Clinical trials: Inflammatory Disorder
Crohn's Disease
Efficacy Study of Tripterygium Glycoside Combined With Enteral Nutrition in the Treatment of Crohn's Disease for Induction Remission
The purpose of this study is to assess the effect of Tripterygium Glycosides Combined with enteral nutrition in the treatment of Crohn's disease for induction remission and compare the therapeutic effect with patients who only…
- Trial name
- NCT01820247
- Testing
- enteral nutrition, Tripterygium glycosides
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhu Weiming
Acne Vulgaris
Sebacia Postmarket Study of Real-World Use
Postmarket study of Sebacia Microparticles treatment during adoption into clinical use for patients with mild to moderate inflammatory acne vulgaris.
- Trial name
- NCT03818555
- Testing
- Sebacia Microparticles Treatment
- Where
- 6 sites in United States
- Volunteers
- 125 people
- Sponsor
- Sebacia, Inc.
Rheumatoid Arthritis
ART-I02 in Patients With Rheumatoid Arthritis With Inflamed Wrists
This study will evaluate the safety and tolerability of a single intra-articular administration of ART-I02 (AAV5.NF-kB.IFN-β), a recombinant adeno-associated virus (AAV) type 5 vector in subjects with RA and active arthritis of a…
- Trial name
- NCT03445715
- Testing
- ART-I02
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Arthrogen
Systemic Lupus Erythematosus, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Safety and Efficacy Study of CD19-CAR-DNT Cells in Autoimmune Diseases
To evaluate the safety and efficacy of CD19-CAR-DNT cells in subjects with relapsed/refractory autoimmune diseases
- Conditions
- Systemic Lupus Erythematosus, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Idiopathic Inflammatory Myopathies, Systemic Sclerosis
- Trial name
- NCT06316076
- Testing
- CD19-CAR-DNT cells
- Where
- China
- Volunteers
- 48 people
- Sponsor
- RenJi Hospital
Idiopathic Inflammatory Myopathies
Clinical Characteristics and Mechanism Research of Inhibitors of Janus Kinase in the Idiopathic Inflammatory Myopathies
This study aims to explore the clinical characteristics and mechanism of inhibitors of janus kinase in the treatment of idiopathic inflammatory myopathies
- Trial name
- NCT05400889
- Testing
- tofacitinib
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Peking University People's Hospital
Ulcerative Colitis
Impact of Anti-TNF, Vedolizumab and Tofacitinib on Aortic Stiffness, Carotid Intima-media Thickness and Cardiovascular Risk of Patients With Ulcerative Colitis
An increased risk of cardiovascular (CV) diseases has been observed in patients with inflammatory bowel diseases (IBD). The impact of IBD drugs, such as anti-TNF, anti-integrins or anti-JAK, on the risk of CV events in IBD is…
- Trial name
- VASC-UC (NCT04743518)
- Testing
- Aortic pulse wave velocity, carotid intima media thickness (CIMT)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Inflammatory Breast Cancer
Establishing an Inflammatory Breast Cancer Registry
Inflammatory breast carcinoma (IBC) is an extremely rare, aggressive form of breast cancer that disproportionately impacts young women.
- Trial name
- NCT00340158
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- National Cancer Institute (NCI)
Nosocomial Infection
New Dosages of Inflammatory Markers for the Early Diagnosis of Nosocomial Bacterial Infections of the Newborn
This study aims to evaluate new dosage of inflammatory markers or new inflammatory markers for the diagnosis of nosocomial bacterial infection.
- Trial name
- NOSODIAG (NCT00701948)
- Where
- 2 sites in France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Strasbourg, France
Fatty Liver
Association Between Fatty Liver and Inflammatory Biomarkers
The newly adapted definition for MASLD includes evidence for hepatic steatosis by imaging or biopsy with at least one of the five cardiometabolic criteria; BMI ≥ 25 kg/m2 (≥23 kg/m2 in Asian) or waist circumference >94 cm in men…
- Trial name
- MASLD (NCT07636915)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Acute Respiratory Distress Syndrome, Sepsis
Cardiovascular Magnetic Resonance Prognosticators in Pediatric Oncology Patients With Sepsis
The overall purpose of this protocol is to identify subacute sepsis-associated cardiac disease in pediatric patients with cancer by CMR and evaluate the CMR findings during their follow-up.
- Conditions
- Acute Respiratory Distress Syndrome, Sepsis, Cardiovascular Shock
- Trial name
- NCT05930418
- Testing
- Cardiac MRI
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- St. Jude Children's Research Hospital
Ulcerative Colitis, Proctitis
Assessment of Photopill Capsule Treatment for Safety and Feasibility in Ulcerative Proctitis
Low Level Light therapy (LLLT) has been used for tissue healing in many mucosal diseases that involve wounds, ulcers and inflammation, oral chemotherapy-induced mucositis in particular.
