Clinical trials: Inflammatory Bowel Diseases (IBD)
Perianal Fistula, Crohn Disease
Autologous Adipose-derived Stem Cells (ASCs) for the Treatment of Perianal Fistula in Crohn Disease: A Pilot Study
Crohn's disease is an immunologically mediated inflammatory bowel disease with a reported incidence of 4.0-7.0, 7.1, and 1.34 per 100,000 persons in Europe, the U.S., and Korea, respectively.
- Trial name
- ASPEFIC1 (NCT02403232)
- Testing
- ASCs injection, Closure of fistula tract.
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Papa Giovanni XXIII Hospital
Crohn Disease
Study to Evaluate Efficacy and Safety of Certolizumab Pegol for Induction of Remission in Patients With Crohn's Disease
The primary objective of the study is to evaluate efficacy of certolizumab pegol in inducing clinical remission in patients with moderate to severe Crohn's disease as compared with placebo based on Crohn's Disease Activity Index…
- Trial name
- NCT00552058
- Testing
- certolizumab pegol (CDP870, CZP)
- Where
- 116 sites in United States, Australia and 18 more
- Volunteers
- 439 people
- Sponsor
- UCB Pharma
Inflammatory Bowel Diseases, Quality of Life
Delayed Surgery in Inflammatory Bowel Disease
The timing of elective surgery in inflammatory bowel disease (IBD) may be crucial according to progression of the disease. In most cases, medical treatment has failed when surgery is discussed.
- Conditions
- Inflammatory Bowel Diseases, Quality of Life, Surgery
- Trial name
- NCT05810155
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Sahlgrenska University Hospital
Inflammatory Bowel Diseases
Tacrolimus Versus Methotrexate as Rescue Therapy for Refractory Inflammatory Bowel Disease
Mesalazine, steroid, immunosuppressants and biologic agents are main medical treatments in treating inflammatory bowel diseases. Yet some patients develop severe side effects or initial invalid to conventional therapies.
- Trial name
- NCT03204136
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, China
Crohn Disease
Early Bowel Resection for Terminal Ileal Crohn's Disease
The goal of this multicentre mixed -methods study is to understand the patient and clinician perspective on the ideal timing of an operation for Crohn's disease of the terminal ileum (last part of the small bowel).
- Trial name
- E-BRIC (NCT06116604)
- Where
- United Kingdom
- Volunteers
- 496 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Crohn Disease (CD)
Evaluation of Muscle Strength and Muscle Mass in Patients With Inflammatory Bowel Disease
This prospective observational study aims to evaluate the validity of ultrasonographic muscle measurements in patients with inflammatory bowel disease (IBD).
- Trial name
- IBDSARC (NCT07441447)
- Testing
- Muscle Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Sakarya University
Bowel Cancer, Bowel Diseases, Inflammatory
LuCID - Investigating the Use of a Novel Digital Rectoscope for Community Examinations During COVID-19
The LumenEye scope and CHiP platform will be piloted in a number of clinical settings including remote colorectal clinics. The rationale is to perform an initial pilot study to determine the clinical utility of the LumenEye…
- Conditions
- Bowel Cancer, Bowel Diseases, Inflammatory, Rectal Bleeding
- Trial name
- LuCID (NCT05043363)
- Testing
- LumenEye X1 digital rectoscope
- Where
- United Kingdom
- Volunteers
- 114 people
- Sponsor
- Imperial College London
Crohn Disease
Study of Treat to Target Versus Routine Care Maintenance Strategies in Crohn's Disease Patients Treated With Ustekinumab
The purpose of this study is to evaluate the efficacy of a treat to target strategy coupled with early endoscopic assessment versus a clinically driven (routine care) approach in achieving endoscopic response.
- Trial name
- STARDUST (NCT03107793)
- Testing
- Ustekinumab
- Where
- 107 sites in Belgium, Czechia and 10 more
- Volunteers
- 500 people
- Sponsor
- Janssen-Cilag Ltd.
Colon Cancer, Colon Polyp
Feasibility and Safety of Single Port Robot in Colorectal Procedures
The purpose of this study is to evaluate the safety and feasibility of using the Single Port (SP) robot (daVinci, Intuitive Surgical) to perform single port robotic colon surgery and transanal robotic surgery.
- Conditions
- Colon Cancer, Colon Polyp, Rectal Cancer, Diverticulitis
- Trial name
- NCT03700593
- Testing
- Single Port Robotic Colorectal Surgery
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Marks Colorectal Surgical Associates
Crohn's Disease
CP-461 for the Treatment of Crohn's Disease
Patients with moderately to severely active Crohn's disease will be treated with oral CP-461 200 mg (2 x 100 mg capsules) twice-daily for 8 weeks.
