Clinical trials: Inflammatory Bowel Diseases (IBD)
Crohn Disease
Reverse Engineering of Exclusive Enteral Nutrition
Primary: Nutritional therapy in the form of a whole-food based smoothie can be used to induce remission of active Crohn's disease.
- Trial name
- RE-EEN (NCT03508193)
- Testing
- Nutritional therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Dale Lee
Ulcerative Colitis
Tofacitinib Versus Cyclosporine for Steroid Refractory Acute Severe Ulcerative Colitis
This randomised trial plans to compare oral tofacitinib with intravenous cyclosporine in patients with acute severe ulcerative colitis who have failed to respond to intravenous steroids
- Trial name
- TOCASU (NCT05112263)
- Testing
- Tofacitinib, Cyclosporine
- Volunteers
- 96 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Inflammatory Bowel Diseases, Chronic Pain
Somatosensory Profiles in Individuals With Persistent Musculoskeletal Pain and Inflammatory Bowel Disease
This study evaluates nervous system hypersensitivity in individuals with inflammatory bowel disease (IBD) and experiences of ongoing musculoskeletal (MSK) pain.
- Conditions
- Inflammatory Bowel Diseases, Chronic Pain, Central Sensitization
- Trial name
- NCT03799471
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Ulcerative Colitis
Clinical Study on the Fecal Microbiota Transplantation in the Treatment of Ulcerative Colitis With Depression
This is a single-center trial, randomized, single-blind, placebo-controlled clinical intervention study which intends to explore the safety and effectiveness of FMT capsule for the treatment of ulcerative colitis with depression.
- Trial name
- NCT05030064
- Testing
- Intestinal flora capsule
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Third Military Medical University
Ulcerative Colitis
Diet Study on Ulcerative Colitis
The primary purpose of this study is to determine the effectiveness of a low-fat or standard American diet (high in fat) in helping people with ulcerative colitis improve their symptoms and the signs of inflammation in blood…
- Trial name
- NCT04147598
- Testing
- LFD, SAD
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Miami
Inflammatory Bowel Diseases
Efficacy Assessment and Monitoring of Subcutaneous Infliximab Levels.
Retrospective observational study in which the efficacy of infliximab is studied in patients with inflammatory bowel disease and its subcutaneous levels are monitored.
- Trial name
- Infliximab (NCT05071404)
- Where
- Spain
- Volunteers
- 17 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Crohn Disease
Efficacy and Safety of CDED With Anti-TNF-α Biologics in Crohn's Disease
Crohn's disease (CD) is a chronic inflammatory bowel disease with high recurrence and surgical rates. Mucosal healing is a key therapeutic goal, yet current anti-TNF-α biologics achieve only about 30% mucosal healing.
- Trial name
- CDED (NCT07344428)
- Testing
- Crohn's Disease Exclusion Diet
- Where
- China
- Volunteers
- 185 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Crohn Disease
The CROCO Study: CROhn's Disease COhort Study
The investigators propose to create a prospective Crohn Disease cohort, where patients receiving the most up-to-date therapies with a treat-to-target strategy, will be closely followed to characterize the progression of Crohn…
- Trial name
- CROCO (NCT05420233)
- Testing
- MRE
- Where
- 19 sites in Belgium, Cyprus and 9 more
- Volunteers
- 533 people
- Sponsor
- GLSMED Learning Health S.A.
Ulcerative Colitis
A Study Evaluating the Effect of Filgotinib Dose De-escalation in Participants With Ulcerative Colitis (UC) in Remission
Participants who were in clinical remission on 200 milligram (mg) filgotinib once daily for at least 2 consecutive quarterly visits in the ongoing SELECTION-LTE study (GS-US-418-3899, NCT02914535), were planned to be rolled over…
- Trial name
- CAPYBARA (NCT05479058)
- Testing
- Filgotinib
- Where
- 50 sites in United States, Belgium and 11 more
- Volunteers
- 22 people
- Sponsor
- Lakefront Biotherapeutics NV
Ulcerative Colitis
Study to Evaluate the Clinical Activity and Safety of Oral NX-13 in Moderate to Severe Ulcerative Colitis
Phase 2 induction study with a long-term extension (LTE) period in participants with moderate to severe ulcerative colitis (UC).
