Clinical trials: Inflammatory Bowel Diseases (IBD)
Inflammatory Bowel Diseases, Crohns Disease
Autoimmune Paradoxical Reactions in IBD Longitudinal Cohort
Purpose: Inflammatory bowel disease patients undergoing treatment with varying biologic agents will be evaluated for incidences of paradoxical immune reactions, the risk factors associated with those paradoxical immune reactions…
- Conditions
- Inflammatory Bowel Diseases, Crohns Disease, Ulcerative Colitis, Colitis
- Trial name
- APRIL (NCT02503514)
- Where
- United States
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Ulcerative Colitis
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 181 in Healthy Subjects and Subjects With Mild to Moderate Ulcerative Colitis
To assess the safety and tolerability of single subcutaneous (SC) and intravenous (IV) doses of AMG 181 in healthy subjects and of a single SC dose in subjects with mild to moderate ulcerative colitis (UC)
- Trial name
- NCT01164904
- Testing
- Amg 181
- Where
- 10 sites in United States, Australia and 1 more
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Amgen
IBD, Crohns Disease
IBDSL Biobank Project. Molecular Markers for Diagnosis and Therapy Response in IBD.
The IBD South Limburg (IBDSL) project was initially designed as a prospective population based cohort study. Since 1991, all new IBD cases have been enrolled in the cohort and prospectively followed.
- Conditions
- IBD, Crohns Disease, Ulcerative Colitis
- Trial name
- IBDSL (NCT02130349)
- Where
- 3 sites in Netherlands
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Crohn's Disease, CAM
Efficacy of Acupuncture and Moxibustion Treatment in Patients With Quiescent Crohn's Disease:Evaluation With fMRI
The purpose of this study is to determine whether acupuncture or moxibustion therapies are effective in the treatment of Crohn's disease.
- Trial name
- NCT01696838
- Testing
- electroacupuncture, moxibustion
- Where
- China
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Crohn's Disease
Mucosal Healing Study in Crohn's Disease (CD)
The aim of the study will be to investigate the effect of certolizumab pegol on the intestinal mucosa in active Crohn's disease.
- Trial name
- MUSIC (NCT00297648)
- Testing
- Certolizumab pegol
- Where
- 19 sites in Belgium, France and 1 more
- Volunteers
- 89 people
- Sponsor
- UCB Pharma
Ulcerative Colitis
Allogeneic Adipose Tissue-derived Mesenchymal Stem Cells for the Induction of Remission in Ulcerative Colitis
The aims of our study are to evaluate the feasibility and safety of endoscopic injection of adipose tissue-derived mesenchymal stem cells in human subjects with moderate active ulcerative colitis, assessing the absence of adverse…
- Trial name
- ALOASCU (NCT01914887)
- Testing
- Allogeneic adipose tissue-derived mesenchymal stem cells
- Where
- Spain
- Volunteers
- 8 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Inflammatory Bowel Diseases, Pregnancy Related
Pregnancy in Greek Female Patients With Inflammatory Bowel Disease - Panhellenic Recording
The aim of the present study is to retrospectively record all the successful pregnancies in Greek IBD patients within the last 10 years and prospectively record all the future pregnancies for the next 4 years.
- Trial name
- NCT05562726
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Alexandra Hospital, Athens, Greece
Ulcerative Colitis, Colon Cancer
Study of Effects of L-Arginine in Colitis and Colon Cancer
The purpose of this study is to look at the importance of L-Arginine in the digestive tract. L-Arginine is an amino acid and is important in making proteins within the cell.
- Trial name
- NCT01091558
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Periodontitis, Inflammatory Bowel Diseases
The Effect of Non-Surgical Periodontal Therapy on Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a chronic and recurrent inflammatory disease of the gastrointestinal tract characterised by complex interactions between genetic susceptibility, environmental factors, microbiota and host…
- Trial name
- NCT06245278
- Testing
- ELISA (Enzyme-Linked ImmunoSorbent Assay)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Biruni University
Colon Cancer, Inflamatory Bowel Disease (Crohn's and Ulcerative Colitis)
Effectiveness of Health Education as a Nursing Intervention in Improving Quality of Life and Reducing Symptoms of Anxiety and Depression in Ostomy Patients Following Digestive Surgery: A Quasi-Experimental Study.
The proposed project is a prospective quasi-experimental study to be conducted at the Ostomy Clinic of the University Hospital Complex of Santiago de Compostela.
- Conditions
- Colon Cancer, Inflamatory Bowel Disease (Crohn's and Ulcerative Colitis), Colitis Ulcerative
- Trial name
- NCT07347158
- Testing
- Health Education
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Hospital Clinico Universitario de Santiago
Crohn's Diseases, Crohn's Disease
A Phase 1 Study of ATORM-C in Patients With Crohn's Disease
This Phase 1 study evaluates the safety and tolerability of ATORM-C in patients with Crohn's disease. ATORM-C is an investigational product consisting of autologous adult stem cell-derived intestinal organoids.
