Clinical trials: Inflammatory Disorder
Inflammatory Breast Carcinoma, Invasive Breast Carcinoma
Biospecimen and Medical Data Collection and Tumor Biopsy in Creating Research Tissue Registry in Patients With Inflammatory or Invasive Breast Cancer
This trial studies the biospecimen and medical data collection in creating a research tissue registry in patients with inflammatory or invasive breast cancer.
- Conditions
- Inflammatory Breast Carcinoma, Invasive Breast Carcinoma, Second Primary Malignant Neoplasm
- Trial name
- NCT00477100
- Testing
- Biospecimen Collection, Interview, Medical Chart Review
- Where
- 10 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- M.D. Anderson Cancer Center
Ulcerative Colitis
Gastrointestinal Motility in Severe Ulcerative Colitis Obtained by Motilis-3D-transit
The purpose of this study is to describe gastrointestinal (GI) motility in patients suffering from severe Ulcerative Colitis (UC) and to compare these results with similar results obtained in remission.
- Trial name
- NCT01745029
- Testing
- Motilis-3D-transit
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Septic Shock
Discontinuation Order of Vasopressors in Septic Shock
The purpose of this study is to evaluate the incidence of hypotension based on the discontinuation order of norepinephrine and vasopressin in patients receiving concomitant norepinephrine and vasopressin infusions for the…
- Trial name
- DOVSS (NCT01493102)
- Testing
- Vasopressin, Norepinephrine
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Samsung Medical Center
Ulcerative Colitis
A Study of Guselkumab in Participants With Moderately to Severely Active Ulcerative Colitis
The purpose of this study is to evaluate the efficacy and safety of guselkumab in participants with moderately to severely active ulcerative colitis (UC).
- Trial name
- QUASAR (NCT04033445)
- Testing
- Guselkumab
- Where
- 392 sites in United States, Argentina and 32 more
- Volunteers
- 1,064 people
- Sponsor
- Janssen Research & Development, LLC
Osteoarthritis, Rheumatoid Nodule
Cellular & Biocellular Regenerative Therapy in Musculoskeletal Pain, Dysfunction,Degenerative or Inflammatory Disease
Musculoskeletal disorders and degeneration represent injuries or pain in the body's joint ligaments, tendons, muscles, nerves, and skeletal elements that support extremities, spine and related tissues.
- Conditions
- Osteoarthritis, Rheumatoid Nodule, Degenerative Joint Disease, Tendinopathy
- Trial name
- BRT (NCT03090672)
- Testing
- Normal Saline, Tissue Stromal Vascular Fraction, Platelet Rich Plasma
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Robert W Alexander, MD
Emergency Service, Hospital, Child/Adolescent Problem
A RCT of a Combination of Analgesics for Pain Management in Children With a Suspected Fracture
MSK-I is the most common cause for ED visits for children with pain, with a child's risk of sustaining a fracture ranging from 27-42% by the age of 16 years.
- Conditions
- Emergency Service, Hospital, Child/Adolescent Problem, Acute Pain, Fentanyl
- Trial name
- CAST (NCT02985177)
- Testing
- INF2.0 + IBU, INF1.0 + IBU
- Where
- 3 sites in Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Colitis, Ulcerative, Gastrointestinal Diseases
Remote Ischemic Conditioning in Patients With Ulcerative Colitis
Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease (IBD). At the time of diagnosis it is not possible to predict the course of the disease, which can range from a few flares in a lifetime to uncontrollable…
- Conditions
- Colitis, Ulcerative, Gastrointestinal Diseases, Pathologic Processes, Intestinal Diseases
- Trial name
- NCT02445365
- Testing
- AutoRIC device
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- Odense University Hospital
Inflammatory Bowel Diseases, Crohn Disease
Shared Decision Making in Paediatric Inflammatory Bowel Disease
The goal of this mixed-methods prospective cohort study is to assess the impact of shared decision-making (SDM) on newly diagnosed pediatric inflammatory bowel disease (IBD) patients and their families.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, IBD
- Trial name
- SDM-IBD (NCT05689892)
- Testing
- Decision Coach Sessions
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre
Psoriatic Arthritis
Sex and Gender-based Analysis of the Effectiveness of Advanced Therapies in Psoriatic Arthritis
Sex and gender are important factors that influence treatment response in PsA. The goal of this multi-centre observational study is to understand how sex and gender influence response to advanced therapies in psoriatic arthritis…
- Trial name
- SAGE-PsA (NCT05954364)
- Where
- Canada
- Volunteers
- 540 people
- Sponsor
- Women's College Hospital
UC - Ulcerative Colitis
Upadacitinib in Patients Hospitalized With Acute Severe Ulcerative Colitis
The goal of this clinical trial is to learn if the oral medication upadacitinib can safely and effectively treat acute severe ulcerative colitis (ASUC) in adults who are hospitalized.
