Clinical trials: Inflammatory Disorder
Ulcerative Colitis
A Long Term Safety Study of Infliximab (Remicade) in in Ulcerative Colitis Patients
The purpose of this study is to evaluate long-term safety information of infliximab in patients who have participated in infliximab clinical studies in ulcerative colitis.
- Trial name
- NCT00207688
- Testing
- Infliximab 5 mg/kg, Infliximab 10 mg/kg
- Where
- 102 sites in United States, Argentina and 13 more
- Volunteers
- 505 people
- Sponsor
- Janssen Research & Development, LLC
Periodontitis, Gingivitis
Relationship Between Periodontal Inflammation Severity and Pan-Immune System Inflammation Value
This cross-sectional observational study aims to evaluate the relationship between periodontal inflammation severity and the Pan-Immune-Inflammation Value (PIV) in systemically healthy adults.
- Conditions
- Periodontitis, Gingivitis, Periodontal Health
- Trial name
- NCT07628803
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Inflammatory Bowel Diseases, Crohn Disease
The PRognostic Effect of Environmental Factors in Crohn's and Colitis
The PREdiCCt Study: This is a major study that is now being launched. This is the first study of its kind and is specifically directed toward understanding how environmental factors and the gut microorganisms influence IBD flare…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- PREdiCCt (NCT03282903)
- Where
- 41 sites in United Kingdom
- Volunteers
- 2,629 people
- Sponsor
- University of Edinburgh
Neonatal Hypocalcemia, Neonatal Sepsis
Effects of Cord Blood 25-hydroxy-vitamin D Level on Early Neonatal Morbidities
Cholecalciferol (vitamin D3) is a prohormone and its active form is 1,25 dihydroxycholecalciferol. This hormone has effect on both calcium, phosphorus and bone metabolism and also bone morrow, muscle, heart and immune system.
- Trial name
- NCT02147327
- Volunteers
- 120 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Lung Cancer
Effect on the Nutritional and Inflammatory Status of Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA)- Containing Supplement in Patients With Advanced Lung Cancer
Background: A frequent manifestation of advanced lung cancer is malnutrition, timely identification and treatment of which can lead to improved patient quality of life, response rate to chemotherapy and survival.
- Trial name
- NCT01048970
- Testing
- Nutritional Assessment, EPA-DHA arm
- Where
- 2 sites in Mexico
- Volunteers
- 120 people
- Sponsor
- National Institute of Cancerología
Kidney Calculi, Urinary Tract Infections
Do Dynamic Urinary Leukocyte and Nitrite Changes Improve Risk Prediction for Infectious Complications Following PCNL?
Background Percutaneous nephrolithotomy (PCNL) is widely recognized as the primary surgical approach for managing sizable and anatomically complex kidney stones., yet postoperative infection-related complications remain common…
- Conditions
- Kidney Calculi, Urinary Tract Infections, Sepsis
- Trial name
- NCT07238673
- Where
- China
- Volunteers
- 346 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Severe Coronary Artery Disease, Obesity
Chronic Inflammatory Activation in Fat Tissue: An Atherogenic Factor in Severe Coronary Artery Disease
Chronic inflammatory activation in fat tissue can be the link between adiposity and an increased risk for atherosclerosis. The aim of this study is to investigate how molecular alterations in fat tissue can be influenced by…
- Conditions
- Severe Coronary Artery Disease, Obesity, Impaired Glucose Tolerance
- Trial name
- KFO (NCT00510705)
- Testing
- exercise training, exercise training + metformin, exercise training + glitazone
- Where
- Germany
- Volunteers
- 29 people
- Sponsor
- University of Leipzig
Ulcerative Colitis, Colonoscopy
Ulcerative Colitis Mayo Score With Artificial Intelligence
This project will use deep learning to classify colonoscopy images of different severity of ulcerative colitis, so as to assist clinicians in the accurate diagnosis of ulcerative colitis.
- Conditions
- Ulcerative Colitis, Colonoscopy, Deep Learning
- Trial name
- NCT05336773
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Third Military Medical University
Obesity, Hyperlipidemia
Effects of Dietary Antioxidants on Cardiovascular Risk Factors
The aim of the Antioxidant Study was to compare the efficacy of foods naturally rich in antioxidants with that of antioxidants in a pill form on markers of inflammation and plasma cholesterol in healthy adults at risk of…
- Conditions
- Obesity, Hyperlipidemia, Hypertension
- Trial name
- NCT00756405
- Testing
- Antioxidant diet, Antioxidant supplement
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Christopher Gardner
Osteoporosis
An Efficacy and Safety Trial of Intravenous Zoledronic Acid Twice Yearly in Osteoporotic Children Treated With Glucocorticoids
This study was designed to evaluate the efficacy and safety of zoledronic acid compared to placebo in osteoporotic children treated with glucocorticoids
- Trial name
- NCT00799266
- Testing
- Zoledronic acid
- Where
- 12 sites in Australia, Canada and 4 more
- Volunteers
- 34 people
- Sponsor
- Novartis Pharmaceuticals
Crohn Disease
Therapeutic Optimization Study Based on MR Enterocolonography in Patients With Crohn's Disease
This randomized, controlled study aims to evaluate the impact of therapeutic intervention (step up) for the patients who are clinical remission with Magnetic Resonance Enterocolonography (MREC) active.
