Clinical trials: Inhalation
Chronic Obstructive Pulmonary Disease, Pulmonary Hypertension
Effects of Ventavis in Patients With Pulmonary Hypertension (PH) Secondary to Chronic Obstructive Pulmonary Disease (COPD)
This is a phase 2, Multi-center, double-blind, randomized, placebo-controlled study to evaluate the effects of inhaled Iloprost in patients with pulmonary hypertension secondary to COPD.
- Trial name
- NCT01437878
- Testing
- Iloprost
- Where
- 11 sites in United States, France and 1 more
- Volunteers
- 2 people
- Sponsor
- Actelion
High Blood Pressure, Stroke
Innovative Tools to Expand Music-Inspired Strategies for Blood Pressure and Stroke Prevention
Expanding evidence-based interventions for hypertension and stroke prevention among youth and their caregivers is crucial for meeting World Health Organization and Nigerian health goals.
- Trial name
- ITEST-BPStroke (NCT07386535)
- Testing
- Music4Health Intervention
- Where
- Nigeria
- Volunteers
- 1,412 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Spinal Cord Injuries, Spine Disease
Outcomes Post Treatment: Impact on Motor Impairment of Sleep Efficiency in SCI (OPTIMISE SCI Trial)
This randomized clinical trial will compare three groups of individuals with cervical/thoracic, complete or incomplete spinal cord injury (SCI) that will undergo: (i) early CPAP therapy in the management of moderate-to-severe…
- Trial name
- NCT05473689
- Testing
- Continuous positive airway pressure (CPAP) therapy
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- University Health Network, Toronto
Heart Diseases
Inhaled Anesthetics and Myocardial Strain
Speckle tracking imaging measuring software will be used for offline analysis of transesophageal echocardiogram (TEE) -acquired images of the left ventricle(LV) in four chambers(4C), two chambers (2C) and long axis (LAX) views to…
- Trial name
- NCT03569085
- Testing
- Sevoflurane, Isoflurane
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Kathirvel Subramaniam
ARDS
Effect of Inhalation Sedation Compared With Propofol on the Sepsis-related Acute Respiratory Distress Syndrome Course
Investigation of effect of inhalation sedation by administration of Sevoflurane compared with Propofol on the moderate acute respiratory distress syndrome course in mechanically ventilated patients with sepsis.
- Trial name
- NCT04014218
- Testing
- Inhalation Sedation, Intravenous Sedation
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Moscow Regional Research and Clinical Institute (MONIKI)
COPD
NEXThaleR Real-world Study Assessing the EffectivenesS of BDP/FF/G Fixed triPle cOmbiNation on Symptom scorEs in COPD Patients
The goal of this observational study is to measure improvement in health related quality of life in moderate to severe COPD patients treated with Trimbow inhalation powder.
- Trial name
- RESPONSE (NCT05743608)
- Where
- 39 sites in Hungary
- Volunteers
- 1,336 people
- Sponsor
- Chiesi Hungary Ltd.
Respiratory Monitoring, Thoracic Surgery
AirGo™ Respiratory Monitoring in Lung Resection
Patients undergoing lung resection surgery may experience changes in respiratory function during the perioperative period. Current monitoring methods provide important clinical information but are often limited to specific time…
- Conditions
- Respiratory Monitoring, Thoracic Surgery, Lung Resection Surgery, Respiratory Function
- Trial name
- NCT07838025
- Testing
- AirGoTM system
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Glycogen Storage Disease Type II, Pompe Disease (Late-onset)
Inspiratory Muscle Training (IMT) in Adult People With Pompe Disease
The goal of this multicentre, randomized and controlled cross-over trial is to evaluate the efficacy of a programme of Inspiratory Muscle Training in subjects with Late On-set Pompe Disease (LOPD).
- Trial name
- LOPD01 (NCT05951790)
- Testing
- Inspiratory Muscle Training (IMT), Inspiratory Muscle Training (IMT) + Air Stacking
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Xerostomia Following Radiotherapy, Xerostomia Following in Neck or Head After Cancer Surgery
Does Craniosacraltherapy Combined With Exercises That Focuses om Respiration and Posture in the Upper Body Have an Effect on Xerostomia and Other Late Sequelae on People Who Has Been Suffering From Cancer in Mouth and Throat?
The current study aims to assess the efficacy of manual treatment with craniosacral therapy of fascial tissue in throat, neck, cranial and mouth region, on radiation and/or surgery-induced salivary gland hypofunction and…
- Conditions
- Xerostomia Following Radiotherapy, Xerostomia Following in Neck or Head After Cancer Surgery, Other Late Sequelae Following Radiotherapy and Cancer Surgery in Neck or Head
- Trial name
- NCT05882890
- Testing
- Craniosacral Therapy, Exercices Targeting Upper Posture and Respiration
- Where
- 2 sites in Denmark
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Cathrine Rahbek
COPD
Single and Multiple Ascending Dose Study of AER-01
This is a first-in-human, randomized, double-blind, placebo-controlled, Phase 1 study of AER-01 (solution for inhalation, delivered via nebulizer) to assess the safety, tolerability and PK of AER-01.
