Clinical trials: Inflammatory Bowel Diseases (IBD)
Ulcerative Colitis
Combined Microbiota and Metabolic Signature in Ulcerative Colitis Predicts Anti-Inflammatory Therapy Success
The primary goal of the study is to develop an early (within 4 weeks) combined microbiota/metabolic signature predicting clinical response upon anti-inflammatory treatment in UC patients.
- Trial name
- COMMIT (NCT05702879)
- Testing
- Ozanimod, TNF Inhibitor, Steroids
- Where
- Switzerland
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Ulcerative Colitis (UC)
The Association Between Interleukin-7 Receptor Gene Polymorphism and the Risk of Ulcerative Colitis
From January 2020 to December 2024, diagnosed ulcerative colitis(UC) patients and gender- and age-matched normal controls were enrolled from the Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical…
- Trial name
- NCT07398586
- Testing
- Vedolizumab
- Where
- China
- Volunteers
- 898 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Irritable Bowel Disease, Ulcerative Colitis (UC)
Health-Related Quality of Life Among Patients With Inflammatory Bowel Disease
The primary aim of this study is to assess HRQOL and its associated factors among people with IBD. The target sample will be 385 adult patients diagnosed with IBD (both Crohn's Disease and Ulcerative Colitis).
- Conditions
- Irritable Bowel Disease, Ulcerative Colitis (UC), Crohn Disease (CD)
- Trial name
- NCT07436910
- Where
- Egypt
- Volunteers
- 385 people
- Sponsor
- Cairo University
Ulcerative Colitis
ABTECT - Maintenance
This is a multicenter, randomized, placebo-controlled study to evaluate the long-term efficacy and safety of ABX464 50mg and 25mg administered once daily (QD) as maintenance therapy in subjects with moderately to severely active…
- Trial name
- NCT05535946
- Testing
- ABX464
- Where
- 413 sites in United States, Argentina and 32 more
- Volunteers
- 1,116 people
- Sponsor
- Abivax S.A.
Inflammatory Bowel Diseases
Clinical Value of Intestinal Ultrasound in Predicting Clinical Relapse in Crohn's Disease Patients in Deep Remission: a Multicenter Prospective Observational Study
Crohn's disease (CD) is a nonspecific chronic inflammatory condition characterized by a protracted course with alternating periods of relapse and remission.
- Trial name
- NCT07539727
- Testing
- Transabdominal Intestinal Ultrasound
- Where
- China
- Volunteers
- 420 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Crohn Disease
Effects of Enteral Nutrition and Corticosteroid on Intestinal Flora in Induction Remission of Crohn Disease in Adult
The pathogenesis of Crohn Disease (CD) is unknown, but there is evidence show that the inadequate immune response or overreaction of the immune system against food antigens or components of the commensal flora involve it.
- Trial name
- EN (NCT02056418)
- Testing
- enteral nutrition, corticosteroid
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Crohn Disease, Anal Fistula
Study on the Treatment of Anal Fistulas Using Alofisel Versus Fat Autologous Stem Cells
One of the newest and most innovative medicinal approaches is cell therapy. Several clinical trials and experimental investigations have looked into the feasibility of treating CD-related fistulas with stem cells.
- Trial name
- CHAZAM (NCT05974280)
- Testing
- Alofisel, Fat stem cell
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Nantes University Hospital
Ulcerative Colitis, Crohn's Disease
Epidemiology of Ulcerative Colitis and Crohn's Disease in Non Jewish Israel Population
The aim of the present study was to describe the incidence and prevalence of IBD in non Jewish Israel population
- Trial name
- NCT00815061
- Where
- Israel
- Sponsor
- Rabin Medical Center
Ulcerative Colitis
Photodynamic Therapy for Ulcerative Colitis
Objectives: Primary: The primary study objective is to determine a clinical response as assessed by the Mayo score to low dose PDT in patients with moderate to severe active distal UC.
- Trial name
- NCT01697670
- Testing
- Photodynamic therapy with Gliolan
- Where
- Switzerland
- Volunteers
- 7 people
- Sponsor
- University of Zurich
Inflammatory Bowel Disease (IBD), Clostridium Difficile Infection (CDI)
Study to Evaluate the Pharmacokinetics of Fidaxomicin in Inflammatory Bowel Disease (IBD) Subjects With Clostridium Difficile Infection (CDI)
The purpose of this study is to investigate the plasma pharmacokinetics (PK) of fidaxomicin (FDX) and primary metabolite OP-1118 in Subjects with Inflammatory Bowel Disease (IBD) and C. difficile Infection (CDI).
- Trial name
- PROFILE (NCT02437591)
- Testing
- fidaxomicin
- Where
- 12 sites in Austria, France and 5 more
- Volunteers
- 25 people
- Sponsor
- Astellas Pharma Europe Ltd.
