Clinical trials: Inflammatory Bowel Diseases (IBD)
Crohn's Disease
Top-down Infliximab Study in Kids With Crohn's Disease
The purpose of this study is to determine whether a top-down treatment approach, prescribing infliximab (IFX) and azathioprine (AZA) at diagnose, yields better outcome in comparison to the usual step-up treatment approach…
- Trial name
- TISKids (NCT02517684)
- Testing
- Infliximab, Prednisolone, Exclusive enteral nutrition
- Where
- 13 sites in Belgium, Finland and 1 more
- Volunteers
- 100 people
- Sponsor
- Erasmus Medical Center
Ulcerative Colitis
Use of Rectal Dialysis Technique to Measure Rectal 5-ASA Levels in Healthy Volunteers Receiving Asacol
The investigators plan to develop a novel method of estimating 5-ASA levels in the rectum at a mucosal level using in vivo rectal dialysis technique towards the eventual goal of determining the optimal dosing of Asacol® that…
- Trial name
- NCT04032652
- Testing
- Rectal dialysis
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Adult Patients With Moderately to Severely Active Ulcerative Colitis
A Phase 2 Clinical Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of HRS-7085 Tablets in Patients With Inflammatory Bowel Disease
This study is a randomized, double-blind, placebo-controlled Phase II clinical trial comprising screening period, treatment period, and follow-up period.
- Trial name
- NCT07229950
- Testing
- HRS-7085
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Moderate to Severe Crohn's Disease
Rapidity of Response to Adalimumab Treatment in Patients With Crohn´s Disease
The purpose of this study is to evaluate the rapidity of onset of clinical response to adalimumab therapy in patients with luminal Crohn's disease.
- Trial name
- RAPIDA (NCT02148718)
- Testing
- adalimumab
- Volunteers
- 100 people
- Sponsor
- AbbVie
Crohn´s Disease
Endomicroscopy and Crohn´s Disease
Purpose: The main objective of this study is to determine endomicroscopic features of Crohn´s disease. Background: Crohn´s disease is an inflammatory disease of the intestines that may affect any part of the gastrointestinal…
- Trial name
- NCT01102855
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Ulcerative Colitis in Remission
Nutritional State and Intake Nutrients Assessment in Ulcerative Colitis
The purpose of this study is to determine the reason patients are deficient in nutrients intake such as antioxidants vitamins.
- Trial name
- NCT01301976
- Where
- Brazil
- Volunteers
- 59 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Crohn's Disease
Safety and Efficacy of ALX-0600 in Subjects With Active Crohn's Disease Who Completed Protocol CL0600-008
The purpose of the study is to determine whether an investigational compound, ALX-0600, is safe and effective in treating Crohn's Disease.
- Trial name
- NCT00308438
- Testing
- Teduglutide (ALX-0600)
- Where
- 24 sites in United States, Canada
- Volunteers
- 67 people
- Sponsor
- Shire
Crohns Disease, Pregnancy
Pregnant Women With and Without Crohns Disease to Explore the Role of Plastics and Toxins in Intestinal Inflammation
The PLANET Study aims to determine the impact of microplastics on intestinal inflammation and gut microbiome in order to understand the role of this pollutant on the risk of developing inflammatory bowel disease (IBD) as well as…
- Conditions
- Crohns Disease, Pregnancy, Inflammatory Bowel Disease
- Trial name
- PLANET (NCT06001450)
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Ulcerative Colitis
Role of Roflumilast in Ulcerative Colitis
This study aims to investigate possible efficacy and safety of Roflumilast in adult patients with ulcerative colitis disease .
- Trial name
- NCT05684484
- Testing
- Roflumilast 500 MCG Oral Tablet [DALIRESP], amino salicylic acid
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Tanta University
Colitis
Intestinal Microbiome and Chronic Inflammatory Bowel Disease
The aim is to examine the role of intestinal microbiota in the pathogenesis of chronic inflammatory bowel diseases (IBD)
- Trial name
- NCT02768038
- Testing
- Observational
- Where
- Finland
- Sponsor
- Turku University Hospital
Juvenile Idiopathic Arthritis (JIA), Crohn Disease (CD)
Study on Eating Habits and Association with "omic" Profiles in Families with a Subject Affected by a Chronic Immune-mediated Inflammatory Pathology. Observational Multicenter Study.