- Trial name
- NCT05862623
- Testing
- AER-01
- Where
- 2 sites in Australia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Aer Therapeutics
Pulmonary Hypertension, Bronchopulmonary Dysplasia
Inhaled Nitric Oxide for Pulmonary Hypertension and Bronchopulmonary Dysplasia
Inhaled nitric oxide (iNO) is an effective treatment for pulmonary hypertension (PH) in term and near-term infants. Preterm infants are at risk for early PH that is associated with high risk for bronchopulmonary dysplasia or…
- Trial name
- NCT03576885
- Testing
- inhaled nitric oxide
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- AdventHealth
Chronic Obstructive Pulmonary Disease, Asthma
Lung Deposition of Beclometasone Dipropionate/Formoterol Fumarate/Glycopyrronium Bromide Administered Via pMDI in Healthy, Asthmatic and COPD Patients
The purpose of this study is to investigate the lung deposition and distribution pattern of Beclometasone dipropionate/Formoterol Fumarate/Glycopyrronium Bromide using a Gamma-scintigraphic technique after inhalation of a single…
- Trial name
- NCT02975843
- Testing
- Beclometasone dipropionate/Formoterol Fumarate/Glycopyrronium
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Cystic Fibrosis (CF), Gene Therapy
A Prospective, Single-center, Open-label Study of Inhaled BMD003 (CFTR mRNA) in Chinese Adults With Cystic Fibrosis
The study uses a prospective, single-center, open-label clinical trial design to evaluate the safety and efficacy of inhaled BMD003 (CFTR mRNA) in adult Chinese patients with cystic fibrosis.
- Trial name
- NCT06963008
- Testing
- inhaled BMD003(CFTR mRNA)
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Peking Union Medical College Hospital
Chronic Obstructive Pulmonary Disease
Study to Evaluate the Safety and Efficacy of Inhaled PT001 in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to evaluate the safety and efficacy of inhaled PT001 compared to placebo and tiotropium in patients with mild to moderate chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00871182
- Testing
- Inhaled PT001, Tiotropium Handihaler
- Where
- 6 sites in United States
- Volunteers
- 33 people
- Sponsor
- Pearl Therapeutics, Inc.
Respiratory Distress Syndrome, Positive-Pressure Respiration
Personalized Ventilation Based on Ventilation-perfusion Mismatch and Lung Recruitability
This observational study will explore the effects of PEEP and position on regional lung ventilation-perfusion mismatch by electrical impedance tomography (EIT) in moderate-to-severe ARDS patients with different lung…
- Conditions
- Respiratory Distress Syndrome, Positive-Pressure Respiration, Mechanical Ventilation
- Trial name
- NCT06430554
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhongda Hospital
Chronic Obstructive Pulmonary Disease, COPD
The Effect of Breathing Helium-Hyperoxia During Pulmonary Rehabilitation in Patients With COPD
The purpose of this study is to examine whether breathing helium-hyperoxia during exercise in a pulmonary rehabilitation program can improve the exercise tolerance and health related quality of life of patients with Chronic…
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD, Emphysema, Lung Diseases
- Trial name
- NCT00406705
- Testing
- Helium-Hyperoxia
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- University of Alberta
Asthma, Wheezing
Pulmonary Epithelium, Immunology and Development of Asthma: Breathing Together
The investigators want to know why some babies wheeze and some of these go on to develop asthma. The investigators are going to find out if babies who develop wheeze and asthma have abnormal airway lining cells (taken from the…
- Trial name
- NCT04063631
- Where
- United Kingdom
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Imperial College London
End Stage Heart Disease, Right Ventricular Dysfunction
Inhaled Milrinone Use in Patients Receiving HeartMate II LVAD: A Pilot Study
Right ventricular (RV) failure occurs in an estimated 5-41% of cases involving left ventricular assist device (LVAD) implantation and has been shown to adversely affect peri-operative morbidity and mortality.
- Trial name
- NCT01571037
- Testing
- Inhaled, nebulized, Milrinone, inhaled nebulized milrinone
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Nebraska
Heart Failure
Exercise Training Associated With Inspiratory Muscle Training in Heart Failure
The investigators hypothesize that aerobic exercise training associated with respiratory muscle training will cause additional benefits compared to isolated exercise training or respiratory training in chronic heart failure…
- Trial name
- NCT01747395
- Testing
- Exercise training
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Asthma
Study Evaluating the Effects of AIR645 on Allergen-Induced Airway Responses in Subjects With Mild Atopic Asthma
To assess the efficacy of inhaled AIR645 in the suppression of the Asthmatic Responses in subjects with mild asthma inhaling an allergen.
- Trial name
- NCT00941577
- Testing
- AIR645, Physiologic saline solution
- Where
- 3 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Altair Therapeutics, Inc.
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