Clinical trials: Inflammatory Marker
- Condition Inflammatory Marker
- Funder type Industry (pharma, biotech, devices)
- Accepts healthy volunteers yes
Healthy
A Methodology Study in Healthy Subjects to Evaluate the Effect of AZD8309 After Nasal Administration of Lipopolysaccharide (LPS)
The purpose of this methodology study is to evaluate the effect of AZD8309 on cells and inflammatory biomarkers in nasal lavage and blood after nasal challenge with lipopolysaccharide (LPS)
- Trial name
- NCT00860821
- Testing
- AZD8309
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Arthritis, Rheumatoid
Lipopolysaccharide (LPS) or Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Challenge Study on Healthy Subjects
This exploratory study aims to assess exposure of healthy subjects to systemic challenge with either LPS or GM-CSF. This will be done by measuring inflammatory mediators and cellular activation markers both in circulation and in…
- Trial name
- NCT03306589
- Testing
- Cantharidin, Lipopolysaccharide, Granulocyte-Macrophage Colony-Stimulating Factor
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Airway Inflammation
Study of Biomarkers of Airway Inflammation (0000-128)
This study will evaluate the effects of inhaled fluticasone on cell counts and inflammatory mediators measured in sputum of healthy volunteers following exposure to inhaled lipopolysaccharide.
- Trial name
- NCT00869596
- Testing
- fluticasone propionate, Comparator: Lipopolysaccharide (LPS), Comparator: albuterol
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Irritable Bowel Disease
Assessing Uniqueness of Inflammatory Bowel Disease Related Microbiome-derived Biomarkers
To assess the differential expression of IBD-related microbiome-derived biomarkers including bacterial strains and peptides such as antimicrobial peptides (AMP) found in inner-colonic samples (HygiSample™) in comparison to home…
- Trial name
- NCT05640583
- Testing
- Hygieacare System
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- HyGIeaCare, Inc.
Sjogren's Syndrome
Assessment of Inflammatory Biomarkers Expressed in a Sjogren's Population: Effect of a Topical Steroid Intervention
The primary purpose of this study is to quantify the change in expression of biomarkers on the ocular surface of Sjogren's Syndrome participants after treatment with Maxidex.
- Trial name
- NCT00631358
- Testing
- Maxidex, No treatment
- Where
- 2 sites in Canada
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Infectious Disease, Fever
Validation of a Proteomic Signature and Assessment of Viremia in Children With Fever Without Source
The study is an observational blinded Validation study in pediatric patients below 3 years old with a diagnosis of Fever Without Source (FWS).
- Conditions
- Infectious Disease, Fever, Viremia
- Trial name
- NCT03224026
- Where
- Switzerland
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- MeMed Diagnostics Ltd.
Acute Stroke, Transient Ischemic Attack
The Recurrence Study
The primarily goal of the research is to better understand progression of disease in patients who present with an acute stroke to the Hamad General Hospital (HGH) stroke and Transient Ischemic Attack (TIA) clinic.
- Trial name
- NCT03244215
- Testing
- Corneal Confocal Imaging, Magnetic resonance Imaging, Blood sample
- Where
- Qatar
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Supplementation in Healthy Adults to Assess Impact on Omega 3 Index and Cardiometabolic Health
Change in Omega 3 Index in Healthy Adults With OmeGo or a Standard Omega-3 Oil Supplement
Omega-3 index is used as a proxy for an adequate intake of fish unsaturated fats in the diet. However, omega-3 supplements have not consistently shown the health benefits of eating fresh fish.
- Trial name
- NCT06802068
- Testing
- whole salmon oil, Cod liver oil
- Where
- 2 sites in United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Hofseth Biocare ASA
Aging, Inflammation
Quantifiably Determine if the Botanical Formulation, LLP-01, Has a Significant Clinical Effect on Proteomic Inflammatory and Cardiovascular Biomarkers in Healthy, Older Individuals.
This is a prospective, interventional, double-blinded placebo-controlled study of up to 40 participants to evaluate the effect of a botanical formulation on inflammatory and cardiovascular biomarkers .
- Trial name
- NCT06065241
- Testing
- LLP-01
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- LL Prosper Inc.
Nutrition
Validation of a Food Frequency Questionnaire
The purpose of this study is to collect nutritional information from young children aged 15-36 months to validate a newly developed food frequency questionnaire.
- Trial name
- NCT03138330
- Testing
- this study is observational, it is not an intervention
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
Sepsis, Acute Infection
A Multicenter Prospective Observational Study to Derive and Verify the Performance of a Host-response Based Diagnostic Tool for Early Detection of Severe Infections.
