Clinical trials: Inhalation
Sleep-disordered Breathing
Leukotrienes Pathway in Chinese Children With Sleep-disordered Breathing
Our goals are to demonstrate an active leukotrienes (LTs) mediated inflammatory response is involved in pathophysiology of sleep-disordered breathing (SDB), and to provide a theoretical evidence for LTs modify therapy in treating…
- Trial name
- NCT01344746
- Where
- China
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Beijing Children's Hospital
Covid-19 Infection, Hospitalization in Respiratory Disease Department
Protective Role of Inhaled Steroids for Covid-19 Infection
We hypothesize that inhaled steroid therapy and long acting beta 2 adrenergic agonist, widely prescribed in asthma patients, may also have a local protective effect against coronavirus infection, even in patients without asthma.
- Trial name
- INHASCO (NCT04331054)
- Testing
- 2: Usual practice + SYMBICORT RAPIHALER, 1: Usual practice
- Where
- France
- Volunteers
- 146 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Protective Ventilation
Comparison of Tidal Volume Between Pediatric Anaesthesia and Paediatric Intensive Care Patients
Paediatric anaesthesiology and paediatric intensive care unit data will be retrospectively screened for the data regarding mechanical ventilation.
- Trial name
- TIVAC (NCT03877354)
- Testing
- Data from anaesthesia records for ventilation setting screening, Data from intensive care records for ventilation setting screening
- Where
- Czechia
- Volunteers
- 1,000 people
- Sponsor
- Brno University Hospital
Asthma
Effect of Inhaled Ciclesonide in Adult Patients With Asthma (BY9010/M1-125)
Ciclesonide is a novel inhaled corticosteroid for the treatment of asthma. In this study the effect of ciclesonide on airway hyperresponsiveness (AHR), exhaled nitric oxide (NO), and induced sputum inflammatory biomarkers will be…
- Trial name
- NCT00546520
- Testing
- Ciclesonide
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- AstraZeneca
Asthma
Effect of Inhaled Mometasone/Formoterol Versus Inhaled Fluticasone/Salmeterol in Asthma Patients
The purpose of this study is to investigate the effectiveness of inhaled mometasone/formoterol versus inhaled fluticasone/salmeterol on peripheral airway function in treatment of asthma.
- Trial name
- NCT02415179
- Testing
- Inhaled Mometasone/formoterol, Inhaled Fluticasone/Salmeterol
- Where
- Thailand
- Volunteers
- 52 people
- Sponsor
- Mahidol University
Covid19, SARS-CoV-2 PNEUMONIA
Safety and Efficiency of Method of Exosome Inhalation in COVID-19 Associated Pneumonia
Coronavirus is an acute viral disease with prevailing upper respiratory tract infections caused by the RNA-containing virus of the genus Betacoronavirus of the Coronaviridae family.
- Conditions
- Covid19, SARS-CoV-2 PNEUMONIA, COVID-19
- Trial name
- COVID-19EXO2 (NCT04602442)
- Testing
- EXO 1 inhalation, EXO 2 inhalation
- Where
- Russia
- Volunteers
- 90 people
- Sponsor
- Olga Tyumina
Respiratory Insufficiency
Effectiveness Inspirational Muscle Training
The long stay in mechanical ventilation can induce several complications, among them respiratory muscle weakness, this has been related to the duration of mechanical ventilation, delay and failure to wean, resulting in longer…
- Trial name
- IMTversusMV (NCT03758573)
- Testing
- Inspiratory Muscle Training (IMT), Intensive Physiotherapy (IPT)
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal do vale do São Francisco
Overweight and Obese, Young Adult
Effects of Kettlebell Swing Training Combined With Breathing Exercises on Respiratory Muscle Strength and Pulmonary Function in Overweight and Obese Young Adults
Overweight and obesity are associated with impaired breathing mechanics, including reduced chest wall and diaphragmatic movement, decreased respiratory muscle strength and endurance, and inefficient breathing patterns.
- Trial name
- Kettlebell (NCT07802080)
- Testing
- Kettlebell swing training, Control
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Phayao
Asthma, Status Asthmaticus
Bilevel Positive Airway Pressure (BiPAP) for the Treatment of Moderate to Severe Acute Asthma Exacerbations
Bilevel Positive Airway Pressure (BiPAP) is increasingly being reported as an effective and safe method of respiratory support for children with severe asthma exacerbations unresponsive to standard therapies and with impending…
- Trial name
- NCT02347462
- Testing
- Bilevel Positive Airway Pressure (BiPAP) (Trilogy BiPAP, Philips Respironics), Standard care
- Where
- Canada
- Sponsor
- University of British Columbia
Mechanical Ventilation, Spontaneous Breathing Trial
Trial of Spontaneous Breathing Test
The hypothesis is that the Spontaneous Breathing Test (SBT) without pressure support (PS) is not inferior to the SBT with pressure support in relation to the following outcomes: a) extubation failure; b) time on MV.