- Trial name
- NCT07502339
- Testing
- Upadacitinib
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Metabolic Syndrome
Trial of Supplementation With Aged Garlic Extract to Improve Endothelial Function in Patients With Metabolic Syndrome
Many studies have addressed the relationship between metabolic syndrome and cardiovascular disease. Risk factors include abdominal obesity, insulin resistance, abnormal lipid profile and hypertension.
- Trial name
- Kymes (NCT01168700)
- Testing
- aged garlic extract
- Where
- Colombia
- Volunteers
- 46 people
- Sponsor
- Universidad de Santander
Ulcerative Colitis
Qualitative Study of Topical Mesalamine Adherence in Patients With Ulcerative Colitis(UC)
The purpose of this protocol is: 1. To quantify the prevalence of adherence to topical mesalamine in patients with UC 2. To describe the determinants of medication adherence in patients with UC prescribed topical mesalamine
- Trial name
- NCT01678300
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Beth Israel Deaconess Medical Center
Cryopyrin Associated Periodic Syndrome
The Safety and Efficacy of Canakinumab in Patients Aged 4 Years or Older Diagnosed With Cryopyrin-associated Periodic Syndromes (CAPS) in Canada
This study will assess the safety, tolerability and efficacy of canakinumab treatment in Canadian patient diagnosed with cryopyrin-associated periodic syndrome over a period of 18 months.
- Trial name
- NCT01105507
- Testing
- canakinumab (company code: ACZ885D)
- Where
- 2 sites in Canada
- Volunteers
- 4 people
- Sponsor
- Novartis Pharmaceuticals
Inflammatory Arthritis, Immune-related Adverse Event
Early Adalimumab Induction for Immune Checkpoint Inhibitor Associated Inflammatory Arthritis
This study will examine the effectiveness of administering adalimumab as a treatment for patients in the early stages of steroid-dependent immune checkpoint Inhibitor associated inflammatory arthritis (ir-IA).
- Trial name
- NCT06037811
- Testing
- Adalimumab, Prednisone
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Tom Appleton
Rhinitis, Allergic, Perennial
ATAREAL (Antihistamine Treatment for Allergic Rhinitis in Real Life)
Comparison of clinical efficacy and safety of levocetirizine in PER continuous versus on demand, measured by evolution of individual symptom scores during 6 months.
- Trial name
- NCT00160680
- Testing
- Levocetirizine
- Where
- Italy
- Volunteers
- 62 people
- Sponsor
- UCB S.A. - Pharma Sector
Initial Phase of Severe Sepsis and Septic Shock
Population Pharmacokinetics and Monte Carlo Dosing Simulations of Meropenem During the Early Phase of Severe Sepsis and Septic Shock in Critically Ill Patients in Intensive Care Units
This is a prospective, noncomparative study to assess the pharmacodynamics of meropenem during early phase of severe sepsis and septic shock in critically ill patients in an intensive care unit.
- Trial name
- NCT02213796
- Testing
- Meropenem
- Where
- Thailand
- Volunteers
- 9 people
- Sponsor
- Sutep Jaruratanasirikul
Chronic Pelvic Pain
The Effect of Jincaopian Tablets on Chronic Pelvic Pain After Pelvic Inflammatory Disease
This phase II trial attempts to evaluate the efficacy and safety of Jincaopian Tablets in the treatment of subjects with chronic pelvic pain after pelvic inflammatory disease.
- Trial name
- NCT05460546
- Testing
- Jincaopian Tablets high dose, Jincaopian Tablets low dose
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Beijing Konruns Pharmaceutical Co., Ltd.
Ulcerative Colitis
Effects of Eicosapentaenoic Acid on Subjects at High Risk for Colorectal Cancer
The aim of this study is to test Eicosapentaenoic acid's effects on markers relevant to colorectal carcinogenesis, RNA and DNA profiles, and the possibility that Eicosapentaenoic Acid treatment might be associated with changes of…
- Trial name
- EPAUC (NCT02069561)
- Testing
- Eicosapentaenoic Acid
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Crohn's Disease, Vitamin D Deficiency
Vitamin D Supplementation as Non-toxic Immunomodulation in Children With Crohn's Disease
IBD is caused by an abnormal immune response to the gut bacteria in people who are genetically predisposed. There has been a huge increase in the number of people diagnosed with IBD since World War II, likely due to changes in…
- Trial name
- NCT01046773
- Testing
- Cholecalciferol
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of California, Los Angeles
Sepsis, Septic Shock
Pharmacokinetics of Amikacin and Cefuroxime in Critically Ill Patients.
Infections in critically ill patients are a major healthcare problem and an important source of morbidity and mortality. Since critically ill patients often have altered pharmacokinetics (PK) compared to non-critically ill…
- Conditions
- Sepsis, Septic Shock, Infection, Bacterial, Critically Ill
- Trial name
- PHARAOH (NCT04470973)
- Testing
- Cefuroxime, Amikacin
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
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