The proposed study is part of a PNRR 2022 project (call "Non-Communicable Chronic Diseases (NCDs) with high impact on healthcare and social assistance systems," currently awaiting funding response) and represents the continuation…
- Conditions
- Juvenile Idiopathic Arthritis (JIA), Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- DIETA-MICIREUM (NCT06862843)
- Testing
- Collecting questionnaires and biological samples
- Where
- 4 sites in Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Meyer Children's Hospital IRCCS
Inflammatory Bowel Diseases, Crohn Disease
Quantify the Value of Transmural Inflammation in the Treatment of Crohn's Disease With Ustekinumab:an Analysis Based on Imaging Science
Crohn's disease(CD),a type of inflammatory bowel disease(IBD), is a chronic intestinal recurrent inflammatory disease involving the entire digestive tract.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Biologics
- Trial name
- NCT05642247
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Fistula Vagina, Crohn Disease
Stem Cell Coated Fistula Plug in Patients With Crohn's RVF
The purpose of this study is to determine the safety of using an autologous mesenchymal stromal cell (MSC) coated fistula plug in people with rectovaginal fistulizing Crohn's disease.
- Trial name
- NCT03220243
- Testing
- MSC-AFP
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Mayo Clinic
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Fecal Calprotectin Collection Protocol
The primary objective is to obtain stool samples from subjects diagnosed with , and displaying signs and/or symptoms of IBD and/or IBS will be evaluated in this study.
- Conditions
- Inflammatory Bowel Diseases, Irritable Bowel Syndrome, Ulcerative Colitis, Crohn Disease
- Trial name
- CALFE (NCT03143517)
- Testing
- Stool collection
- Where
- 13 sites in United States
- Volunteers
- 240 people
- Sponsor
- DiaSorin Inc.
Crohn's Disease
Effect of ITF2357 on Mucosal Healing in Patients With Moderate-to-severe Active Crohn's Disease
Objectives: The primary objective of the study was to determine the ability of ITF2357, administered orally at the dose of 50 mg b.i.d.
- Trial name
- CD (NCT00792740)
- Testing
- ITF2357
- Where
- 10 sites in Belgium, Italy and 1 more
- Volunteers
- 51 people
- Sponsor
- Italfarmaco
Inflammatory Bowel Diseases
Magnification Endoscopy and Electronic Chromoendoscopy in Patients With Inflammatory Bowel Disease
In this study the investigators aim to evaluate the ability of i-scan OE together with magnification endoscopy to detect and assess microscopic inflammation in patients with inflammator bowel diseases (IBD).
- Trial name
- NCT03536091
- Testing
- Magnification endoscopy
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Crohn's Disease
Diagnostic Accuracy of Capsule Endoscopy in Small Bowel Crohn's Disease
Prospective study to compare in a blinded fashion four different diagnostic modalities to detect active small bowel Crohn's disease: a) colonoscopy with ileoscopy; b) small bowel follow through; c) capsule endoscopy; and d)…
- Trial name
- NCT00588653
- Testing
- Capsule endoscopy, CT enterography, colonoscopy, small bowel follow-through
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Mayo Clinic
Ulcerative Colitis
Efficacy of Treatment With Berberine to Maintain Remission in Ulcerative Colitis
The research aim to find out whether berberine can reduce the annual recurrence rate of ulcerative colitis in remission. A total of 238 patients with ulcerative colitis in remission will be randomly divided into two groups.One…
- Trial name
- NCT02962245
- Testing
- berberine, regular treatment
- Sponsor
- Xijing Hospital of Digestive Diseases
Crohn Disease, Azathioprine
Comparison of Azathioprine to Methotrexate in Combination Therapy With Adalimumab in Crohn's Disease: an Open-label Randomized Controlled Trial
Combination therapy, the association of an anti-Tumor Necrosis Factor (TNF) to an immunosuppressant, is recognized as the most effective treatment during Crohn's disease (CD).
- Conditions
- Crohn Disease, Azathioprine, Methotrexate
- Trial name
- COMET (NCT05040464)
- Testing
- AZA capsules, MTX, blood sample
- Where
- France
- Volunteers
- 166 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Crohn Disease (CD)
Efficacy of MIrikizumab to Achieve Transmural Healing in patiENTs With Crohn's Disease
Efficacy of Mirikizumab to achieve transmural healing in patients with Crohn's Disease
- Trial name
- EMINENT-CD (NCT07292012)
- Testing
- Mirikizumab - IV, Mirikizumab - SC
- Where
- 6 sites in France
- Volunteers
- 75 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
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