Clinical trials: Inflammatory Disorder
Acne
577-nm Diode Laser in the Treatment of Non -Inflammatory Acne
The aim of this study is to evaluate the clinical efficacy and safety of the 577 nm diode laser in the treatment of non -inflammatory acne.
- Trial name
- NCT06909344
- Testing
- 577 nm Diode laser
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Chronic Inflammatory Disease
Chronic Inflammatory Rheumatism: Management of Comorbidities in Ambulatory Medicine
Identification of factors limiting compliance with the recommendations established during the evaluation of the SCORIC population by the rheumatology department of the CHU Grenoble Alpes
- Trial name
- SCORIC-A (NCT05613712)
- Testing
- Patients, Referring physician
- Where
- France
- Volunteers
- 229 people
- Sponsor
- University Hospital, Grenoble
Crohn's Disease of Both Small and Large Intestine
Crohn's Disease - Inflammation and Microbial Proteolytic Activity
This study postulates that altered microbiota associated with areas of mucosal inflammation in CD, can be characterized by an increased proteolytic profile.
- Trial name
- CIMPA (NCT06503081)
- Testing
- Colonoscopy
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Periodontitis, Type 2 Diabetes
Inflammatory Response and Gingival iNOS Levels in Diabetic vs. Non-Diabetic Periodontitis Patients
This study investigates the relationship between Type 2 diabetes mellitus (T2DM), glycemic control, and periodontal disease. Researchers analyzed the levels of inducible nitric oxide synthase (iNOS) and proinflammatory cytokines…
- Conditions
- Periodontitis, Type 2 Diabetes, Glycemic Control
- Trial name
- NCT06803836
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Systemic Sclerosis
Effect of Rosuvastatin on Systemic Sclerosis-related Pulmonary Hypertension
Although the aetiology of SSc-PAH remains elusive, vascular dysfunction seems to be the initial event and statins through their vasculoprotective effect might be of value in the treatment armamentarium of PAH related to SSc.
- Trial name
- NCT00984932
- Testing
- Rosuvastatin
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alexandria
Ulcerative Colitis
Safety and Efficacy Study of TLL018 in the Treatment of Ulcerative Colitis
A study to investigate the safety and efficacy of TLL018 compared with placebo in subjects with moderate to severe ulcerative colitis.
- Trial name
- NCT05121402
- Testing
- TLL018
- Where
- United States
- Sponsor
- TLL Pharmaceutical, LLC
Inflammatory Bowel Diseases
Correlation Between RISANKIZUMAB's Trough Levels, Clinical and Biological Remission in Moderate to Severe Crohn's Disease: a Retrospective Multicentric Study
The goal of this observational study is to determine if, as with other therapeutics such as anti-TNF, trough levels of Risankizumab are correlated with clinical and biological remission in patients with moderate to severe Crohn's…
- Trial name
- RISE-CD (NCT06589895)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Crohn Disease
A Study on the Impact of Online Positive Psychological Intervention on the Mental Health and Quality of Life of Crohn's Disease Patients
Crohn's disease (CD) is a chronic, nonspecific inflammatory disease that can affect the entire digestive tract. It is difficult to cure and often relapses, causing long-term suffering for patients.
- Trial name
- NCT06939712
- Testing
- Online Positive Psychology Intervention, Routine Care
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Community-acquired Pneumonia, Sepsis
Anti-inflammatory Action of Oral Clarithromycin in Community-acquired Pneumonia
Traditional management of community-acquired pneumonia (CAP) relies on the prompt administration of antimicrobials that target the most common causative pathogens.
- Conditions
- Community-acquired Pneumonia, Sepsis, Inflammatory Response, Mortality
- Trial name
- ACCESS (NCT04724044)
- Testing
- Tablets, Clarithromycin 500mg
- Where
- 18 sites in Greece
- Volunteers
- 278 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Non Alcoholic Steatohepatitis
The Effects of Flaxseed Supplement on Biochemical Factors and Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease
To study the effects of Flaxseed supplement on lipid profile, liver enzymes, inflammatory factors and hepatic fibrosis in patients with Nonalcoholic Steatohepatitis (NASH), 50 patients who referred to Gastrointestinal (GI) clinic…
- Trial name
- NCT02395900
- Testing
- Flaxseed, control
- Volunteers
- 50 people
- Sponsor
- National Nutrition and Food Technology Institute
Breast Cancer, Breast Cancer Mortality
Influence of Lifestyle, Inflammatory Biomarkers, and Genetic Factors on Long-term Breast Cancer Prognosis
The MARIEplus study is a prospective cohort of breast cancer patients recruited into the MARIE (Mamma Carcinoma Risk factor InvEstigation) study, a population-based case-control study of breast cancer conducted in two German…
- Conditions
- Breast Cancer, Breast Cancer Mortality, Breast Cancer Survival, Postmenopausal Breast Cancer
- Trial name
- NCT03401034
- Volunteers
- 3,813 people
- Sponsor
- German Cancer Research Center
Crohn Disease
Prospective Observational Study on Ustekinumab (Stelara) Assessing Efficacy and Healthcare Resource Utilization in Crohn's Disease
The main purpose of this study is to assess ustekinumab's ability to induce clinical response and remission ("effectiveness") at Week 16 and remission at Week 52 and Week 104 in participants with Crohn's disease (CD).
