalis, Alopecia Universalis, Alopecia Areata (& Ophiasis)
- Trial name
- NCT05098600
- Testing
- Exposure of interest
- Where
- Czechia
- Volunteers
- 123 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
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