- Trial name
- NCT02332356
- Testing
- azathioprine or adalimumab and infliximab
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Tokyo Medical and Dental University
Inflammatory Bowel Diseases
Preparation Prior to Colonoscopy in Children
Colonoscopy is a routinely performed examination of children and adolescents in the diagnostic process of inflammatory bowel disease (IBD). It is necessary that the bowel is clean so the colonoscopy can be optimally performed.
- Trial name
- NCT02009202
- Testing
- polyethylene glycol, picosulphate
- Where
- Sweden
- Volunteers
- 71 people
- Sponsor
- Skane University Hospital
Crohn´s Disease
The Role of IL-23-Responsive Immune Cell Subsets in Post-Operative Recurrence in Patients With Crohn's Disease.
Inflammatory Bowel Diseases (IBDs), including ulcerative colitis and Crohn's disease (CD), constitute a group of debilitating chronic diseases that profoundly impact patient quality of life and incurs large costs in terms of…
- Trial name
- DIVE-23 (NCT06006039)
- Where
- 2 sites in Canada, Netherlands
- Volunteers
- 40 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Multisystem Inflammatory Syndrome in Children (MIS-C) Associated With Coronavirus Disease (COVID-19)
Intermediate-size Expanded Access Program (EAP), Mesenchymal Stromal Cells (MSC) for Multisystem Inflammatory Syndrome in Children (MIS-C) Associated With Coronavirus Disease (COVID-19)
The objectives of this intermediate-size expanded access protocol are to assess the safety and efficacy of remestemcel-L in participants with MIS-C associated with COVID-19.
- Trial name
- NCT04456439
- Testing
- Remestemcel-L, Hydrocortisone, Diphenhydramine
- Sponsor
- Mesoblast International Sàrl
Diabetic Nephropathy
Evaluating The Roles of Novel Inflammatory Markers Compared to MCP-1 in Type 2 Diabetic Nephropathy
Diabetic kidney disease (DKD) is one of the most common microvascular complications of type 2 diabetes mellitus (T2DM), affecting up to 40% of diabetic patients and accounting for the leading cause of end-stage renal disease…
- Trial name
- NCT07173686
- Volunteers
- 80 people
- Sponsor
- Assiut University
Septic Shock
Angiotensin II vs. Vasopressin in Septic Shock
This will be a randomized controlled unblinded pragmatic single-center pilot trial of the use of vasopressin vs. angiotensin II as a second-line vasopressor in patients with septic shock and persistent hypotension despite…
- Trial name
- NCT05193370
- Testing
- Angiotensin II, Vasopressin
- Where
- United States
- Sponsor
- University of New Mexico
Lumbar Spondylolisthesis, Arthrosis; Spine
Analysis of the Clinical Efficacy of Intravenous Application of Hemostatic Drugs in Improving the Clarity of Vision Under Endoscope, Perioperative Bleeding Volume and Anti-inflammatory Effect of Spinal Endoscopic Lumbar Fusion
To study the clinical efficacy of carosodiumsulfonate and desmopressin in improving the clarity of vision under endoscope, perioperative bleeding volume and anti-inflammatory effect in endoscopic lumbar fusion
- Trial name
- NCT06255366
- Testing
- Caroxime sodium sulfonate, Desmopressin, 0.9% Sodium Chloride Injection
- Volunteers
- 126 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Severe Sepsis, Coagulopathy
Phase 3 Safety and Efficacy Study of ART-123 in Subjects With Severe Sepsis and Coagulopathy
The purpose of the study is to evaluate if ART-123 given to patients who have severe sepsis can decrease mortality.
- Trial name
- NCT01598831
- Testing
- ART-123
- Where
- 161 sites in United States, Argentina and 22 more
- Volunteers
- 816 people
- Sponsor
- Asahi Kasei Pharma America Corporation
Inflammatory Bowel Disease, Anxiety
Managing Stress With Inflammatory Bowel Disease
This study will recruit persons with Inflammatory Bowel Disease. The investigators will contact people in an ongoing study (called IMAGINE) to recruit persons with high levels of stress, anxiety, or depression who are interested…
- Conditions
- Inflammatory Bowel Disease, Anxiety, Depression
- Trial name
- NCT03852745
- Testing
- Cognitive Behavioral Therapy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Manitoba
Colitis, Ulcerative
An Open Label Phase 4 Study to Evaluate Efficacy of Early Versus Late Use of Vedolizumab in Ulcerative Colitis
This multi-centre open label study will involve a minimum of 120 patients in 2 cohorts: 60 patients with 'early UC' defined as disease duration < 4 years and no other treatments than aminosalicylates and/or corticosteroids and 60…
- Trial name
- LOVE-UC (NCT02646657)
- Testing
- Vedolizumab 300 mg
- Where
- 20 sites in Belgium, Hungary and 1 more
- Volunteers
- 120 people
- Sponsor
- Geert D'Haens
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