Clinical trials: Inflammatory Response After Surgery
Sepsis, Burn Injury
TDAP in Burn Patients (Group 2)
This study is following adult patients with serious burn injuries to better understand how their bodies respond to treatment and recovery.
- Conditions
- Sepsis, Burn Injury, Wound Healing, Critical Illness
- Trial name
- NCT07223684
- Testing
- Observational Cohort (No Intervention)
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Cardiac Arrest, Extracorporeal Circulation
Cytokine Adsorption in Post-cardiac Arrest Syndrome in Patients Requiring Extracorporeal Cardiopulmonary Resuscitation
Almost all patients with refractory cardiac arrest, who are primarily stabilized under ongoing cardiopulmonary resuscitation by transcutaneous implantation of a venoarterial extracorporeal membrane oxygenation system (va-ECMO for…
- Conditions
- Cardiac Arrest, Extracorporeal Circulation, Extracorporeal Membrane Oxygenation, Cytokine Storm
- Trial name
- CYTER (NCT03685383)
- Testing
- Cytosorb removal column in eCPR, standard eCPR (va-ECMO)
- Where
- Germany
- Volunteers
- 41 people
- Sponsor
- University Hospital Freiburg
Hernia, Inguinal, Laparoscopy
Transabdominal Preperitoneal Inguinal Hernia Repair
The present study seeks to determine whether improved visual acuity and enhanced flexibility of the robotic platform results in a reduced surgical stress response and an improvement in indices of surgical outcome measures for…
- Trial name
- TAPP (NCT05839587)
- Testing
- Robotic TAPP, Laparoscopic TAPP
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- University of Southern Denmark
Sepsis
Preclinical Detection of Sepsis Early in Hospitalized Patients Following Surgery, Injury or Severe Illness
This clinical study is to evaluate a novel biomarker - CNA Rapid Sepsis Dx - to predict the development of sepsis in patients admitted to the hospital with non-sepsis conditions.
- Trial name
- Pre-SEPSIS (NCT04189549)
- Testing
- CNA Rapid Sepsis Dx
- Where
- 5 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Robert Ehrman
Pain
Study of the Effect of Regional Nerve Blocks on Pain and Inflammation After Video Assisted Thorascopic Lung Surgery
The purpose of this study is to compare: 1. The degree of systemic postoperative inflammation (cytokine measurement) with the degree of post-operative pain 2. The degree of pain and nausea and 3.
- Trial name
- VATS_IM (NCT00639795)
- Testing
- Thoracic Paravertebral Nerve Block
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Memorial Medical Center
Abdominal Neoplasms
Continuous Pre-peritoneal Wound Infiltration Versus Epidural Analgesia in Cancer Surgery
the investigators aim is to investigate the effect of continuous preperitoneal bupivacaine wound infiltration versus epidural analgesia on the inflammatory cytokines response following radical cytectomy
- Trial name
- NCT03002909
- Testing
- epidural catheter, preperitoneal catheter
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Colon Carcinoma
Dipeptide Alanyl Glutamine and Postoperative Insulin Resistance in Colon Carcinoma Patients
Rationale: It is well known that insulin resistance occurs after mediocre and intensive surgery, such as colon cancer surgery. Disturbances in insulin action negatively affect the postoperative recovery, either by prolonging the…
- Trial name
- AIRCo (NCT00922688)
- Testing
- Dipeptide Alanyl-Glutamine
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Medical Center Alkmaar
Shock, Surgical, Systemic Inflammatory Response Syndrome
Thromboelastography in in Patients With Sepsis
Methods: The study is an observational prospective trial that includes 150 patients 18 or older admitted to our icu because of severe sepsis or septic shock as defined by the American College of Chest Physicians/ Society of…
- Trial name
- NCT00994877
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Femoral Neck Fractures, Postoperative Complications
Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty
Hip fractures incidence grows rapidly with the aging of the population. After indicated surgical treatment, hip fracture patients experience high rates of postoperative complications, postoperative delirium (PD), postoperative…
- Conditions
- Femoral Neck Fractures, Postoperative Complications, Inflammatory Response, Postoperative Delirium
- Trial name
- NCT01934049
- Testing
- hip arthroplasty, Total Intravenous Anesthesia and Peripheral nerve blocks
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese PLA General Hospital
Myocardial Ischemia, Inflammatory Response
Remote Ischemic Preconditioning and Postoperative Myocardial Ischemia
High-risk abdominal surgery is frequently complicated by postoperative complications, such as sepsis, pneumonia or anastomotic dehiscence.
- Trial name
- MICOLON2 (NCT03460938)
- Testing
- Remote ischemic preconditioning
- Where
- Netherlands
- Volunteers
- 90 people
- Sponsor
- St. Antonius Hospital
Inflammatory Response, Erythrocyte Destruction
Electric Polarization of Red Blood Cells : A Cohort Study to Assess the Erythrocytes Membrane Integrity Through Charge Conservation, Following Cardiac Surgery.
An immediate perioperative parameter that assess the integrity of the Erythrocytes Membrane and therefore their structural quality isn't available in clinical practice and medical diagnostics except through indirect clinical…
- Conditions
- Inflammatory Response, Erythrocyte Destruction, Red Blood Cell Disorder, Hemolysis
- Trial name
- Polaris (NCT05754294)
- Testing
- Polarization of red blood cells
- Where
- Italy
- Sponsor
- Anthea Hospital Bari
Postoperative Cognitive Decline, Biomarkers
Patients Experiences of Early Postoperative Cognition
The study has a mixed-methods design i.e. integration of qualitative and quantitative data within a single investigation. Participants included will be patients ≥60 years that are undergoing major elective joint replacement…
- Conditions
- Postoperative Cognitive Decline, Biomarkers, Postoperative Recovery, Joint Replacement Surgery
- Trial name
- COME (NCT05361460)
- Testing
- Cognitive decline
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Crp
CRP/Albumin Ratio as a Predictive Inflammatory Marker for Postoperative SIRS and/or Sepsis
The goal of this observational study is to determine the value of CRP/Albumin Ratio as an inflammatory marker for predicting the development of postoperative Systemic Inflammatory Response Syndrome and/or Sepsis in…
- Trial name
- NCT06050759
- Testing
- CRP and Albumin level in blood sample
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Kidney Calculi, Urinary Tract Infections
Do Dynamic Urinary Leukocyte and Nitrite Changes Improve Risk Prediction for Infectious Complications Following PCNL?
Background Percutaneous nephrolithotomy (PCNL) is widely recognized as the primary surgical approach for managing sizable and anatomically complex kidney stones., yet postoperative infection-related complications remain common…
- Conditions
- Kidney Calculi, Urinary Tract Infections, Sepsis
- Trial name
- NCT07238673
- Where
- China
- Volunteers
- 346 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Postoperative Pain, Inflammatory Response
Bilateral Ultrasound Guided Quadratus Lumborum Versus Lumbar Epidural Block on Postoperative Analgesia, and Inflammatory Response in Abdominal Surgery
This study aims at comparing the effects of bilateral ultrasound-guided quadratus lumborum block versus lumbar epidural block on postoperative analgesia and inflammatory response following major lower abdominal cancer surgery.
- Trial name
- NCT03958942
- Testing
- Ultrasound quadratus lumborum block with bupivacaine 25%, lumbar epideural block with bupivacaine 25%
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Sepsis, Shock
Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit
In clinical practice, the oxidative stress is related to circulatory shock, sepsis, acute lung injury, and acute respiratory distress syndrome. There are some questions on the oxidative stress of the critical illness.
- Trial name
- NCT00745888
- Testing
- Chemiluminescence Analyzer
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital