Clinical trials: Inflammatory Disorder
Asthma
Roflumilast Plus Montelukast in Adults With Severe Asthma
This study will evaluate the effect of roflumilast 500 μg once daily (QD) plus montelukast 10 mg QD versus 10 mg montelukast QD alone on predose (trough) prebronchodilator forced expiratory volume in the first second (FEV1).
- Trial name
- NCT01765192
- Testing
- Roflumilast, Montelukast
- Where
- 13 sites in Germany, Hungary and 1 more
- Volunteers
- 64 people
- Sponsor
- AstraZeneca
Inflammatory Bowel Diseases
Effect of Anti-inflammatory Diet in Patients With Inflammatory Bowel Disease
For the first time, this study developed an anti-inflammatory diet （AID） recipe suitable for Inflammatory bowel disease（IBD） patients and developed an AID application program to verify the intervention effect of AID on IBD…
- Trial name
- NCT06342011
- Testing
- Anti-inflammatory diet group
- Where
- China
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Inflammatory Myopathy, Idiopathic, Dermatomyositis
Add-on Intravenous Immunoglobulins in Early Myositis
In patients with myositis early immunomodulation by intensive treatment ("hit-early/hit-hard" principle) may induce faster reduction of disease activity and prevent chronic disability.
- Conditions
- Inflammatory Myopathy, Idiopathic, Dermatomyositis, Antisynthetase Syndrome, Immune-Mediated Necrotizing Myopathy
- Trial name
- TIMEISMUSCLE (NCT05832034)
- Testing
- Immune Globulin Intravenous (Human)
- Where
- Netherlands
- Volunteers
- 44 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Crohn Disease
Reverse-Engineering of Exclusive Enteral Nutrition (RE-EEN) in Crohn's Disease: A Multi-Center Trial
This study will compare the tolerability and efficacy of conventional formula Exclusive Enteral Nutrition (EEN) and whole-food blended smoothie EEN by enrolling a total of 60 participants with newly diagnosed pediatric Crohn's…
- Trial name
- mRE-EEN (NCT06216899)
- Testing
- Whole-food based smoothie, Formula
- Where
- 3 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- Seattle Children's Hospital
Inflammatory Bowel Diseases, Neutropenia
The Prevalence and Impacts of Nudix Hydrolase 15 (NUDT15) Gene Variants in Taiwanese Inflammatory Bowel Disease
The study will include participants who were diagnosed with inflammatory disease and followed up at National Taiwan University Children's Hospital.
- Conditions
- Inflammatory Bowel Diseases, Neutropenia, Nudt15 Deficiency
- Trial name
- NCT06913998
- Where
- Taiwan
- Volunteers
- 65 people
- Sponsor
- National Taiwan University Hospital
Acute Kidney Injury, Sepsis
Labile Iron Removal by Adding the Iron Chelator MEX-CD1 to Dialysate in Sepsis-Associated Acute Kidney Injury
The goal of this clinical trial is to learn if adding the iron-binding drug MEX-CD1 to dialysis fluid can help remove excess iron in adults with sepsis-associated acute kidney injury (AKI) requiring dialysis who are in the…
- Trial name
- IRON-IC (NCT07236463)
- Testing
- Continuous veino-veinous dialysis with iron-chelator supplemented dialysate
- Where
- 2 sites in France
- Volunteers
- 14 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Sepsis, Septic Shock
The Effect of Dexmedetomidine on the Renal Functions in Septic Critically Ill Patients
This clinical trial aims to evaluate the effect of dexmedetomidine in Sepsis-Associated Acute Kidney Injury in critically ill patients by answering the following questions: 1.
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT06570187
- Testing
- Dexmedetomidine, Propofol
- Where
- Egypt
- Volunteers
- 128 people
- Sponsor
- Cairo University
Breast Neoplasms, Neoplasm Metastasis
A Multimodality Treatment Approach to Patients With Inflammatory Cancer of the Breast and Locally Advanced Non-Inflammatory Stage III Breast Cancer and Stage IV Breast Cancer
This study is designed to evaluate the efficacy of high dose melphalan and autologous bone marrow transplantation given as consolidation therapy to patients with inflammatory or metastatic carcinoma of the breast in complete…
- Trial name
- NCT00001193
- Testing
- high dose melphalan and autologous bone marrow transplantation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Cancer Institute (NCI)
Colon Cancer
NIMA-Colon Cancer Study
The goal of this study is to evaluate the effects of nutritional supplementation and physical activity interventions on recovery, muscle strength, nutritional status, inflammation, and metabolic health in adults with colon cancer…
- Trial name
- NIMA (NCT07534852)
- Testing
- Standard hypercaloric-hyperproteic nutritional supplementation, HMB-enriched hypercaloric-hyperproteic nutritional supplementation with vitamin D and calcium, Supervised exercise program
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Memory Disorders
Anti-Inflammatory Treatment for Age-Associated Memory Impairment: A Double-Blind Placebo-Controlled Trial
This project is designed to study whether anti-inflammatory drugs, such as celecoxib, may delay age-related mental decline. We are also looking at genetic risk and brain structure as potential predictors of mental decline.