- Trial name
- NCT00042055
- Testing
- CP-461
- Where
- 10 sites in United States
- Volunteers
- 30 people
- Sponsor
- Astellas Pharma Inc
Crohn Disease, Inflammatory Bowel Diseases
Feasibility of a Wireless Thermal Capsule Endoscopy to Detect Gastrointestinal Thermal Variance
The goal of this research is to learn how a new device called the wireless thermal capsule (WTC) can collect thermal data to help see diseases that happen in the gastrointestinal (GI) tract, such as Crohn's Disease.
- Conditions
- Crohn Disease, Inflammatory Bowel Diseases, Healthy
- Trial name
- NCT07033208
- Testing
- Feasibility to obtain thermal variance measurements using a wireless thermal capsule
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Vitamin D, Iron Deficiency and Overload
Can Vitamin D Replacement Correct Chronic Disease Anemia?
This prospective, single-arm interventional pilot study evaluated whether vitamin D supplementation alone improves iron status in adults with inflammatory bowel disease (IBD) who are in clinical remission and have concurrent…
- Conditions
- Vitamin D, Iron Deficiency and Overload, Inflammatory Bowel Disease (Crohn's Disease; Ulcerative Colitis)
- Trial name
- NCT07673497
- Testing
- Cholecalciferol (Vit D3)
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Gazi University
Infliximab, Infusion
Infliximab Infusion Rates in Pediatric Inflammatory Bowel Disease
OBJECTIVES OF THE STUDY 1. Investigate whether there are just as few infusion reactions with infliximab infusions of 60 min and 30 min. 2. Investigate patient and nurse satisfaction with infusions of 60 min and 30 min. 3.
- Conditions
- Infliximab, Infusion, IBD (Inflammatory Bowel Disease), Patient Satisfaction
- Trial name
- iRAPID (NCT06839820)
- Testing
- Infusion rate of infliximab
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- University Hospital, Akershus
Crohn Disease (CD)
R-3750 in Patients With Crohn's Disease
This is a multicenter, randomized, double-blind, placebo-controlled study evaluating the safety, tolerability, clinical activity, and pharmacodynamic effects of R-3750 in adults with active Crohn's disease.
- Trial name
- NCT07791888
- Testing
- R-3750
- Volunteers
- 40 people
- Sponsor
- Rise Therapeutics LLC
Colitis, Ulcerative
The Utility of Second Generation Colon Capsule Endoscopy in Ulcerative Colitis
The purpose of this study is to investigate the accuracy of second generation colon capsule (C2) in evaluating colonic mucosal inflammation of ulcerative colitis patients, using conventional endoscopy as the gold standard.
- Trial name
- NCT02469103
- Testing
- C2, colonoscopy
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
Fatigue, Inflammatory Bowel Disease
Electroacupuncture vs. Sham Electroacupuncture for Treatment of Fatigue in Patients With Inflammatory Bowel Disease
Fatigue is a common symptom in inflammatory bowel diseaseI and persists despite clinical remission. Fatigue in patients with chronic diseases can be objectified by the FACIT-F scale.
- Trial name
- NCT02733276
- Testing
- electroacupuncture
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Corporacion Parc Tauli
Inflammatory Bowel Disease
Study Assessing Risk Factors for Abdominal Pain in Children With Inflammatory Bowel Disease
To characterize persistent abdominal pain in children with inflammatory bowel disease (IBD) by examining factors such as disease type, activity and location, psychosocial factors, and genetics.
- Trial name
- NCT02984059
- Testing
- Genomic DNA, RNA analysis, Microbiome
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Connecticut Children's Medical Center
Crohn Disease, Ulcerative Colitis
Digital Nutrition Therapy for Patients With IBD
Background: Alberta's Center of Excellence for Nutrition in Digestive Diseases (Ascend) is dedicated to generating new discoveries regarding the link between nutrition and digestive diseases and mobilizing existing research to…
- Trial name
- LYFEMD (NCT04653259)
- Testing
- LYFE MD app
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University of Calgary
Crohn Disease, Pain
Pain in Patients With Crohn Disease (PAINCD)
Abdominal pain is a common symptom in patients with Crohn disease (CD). Pain is multifactorial, may result from inflammation but persists in many patients during remission.
- Conditions
- Crohn Disease, Pain, Depression, Anxiety
- Trial name
- PAINCD (NCT04488146)
- Volunteers
- 200 people
- Sponsor
- University of Liege
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Ulcerative Colitis (UC)
Narrow Band Imaging Versus Artificial Intelligence for Colonic Surveillance in Inflammatory Bowel Disease
Patients with inflammatory bowel disease (IBD) - ulcerative colitis or Crohn's disease - have a higher risk of developing colorectal cancer than the general population.
- Conditions
- Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Ulcerative Colitis (UC), Crohn's Disease Colon, Colonic Dysplasia/Adenomata
- Trial name
- CLEAR-IBD (NCT07694362)
- Testing
- ENDO-AID CADe System (Olympus, Tokyo, Japan) (AI device)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Vall d'Hebron Institute Research