Clinical trials: Inflammatory Mediators
Growth, Development
Assisted Exercise in Prematurity; Effects and Mechanisms
Briefly our study is looking at the effects of 4 weeks of assisted exercise on the body composition and neurological/behavioral development of healthy growing premature infants enrolled between the ages of 30-33 weeks.
- Trial name
- NCT00580099
- Testing
- assisted exercise, cuddle
- Where
- United States
- Sponsor
- University of California, Irvine
COPD, Chronic Bronchitis
Regulation of the Release of Inflammatory Mediators From Lung Macrophages.
The aim of this study is to investigate the mechanisms whereby specific white cells called macrophages found in the lung release inflammatory mediators or chemicals together with enzymes that destroy the surrounding lung tissue.
- Conditions
- COPD, Chronic Bronchitis, Emphysema
- Trial name
- NCT00147017
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- Imperial College London
Critically Ill Patients
Clearance of Vasoactive Metabolites With Blood Purification
Extracorporeal blood purification is a supportive therapy in the management of patients with sepsis or vasoplegic shock. The pathophysiology of sepsis is based on an inappropriate host response to infection.
- Trial name
- VITAL (NCT06109142)
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Berberine, COVID-19
The Effect of Berberine on Intestinal Function and Inflammatory Mediators in Severe Patients With Covid-19
Coronavirus disease 2019 (COVID-19) rapidly spread across China and throughout the world, causing hundreds of thousands died. Studies had shown that "cytokine storms" and subsequent multiple organ dysfunction (MODS) are important…
- Trial name
- BOIFIM (NCT04479202)
- Testing
- Berberine, Montmorrillonite
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Chinese Medical Association
Sepsis, Septic Shock
OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study
This study examines how well the Oxiris® hemofilter works over time in adults with septic shock who require continuous kidney support in the intensive care unit (ICU).
- Conditions
- Sepsis, Septic Shock, Blood Purification, Hemoadsorption
- Trial name
- OxiCLEAR (NCT07419802)
- Testing
- AN69-polyethylenimine hemofilter (Oxiris®) used for continuous veno-venous hemofiltration (CVVH)
- Where
- Latvia
- Volunteers
- 29 people
- Sponsor
- Pauls Stradins Clinical University Hospital
Erythema Migrans
Inflammatory Mediators in Erythema Migrans
The main objective of this study is to characterize the inflammatory proteins, gene polymorphisms, and transcriptome profiles in patients with erythema migrans to gain better insight into pathogenesis of early Lyme borreliosis…
- Trial name
- NCT03956212
- Testing
- Doxycycline 7 days, Doxycycline 14 days
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Ljubljana
Atherosclerosis, Inflammation
Sitagliptin Effects on Arterial Vasculature and Inflammation in Obesity
Abdominal obesity is a major risk factor for heart attack, stroke, peripheral vascular disease, dementia, cancer and Type 2 diabetes.
- Trial name
- SAVORO (NCT02576288)
- Testing
- Sitagliptin
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Ulcerative Colitis
Utility of Low Intensity Pulsed Ultrasound Stimulation (LIPUS) to Modulate the Release of Mediators Capable of Reflecting the Inflammatory State in the Affected Colonic Tract of Ulcerative Colitis Patients
The goal of this clinical trial is to learn whether Low Intensity Pulsed Ultrasound (LIPUS) is capable of promoting the release of extracellular vesicles from the gut into the bloodstream of Ulcerative Colitis (UC) patients…
- Trial name
- LIPUSinVIVO (NCT06569888)
- Testing
- LIPUS stimulation
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Molar-Incisor Hypomineralization (MIH)
Assessment of Peridontal Inflamatuar Markers in MIH
The goal of this observational study is to investigate periodontal inflammatory mediators in systemically healthy children aged 8-13 years with and without molar-incisor hypomineralization (MIH) who require initial periodontal…
- Trial name
- NCT07701642
- Testing
- Initial periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Marmara University
Healthy
Effect of Daily Low Dose Aspirin on Exhaled Inflammatory Mediators in Normal Subjects
Hypothesis: Low dose aspirin does not change exhaled inflammatory breath mediators in normal subjects.