Crohn Disease
Post-Marketing Surveillance for Crohn's Disease Participants Treated With Stelara (Ustekinumab)
The purpose of post-marketing surveillance (PMS) is to assess the safety and effectiveness of ustekinumab (Stelara) for Crohn's disease participants under real world clinical practice.
- Trial name
- STELARA CD PMS (NCT03942120)
- Testing
- Ustekinumab
- Where
- 43 sites in South Korea
- Volunteers
- 685 people
- Sponsor
- Janssen Korea, Ltd., Korea
Crohn's Disease
STA-5326 in Crohn's Disease Patients
The purpose of this study is to determine the safety and tolerability of STA-5326 given once daily or twice daily to Crohn's Disease patients with moderate disease.
- Trial name
- NCT00088062
- Testing
- STA-5326
- Where
- 18 sites in United States
- Volunteers
- 48 people
- Sponsor
- Synta Pharmaceuticals Corp.
Inflammatory Bowel Diseases, Food Intolerance
Impact of Different Dietary IgGs on the Pathogenesis of IBD
Identify the association between certain food IgGs (Wheat, rice, broad beans, cow milk, eggs, chicken and beef) and the immunological response in patients with IBD
- Trial name
- NCT03885479
- Testing
- ELISA for the semi-quantitative analysis of serum food-specific IgGs against food-derived antigens
- Volunteers
- 150 people
- Sponsor
- Assiut University
Inflammatory Bowel Disease
Influence of Vitamin D on Inflammatory Bowel Disease Remission
Vitamin D has been shown to influence a multitude of systems. We intend to see whether different types of Vitamin D supplements have an effect on inflammatory bowel disease.
- Trial name
- NCT01121796
- Testing
- Vitamin D, Water or milk, Vitamin D enriched milk
- Where
- Israel
- Volunteers
- 90 people
- Sponsor
- Hillel Yaffe Medical Center
Ulcerative Colitis, Crohn's Disease
A Study in Adults With Inflammatory Bowel Disease (IBD) Receiving Vedolizumab in the Patient Support Program (PSP) in Brazil
The primary reason of this study is to observe current and past treatment in adult participants receiving Vedolizumab, intravenous (IV) or subcutaneous (SC), for IBD in Brazil.
- Trial name
- NCT05626088
- Testing
- No Intervention
- Where
- Brazil
- Volunteers
- 1,006 people
- Sponsor
- Takeda
Ulcerative Colitis
Tofacitinib in Adult Patients With Moderate to Severe Ulcerative Colitis
This is an observational prospective study with two years of follow-up, designed to evaluate the effectiveness of tofacitinib in patients with moderate to severe ulcerative colitis in French clinical practice
- Trial name
- TOFAST (NCT04424303)
- Testing
- Tofacitinib
- Where
- 38 sites in France
- Volunteers
- 152 people
- Sponsor
- Pfizer
Crohn's Disease
An Analysis of the Relationship Between the Genetic Polymorphisms of Interleukin 12 Receptor Subunit Beta 1 and Crohn's Disease in Chinese Patients
From January 2018 to May 2025, diagnosed CD patients and gender- and age-matched normal controls were collected from Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University.
- Trial name
- NCT07057856
- Testing
- Ustekinumab (UST)
- Where
- China
- Volunteers
- 866 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Ulcerative Colitis, Postoperative Complications
TAMIS-IPAA vs. Lap-IPAA for Ulcerative Colitiis
The objective of this RCT is to compare the postoperative outcome of transanal versus transabdominal minimally invasive proctectomy with ileal pouch-annal anastomosis in patients with ulcerative colitis.
- Conditions
- Ulcerative Colitis, Postoperative Complications, Ileal Pouch
- Trial name
- NCT03536988
- Testing
- TAMIS-IPAA, Lap-IPAA
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Jinling Hospital, China
Inflammatory Bowel Diseases, Crohn's Disease
A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease
This is a Phase 2, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of 3 active dose regimens of MORF-057 in adult study participants with moderately to severely active Crohn's…
- Trial name
- GARNET (NCT06226883)
- Testing
- MORF-057
- Where
- 225 sites in United States, Australia and 26 more
- Volunteers
- 385 people
- Sponsor
- Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company)
Crohn's Disease
Relationship Between Prophylactic Drainage and Postoperative Complications (PPOI) in Crohn's Patients After Surgery
For patients with Crohn's diseases，whether prophylactic abdominal drainage is necessary need further exploration. the present study is focusing on the necessity of prophylactic abdominal drainage in CD patients after surgery.
- Trial name
- RBPD (NCT03815851)
- Testing
- prophylactic drainage, no prophylactic drainage
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jinling Hospital, China
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