Clinical trials: Inflammatory Bowel Syndrome
Bowel Disease, Crohn Disease
Development of New Diagnostic Tools in Capsule Endoscopy
Patients participating to this study will provide images and videos of capsule endoscopy to train, tune and evaluate technological bricks of artificial intelligence solutions, in order to improve diagnostic performances of the…
- Conditions
- Bowel Disease, Crohn Disease, Celiac Disease, Chronic Diarrhea
- Trial name
- NOCE (NCT06152289)
- Where
- France
- Volunteers
- 10,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Inflammatory Bowel Syndrome
ALPCO Calprotectin CLIA Assay - Measurement of Calprotectin Levels in Human Stool
The ALPCO Calprotectin CLIA is an in vitro diagnostic test intended to quantitatively measure concentrations of fecal calprotectin in human stool samples. Calprotectin is a protein biomarker of mucosal inflammation.
- Trial name
- NCT06810518
- Testing
- ALPCO Calprotectin CLIA
- Where
- 3 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- American Laboratory Products Company
Cancer
Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer
Phase I trial to study the effectiveness of trastuzumab plus R115777 in treating patients who have advanced or metastatic cancer.
- Trial name
- NCT00005842
- Testing
- trastuzumab, tipifarnib
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Irritable Bowel Syndrome, Cyclical Vomiting Syndrome
Multi Modal Imaging: An MRI Study to Investigate Differences in the Structure and the Function of the Brain at Rest.
The structural/RSN study involves Structural and Resting State Neuroimaging. The purpose of Structural Neuroimaging is to use MRI technology to identify cortical and white matter morphometric differences between patients with…
- Conditions
- Irritable Bowel Syndrome, Cyclical Vomiting Syndrome, Ulcerative Colitis, Vulvodynia
- Trial name
- MMI (NCT01517516)
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Gut Microbiome, Inflammation
Targeted Metabolomics to Decipher Dietary Contributions to Pediatric Inflammatory Bowel Disease (IBD) - Main Study
The overall goal of the study is to investigate the dietary differences between children with well-controlled inflammatory bowel disease (IBD) and those with active disease by using targeted food metabolomics.
- Conditions
- Gut Microbiome, Inflammation, Irritable Bowel Syndrome
- Trial name
- TAMED IBD (NCT05014243)
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Sepsis
the Effect of Gut Microbiota on the Prognosis of Sepsis
Sepsis is a life-threatening condition that arises when the body's response to infection injures its own tissues and organs. Common signs and symptoms include fever, increased heart rate, increased breathing rate, and confusion.
- Trial name
- NCT02768324
- Volunteers
- 30 people
- Sponsor
- Jinan University Guangzhou
Chronic Mesenteric Ischemia, Median Arcuate Ligament Syndrome
Intestinal Ischemia Biomarker in Patients With Chronic Mesenteric Ischemia
Plasma Alpha glutathione S transferase (Alpha GST) has been previously demonstrated to be raised in patients with chronic mesenteric ischemia (CMI) caused by atherosclerosis and in patients with median arcuate ligament syndrome…
- Conditions
- Chronic Mesenteric Ischemia, Median Arcuate Ligament Syndrome, Crohn Disease, Cholelithiasis
- Trial name
- NCT06468774
- Testing
- Laparoscopic surgery
- Where
- Norway
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Familial Adenomatous Polyposis, Duodenal Neoplasms
Prevention of Progression of Duodenal Adenomas in Patients With Familial Adenomatous Polyposis
Duodenal carcinomas are the leading cause of mortality in patients with Familial Adenomatous Polyposis (FAP) who underwent prophylactic colorectal surgery.
- Conditions
- Familial Adenomatous Polyposis, Duodenal Neoplasms, Duodenal Polyps
- Trial name
- PreDuoFAP (NCT00808743)
- Testing
- Celecoxib, Ursodeoxycholic acid
- Where
- 5 sites in Netherlands
- Volunteers
- 37 people
- Sponsor
- Radboud University Medical Center
Preterm, Necrotizing Enterocolitis
The Effect of Probiotics Added to the Mother's Diet on Preterm Babies
Abstract According to the definition by World Health Organization; births before the completion of the 37th gestational week are called, preterm birth.
- Conditions
- Preterm, Necrotizing Enterocolitis, Late-Onset Neonatal Sepsis, Breast Milk Expression
- Trial name
- NCT06118801
- Testing
- Probiotic Product Supplement
- Volunteers
- 50 people
- Sponsor
- Harran University
Systemic Lupus Erythematosus, Sjogren's Syndrome
Cell Surface Marker Expression in Autoimmune Diseases
This study is designed to explore the expression of cell-surface markers in the following seven disease areas: (a) systemic lupus erythematosus, (b) Sjogren's syndrome, (c) multiple sclerosis, (d) systemic sclerosis, (e) Crohn's…
- Conditions
- Systemic Lupus Erythematosus, Sjogren's Syndrome, Multiple Sclerosis, Systemic Sclerosis
- Trial name
- CASCADE (NCT03757065)
- Where
- 2 sites in Canada
- Volunteers
- 14 people
- Sponsor
- Alpine Immune Sciences, Inc.