- Trial name
- NCT00898222
- Testing
- aspirin
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
COVID-19
Cytokine and Eicosanoid Mediators in Coronavirus Disease 2019 (COVID-19)
This study is a prospective, single center, observational, cohort study of patients to (1) describe the kinetics and temporal relationship of changes in eicosanoid and cytokine mediators in patients with severe COVID-19 admitted…
- Trial name
- NCT04452942
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- EicOsis Human Health Inc.
Acute Respiratory Failure
Effect Of Acute Inflammatory Mediators On Functional Limitations In Patients With Acute Respiratory Failure
This is a randomized, controlled, pilot study of two separate Cohorts of patients from the intensive care unit. Cohort I will enroll 50 patients and randomize to receive one physical therapy session per day or receive usual ICU…
- Trial name
- NCT01707303
- Testing
- Early ICU rehabilitation strategies, Usual Care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University
Pain, Inflammation
Effects of Cryotherapy on Joint Function and Pressure Pain Threshold in Patients With Subacromial Impingement Syndrome.
Background: Subacromial impingement syndrome (SIS) is a chronic and disabling disease, characterized by compression and mechanical abrasion of the tendons of the rotator cuff muscles, subacromial bursa and tendon of the long head…
- Trial name
- NCT02351986
- Testing
- physical therapy, ice pack
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sao Carlos
Chronic Obstructive Pulmonary Disease (COPD), Emphysema
Evaluating Genes in Sputum to Measure Drug Response in COPD
The purpose of this research study is to determine whether analysis of genes in sputum is a useful noninvasive technique for measuring response to drugs in patients with COPD.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Emphysema, Chronic Bronchitis
- Trial name
- NCT00233051
- Testing
- Salmeterol or Salmeterol/Fluticasone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Jewish Health
Preterm Labor, Preterm Birth
Biomarkers Associated With Spontaneous Preterm Birth Less Than 32 Wks Gestation
Preterm delivery (PTD) is a leading cause of neonatal mortality and continues to be a major public health concern, reaching 12.9% in 2006, despite intense research to reverse this trend.
- Trial name
- NCT02317315
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ranjith Kamity, MD
Chronic Obstructive Airway Disease, Healthy Volunteers
Regulation of the Release of Inflammatory Mediators From Blood Leukocytes
Chronic obstructive pulmonary disease (COPD for short) involves inflammation inside the air passages of the lungs. This inflammation might be partly responsible for the shortness of breath, cough and susceptibility to chest…
- Trial name
- NCT00180765
- Testing
- Up to 100ml blood will be taken by venupuncture.
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Imperial College London
Myocardial Infarction
Evaluation of the Predictive Effect of Inflammatory Markers in MI Patients
Acute myocardial infarction (AMI), triggered by myocardial ischemia and reperfusion injury, is a disease with high morbidity and mortality, and there is a tendency for its incidence to increase at younger ages.
- Trial name
- NCT05479838
- Testing
- Percutaneous coronary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Abant Izzet Baysal University
Temporomandibular Joint Disorder
Study of Etanercept and Celecoxib to Treat Temporomandibular Disorders (Painful Joint Conditions)
This 2-part study will evaluate the effectiveness and side effects of two anti-inflammatory drugs for relieving pain and improving jaw function in patients with temporomandibular disorder (TMD).
- Trial name
- NCT00001955
- Testing
- Etanercept, Celecoxib
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Large Bowel Cancer
Effects of Different Strategy of Fluids Administration on Acid/Base Disorders and Inflammatory Mediators
Aim of the study is to ascertain whether a different strategy of fluids administration can be responsible of differences in terms of acid/base disorders (Stewart approach), pro-inflammatory and inflammatory mediators.
- Trial name
- NCT01320891
- Testing
- balanced solutions, not balanced
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Università degli Studi di Ferrara
Obesity
Adipokines in Obese Adolescents With Insulin Resistance
The purpose of this study is to compare serum concentrations of inflammatory cytokines, interleukin 6 (IL-6), High-sensitivity C-reactive protein (hs-CRP), adiponectin, and tumour necrosis factor alpha (TNFα), before and after…
- Trial name
- NCT01410604
- Testing
- Metformin
- Where
- 2 sites in Mexico
- Volunteers
- 31 people
- Sponsor
- Hospital Regional de Alta Especialidad del Bajio