Clinical trials: Inflammatory Bowel Diseases (IBD)
Inflammatory Bowel Diseases
Receptor for Advanced Glycation End Products (RAGE) Polymorphisms In Inflammatory Bowel Disease
The inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the gastrointestinal tract that manifests as Crohn's disease (CD) and Ulcerative colitis (UC .
- Trial name
- NCT04286659
- Volunteers
- 180 people
- Sponsor
- Assiut University
Ulcerative Colitis
Long-term Safety and Efficacy of Sacral Nerve Stimulation in Patients With Ulcerative Colitis
Although the incidence of inflammatory bowel disease is stable in North American and European countries, the incidence of inflammatory bowel disease is increasing in newly industrialized countries, especially in China.
- Trial name
- NCT07114159
- Testing
- Sacral nerve stimulation
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Xijing Hospital
Ulcerative Colitis, Crohn Disease
A Specific Probiotic in thE MOdulation of Gut Microbiota of patieNts With Mild-to-modErate Ulcerative Colitis
Probiotics are live microorganisms that provide health benefits when consumed in sufficient amounts. Traditional probiotics, mainly from the Lactobacillus and Bifidobacterium genera, originate from fermented foods or the human…
- Trial name
- ANEMONE (NCT07724990)
- Testing
- For a bipsies, rectal administration
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Catholic University of the Sacred Heart
Inflammatory Bowel Disease
Testing the Impact of Measurement-Based Care on Quality of Life and Disease Management Among Veterans With Inflammatory Bowel Disease
This research study is addressing issues related to Inflammatory bowel disease (IBD), which is a chronic autoimmune disorder that affects over 60,000 Veterans.
- Trial name
- MBC-IBD (NCT07210580)
- Testing
- MBC-IBD Intervention, Enhanced Treatment as Usual (E-TAU)
- Where
- 4 sites in United States
- Volunteers
- 250 people
- Sponsor
- VA Office of Research and Development
Inflammatory Bowel Diseases
Exercise and Nutrition in IBD & Preconception
The objectives are to: 1) Assess the independent and synergistic efficacy of exercise and nutrition interventions to manage major symptomatic concerns of inflammatory bowel diseases (IBD), 2) Assess the independent and…
- Trial name
- IBDPreconcep (NCT02945488)
- Testing
- Exercise, Dietary plan, Stretching
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University of Saskatchewan
Ulcerative Colitis
FACTS II: A Study to Test the Safety and Effectiveness of a New Medication on the Treatment of Active Ulcerative Colitis
The purpose of this study is to evaluate the safety and efficacy of the drug OPC-6535 compared to a placebo in patients with active Ulcerative Colitis.
- Trial name
- NCT00064454
- Testing
- OPC-6535 Tablets (drug)
- Where
- 28 sites in United States
- Volunteers
- 375 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Crohn's Disease
Exclusive Enteral Nutrition Therapy for Active and Complicated Crohn's Disease
The goal of this observational study is to evaluate the effectiveness and safety of exclusive enteral nutrition (EEN) in adults with active Crohn's disease (CD), particularly in patients with complicated disease such as…
- Trial name
- EEN-CD (NCT07504510)
- Testing
- Exclusive Enteral Nutrition
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Crohn's Disease
Adalimumab for the Induction and Maintenance of Clinical Remission in Subjects With Crohn's Disease
The purpose of this study is to test whether Adalimumab (at two different doses) can induce and maintain clinical remission in subjects with active Crohn's disease when compared to placebo (a substance containing no medication)
- Trial name
- CHARM (NCT00077779)
- Testing
- Adalimumab
- Where
- 43 sites in United States
- Volunteers
- 854 people
- Sponsor
- Abbott
Ulcerative Colitis
Controlling the Mental Health for a Better Response to Treatment in Patients With Ulcerative Colitis
The project aims to implement the Internet Of Thing (IoT) platform of the San Raffaele Hospital (OSR) with data from stress conditions perceived by the patient through the synergistic collaboration between patients…
- Trial name
- TIMAEUS (NCT06306261)
- Testing
- questionnaire
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS San Raffaele
Ulcerative Colitis, Inflammatory Bowel Diseases
Fecal Microbiota Transplantation in an Expanded Ulcerative Colitis Population
This is a multi-centre, randomised controlled trial comparing fecal microbiota transplantation to placebo in an expanded ulcerative colitis population: a feasibility study (FRONTIER-UC) to determine whether a full-scale…
- Conditions
- Ulcerative Colitis, Inflammatory Bowel Diseases, Clostridioides Difficile Infection
- Trial name
- FRONTIER-UC (NCT07401680)
- Testing
- Lyophilized Fecal Microbiota Transplantation (LFMT)
- Where
- 2 sites in Canada
- Volunteers
- 85 people
- Sponsor
- University of Alberta
Chronic Disease
Integrative Therapy of Chronic Diseases
The observational study aims to investigate the extent to which a two-week stay in an internal medicine clinic for integrative medicine and naturopathy results in an improvement of complaints, impairments, quality of life…
- Trial name
- InteChron (NCT04927403)
- Testing
- multimodal integrative naturopathic therapy concept
- Where
- 3 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- Universität Duisburg-Essen
Crohn Disease, Ulcerative Colitis
TARGET Registry A Project of the German Network for Intestinal Diseases in Cooperation With Other Corporate Partners
By capturing possible or known risk factors, it will be possible to recognize connections between these risk factors and the disease, thus obtaining valuable insights into the cause of the disease.