Obesity, Abdominal, Surgery
Perioperative Blood Adiponectin Dynamics and Systemic Infflamatory Response After Major Colorectal Surgery
Surgical stress after major abdominal surgery in perioperative period causes neuroendocrine, metabolic and imunologic changes in organism with production of proinfflamatory citokines and results with appearance of systemic…
- Conditions
- Obesity, Abdominal, Surgery, Systemic Inflammatory Response Syndrome, Postoperative Complications
- Trial name
- ADIPOS (NCT06057207)
- Testing
- serum levels of adiponectin, IL-6, Postoperative systemic infflamation
- Where
- 2 sites in Croatia
- Volunteers
- 58 people
- Sponsor
- Osijek University Hospital
Clostridium Difficile Infection, Multi Drug Resistant Organisms
Establishment of the Human Intestinal and Salivary Microbiota Biobank - Gastrointestinal Diseases
This is a prospective, clinical, multicentre study aimed to collect biological samples and study microbiota from subjects with Clostridium Difficile (CDI), subjects affected by Multi Drug Resistant Organisms (MDRO) infection…
- Conditions
- Clostridium Difficile Infection, Multi Drug Resistant Organisms, Chronic Inflammatory Bowel Disease, Irritable Bowel Syndrome
- Trial name
- BIOMIS-Gastr (NCT04698148)
- Testing
- Biological sample collection, Questionnaire, Medical examination
- Where
- 3 sites in Italy
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Sepsis, Bronchopulmonary Dysplasia
Cysteine Supplementation in Critically Ill Neonates
Critically ill babies less than 1 month of age have deficient amounts of the antioxidant glutathione and a high incidence of disease associated with oxidative injury compared to healthy babies.
- Conditions
- Sepsis, Bronchopulmonary Dysplasia, Necrotizing Enterocolitis, Retinopathy of Prematurity
- Trial name
- NCT00254176
- Testing
- Parenteral cysteine-HCl supplementation
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of California, Los Angeles
Irritable Bowel Disease
Plant Exosomes +/- Curcumin to Abrogate Symptoms of Inflammatory Bowel Disease
The trial will test the hypothesis that edible structures within plant cells (ginger) will have clinically important anti-inflammatory effects on the gut lining of patients with inflammable bowel disease.
- Trial name
- NCT04879810
- Testing
- Sigmoidoscopy and biopsy, blood work
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Louisville
IBS - Irritable Bowel Syndrome, Inflammation
Study of Inflammatory Markers and Symptom Severity in Personalized Nutritional Intervention in IBS
Irritable Bowel Syndrome (IBS) is a widespread disease with variable symptoms that have an important impact on the quality of life.
- Trial name
- NCT04348760
- Testing
- Rotation Diet
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- GEK Srl
Malnutrition, Pneumonia
Childhood Acute Illness and Nutrition Network
The CHAIN Network aims to identify modifiable biomedical and social factors driving the greatly increased risk of mortality among young undernourished children admitted to hospital with acute illness, as inpatients and after…
- Conditions
- Malnutrition, Pneumonia, Diarrhea, Sepsis
- Trial name
- CHAIN (NCT03208725)
- Where
- 8 sites in Bangladesh, Kenya and 3 more
- Volunteers
- 4,335 people
- Sponsor
- University of Oxford
IBD (Inflammatory Bowel Disease), IBS - Irritable Bowel Syndrome
ALPCO/Calprotectin CLIA Assay: Expected Values of Calprotectin in Healthy Subjects
This study is evaluating the levels of calprotectin, a protein found in stool, in healthy adults. Calprotectin is a marker of inflammation in the intestines and can help doctors tell the difference between inflammatory bowel…
- Conditions
- IBD (Inflammatory Bowel Disease), IBS - Irritable Bowel Syndrome, Crohn Disease (CD), UC - Ulcerative Colitis
- Trial name
- NCT07089420
- Testing
- ALPCO Calprotectin CLIA
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- American Laboratory Products Company
Irritable Colon, Colorectal Cancer
Colon Investigation - Factors Determining Choice of Procedure
Registration of patients referred for colon investigation by barium enema, CT colonography and colonoscopy in two hospitals and one radiology centre in Telemark, Norway, for a period of minimum six months.
- Conditions
- Irritable Colon, Colorectal Cancer, Inflammatory Bowel Disease
- Trial name
- NCT00423345
- Where
- 3 sites in Norway
- Volunteers
- 750 people
- Sponsor
- Sykehuset Telemark
Capsule Endoscopy, Inflammatory Bowel Diseases
Differences in Preparation for Small Bowel Capsule Endoscopy
The introduction of video capsule endoscopy in 2000 has provided a convenient and minimally invasive imaging method for the whole small bowel.
- Conditions
- Capsule Endoscopy, Inflammatory Bowel Diseases, Celiac Disease
- Trial name
- NCT03351972
- Testing
- Klean Prep, Clear liquids only
- Where
- 2 sites in Canada, United Kingdom
- Volunteers
- 230 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Critical Illness, Intensive Care Unit Delirium
The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units?
Here, the investigators propose to study host responses to reduced microbiome complexity driven by treatment with broad spectrum antibiotics in patients with severe infections or sepsis.
- Conditions
- Critical Illness, Intensive Care Unit Delirium, Neurocognitive Deficit, Microbiome,immune Function, Critically Ill
- Trial name
- MS-ICU (NCT06749483)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Jena University Hospital