- Conditions
- Mechanical Ventilation, Spontaneous Breathing Trial, Extubation Readiness, Extubation Failures
- Trial name
- NCT06593288
- Testing
- Pressure Support Ventilation, continuous positive airway pressure (CPAP)
- Where
- Brazil
- Volunteers
- 170 people
- Sponsor
- University of Sao Paulo
Chronic Obstructive Pulmonary Disease
An Exploratory Study, to Assess the Effect of Repeat-dose Inhaled Indacaterol Maleate (300 μg) on Dynamic and Static Lung Hyperinflation, Subjective Breathlessness and Health Status in Patients With Chronic Obstructive Pulmonary Disease(COPD)
This study evaluated the effect of QAB149 on dynamic and static hyperinflation, breathlessness, and health status in COPD patients
- Trial name
- NCT00636961
- Testing
- Indacaterol 300μg
- Where
- 3 sites in Germany
- Volunteers
- 27 people
- Sponsor
- Novartis
Anesthesia
The Effect of Pressure Support Ventilation on Spontaneous Breathing in Anesthetized Subjects
The aim of this prospective study is to determine the effect of pressure support ventilation (PSV) on minute alveolar ventilation (MAV) and end-tidal carbon dioxide (ETCO2) in anesthetized spontaneously breathing subjects by…
- Trial name
- NCT02385305
- Testing
- Pressure support ventilation by anesthesia machine (Apollo, Dräger)
- Sponsor
- Massachusetts General Hospital
Anesthesia, Hypoxia
Assessment of Preoxygenation Strategies in the Prehospital Environment
Comparison of the preoxygenation efficacy of tidal volume breathing using three different preoxygenation techniques which are available to providers in the prehospital environment.
- Trial name
- NCT02694705
- Testing
- Continuous Positive Airway Pressure (CPAP), Bag-Valve-Mask (BVM), Non-rebreather Mask (NRM)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Influenza
Efficacy and Safety Study of Laninamivir Octanoate TwinCaps® Dry Powder Inhaler in Adults With Influenza
This Phase 2 protocol is designed to compare two dose levels of laninamivir octanoate versus placebo. The objectives are to obtain safety and efficacy in adults aged 18 to 64 years who present to clinic with symptomatic…
- Trial name
- Igloo (NCT01793883)
- Testing
- 40 mg Laninamivir Octanoate, 80 mg Laninamivir Octanoate
- Where
- 221 sites in United States, Australia and 14 more
- Volunteers
- 639 people
- Sponsor
- Biota Scientific Management Pty Ltd
Asthma
Multicentre Post-market Study of Ectoin® Inhalation Solution in Treatment of Asthma.
The goal of this multi-centre, prospective, open-label, single-arm, post-market clinical follow-up study is to further strengthen the already existing clinical evidence for supportive treatment and symptoms alleviation in asthma…
- Trial name
- EIL-AST (NCT05699941)
- Testing
- Ectoin® Inhalation Solution
- Where
- 5 sites in Poland
- Volunteers
- 204 people
- Sponsor
- Bitop AG
Pulmonary Hypertension
Vasopressin and Inhaled Prostacyclin in Pediatric Pulmonary Hypertension
To diagnose pulmonary hypertension, children have a cardiac catheterization to check the blood pressure in their lungs. Children with pulmonary hypertension have high blood pressure in their lungs.
- Trial name
- NCT01370096
- Testing
- Vasopressin infusion, Vasopressin infusion and epoprostenol inhalation
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University of Alberta
Anesthesia and Analgesia
Diaphragmatic Breathing Exercises in Total Knee Arthroplasty Patients
Rationale: While total knee replacements (TKA) are one of the most commonly performed surgical procedures in the United States, this procedure can also be very painful.
- Trial name
- NCT04336579
- Testing
- Diaphragmatic Breathing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Southern California
Anesthesia, Pediatric
Changes in Pulmonary Ventilation Distribution Assessed by Electrical Impedance Tomography in Healthy Children Under General Anesthesia
The incidence of atelectasis is high in patients undergoing general anesthesia. This may cause oxygenation impairment and further contribute to post-operative pulmonary complications.
- Trial name
- EIT_ped (NCT06262360)
- Testing
- General anesthesia with mask ventilation, General anesthesia and spontaneous laryngeal mask ventilation, General anesthesia with spontaneous laryngeal mask ventilation with pressure support
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Queen Fabiola Children's University Hospital
Cystic Fibrosis
Backpack Carrying in Children With Cystic Fibrosis
Cystic Fibrosis is a hereditary, chronic respiratory illness. Cystic Fibrosis leads to a progressive decline in lung function. School-aged children with cystic fibrosis experience backpack carrying everyday.
- Trial name
- NCT02700282
- Testing
- Backpack Carrying
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier du Havre
Breathing Technique
Effects of BBT Versus Diaphragmatic Breathing on Exercise Capacity and Quality of Life in Patients With COPD
Group A will be treated with manual chest physical therapy and Buteyko breathing technique Group-B will be treated with manual chest physical therapy and Diaphragmatic breathing technique.
- Trial name
- NCT05947227
- Testing
- Buteyko breathing technique, Diaphragmatic breathing technique.
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Riphah International University
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