Clinical trials: Inflammatory Bowel Diseases (IBD)
Colon Cancer, Inflammatory Bowel Diseases
Local Anesthetic Wound Infusion and Functional Recovery After Colon Surgery
This is a double blinded randomized controlled trial in patients undergoing colon open surgery. The purpose is to evaluate the effectiveness of two different analgesic techniques on functional recovery after surgery.
- Conditions
- Colon Cancer, Inflammatory Bowel Diseases, Diverticulitis
- Trial name
- NCT01062919
- Testing
- Epidural analgesia, Wound catheter
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Franco Carli
Ulcerative Colitis (UC)
A Direct Head-to-head Comparison of Ustekinumab With Infliximab for the Treatment of Ulcerative Colitis
the goal of this study is to compare the efficacy of ustekinumab with infliximab for the treatment of ulcerative colitis aim of the study : 1.
- Trial name
- NCT06786507
- Testing
- Ustekinumab 90 mg, Infliximab
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Helwan University
Crohns Disease
Atorvastatin in Moderate Active Crohns Disease
Open pilot study to collect information regarding the effect of atorvastatin on patients with active Crohns disease.
- Trial name
- NCT00454545
- Testing
- Atorvastatin
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Skane University Hospital
Ulcerative Colitis
NBI With Magnification for Dysplasia Detection in Ulcerative Colitis
The purpose of the study is to determine whether a new colonoscopic viewing technique called narrow band imaging (NBI) helps doctors detect more patients with at leat one pre-cancerous area (dysplasia associated lession or mass…
- Trial name
- NCT00292175
- Testing
- Narrow Band Imaging, colonoscopy
- Where
- 2 sites in United Kingdom
- Volunteers
- 110 people
- Sponsor
- London North West Healthcare NHS Trust
Ulcerative Colitis
A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis
Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine).
- Trial name
- MIGHTY (NCT07071519)
- Testing
- Risankizumab
- Where
- 73 sites in United States, Belgium and 14 more
- Volunteers
- 120 people
- Sponsor
- AbbVie
Polyps, Neoplasms
Trial on Innovative Technologies in Colonoscopy
The trial will compare results of screening colonoscopy performed by means of conventional colonoscopy and using new visualisation techniques during endoscopic examination.
- Conditions
- Polyps, Neoplasms, Inflammatory Bowel Disease
- Trial name
- RCT-IC (NCT01688557)
- Testing
- Innovative colonoscopy (Olympus CF-HQ190F, NBI + Dual Focus), Conventional colonoscopy (Olympus CF-H180DL)
- Where
- 2 sites in Poland
- Volunteers
- 600 people
- Sponsor
- Jagiellonian University
Crohn Disease (CD), Ileocolic Resection
Evaluation of Therapeutic Strategy to Prevent Crohn's Disease Endoscopic poSToperatIve recurreNce Based on earlY Dosage of Faecal Calprotectin
Crohn's disease (CD) (> 200,000 patients in France) is a chronic inflammatory disease that can lead to progression of intestinal destruction and impaired quality of life.
- Conditions
- Crohn Disease (CD), Ileocolic Resection, Post-endoscopic Operative Reccurence
- Trial name
- DESTINY II (NCT06972901)
- Testing
- Early faecal calprotectin dosage
- Where
- 8 sites in France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Clermont-Ferrand
Irritable Bowel Syndrome, Ulcerative Colitis
Phenotyping IBS: Perceptions and Modulations of Visceral Sensations
The purpose of this research study is to improve the understanding of irritable bowel syndrome (IBS) and its underlying cause. The investigators will use magnetic resonance imaging (MRI) to observe differences in the brain…
- Conditions
- Irritable Bowel Syndrome, Ulcerative Colitis, Inflammatory Bowel Disease
- Trial name
- PMVS-P (NCT02693730)
- Where
- United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Ulcerative Colitis
Mesalamine Pellet to Maintain Remission of Mild to Moderate Ulcerative Colitis
The purpose of this study is to compare the maintenance of mild to moderate ulcerative colitis remission with six months of treatment with 1.5 grams of mesalamine pellets each day versus placebo.
- Trial name
- NCT00767728
- Testing
- Granulated mesalamine
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- Bausch Health Americas, Inc.
Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA), Non-radiographic Axial Spondyloarthritis (Nr-axSpA)
German Spondyloarthritis Inception Cohort
The German Spondyloarthritis Inception cohort (GESPIC) was started 2000 as a prospective, longitudinal, multicentre, nationwide study in Germany on patients with early SpA including ankylosing spondylitis (AS, also known as…
- Conditions
- Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA), Non-radiographic Axial Spondyloarthritis (Nr-axSpA), Axial Psoriatic Arthritis (axPsA), Acute Anterior Uveitis (AAU)
- Trial name
- GESPIC (NCT01277419)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Charite University, Berlin, Germany
Inflammatory Bowel Diseases
Ex Vivo Study of hAMSC Secretome in Inflammatory Bowel Disease: Effects on Inflammation and Fibrosis (TARGET)
Inflammatory Bowel Diseases (IBD), including ulcerative colitis and Crohn's disease, are chronic immune-mediated disorders characterized by relapsing gastrointestinal inflammation driven by genetic, immune, microbial, and…
- Trial name
- TARGET (NCT07721207)
- Testing
- Human amniotic mesenchymal stromal cell (hAMSC)-derived secretome
- Volunteers
- 40 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Inflammatory Bowel Diseases, Osteoporosis
Analysis of Bone Quality in Adult Patients With Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is considered a risk factor for the development of osteoporosis, which leads to an increased risk of fractures.
- Trial name
- NCT05171153
- Testing
- Densitometry with Trabecular Bone Score, Quantitative Ultrasound of Calcaneus, Laboratory test
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Quironsalud
Ulcerative Colitis
Progression of Damage in Ulcerative Colitis
The hypothesis of the study is that in ulcerative colitis repeated flares of inflammatory activity, as well as mechanisms involved in resolution of the inflammatory response, may contribute to accumulation of damage in the colon…
- Trial name
- PRODUC (NCT03955328)
- Testing
- Magnetic Resonance Imaging
- Where
- 4 sites in Spain
- Volunteers
- 20 people
- Sponsor
- David Garcia Cinca
Inflammatory Bowel Diseases, Colitis, Ulcerative
A Study to Evaluate MORF-057 in Adults With Moderately to Severely Active UC
This is a Phase 2b randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of three active dose regimens of MORF-057 in adult patients with moderately to severely active Ulcerative Colitis (UC).
- Trial name
- EMERALD-2 (NCT05611671)
- Testing
- MORF-057
- Where
- 102 sites in United States, Australia and 19 more
- Volunteers
- 280 people
- Sponsor
- Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company)
Crohn's Disease
Certolizumab in Crohn's Disease Patients With Loss of Response or Intolerance to Infliximab
To assess the clinical efficacy of subcutaneous (sc) certolizumab pegol administration over 26 weeks in patients suffering from Crohn's Disease (CD) and previously treated with infliximab
- Trial name
- NCT00308581
- Testing
- Certolizumab pegol
- Where
- 107 sites in United States, Austria and 12 more
- Volunteers
- 539 people
- Sponsor
- UCB Pharma
Microscopic Colitis
External Validation of a Microscopic Colitis Clinical Scoring System in Patients With Chronic Watery Diarrhoea
Chronic watery diarrhoea is a very common problem in the population and most of these patients will be referred for colonoscopy.
- Trial name
- NCT06031064
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Mutua de Terrassa
Crohn Disease
Fecal Microbiota Transplantation in Pediatric Crohn's Disease
This study will test the safety and effectiveness of fecal microbiota transplantation (FMT) plus partial enteral nutrition (PEN) in refractory pediatric Crohn's disease (CD) who have failed conventional treatment
- Trial name
- FMT (NCT05321745)
- Testing
- Standardized FMT
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Biao Zou
Ulcerative Colitis in Remission
Safety and Efficacy of a STOPping Strategy Versus Classical Maintenance Dose of JAK Inhibitors in Deep Remission Patients With Ulcerative Colitis
This phase IV, multicenter, open-label randomized controlled trial will evaluate whether a JAK inhibitor discontinuation strategy is superior to standard maintenance therapy in adult patients with ulcerative colitis who are in…
- Trial name
- STOP (NCT07718529)
- Testing
- treatment withdrawal
- Where
- 22 sites in France
- Volunteers
- 224 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Crohn's Disease
An Open-Label, Proof of Consent Study of Vorinostat for the Treatment of Mdoerate-to-Severe Crohn s Disease and Maintenance Therapy With Ustekinumab
Background: Crohn s disease (CD) is an inflammatory bowel disease. It causes inflammation of the gut. Symptoms may include diarrhea, abdominal pain, fatigue, weight loss and malnutrition.
- Trial name
- NCT03167437
- Testing
- Vorinostat, Ustekinumab
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Colitis, Ulcerative
A Safety and Effectiveness Study of Golimumab in Japanese Patients With Moderately to Severely Active Ulcerative Colitis.
The purpose of this study is to evaluate safety and effectiveness of golimumab in Japanese participants with moderately to severely active ulcerative colitis.
- Trial name
- NCT01863771
- Testing
- Golimumab
- Where
- 38 sites in Japan
- Volunteers
- 144 people
- Sponsor
- Janssen Pharmaceutical K.K.
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