- Trial name
- PROSE (NCT03495973)
- Testing
- Ustekinumab
- Where
- Sweden
- Volunteers
- 114 people
- Sponsor
- Janssen-Cilag Ltd.
Heart Rate Monitoring, Vagal Bradycardia
Heart Rate Variability and Early Cytokine Profile in Pediatric Adenotonsillectomy
This prospective observational cohort study will assess whether perioperative short-term heart rate variability (HRV) indices and early inflammatory cytokine levels are associated with respiratory and cardiac adverse events in…
- Conditions
- Heart Rate Monitoring, Vagal Bradycardia, Adenotonsillar Hypertrophy, Tonsillitis; Hypertrophic
- Trial name
- NCT07719439
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Duzce University
Endometriosis
A Randomized Controlled Trial of a Nutritional Intervention for Endometriosis
This randomized, controlled study will investigate the efficacy of a dietary intervention for women with endometriosis. Participants will be randomly assigned to follow a whole food plant-based (intervention) diet or stay on…
- Trial name
- NCT07090096
- Testing
- A whole food plant based diet
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
Crohn Disease, Ileocolic Resection
CRP Monitoring After ICR in CD Patients
Aim: The aim of this study was to assess the accuracy of the C-reactive protein as an early predictor of intra-abdominal septic complicationss after ileocolic resection for Crohn disease.
- Trial name
- C-ICR-CD (NCT04643496)
- Testing
- Laparoscopic or open Ileocolic resection
- Where
- France
- Volunteers
- 159 people
- Sponsor
- University Hospital, Montpellier
Crohn Disease
CD-TREAT Diet: a Novel Therapy for Active Luminal Crohn's Disease
Crohn's disease (CD) is a chronic inflammatory condition of the gut with severe complications. There is strong evidence to suggest that diet and gut bacteria are key components in the onset, perpetuation and management of CD.
- Trial name
- NCT03171246
- Testing
- Solid food-based intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- NHS Greater Glasgow and Clyde
Myocarditis, Takotsubo Cardiomyopathy
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) in Ischaemic, Inflammatory and Takotsubo Cardiomyopathy (MEMORY)
Manganese is a calcium analogue which actively enters viable cells with intact calcium-handling mechanisms and its uptake is evident by an increase in MRI-detectable T1 relaxivity of tissues.
- Conditions
- Myocarditis, Takotsubo Cardiomyopathy, Reversible Coronary Ischaemia
- Trial name
- MEMORY (NCT04623788)
- Testing
- Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Crohn Disease
A Study to Evaluate Efficacy, of Early Versus Late Use of Vedolizumab in Crohn's Disease: the LOVE-CD Study
This multi-centre open label study will involve a minimum of 260 patients in 2 cohorts: 86 patients with 'early CD' defined as disease duration < 24 months and no other treatments than corticosteroids and/or thiopurines and 174…
- Trial name
- LOVE-CD (NCT02646683)
- Testing
- vedolizumab
- Where
- 23 sites in Belgium, Hungary and 1 more
- Volunteers
- 260 people
- Sponsor
- Geert D'Haens
Body Mass Index Quantitative Trait Locus 5 Disorder, Tangier Disease
Effect of High Protein Diet on Adiponectin and Inflammation Among Overweight and Obese Children
The investigators aimed to determine the effects of HP diet on adiponectin and inflammatory factors among overweight and obese children.
- Trial name
- NCT01886495
- Testing
- nutrition intervention
- Where
- Iran
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Peri-Implantitis, Periodontitis
Cellular and Molecular Inflammatory Mechanisms Leading to Bone Resorption in Peri-implantitis Vs Periodontitis
Recent data found that peri-implantitis may differ from periodontitis at the histological level in terms of extent and composition of the cellular components.
- Trial name
- DUOROPA (NCT02664675)
- Testing
- Crown lengthening, Open Flap Debridement
- Where
- 2 sites in France
- Volunteers
- 33 people
- Sponsor
- University of Paris 5 - Rene Descartes
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