- Trial name
- NCT05785715
- Testing
- NX-13 250mg, NX-13 750mg
- Where
- 35 sites in United States, Belgium and 2 more
- Volunteers
- 81 people
- Sponsor
- AbbVie
Ulcerative Colitis, Ileal Pouch
Aquamin® for Prevention of Ulcerative Colitis J-Pouch-associate Intestinal Inflammation
Ulcerative colitis (UC) is a disease that causes long-term inflammation in the digestive tract, and many people with this condition require surgery to remove the colon and create a new J-pouch for stool.
- Trial name
- NCT07501078
- Testing
- Aquamin
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Muhammad N Aslam, MD
Crohns Disease, Ulcerative Colitis
Integrative Gastroenterology - an Observational Trial
This study aims to test, if a two-week integrative therapy in an internal medicine ward will improve symptoms, disability and quality of life in patients with inflammatory bowel disease or irritable bowel syndrome.a It shall…
- Conditions
- Crohns Disease, Ulcerative Colitis, Irritable Bowel Syndrome
- Trial name
- InteGast (NCT02476643)
- Testing
- Integrative Therapy
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Universität Duisburg-Essen
Crohn's Disease, Ultrasound
Ultrasound Stiffness Imaging in Crohn's Disease
The purpose of this study is to determine whether ultrasound-based assessment of intestinal stiffness in patients with Crohn's disease predicts the effectiveness of medical therapy or the need for surgical resection.
- Conditions
- Crohn's Disease, Ultrasound, Intestinal Fibrosis, Shear Wave Imaging
- Trial name
- NCT01666626
- Testing
- Ultrasound stiffness imaging
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan
Crohns Disease, Vitamin D Deficiency
Maintenance Dosing of Vitamin D in Crohn's Disease
Vitamin D repletion is important for bone health in patients with Crohn's disease. While repletion strategies in the general population yield similar results in those with Crohn's disease, maintenance strategies are variable.
- Trial name
- NCT03615378
- Testing
- 5000 IU D3, 1000 IU D3
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cedars-Sinai Medical Center
Inflammatory Bowel Diseases
Lymphoid Tyrosine Phosphatase Gene Polymorphisms in Inflammatory Bowel Disease
This study aims: 1. To investigate the association between single nucleotide polymorphisms of PTPN22 gene (rs2476601, rs33996649 and rs2488457) and inflammatory bowel disease. 2.
- Trial name
- NCT04284878
- Testing
- PCR-RFLP
- Volunteers
- 200 people
- Sponsor
- Assiut University
Inflammatory Bowel Disease
Effect of Standardized Nutritional Therapy on Clinical Prognosis and Cost-effectiveness of Inflammatory Bowel Disease
To construct a standardized stepped nutritional treatment process for inpatients with inflammatory bowel disease, including nutritional risk screening and assessment, standardized nutritional treatment implementation, therapeutic…
- Trial name
- NCT04349943
- Testing
- nutrition therapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Crohn's Ileocolitis, Crohn Disease
Effect of Statins on Crohn's Disease
The goal of this clinical trial is to learn if statins work to prevent strictures in adults with Crohn's disease. The main question it aims to answer is: Can statins reduce the formation of strictures in participants with…
- Trial name
- NCT06538649
- Testing
- Rosuvastatin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Ulcerative Colitis
Follow-up Study With Retarded Release Phosphatidylcholine in Ulcerative Colitis
Follow-Up Study with Retarded Release Phosphatidylcholine in Ulcerative Colitis Objectives: The objective of the study is to evaluate the follow up of patients treated with retarded release phosphatidylcholine in three…
- Trial name
- NCT00463619
- Testing
- Retarded release phosphatidylcholine
- Where
- Germany
- Volunteers
- 132 people
- Sponsor
- Heidelberg University
Crohns Disease, Fistula
Study to Look at Benefit of Surgical Drainage Before Beginning Medical Therapy for Crohns Perianal Fistulas
This study is looking at the advantage of establishing surgical drainage for Crohn's fistulas and abscesses prior to starting medical therapy.
- Conditions
- Crohns Disease, Fistula, Abscess
- Trial name
- NCT01145365
- Testing
- Exam under anesthesia (EUA)
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Vanderbilt University Medical Center
Ulcerative Colitis
Optimal Fecal Microbiota Transplant Dosing for Mild to Moderate Ulcerative Colitis
This is a prospective unblinded, randomized trial for the use of Fecal Microbiota Transplantation (FMT) for the treatment of Ulcerative Colitis (UC), in combination with or without antibiotic pretreatment.
- Trial name
- NCT03006809
- Testing
- Fecal Microbiota Transplantation (FMT), OpenBiome, pretreatment antibiotics
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Najwa Elnachef
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