- Trial name
- Photopill (NCT01837615)
- Testing
- Photopill treatment
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Ulcerative Colitis
A Phase I, Randomized, Double-Blind, Placebo-Controlled Study of EQ504 in Single and Multiple Ascending Doses in Healthy Volunteers
This is a Phase 1, first in human, three-part randomized, double-blind, placebo-controlled dose escalation trial to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of EQ504 following single…
- Trial name
- NCT07869225
- Testing
- EQ504
- Where
- Australia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Equillium
Renal Cancer
Image Guided RFA/MWA/CRYO of RCC Biomarker Profile Study
Often kidney cancer is diagnosed when the tumour is small and hasn't spread. Rather than major surgery to remove the whole kidney, image-guided ablation involving heat (microwave or radiofrequency) or freezing (cryotherapy) is…
- Trial name
- NCT04392076
- Testing
- Image Guided Ablation
- Where
- United Kingdom
- Volunteers
- 43 people
- Sponsor
- University of Leeds
Crohn Disease
Efficacy, Safety and Pharmacokinetics of BI 655066/ABBV-066 (Risankizumab) in Patients With Active, Moderate-to-severe Crohn's Disease.
This study is a proof of concept, multi-center, randomized, double-blind, placebo-controlled, parallel-group phase 2 dose-ranging study of BI 655066/ABBV-066 (risankizumab), an IL-23 p19 antagonist monoclonal antibody, in…
- Trial name
- NCT02031276
- Testing
- risankizumab IV, risankizumab SC
- Volunteers
- 121 people
- Sponsor
- AbbVie
Colon Cancer, Inflammatory Bowel Diseases
Bowel Function After Laparoscopic Colon Surgery: Effect of IV Lidocaine
Patients receiving perioperative intravenous lidocaine, post operative restoration of bowel movement will be faster and decrease pain intensity, opioid consumption and side effects, length of hospital stay; probably as a result…
- Conditions
- Colon Cancer, Inflammatory Bowel Diseases, Diverticulitis
- Trial name
- NCT01155440
- Testing
- Lidocaine, Thoracic epidural block
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Crohn's Disease
Endoscopic Severity Score of Small Bowel Crohn's Disease With Wireless Capsule Endoscopy
The endoscopic capsule is a new tool for exploration of the small intestine. The superiority of this technique on the radiological conventional examinations was shown in Crohn's disease.
- Trial name
- CAPSCDEIS (NCT00492791)
- Testing
- wireless endoscopy capsule
- Where
- 20 sites in Belgium, France
- Volunteers
- 158 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Myeloproliferative Neoplasm
Remotely Administered Diet Intervention to Impact Symptom Burden in Myeloproliferative Neoplasm
Myeloproliferative Neoplasm (MPN) is a chronic blood cancer without cure. The major clinical issues in MPN are 1) an increased risk of blood clots 2) symptoms thought to be driven by chronic inflammation which in some cases can…
- Trial name
- NCT04744974
- Testing
- Diet intervention
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, Irvine
Ulcerative Colitis
A Study to Evaluate the Safety of Ozanimod Exposure During Pregnancy in Women With Ulcerative Colitis and Their Infants
The purpose of this retrospective observational cohort study is to assess pregnancy and infant outcomes in three groups: the first is women with ulcerative colitis (UC) who were exposed to ozanimod during pregnancy; the second is…
- Trial name
- NCT06126835
- Testing
- Ozanimod, Conventional therapy, Advanced therapy
- Where
- United States
- Volunteers
- 2,828 people
- Sponsor
- Bristol-Myers Squibb
Ulcerative Colitis
Multi-interventional Program to Reduce Chronic Ileoanal Pouch Leaks in UC
The objective of this quality improvement project is to increase the one year anastomotic integrity rate in patients having had completion proctectomy and pouch reconstruction for Ulcerative Colitis by the routine and quality…
- Trial name
- MIRACLE (NCT04939025)
- Testing
- Multi-interventional program
- Volunteers
- 50 people
- Sponsor
- London North West Healthcare NHS Trust
Ulcerative Colitis
Saffron as Anti Inflammatory Agent In Patients With Inflammatory Bowel Disease
Nutritional Saffron supplement has been widely used as food supplement and has known anti-depressant and anti-inflammatory activities. It is generally consumed as stigmas in drinks or dishes.
- Trial name
- NCT04749576
- Testing
- saffron supplement for IBD
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Howard University
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