Clinical trials: Inflammatory Bowel Syndrome
Sepsis, Post Intensive Care Unit Syndrome
Accelerating Recovery After ICU Admission: Post-discharge Supplementation With Pasteurized Akkermansia Muciniphila.
The goal of this clinical trial is to learn if daily oral supplementation with pasteurized Akkermansia muciniphila (PAM), an EFSA-approved food supplement, can support recovery in adults who have recently been treated in the ICU…
- Conditions
- Sepsis, Post Intensive Care Unit Syndrome, Critical Illness, Microbiome Dysbiosis
- Trial name
- PAM-ICU (NCT07295353)
- Testing
- Pasteurized Akkermansia muciniphila
- Volunteers
- 50 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Hermansky-Pudlak Syndrome (HPS)
Clinical and Basic Investigations Into Hermansky-Pudlak Syndrome
Hermansky-Pudlak Syndrome (HPS) is an inherited disease which results in decreased pigmentation (oculocutaneous albinism), bleeding problems due to a platelet abnormality (platelet storage pool defect), and storage of an abnormal…
- Trial name
- NCT00001456
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Celiac Disease
Celiac Disease and Vitamin Status: Evaluation of the Effect of Supplementation With a Probiotic (VIVOMIXX®) in a Cohoort of Celiac Patients
Celiac disease is a disorder caused by a disregulation of the immune system which leads to immune response to gluten. Diet therapy is the gold standard of treatment, and the only effective one.
- Trial name
- VIVOMIXX (NCT04160767)
- Testing
- Probiotic Vivomixx, Gluten free diet
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- University of Milan
Sepsis, Intestinal Mucosal Barrier
The Roles of IL-9/E-cadherin and Ferroptosis in Intestinal Mucosal Barrier Injury in Sepsis
The investigators aim to evaluate the roles of IL-9/E-cadheirin and ferroptosis in the intestinal mucosal barrier injury of sepsis.
- Conditions
- Sepsis, Intestinal Mucosal Barrier, Ferroptosis
- Trial name
- NCT05410665
- Testing
- Standard treatments for sepsis
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Metabolic Syndrome, Obesity
Kefir and Metabolic Syndrome
Metabolic syndrome is a cluster of metabolic disorders which increases the risk for diabetes and cardiovascular disease. In recent years, research has shown that probiotics may have positive effects on metabolic syndrome…
- Conditions
- Metabolic Syndrome, Obesity, Hypertension, Hyperlipidemias
- Trial name
- NCT03966846
- Testing
- Kefir, Milk
- Volunteers
- 62 people
- Sponsor
- Izmir Katip Celebi University
Fabry Disease
Screening of Fabry Disease in Patients With GI Symptoms
Fabry disease screening study in patients diagnosed with gastrointestinal tract (GIT) disease, i.e. with the diagnosis of non-infectious inflammatory bowel disease, functional dyspepsia or irritable bowel syndrome in particular…
- Trial name
- GiFD (NCT04184986)
- Testing
- dry blood test
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- General University Hospital, Prague
Autoimmune Diseases, Ulcerative Colitis
A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease
The most clinically meaningful way to discover new targets of T cells in autoimmune diseases is to study the tissues of patients with active autoimmune disease mediated organ inflammation.
- Conditions
- Autoimmune Diseases, Ulcerative Colitis, Multiple Sclerosis, Scleroderma
- Trial name
- NCT06587828
- Testing
- Companion blood samples with procedure
- Where
- 11 sites in United States
- Volunteers
- 238 people
- Sponsor
- TScan Therapeutics, Inc.
All Diagnosed Health Conditions, ADD/ADHD
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research.
- Conditions
- All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis
- Trial name
- NCT01931644
- Where
- United States
- Volunteers
- 17,667 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Endotoxemia, Metabolic Syndrome
Effect of Cranberry and Agaves Extract on Microbiota and Intestinal Health
The growing prevalence of obesity and type 2 diabetes (T2D) is a major public health problem. Recent studies have clearly established that the gut microbiota plays a key role in the investigator's propensity to develop obesity…
- Conditions
- Endotoxemia, Metabolic Syndrome, Glucose Metabolism Disorders, Insulin Resistance
- Trial name
- Phenulin (NCT03800277)
- Testing
- Cranberry, Agaves
- Where
- Canada
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Laval University
Celiac Disease
Clinical Trial on the Effects of Bifidobacterium Infantis in Active Celiac Disease
This exploratory study has been designed to determine the effect of the probiotic Bifidobacterium infantis vs. placebo orally administered over a period of 3 weeks on clinical features, Quality of Life parameters (QoL)…
- Trial name
- Celiac (NCT01257620)
- Testing
- Probiotic
- Where
- Argentina
- Volunteers
- 22 people
- Sponsor
- Bai, Julio M.D.