- Conditions
- Crohn Disease, Ulcerative Colitis, Indeterminate Colitis
- Trial name
- TARGET (NCT04031482)
- Testing
- No intervention, only standard care
- Volunteers
- 4,400 people
- Sponsor
- Ced Service GmbH
Ulcerative Colitis
Safety, Tolerability, and Pharmacokinetics of Oral NX-13 in Active Ulcerative Colitis
This is a Phase 1b, randomized, double-blind, multicenter dose-ranging study to evaluate the safety, tolerability, and PK of NX-13.
- Trial name
- NCT04862741
- Testing
- NX-13 250mg IR, NX-13 500mg IR, NX-13 500mg MR
- Where
- 31 sites in United States, Ukraine
- Volunteers
- 39 people
- Sponsor
- Landos Biopharma Inc.
Stenosis, Crohn's Disease
Comparative Prospective Multicenter Randomized Study of Endoscopic Treatment of Stenosis in Crohn´s Disease
This study will be a multicentre randomized controlled trial to assess the efficacy between balloon dilatation and self-expanding metallic stent placement for endoscopic treatment of stenosis in Crohn´s Disease.
- Conditions
- Stenosis, Crohn's Disease, Chronic Inflammation
- Trial name
- PROTDILAT (NCT02395354)
- Testing
- Placing a self-expanding metallic stent, A balloon dilatation
- Where
- Spain
- Volunteers
- 122 people
- Sponsor
- Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa
Crohn Disease
Post-operative CRP Trend After Ileocolic Resection in Crohn's Disease Patients.
Our aim is to analyze C-Reactive Protein trends during the post-operative course in Crohn's Disease patients having undergone ileocolic resection and primary anastomosis, for the purpose of anastomotic leak early diagnosis.
- Trial name
- NCT04739579
- Testing
- C-Reactive Protein
- Where
- France
- Volunteers
- 59 people
- Sponsor
- Central Hospital, Nancy, France
Ulcerative Colitis
Open-label Extension Study of Brazikumab in Ulcerative Colitis
The purpose of this OLE Study D5272C00002 (Legacy #3151-202-008) is to permit participants who previously enrolled in the double-blind Study D5272C00001 (Legacy #3151-201-008) to receive brazikumab, allowing for long-term…
- Trial name
- Expedition (NCT04277546)
- Testing
- Brazikumab Maintenance Dose, Brazikumab Induction Dose
- Where
- 36 sites in United States, Czechia and 9 more
- Volunteers
- 57 people
- Sponsor
- AstraZeneca
Inflammatory Bowel Disease
Effects of Pectin on Flora Intestinal Colonization and Maintenance After Fecal Transplantation
The purpose of this study is to evaluate the effect and safety of pectin and fecal microbiota transplantation on patients with inflammatory bowel disease.
- Trial name
- NCT02016469
- Testing
- co-transplantation of FMT and pectin, single fecal microbiota transplantation, pure give pectin 20g/d for five days
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jinling Hospital, China
Crohn Disease, Enteral Nutrition
Effect of Exclusive Enteral Nutrition on Disease Process, Nutritional Status and Gastrointestinal Microbiota for Chinese Children With Crohn's Disease
Inflammatory bowel diseases (IBD) are chronic inflammatory diseases. It is believed that the inflammation results from sustained abnormal immune response towards altered or pathogenic microbiota in genetically susceptible hosts.
- Conditions
- Crohn Disease, Enteral Nutrition, Gastrointestinal Microbiome
- Trial name
- NCT03755583
- Testing
- Exclusive Enteral Nutrition
- Where
- China
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Inflammatory Bowel Diseases, Crohn Disease
Induction of Immunity Against Streptococcus Pneumoniae in Adults With Inflammatory Bowel Disease
Patients with inflammatory bowel disease are at increased risk for infections due to their baseline disease and the subsequent immunocompromising regimen.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Colitis, Ulcerative
- Trial name
- PCV13inSIBDCS (NCT01908283)
- Testing
- 13-valent pneumococcal conjugated vaccine (PCV13)
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- Klara M. Pósfay Barbe
Inflammatory Bowel Diseases
A Multi-Center Randomized Controlled Trial on the Impact of Disease Subtype-Based Active Video Education on Bowel Preparation Quality in Patients With Inflammatory Bowel Disease
This multi-center, prospective, randomized controlled trial evaluates whether disease subtype-based active video education improves bowel preparation quality in patients with inflammatory bowel disease (IBD) undergoing…
- Trial name
- NCT07582731
- Testing
- Disease Subtype-Based Active Video Education, standard bowel preparation education
- Where
- 12 sites in China
- Volunteers
- 600 people
- Sponsor
- Jie Liang
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