- Trial name
- NCT00009230
- Testing
- Celecoxib
- Where
- United States
- Sponsor
- University of California, Los Angeles
MYOPATHY
Stem Cell Transplantation in Idiopathic Inflammatory Myopathy Diseases
Myositis is a disease, believed to be due to immune cells, cells which normally protect the body, but are now attacking the muscles and other organ systems within body.
- Trial name
- NCT00278564
- Testing
- Hematopoietic stem cell transplantation, Cyclophosphamide, Mesna
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Northwestern University
Anemia, Iron Deficiency, Inflammatory Bowel Diseases
Feraccru® Real World Effectiveness Study in Hospital Practice ( FRESH )
The aim of the study is to understand the early experiences of Feraccru® in patients with inflammatory bowel disease (IBD) and iron deficiency anaemia (IDA) in the UK, including treatment effectiveness, patterns of use and…
- Trial name
- FRESH (NCT03247816)
- Where
- United Kingdom
- Volunteers
- 59 people
- Sponsor
- Shield Therapeutics
Pressure Ulcer, Inflammatory Response
Combined Molecular and Mechanistic Methods for Detection of Pressure Ulcers
This project aims to develop a novel method for identifying early tissue damage related to pressure ulcer (PU) development in vulnerable patients by measuring biomarkers of inflammation on the skin surface.
- Trial name
- NCT06468306
- Testing
- non-invasive ventilation teraphy, NIV
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Linkoeping University
T2DM (Type 2 Diabetes Mellitus)
GLP1-RAs Effects on Inflammatory and Endothelial Biomarkers in T2DM
Type II diabetes mellitus (T2DM) is a chronic disease associated with a very high risk of developing cardiovascular (CV) events, especially because of its long-term effects.
- Trial name
- STABLE-GLP1 (NCT07314684)
- Testing
- semaglutide, Standard Treatment (Guideline-Based)
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Federico II University
Migraine Disorders, Pain
The Role of Cytokines and Regulatory T Lymphocytes in Migraine Pathophysiology.
Migraine is a frequent and debilitating neurologic disorder. It is more frequent in women, and more prevalent in patients with autoimmune and/or inflammatory diseases such as multiple sclerosis (MS), rheumatoid arthritis (RA)…
- Conditions
- Migraine Disorders, Pain, Autoimmune Diseases, Multiple Sclerosis
- Trial name
- SIIM (NCT06426316)
- Testing
- Blood test
- Where
- France
- Volunteers
- 396 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Acne Vulgaris, Acne Vulgaris Superficial Mixed Comedonal and Inflammatory
Full Spectrum Hemp Observational Study
In westernized societies, acne vulgaris is nearly a universal skin disease afflicting 79% to 95% of the adolescent population; older than 25 years - 40% to 54% have facial blemishes and persists into middle age in 12% of women…
- Trial name
- NCT04730414
- Testing
- Full-spectrum hemp (0.018% THC)
- Volunteers
- 50 people
- Sponsor
- Charlotte's Web, Inc
Subarachnoid Hemorrhage, Aneurysmal
Investigate the Relationship Between Inflammatory and Coagulation in SAH CSF
Investigate the role of inflammasome and blood coagulation response in human cerebrospinal fluid after subarachnoid hemorrhage.
- Trial name
- NCT04938414
- Testing
- Lumbar puncture
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Rhinitis, Allergic, Perennial
The Effect of Apple Fruit Extract (Malus Sylvestris Mill) as an Antioxidant and Anti-Inflammatory on Allergic Rhinitis
This study was conducted to see before and after treatment whether it provided improvement in the patient's clinical symptoms.
- Trial name
- NCT07380178
- Testing
- Quercetin, Apple Extract, Loratadine 10 Mg
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Sebelas Maret
Hypertension, Pre-hypertension
Restoring Sleep Homeostasis to Lower Blood Pressure
Cutting back on sleep duration has developed into a common, highly prevalent habit in the adult population, and may lead to a major health problem.
- Trial name
- NCT01008176
- Testing
- Sleep extension
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Beth Israel Deaconess Medical Center
Inflammatory Bowel Diseases
A Self-compassion Intervention for Parents of Children With Inflammatory Bowel Disease (IBD)
Parenting a child with Inflammatory Bowel Disease (IBD) can understandably be challenging and distressing at times. The aim of this study is therefore to investigate the effectiveness of an online self-compassion intervention…
- Trial name
- NCT04717284
- Testing
- Self-compassion intervention (SCI), Control condition
- Where
- United Kingdom
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- University of Sheffield
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