Clinical trials: Inflammatory Joint Disease
Ankylosing Spondylitis
Study to Demonstrate the Efficacy, Safety and Tolerability of an Intravenous Regimen of Secukinumab Compared to Placebo in Subjects With Active axSpA
The purpose of this global study was to demonstrate the efficacy, safety, and tolerability of an intravenous (i.v.) regimen of secukinumab compared to placebo in participants with active ankylosing spondylitis (AS) or…
- Trial name
- NCT04156620
- Testing
- Secukinumab
- Where
- 102 sites in United States, Belgium and 16 more
- Volunteers
- 527 people
- Sponsor
- Novartis Pharmaceuticals
Non-inflammatory Degenerative Joint Disease (NIDJD) of the Knee
Safety and Performance of the Journey™ II UNI Unicompartmental Knee System
This clinical study will evaluate the early to midterm safety and performance of the JOURNEY™ II UNI UKS in patients with non-inflammatory degenerative joint disease of the knee requiring lateral or medial knee compartment…
- Trial name
- JII-Uni (NCT03768128)
- Testing
- Journey™ II UNI Unicompartmental Knee System
- Where
- 6 sites in United States, Italy and 1 more
- Volunteers
- 154 people
- Sponsor
- Smith & Nephew, Inc.
Non-inflammatory Degenerative Joint Disease
36 mm Ceramic-on-Ceramic Acetabular Cup Total Hip Replacement
This study is a supplement to the 28 mm Ceramic-on-Ceramic study which was designed to evaluate artificial hips with a 28 mm ceramic head and liner to determine whether they perform as well as artificial hips with a 28 mm ceramic…
- Trial name
- NCT00953719
- Testing
- 36 mm ceramic head on a ceramic acetabular liner, 28 mm ceramic head on a polyethylene acetabular liner
- Where
- 5 sites in United States
- Volunteers
- 243 people
- Sponsor
- DePuy Orthopaedics
Non-inflammatory Degenerative Joint Disease, Osteoarthritis
CoMplete™ Acetabular Hip System
The primary objective of this investigation is to evaluate survivorship at ten years. For this post approval study (PAS), a maximum acceptable hazard of revision is assumed to be a constant 1% per year.
- Conditions
- Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Post-traumatic Arthritis
- Trial name
- NCT01543230
- Testing
- Total hip replacement
- Where
- 6 sites in United States
- Volunteers
- 58 people
- Sponsor
- DePuy Orthopaedics
Arthritis, Inflammatory
RISC Panel Remnant Sample Collection
The primary objective of this study is to evaluate the usability and clinical utility of the Synovasure® RISC™ Panel. The secondary objective of this study is to create a repository of well-characterized synovial fluid samples…
- Trial name
- NCT05778162
- Testing
- Synovasure® RISC™ Panel
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Zimmer Biomet
Acute Gout
Canakinumab in the Treatment of Acute Gout Flares and Prevention of New Flares in Patients Unable to Use Non-steroidal Anti-inflammatory Drugs (NSAIDs) and/or Colchicines Including a 12 Week Extension and a 1 Year Open-label Extension Study.
The purpose of this study was to demonstrate that canakinumab given upon acute gout flares relieves the signs and symptoms and prevents recurrence of gout flares in patients with frequent flares of gout for whom non-steroidal…
- Trial name
- β-RELIEVED-II (NCT01080131)
- Testing
- Canakinumab 150 mg, Triamcinolone acetonide 40 mg
- Where
- 108 sites in United States, Canada and 3 more
- Volunteers
- 226 people
- Sponsor
- Novartis Pharmaceuticals
SLE - Systemic Lupus Erythematosus, Systemic Sclerosis
CD19/BCMA-Targeted Universal CAR-T Cell Injection for the Treatment of Autoimmune Diseases
This is a single-arm, open-label, investigator-initiated trial (IIT) designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of RD06-05 in patients with autoantibody-mediated autoimmune…
- Conditions
- SLE - Systemic Lupus Erythematosus, Systemic Sclerosis, ANCA Associated Vasculitis, Idiopathic Inflammatory Myopathies
- Trial name
- NCT07596680
- Testing
- RD06-05 CAR-T Cell Injection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nanjing Bioheng Biotech Co., Ltd.
Psoriasis, Colitis, Ulcerative
A Remotely Conducted Study to Assess Concentration of TREMFYA in Breast Milk of Lactating Women Who Are Receiving TREMFYA Therapeutically
The purpose of this post-marketing study is to assess the amount of guselkumab in breast milk of lactating women receiving guselkumab as part of their standard clinical care provided by their treating physician, for any of the…
- Conditions
- Psoriasis, Colitis, Ulcerative, Crohn Disease, Arthritis, Psoriatic
- Trial name
- NCT07654751
- Testing
- Breast Milk Sample Collection, Guselkumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Janssen Research & Development, LLC
Knee Osteoarthritis
Comparative Usability Evaluation of Sustained Acoustic Medicine (SAM) Devices and Topical Gel for OA Knee Pain
The purpose of this study is to evaluate the usability of the ultrasound devices and common pain relief gel. The ability of the three treatment approaches to reduce pain, stiffness, and functionality as measured by NRS scale and…
- Trial name
- NCT05050448
- Testing
- Sustained Acoustic Device with 2.5% Diclofenac Patch, 1% Diclofenac Topical Gel
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ZetrOZ, Inc.
