Clinical trials: Influenza Virus Infection
Respiratory Syncytial Virus Infections
Evaluation of RSV/Flu-01E Vaccine for the Prevention of RSV Infection in Volunteers Aged 18 to 59 Years and Over 60 Years
The aim of the study is to investigate the safety and immunogenicity of the RSV/Flu-01E vaccine for the prevention of respiratory syncytial virus infection in volunteers aged18 to 59 years and over 60 years.
- Trial name
- NCT05970744
- Testing
- RSV/Flu-01E low dose, RSV/Flu-01E high dose
- Where
- Russia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tatyana Zubkova
Influenza, Acute Respiratory Viral Infections
Safety and Pharmacokinetics of Ingavirin Forte, Capsules, 90 mg + 20 mg (Valenta Pharm JSC, Russia) Compared With Ingavirin, Capsules, 90 mg, Under Fasting and Fed Conditions.
This study aims to evaluate the safety and pharmacokinetic profile of the active ingredients Ingavirin forte, capsules, 90 mg + 20 mg (Valenta Pharm JSC, Russia) relative to single-entity Drug Ingavirin, capsules, 90 mg following…
- Trial name
- NCT07645534
- Testing
- Ingavirin forte, capsules, 90 mg + 20 mg, Ingavirin, capsules, 90 mg
- Where
- Russia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Valenta Pharm JSC
Influenza
Safety and Immunogenicity of a Cell Culture-derived Influenza Vaccine in Healthy Adults and Elderly
The present study aims to evaluate the safety and immunogenicity of the new influenza subunit vaccine produced in Madin Darby Canine Kidney (MDCK) cells in healthy adult and elderly subjects.
- Trial name
- NCT00492063
- Testing
- Cell culture-derived trivalent subunit influenza vaccine (cTIV), Egg-derived trivalent subunit influenza vaccine (TIV)
- Where
- 5 sites in Poland
- Volunteers
- 2,654 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Influenza (Pandemic), Avian Influenza
Pandemic Influenza Vaccine in Organ Transplantation (PIVOT Trial)
Influenza is an important pathogen in transplant recipients. The current widespread outbreak of highly pathogenic H5N1 avian influenza (HPAI) in livestock, and the occurrence of several human cases of infection suggest that the…
- Conditions
- Influenza (Pandemic), Avian Influenza, Vaccination
- Trial name
- PIVOT (NCT07240558)
- Testing
- H5N1 vaccine (Arepanrix, GSK)
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Influenza
A Phase 2 Study of Immunogenicity, Safety and Tolerability of CSL412 in Elderly Participants
Current influenza vaccines have a reduced efficacy in the elderly. This study will investigate the immunogenicity, safety and tolerability of an adjuvanted influenza vaccine in elderly participants.
- Trial name
- NCT00479648
- Testing
- CSL412, Inactivated trivalent influenza vaccine
- Where
- United Kingdom
- Volunteers
- 612 people, healthy volunteers welcome
- Sponsor
- Seqirus
Influenza Infection, Infections
Rechallenge With a Low Pathogenicity Avian H10N7 Influenza Virus in Healthy Human Volunteers Previously Challenged With H10N7 Influenza
Background: Influenza (flu) is a virus that can infect humans and animals. In humans, the flu can cause mild symptoms such as fever, cough, sore throat, runny nose, muscle aches, headaches, and fatigue.
- Conditions
- Influenza Infection, Infections, Respiratory Virus Infections, Respiratory Tract Infections
- Trial name
- NCT07215871
- Testing
- A/Mallard/Ohio-99/MM4/1989 H10N7
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Influenza
A Phase 1/2 Study of a Intramuscular Injection of TAK-850 in Healthy Adult Subjects
This clinical trial is a phase 1/2 study of a single intramuscular injection of TAK-850 in healthy Japanese adult participants
- Trial name
- NCT02111252
- Testing
- TAK-850
- Where
- Japan
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Takeda
Influenza
A Study to Evaluate the Safety and Immunogenicity of GSK Biologicals' Seasonal Influenza Vaccine in Adults
This study is designed to test the immunogenicity and safety of an investigational influenza vaccine, in adults compared to two other influenza vaccines.
- Trial name
- NCT01196975
- Testing
- Quadrivalent seasonal influenza vaccine GSK2282512A, FluLavalTM-VB, FluLavalTM-YB
- Where
- 12 sites in United States, Canada and 1 more
- Volunteers
- 1,707 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Influenza Virus Infection
Effect of Early Antiviral Therapy on Duration of Cough in Flu Patients
This study mainly focused on the effect of early antiviral treatment on the duration of cough in influenza patients.investigators conducted an early investigation of patients with positive influenza virus and asked whether…
- Trial name
- NCT03618407
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Renmin Hospital of Wuhan University
ARDS (Acute Respiratory Distress Syndrome)
BALance: ARDS Deconvolution by Bronchoalveolar Lavage Multiomics and Radiomics
Acute respiratory distress syndrome (ARDS) is a major contributor to ICU mortality and is characterised by hypoxaemia and pulmonary oedema.