The study is a multi-center, prospective, observational clinical study enrolling patients from at least 3 medical centers. Study population will include patients over the age of 18 years.
- Trial name
- NCT06665542
- Where
- 8 sites in United States, Israel
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- MeMed Diagnostics Ltd.
Dry Eye Disease
A Study to Explore Signs, Symptoms, and Biomarkers in Dry Eye Disease Participants Following Anti-inflammatory Treatment
This study aims to evaluate the performance of biomarkers and their responsiveness to standard-of-care treatments (Vevye® or Xiidra®), in participants with dry eye disease (DED) compared to healthy volunteers (control…
- Trial name
- NCT07025811
- Testing
- Vevye®, Xiidra®
- Where
- 8 sites in United States
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Polyphenolic Compounds and Metabolism
Acute Effects of Grape Seed Extract on Insulin Sensitivity and Oxidative Stress and Inflammation Markers.
The proposed study aims to investigate that consumption of grape seed extract (GSE) would improve antioxidant status and impaired insulin action following consumption of a pro-oxidative high carbohydrate, high fat (HCHF) meal in…
- Trial name
- GSE2 (NCT01995643)
- Testing
- Active Capsule
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Joint Discomfort, Wellbeing
Assessing the Potential for Improved Joint Health and Wellbeing by Providing a Whole Salmon Oil With Undenatured Type II Collagen Compared to Type II Collagen Alone
This study evaluates the combination of NT-II® salmon undenatured type II collagen with OmeGo® salmon oil in adults who regularly experience knee discomfort.
- Conditions
- Joint Discomfort, Wellbeing, Quality of Life
- Trial name
- NCT07875101
- Testing
- Undenatured collagen, Whole salmon oil
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hofseth Biocare ASA
Atherosclerosis, Inflammatory Activity in Carotid Arteries
Effects of Crestor on Inflammation of Atherosclerotic Plaques
The primary aim of this study is to investigate the effect of 40 mg dose of rosuvastatin on carotid plaque inflammation measured with MRI and PET scanning, to evaluate whether these techniques are promising for future proof of…
- Trial name
- NCT00689416
- Testing
- rosuvastatin
- Where
- Sweden
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Endothelial Function, Oxidative Stress
Black Forest Cocoa Flavanol Supplementation and Health Trial
This randomized, double-blind, controlled clinical trial will evaluate the effects of daily cocoa flavanol supplementation on vascular and inflammatory biomarkers in healthy adult men aged 30 to 75 years.
- Conditions
- Endothelial Function, Oxidative Stress, Inflamation, Vascular Health
- Trial name
- NCT07747714
- Testing
- Cocoa Flavanol Supplement, Low-Flavanol Control Powder
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The Black Forest LLC
IBD (Inflammatory Bowel Disease), IBS (Irritable Bowel Syndrome)
Specimen and Data Collection for a Novel Biomarker Combination for the Differential Diagnosis of Inflammatory Bowel Disease and Irritable Bowel Syndrome.
This study will evaluate how well the a new stool test can distinguish inflammatory bowel disease (IBD) from non-IBD conditions compared with standard calprotectin testing and colonoscopy findings.
- Conditions
- IBD (Inflammatory Bowel Disease), IBS (Irritable Bowel Syndrome), Gastrointestinal Symptoms
- Trial name
- COMBI (NCT07471490)
- Where
- 2 sites in United States, Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- DiaSorin Inc.
COPD
Chronic Obstructive Pulmonary Disease (COPD) Biomarker Identification Study
Chronic obstructive pulmonary disease (COPD) is a common inflammatory disease of the airway affecting approximately 10% of individuals aged 40 years or more with a smoking history.
- Trial name
- NCT01780298
- Where
- United Kingdom
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Parkinson Disease
Parkinson's Disease Inflammatory Biomarker Profiling
This study compares a comprehensive panel of immunological biomarkers between Parkinson's disease patients and healthy, environmentally matched participants.
- Trial name
- NCT03633513
- Testing
- LBT-3627, Immunological profiling
- Where
- 2 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Longevity Biotech
Visual Acuity
Changes in Inflammatory Biomarkers When Symptomatic Contact Lens Wearers Are Refit in Acuvue Oasys 1-Day Lenses
This is a 5-Visit, single-arm, single-site, subject masked, dispensing trial to evaluate contact lens discomfort and inflammatory biomarker expression.
- Trial name
- NCT05120128
- Testing
- Acuvue® Oasys 1-Day
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.