- Trial name
- NCT07822087
- Testing
- Autologous Adult Stem Cell-Derived Intestinal Organoid
- Where
- South Korea
- Volunteers
- 18 people
- Sponsor
- ORGANOIDSCIENCES LTD.
Inflammatory Bowel Diseases, Crohn Disease
A Novel Remote Patient and Medication Monitoring Solution to Improve Adherence and PerSiStence With IBD Therapy
The investigators hypothesize that use of a remote monitoring digital health system that supports medication taking and monitoring of symptoms will improve adherence, clinical outcomes, and decrease healthcare utilization…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- ASSIST (NCT05316584)
- Testing
- Remote monitoring
- Where
- 5 sites in United States
- Volunteers
- 123 people
- Sponsor
- University of Maryland, Baltimore
Supplementation, Bone Health
The Effect of Vitamin K Supplementation on Bone Health in Adult Crohn's Disease Patients
To assess the impact of a 12 month vitamin K supplementation intervention on bone health in adult Crohn's disease patients
- Conditions
- Supplementation, Bone Health, Crohn's Disease
- Trial name
- NCT01235325
- Testing
- phylloquinone (vitamin K1)
- Where
- Ireland
- Volunteers
- 70 people
- Sponsor
- University College Cork
Crohn Disease, Ulcerative Colitis
A Study of the Real-world Use of an Adalimumab Biosimilar and Evaluation of Nutritional Status on the Therapeutic Response
The aim of the study is to describe the real-world profile of patients treated with adalimumab FK in gastroenterology, dermatology or rheumatology in order to evaluate in this population the predictive factors of therapeutic…
- Conditions
- Crohn Disease, Ulcerative Colitis, Psoriasis, Ankylosing Spondylitis
- Trial name
- OPALE (NCT05051943)
- Where
- France
- Volunteers
- 754 people
- Sponsor
- Fresenius Kabi
Bowel Sounds, Intestinal Inflammation
Bowel Sounds Analysis in Paediatric Inflammatory Bowel Disease: Relationship With wPCDAI
The precise and noninvasive evaluation of disease activity among patients with Crohn's disease is not easy, especially for children. It deals with clinical, biological, histological and radiological parameters.
- Conditions
- Bowel Sounds, Intestinal Inflammation, Crohn Disease
- Trial name
- SONO-MICI (NCT05955963)
- Testing
- Abdominal auscultation
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Ulcerative Colitis
ABTECT-2 - ABX464 Treatment Evaluation for Ulcerative Colitis Therapy -2
This is a multicenter, randomized, placebo controlled study to evaluate the efficacy and safety of ABX464 given at 25 or 50 mg QD in inducing clinical remission in subjects with moderately to severely active ulcerative colitis…
- Trial name
- NCT05507216
- Testing
- ABX464
- Where
- 262 sites in United States, Argentina and 25 more
- Volunteers
- 636 people
- Sponsor
- Abivax S.A.
Crohn's Ileocolitis
Safety Study of P28GST Treatment in Crohn's Disease Patients
This multicenter phase 2 clinical trial is designed to assess safety of P28GST (protein 28 Kd glutathion S Transferrase), aiming to control inflammation in moderate Crohn's Disease (CD), before or after intestinal resection…
- Trial name
- ACROHNEM (NCT02281916)
- Testing
- P28GST
- Where
- 5 sites in France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Lille
Colitis, Ulcerative, Crohn's Disease
OTIS Vedolizumab Pregnancy Exposure Registry
The purpose of this study is to assess the prevalence of major structural birth defects in infants of female participants with ulcerative colitis (UC) or Crohn's disease (CD) exposed to vedolizumab during pregnancy, compared to…
- Trial name
- NCT02678052
- Testing
- Vedolizumab, Other Biological Agent
- Where
- United States
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- Takeda
Ulcerative Colitis
Fecal Microbiota Transplantation (FMT) in the Management of Ulcerative Colitis (UC)
Inflammatory bowel disease is a condition caused by gastrointestinal immune system dysregulation and affected by both genetic and environmental factors.
- Trial name
- NCT02516384
- Testing
- Fecal Microbiota Transplantation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
GVHD,Acute, Ulcerative Colitis
Analysis of Intestinal Defensin Expression in Acute GVHD
This study has the aim to analyze intestinal expression of endogenous antimicrobial peptides in patients with acute GVHD. The expression will be compared to intestinal expression of defensins in patients with colitis and patients…
- Conditions
- GVHD,Acute, Ulcerative Colitis, Morbus Crohn
- Trial name
- NCT04522843
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University of Freiburg
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