Rheumatoid Arthritis, Psoriatic Arthritis
A Study in Pregnant Women With Chronic Inflammatory Diseases Treated With Cimzia (Certolizumab Pegol)
The purpose of the study is to assess systemic certolizumab pegol (CZP) exposure, the formation of anti-CZP antibodies and safety of CZP across the course of pregnancy in study participants with chronic inflammatory diseases.
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Crohn's Disease, Axial Spondyloarthritis
- Trial name
- CHERISH (NCT04163016)
- Testing
- Pharmacokinetics of certolizumab pegol
- Where
- 9 sites in United States, France and 4 more
- Volunteers
- 22 people
- Sponsor
- UCB Biopharma SRL
Rheumatoid Arthritis
Anti-Inflammatory Dietary Intervention for Rheumatoid Arthritis
The primary objective of this study is to assess if there is a significant difference in the mean disease activity score in individuals with RA participating in a dietary intervention compared to those in the control group…
- Trial name
- RA-Diet (NCT05291299)
- Testing
- Anti-inflammatory diet, Control/Standard of Care
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Attune Health Research, Inc.
Spondyloarthritis
99mTc-rhAnnexin V-128 in Diagnosis of Spondyloarthritis
This single center, open-label, proof of concept (PoC) Phase II study aimed to assess the investigational imaging agent 99mTc-rhAnnexin V-128 in detecting spondyloarthritis (SpA) lesions.
- Trial name
- Annexin 03 (NCT03232580)
- Testing
- rhAnnexin V-128
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Advanced Accelerator Applications
Total Hip Replacement (Non-inflammatory)
Post Approval Study: NOVATION Ceramic Articulation Hip System
The purpose of this study is to collect and evaluate long-term safety and effectiveness data on the Exactech® NOVATION ™ Ceramic Articulation Hip System ("NOVATION ™ Ceramic AHS").
- Trial name
- NCT00715143
- Testing
- Novation Ceramic
- Where
- 5 sites in United States
- Volunteers
- 126 people
- Sponsor
- Exactech
Non-inflammatory Joint Diseases
Metal on Metal Versus Ceramic on Metal Hip Replacement
The purpose of this study is to compare the performance of artificial hips with metal heads and metal sockets to artificial hips with ceramic heads articulating with metal socket components.
- Trial name
- NCT00208494
- Testing
- Total Hip Replacement
- Where
- 9 sites in United States, Canada
- Volunteers
- 392 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis
Safety and Biologic Activity Study of Gevokizumab to Treat Erosive Osteoarthritis of the Hand
The purpose of this proof-of-concept study is to determine whether gevokizumab is effective in the treatment of active inflammatory, erosive osteoarthritis of the hand.
- Trial name
- NCT01683396
- Testing
- gevokizumab
- Where
- 27 sites in United States
- Volunteers
- 87 people
- Sponsor
- XOMA (US) LLC
Rheumatoid Arthritis &Amp; Other Inflammatory Polyarthropathies, Peripheral Spondyloarthritis
Automated Arthritis Detection Using Artificial Intelligence on Smartphone Photographs
The investigators are testing the ability of convolutional neural networks (CNNs), that is artificial intelligence, on smartphone photographs in detecting inflammatory arthritis.
- Conditions
- Rheumatoid Arthritis &Amp; Other Inflammatory Polyarthropathies, Peripheral Spondyloarthritis, Inflammatory Arthritis
- Trial name
- AISynovitis (NCT06715488)
- Testing
- AI assisted smartphone diagnosis
- Where
- 2 sites in India
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Med2Measure
Rheumatoid Arthritis
A Clinical Trial to Study the Effects of Revamilast in Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune and chronic inflammatory disease that causes progressive damage to joints of the body, affecting the functional capacity.
- Trial name
- TERRA (NCT01430507)
- Testing
- Revamilast
- Where
- 36 sites in India, Philippines and 3 more
- Volunteers
- 406 people
- Sponsor
- Glenmark Pharmaceuticals Ltd. India
Rheumatoid Arthritis
An Open-label Extension Study Evaluating the Safety and Efficacy of Upadacitinib (ABT-494) in Adults With Rheumatoid Arthritis
The primary objective of the study is to evaluate the long-term safety, tolerability, and efficacy of upadacitinib in adults with rheumatoid arthritis (RA) who have completed a preceding randomized controlled trial with…
- Trial name
- BALANCE-EXTEND (NCT02049138)
- Testing
- Upadacitinib, Pneumococcal 13-valent conjugate vaccine (PCV-13)
- Where
- 124 sites in United States, Belgium and 16 more
- Volunteers
- 493 people
- Sponsor
- AbbVie
Arthritis, Rheumatoid
Safety and Efficacy of Mobic® Ampoules in the Initiation of Treatment of Painful Exacerbations of Osteoarthritis, Rheumatoid Arthritis and Other Similar Painful Inflammatory Conditions
Study to determine the safety and efficacy of Mobic® ampoules in the initiation of treatment of painful exacerbations of osteoarthritis, rheumatoid arthritis and other similar painful inflammatory conditions.
- Trial name
- NCT02184052
- Testing
- Meloxicam
- Volunteers
- 121 people
- Sponsor
- Boehringer Ingelheim
Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
The purpose of this study is to measure the safety, tolerability, PK, and PD of AZD5492 administered subcutaneously in adult participants with SLE or IIM or RA Study details include: The study duration will be a minimum of 180…
- Conditions
- Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies, Rheumatoid Arthritis
- Trial name
- TITAN (NCT06916806)
- Testing
- AZD5492
- Where
- 38 sites in United States, Canada and 8 more
- Volunteers
- 72 people
- Sponsor
- AstraZeneca