Hermanski-Pudlak Syndrome, Colitis
Medical Treatment of Colitis in Patients With Hermansky-Pudlak Syndrome
This study will determine if medical treatment of colitis (inflammation of the colon resulting in loose bowel movements, rectal bleeding, and belly pain) that is used for other colitis conditions, such as Crohn's disease and…
- Conditions
- Hermanski-Pudlak Syndrome, Colitis, Cytokines, Lymphocytes
- Trial name
- NCT00514982
- Testing
- Mesalamine, Infliximab, Corticosteroids
- Where
- United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Irritable Bowel Syndrome, Inflammatory Bowel Disease (IBD)
Cognition and Emotion in the SII and IBD
The study aims at showing that the susceptibility in the stress is more raised at the person affected digestive pathologies (SII or IBD) in forgiveness than healthy subjects.
- Conditions
- Irritable Bowel Syndrome, Inflammatory Bowel Disease (IBD), Crohn's Disease(CD), Ulcerative Colitis
- Trial name
- EMOTION (NCT01095042)
- Testing
- emotion
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Intestinal Inflammation
Prospective Study Evaluating the Prevalence of Intestinal Dysfunction
The intestinal tract has multiple functions within the body beyond its primary function of nutrient absorption. It acts as a true barrier protecting the body from living microorganisms and antigens in the intestinal lumen.
- Trial name
- DIR-H (NCT07022548)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Rouen
Human Milk Fortification, Very Low Birth Weight Baby
Enrichment of Human Milk With Human and Bovine Milk-based Fortifiers for Very Preterm Infants: a Meta-analysis
Research has shown that provision of mother's milk is the optimal way to feed very low birthweight (VLBW) infants. Many infants will require a supplement to mother's milk, pasteurized donor human milk (PDHM) compared to preterm…
- Conditions
- Human Milk Fortification, Very Low Birth Weight Baby, Human Milk Nutrition, Human Milk Feeding
- Trial name
- NCT06870318
- Testing
- No intervention; Observational study
- Where
- 2 sites in Canada, Sweden
- Volunteers
- 355 people
- Sponsor
- The Hospital for Sick Children
Chronic Granulomatous Disease, Crohn'S-like IBD
Infliximab to Treat Crohn'S-like Inflammatory Bowel Disease in Chronic Granulomatous Disease
This study will determine if the drug infliximab is safe for treating inflammatory bowel disease (IBD) in patients with chronic granulomatous disease (CGD).
- Conditions
- Chronic Granulomatous Disease, Crohn'S-like IBD, Inflammatory Bowel Disease (IBD)
- Trial name
- NCT00325078
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Necrotising Enterocolitis, Late-Onset Neonatal Sepsis
Characterization of Intestinal Microbiota Stability in Preterm Born Neonates
Study around very-low birthweight preterm infants at high risk of developing necrotizing enterocolitis (NEC) or late-onset sepsis (LOS).
- Trial name
- NEC (NCT04792918)
- Where
- 2 sites in Switzerland
- Volunteers
- 81 people
- Sponsor
- Emma Marie Caroline Slack
Obesity, Endotoxemia
Dietary Green Tea Confection For Resolving Gut Permeability-Induced Metabolic Endotoxemia In Obese Adults
This study is focused on assessing gastrointestinal-level improvements by which green tea limits metabolic endotoxemia. It is completed in two phases.
- Conditions
- Obesity, Endotoxemia, Inflammation
- Trial name
- NCT03413735
- Testing
- Green Tea Extract
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Healthy
Effect of Brazilian Fruits Peel on Metabolic Regulation and Appetite in Healthy Subjects
The purpose of the study was to investigate how Brazilian fruits peel affect acute/postprandial glucose and insulin responses, inflammatory markers, appetite control peptides, antioxidative capacity, as well as subjective…
- Trial name
- BRASIL-MET (NCT02245906)
- Testing
- Control drink, Brazilian fruit peel flour, Negative control drink
- Where
- Sweden
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Lund University
Intestinal Metaplasia, Metabolic Syndrome
Oxidative Stress in Intestinal Metaplasia and Metabolic Syndrome
Intestinal metaplasia is generally considered a precancerous lesion. Although it is associated with a very small increase of gastric cancer risk, European Endoscopic Society and other European academic companies highlighted the…
- Conditions
- Intestinal Metaplasia, Metabolic Syndrome, Oxidative Stress, Inflammatory Response
- Trial name
- NCT02695186
- Testing
- Gastroscopy
- Where
- Greece
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- General Hospital of Filiates
Crohn's Enteritis, Crohn Disease
Impact of a Physical Activity Program on Bone Mineral Density in Children and Adolescents With Chronic Inflammatory Bowel Disease
Muscle and physical activity play an important role in in growth, development and bone health in healthy children, especially during puberty.
- Conditions
- Crohn's Enteritis, Crohn Disease, Ulcerative Colitis, Chronic; Colitis (Noninfective)
- Trial name
- PROPHYSICOS (NCT03774329)
- Testing
- Usual care, adapted physical activity
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Lille