- Trial name
- BALance (NCT07633366)
- Testing
- sampling blood, Lavage with physiologic saline solution
- Where
- Austria
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Influenza
Novartis Pandemic Influenza A (H1N1) Vaccine(s) Observational Comparative Safety Study
The primary objective of this observational, comparative safety study is to evaluate the safety of the Novartis Pandemic Influenza A (H1N1) vaccine in pregnant women and their off spring, followed for up to 3 months of age as…
- Trial name
- NCT01037829
- Testing
- Non-intervention observational study
- Where
- 17 sites in Argentina, Italy and 1 more
- Volunteers
- 4,529 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Influenza
Immunogenicity Trial of Recombinant Influenza Vaccine Among HCP in Israel
This randomized, open-label, active-controlled trial will assess humoral immune responses to a single dose of 2019-20 recombinant hemagglutinin quadrivalent influenza vaccines (RIV4) compared with standard egg-based unadjuvanted…
- Trial name
- NCT04523324
- Testing
- Flublok™ Quadrivalent by Sanofi, Inc., VaxigripTetra™ by Sanofi, Inc.
- Where
- 2 sites in Israel
- Volunteers
- 577 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Avian Influenza
A Study to Evaluate the Safety and Immunogenicity of Two Doses of a Novel H5 Central Antigen mRNA-LNP in Healthy Adults
This is a phase 1, multicenter, randomized, double-blind trial of two influenza A/H5 mRNA-based vaccines on healthy adult participants, 18-49 years of age. Stage 1 will serve as the open-label, dose finding stage.
- Trial name
- NCT07019883
- Testing
- H5 AC-Anhui RNA Vaccine, H5 Astrakhan RNA Vaccine, Sodium Chloride, 0.9%
- Where
- 3 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Influenza, Exposure
Different Regimens in Influenza Postexposure Chemoprophylaxis in Children
Although the vaccination is the preferred method of influenza prevention, there are some occasions on which a postexposure prophylaxis (PEP) is required.
- Conditions
- Influenza, Exposure, Prevention
- Trial name
- NCT04297462
- Testing
- Oseltamivir 3 days, Oseltamivir 7 days
- Where
- Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Centre of Postgraduate Medical Education
Hepatitis B
Antigen-specific Immune Response to Hepatitis B Virus in Utero
This study aims to gain an understanding of the key components of the immune response to hepatitis B present in cord blood of HBV infected mothers.
- Trial name
- NCT00845403
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Influenza
Chinese Medicinal Herbs Treatment on Novel Influenza A (H1N1) : Multi-centre, Prospective, Randomized Controlled Study
The purpose of this study is to determine whether Chinese medicinal herbs are effective and safe for treating novel influenza A (H1N1) infection.
- Trial name
- NCT00935194
- Testing
- oseltamivir, blank, chinese medicinal herbs
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Capital Medical University
Influenza Vaccines
Vaccine Chatbot for Improving Influenza Vaccination Uptake
This study aims to assess the impact of a vaccine chatbot on improving influenza vaccination uptake among children aged between 6 and 59 months through a cluster randomized trial.
- Trial name
- NCT06657573
- Testing
- An AI-enabled chatbot tailored for influenza vaccine consultation
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Fudan University
SARS-CoV-2, Seasonal Influenza
A Study of Modified mRNA Vaccines in Healthy Adults
The main goal of this study is to evaluate the safety, reactogenicity, and immunogenicity of study vaccines.
- Conditions
- SARS-CoV-2, Seasonal Influenza, Respiratory Syncytial Virus, Cytomegalovirus
- Trial name
- NCT05397223
- Testing
- mRNA-1273, mRNA-1010, mRNA-1345
- Where
- 8 sites in United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
Respiratory Tract Infections, Influenza
Trial of Vitamin D Supplementation for the Prevention of Influenza and Other Respiratory Infections (ViDiFlu)
Purpose: The study null hypothesis is that vitamin D supplementation will not influence time to acute respiratory tract infection in sheltered accommodation residents.
- Trial name
- ViDiFlu (NCT01069874)
- Testing
- Cholecalciferol (Vitamin D/Vigantol oil), Miglyol oil
- Where
- 2 sites in United Kingdom
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Influenza
Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Trivalent Split Virion Influenza Vaccine Fluviral™ (2013-2014 Season) in Adults Aged 18 Years and Older
The purpose of this study is to evaluate the immunogenicity, reactogenicity and safety of Fluviral™ containing the influenza strains recommended for the 2013-2014 season in adults aged 18 years and older.
- Trial name
- NCT01878825
- Testing
- Fluviral™
- Where
- Canada
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
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