Clinical trials: Inflammatory Bowel Diseases (IBD)
Inflammatory Bowel Diseases
Service Development of POCUS in the IBD Clinic
Study to determine whether the use of an ultrasound completed during an inflammatory bowel disease (IBD) clinic will speed up diagnosis, treatment initiation, reduce complications, save money and reduce investigations compared…
- Trial name
- NCT05838196
- Testing
- Point-of-care ultrasound
- Where
- United Kingdom
- Volunteers
- 122 people
- Sponsor
- University College, London
Hemorrhoids, Chronic Inflammatory Bowel Disease
Study "HEMORROIDAL SURGERY AND Chronic Inflammatory Bowel Disease"
Hemorrhoidal surgery is considered potentially harmful in patients with chronic inflammatory bowel disease (IBD). Patients with Crohn's disease may have ano-perineal involvement during the course of the disease or even before…
- Trial name
- CHRMICI (NCT04692194)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Inflammatory Bowel Diseases, Insomnia
Feasibility of Insomnia Tracking and Treatment in IBD
This study is a longitudinal clinical trial designed to characterize sleep patterns in individuals with Inflammatory Bowel Disease (IBD) as well as to assess the feasibility of sleep intervention (Cognitive Behavioral Therapy for…
- Trial name
- FITT (NCT04132024)
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I)
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Inflammatory Bowel Diseases, Intestinal Ultrasound
IUS Combined With VAT Predicts Anti-TNF-α Efficacy in Patients With IBD: a Prospective Study
Inflammatory Bowel Disease (IBD) is a chronic recurrent nonspecific inflammatory disease of the intestinal tract that can involve multiple organs and systems, mainly including Crohn's disease (CD) and ulcerative colitis (UC).
- Conditions
- Inflammatory Bowel Diseases, Intestinal Ultrasound, Visceral Adipose Tissue, TNF-α
- Trial name
- NCT06165029
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Crohn's Disease
A Study of Subcutaneous HUMIRA (Adalimumab) Injection to Assess Adverse Events and Change in Disease Activity In Adult Participants With Moderate to Severe Active Crohn's Disease (CD)
Crohn's disease (CD) is an incurable chronic inflammatory disorder of the gastrointestinal tract. This study will assess how safe and effective Humira (adalimumab) is in treating moderately to severely active CD in China.
- Trial name
- NCT05394805
- Where
- 10 sites in China
- Volunteers
- 156 people
- Sponsor
- AbbVie
Crohn's Disease, Inflammatory Bowel Disease
A Study to Evaluate the Safety and Efficacy of Ustekinumab Induction Therapy in Patients With Moderately to Severely Active Crohn's Disease (UNITI-2)
This study (UNITI-2) will compare the effects (both positive and negative) of an initial treatment with ustekinumab to a placebo over 8 weeks in patients with moderately to severely active Crohn's disease.
- Conditions
- Crohn's Disease, Inflammatory Bowel Disease, IBD, Colitis
- Trial name
- NCT01369342
- Testing
- Group 2 ustekinumab 130 mg, Group 3: ustekinumab approximately 6 mg/kg
- Where
- 220 sites in United States, Australia and 20 more
- Volunteers
- 640 people
- Sponsor
- Janssen Research & Development, LLC
Colon Cancer, Colon Polyp
Feasibility and Safety of Single Port Robot in Colorectal Procedures
The purpose of this study is to evaluate the safety and feasibility of using the Single Port (SP) robot (daVinci, Intuitive Surgical) to perform single port robotic colon surgery and transanal robotic surgery.
- Conditions
- Colon Cancer, Colon Polyp, Rectal Cancer, Diverticulitis
- Trial name
- NCT03700593
- Testing
- Single Port Robotic Colorectal Surgery
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Marks Colorectal Surgical Associates
Not Applicable - Healthy Adult Participants
Study of XmAb412 in Healthy Participants
This Phase 1 Study will evaluate the safety, tolerability, pharmacokinectics and pharmacodynamics of XmAb412 in healthy adult participants
- Trial name
- NCT07713485
- Testing
- XmAb412 Monoclonal Bispecific Antibody
- Where
- 2 sites in Australia
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Xencor, Inc.
Inflammatory Bowel Diseases
Preoperative Oral ImmunoNuTrition to Improve Surgical Outcomes for IBD Patients (PINT)
The central focus of this trial is to understand the effectiveness of Preoperative Immunonutrition (PINT) in improving surgical outcomes for patients with inflammatory bowel disease (IBD).
- Trial name
- PINT (NCT03333148)
- Testing
- Nestle IMPACT Immunonutrition, Arm B- Standard of Care
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Crohn's Disease
Study Investigating Tailored Treatment With Infliximab for Active Crohn's Disease
To investigate whether sustained trough levels of IFX can be achieved using IFX (Infliximab) trough level measurements and adjustment of dosing based upon these levels by means of two different standardized algorithms in…
- Trial name
- TAILORIX (NCT01442025)
- Testing
- Infliximab
- Where
- 12 sites in France
- Volunteers
- 121 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Ulcerative Colitis
Study to Evaluate the Clinical Activity and Safety of Oral NX-13 in Moderate to Severe Ulcerative Colitis
Phase 2 induction study with a long-term extension (LTE) period in participants with moderate to severe ulcerative colitis (UC).
- Trial name
- NCT05785715
- Testing
- NX-13 250mg, NX-13 750mg
- Where
- 35 sites in United States, Belgium and 2 more
- Volunteers
- 81 people
- Sponsor
- AbbVie
Ulcerative Colitis
Efficacy and Safety of Rectally Administered BBT-401-1S in Subjects With Ulcerative Colitis
This is an open label, single-arm, proof of mechanism study to explore the efficacy and safety of rectally administered BBT-401-1S in subjects with ulcerative colitis.
- Trial name
- NCT04478825
- Testing
- BBT-401-1S
- Where
- 2 sites in New Zealand
- Volunteers
- 2 people
- Sponsor
- Bridge Biotherapeutics, Inc.
Ulcerative Colitis, Crohn Disease
A Study of Vedolizumab in People With Ulcerative Colitis and Crohn's Disease
Vedolizumab is a medicine that helps to reduce inflammation and pain in the digestive system. In this study, people with ulcerative colitis or Crohn's disease will be treated with vedolizumab.
- Trial name
- NCT04804540
- Testing
- Vedolizumab IV
- Where
- 17 sites in India
- Volunteers
- 150 people
- Sponsor
- Takeda
Anemia, Iron Deficiency, Inflammatory Bowel Diseases
Feraccru® Real World Effectiveness Study in Hospital Practice ( FRESH )
The aim of the study is to understand the early experiences of Feraccru® in patients with inflammatory bowel disease (IBD) and iron deficiency anaemia (IDA) in the UK, including treatment effectiveness, patterns of use and…
- Trial name
- FRESH (NCT03247816)
- Where
- United Kingdom
- Volunteers
- 59 people
- Sponsor
- Shield Therapeutics
Crohn Disease, Inflammatory Bowel Disease
Health-Related Quality of Life in Crohn's Disease Participants With Complex Perianal Fistula Before and After Treatment
The purpose of this study is to assess the impact of treatment (medical and/or surgical) on Health-related Quality of Life (HRQoL) in participants with Crohn's Disease (CD) and Complex Perianal Fistula (CPF), by the Quality of…
- Conditions
- Crohn Disease, Inflammatory Bowel Disease, Gastrointestinal Diseases, Intestinal Diseases
- Trial name
- CALYPSO (NCT04102163)
- Where
- 20 sites in Spain
- Volunteers
- 19 people
- Sponsor
- Takeda
Crohn Disease
Fecal Microbial Transplantation in Patients With Crohn's Disease
Fecal Microbiota Transplantation will be offered to eligible Crohn's disease patient as Investigational New Drug treatment
- Trial name
- NCT03267238
- Testing
- Fecal Microbial Transplantation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Stony Brook University
Crohn Disease, Ulcerative Colitis
Ultra-proactive Therapeutic Drug Monitoring in Inflammatory Bowel Disease
This is a comparative pragmatic trial in patients with UC and CD on maintenance treatment with IFX. All IBD patients from cohort A with maintenance IFX treatment at a referral IBD clinic are prospectively included between June…
- Trial name
- NCT04775732
- Testing
- infliximab therapeutic drug monitoring
- Where
- 2 sites in Belgium
- Volunteers
- 187 people
- Sponsor
- Imelda GI Clinical Research Center
Morbus Crohn, Colitis, Ulcerative
Acupuncture in Pediatrics and Adolescents With Chronic Inflammatory Bowel Diseases
Chronic inflammatory bowel disease (CIBD) with its prevalence of 2.6 million people in Europe is diagnosed in 25% before the age of 18 years.
- Trial name
- NCT04488198
- Testing
- Acupuncture
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
IBD (Inflammatory Bowel Disease)
Diet and Stress Management Combined With Advanced Therapy for Crohn's and Ulcerative Colitis
Inflammatory Bowel Disease (IBD), which includes Crohn's Disease (CD) and Ulcerative Colitis (UC), is a chronic, immune-mediated disease characterized by recurrent episodes of relapse.
- Trial name
- D-SCAPE (NCT07168499)
- Testing
- Diet Management, Stress Management
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Massachusetts General Hospital
Rheumatoid Arthritis, Ankylosing Spondylitis
Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases
TRANSREG will assess the safety and biological efficacy of low-dose IL2 as a Treg inducer in a set of 14 autoimmune and auto-inflammatory diseases, with the aim to select diseases in which further therapeutic development will be…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Systemic Lupus Erythematosus, Psoriasis
- Trial name
- TRANSREG (NCT01988506)
- Testing
- Interleukin 2
- Where
- 11 sites in France
- Volunteers
- 81 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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