Clinical trials: Inhalation
Healthy Participants
ACUTE EFFECTS OF INSPIRATORY MUSCLE WARM-UP ON INSPIRATORY MUSCLE STRENGTH DURING AEROBIC AND ANAEROBIC EXERCISE IN ATHLETES
Inspiratory muscle warm-up (IMW) is a specific pre-exercise breathing intervention designed to prepare the respiratory muscles before physical activity and potentially enhance exercise performance.
- Trial name
- IMW-AE (NCT07445269)
- Testing
- Inspiratory Muscle Warm-Up (40% MIP)
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hitit University
Neonatal Respiratory Distress Syndrome
Impact of Neurophysiological Facilitation of Respiration in Preterm Neonates
Background: Respiratory distress syndrome (RDS) or Neonatal respiratory distress syndrome (NRDS) is characterized by pulmonary insufficiency, in preterm neonates and is the major cause of death in preterm.
- Trial name
- NCT04019886
- Testing
- Neurophysiological Facilitation of Respiration
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Asir John Samuel
Asthma
Safety, Tolerability, and Efficacy of AIN457 in Patients With Uncontrolled Asthma
This study is a preliminary proof of efficacy study of AIN457 in patients with bronchial asthma that is poorly controlled with the current standard of care.
- Trial name
- NCT01478360
- Testing
- AIN457 (secukinumab)
- Where
- 9 sites in Germany, United Kingdom
- Volunteers
- 46 people
- Sponsor
- Novartis Pharmaceuticals
Obesity & Overweight, Morbid Obesity
Investigation of the Effects of Whole Body Vibration Application on Muscle Functional Level, Physical Fitness and Respiratory Parameters After Bariatric Surgery
The aim of this study was to investigate the effects of whole body vibration on muscle functional level, physical fitness and respiratory parameters after bariatric surgery.
- Conditions
- Obesity & Overweight, Morbid Obesity, Morbid Obesity Requiring Bariatric Surgery
- Trial name
- NCT07602959
- Testing
- Resistance Training, Whole Body Vibration, Control Group
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Pulmonary Arteriovenous Malformations, Hereditary Hemorrhagic Telangiectasia
Cardiopulmonary Exercise Testing to Evaluate Pulmonary AVMs With and Without Airflow Obstruction
Pulmonary arteriovenous malformations (PAVMs) are a rare vascular condition affecting the lungs. PAVMs lead to low blood oxygen levels, yet are very well tolerated by patients.
- Conditions
- Pulmonary Arteriovenous Malformations, Hereditary Hemorrhagic Telangiectasia, Asthma, COPD
- Trial name
- ExercisePAVM2 (NCT02458703)
- Testing
- Cardiopulmonary exercise test
- Volunteers
- 60 people
- Sponsor
- Imperial College London
Asthma
Intensity, Specificity and Reversibility of Inspiratory Muscle Training in Asthmatics
Inspiratory muscle training (IMT) can reverse or delay the complications from the deterioration of inspiratory muscle function in asthma. Thus, the IMT has been considered a treatment option for people with asthma.
- Trial name
- NCT02917824
- Testing
- High-intensity IMT, Low-intensity IMT
- Where
- Brazil
- Volunteers
- 29 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
Postoperative Hypoxemia
Transoral Nasal Cannula Oxygen Therapy for Mouth-Breathing Patients in the Postanesthesia Care Unit
Postoperative hypoxemia is a common complication in the postanesthesia care unit (PACU). Patients who breathe through the mouth after tracheal extubation may receive limited benefit from standard nasal cannula oxygen therapy…
- Trial name
- NCT07841223
- Testing
- Transoral nasal cannula oxygen delivery
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Stress Urinary Incontinence (SUI)
Effects of Home-based High-intensity Inspiratory Muscle Training for Stress Urinary Incontinence
Strengthening the diaphragm muscle, the roof of the pelvic floor muscles (PFM), may be an alternative intervention in patients suffering from stress urinary incontinence (SUI).
- Trial name
- NCT06842979
- Testing
- Inspiratory Muscle Training (IMT)
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Izmir University of Economics
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Interstitial
Oxygen Savings With Administered Oxygen and High Flow Ambient Air At Rest
This study is meant to compare the amount of oxygen required for hypoxemia relief between current standard of care (oxygen only) and oxygen with the addition of high flow air for Chronic Obstructive Pulmonary Disease (COPD)…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Lung Diseases, Interstitial, Pulmonary Fibrosis, Hypoxemia
- Trial name
- NCT04170062
- Testing
- Nasal Delivery of High-Flow Air and Oxygen Therapy, Nasal Delivery of Oxygen Therapy
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Johns Hopkins University
Chronic Obstructive Pulmonary Disease (COPD), Congestive Heart Failure (CHF)
Clinical Trials for Elderly Patients With Multiple Disease
The CHROMED project focuses its investigation on the applicability of an integrated solution for a pathological condition which: a) is very prevalent in ageing patients and b) severely impairs quality of life: COPD with other…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Congestive Heart Failure (CHF), Sleep Disordered Breathing (SDB)
- Trial name
- CHROMED (NCT01960907)
- Testing
- CHROMED monitoring system
- Where
- 6 sites in Estonia, Slovenia and 3 more
- Volunteers
- 312 people
- Sponsor
- Restech Srl
Sleep Apnea Syndromes, Nasal Obstruction
Randomized Clinical Trial of Nasal Turbinate Reduction to Improve Continuous Positive Airway Pressure (CPAP) Outcomes for Sleep Apnea
Obstructive sleep apnea occurs in 2-4% of middle age adults and results in significant morbidity and mortality. The first line therapy is provision of continuous positive airway pressure (CPAP) via a nasal mask chronically.
- Conditions
- Sleep Apnea Syndromes, Nasal Obstruction, Turbinate Hypertrophy
- Trial name
- TURBO (NCT00503802)
- Testing
- Radiofrequency Turbinate Reduction
- Where
- 3 sites in United States
- Volunteers
- 242 people
- Sponsor
- University of Washington
Healthy
BreatheWell: Train Your Breathing, Relax Your Body, Open Your Mind
The goal of this study is to determine whether tasks related to breathing training (daily inspiratory muscle training (IMT) and increased access to health data/awareness) performed for 12 weeks leads to positive changes in mental…
- Trial name
- NCT06920407
- Testing
- Breathing training device (Inspiratory Muscle Training), Oura Ring
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Asthma
Comparison of Two Daily Dose Regimens of Tiotropium 5 µg Once Daily and Tiotropium 2.5 µg Twice Daily for 4 Weeks on Top of Maintenance Therapy With Inhaled Corticosteroid Controller Medication
Determine the 24-hour FEV1-profile of tiotropium solution for inhalation after 4 weeks treatment periods of 5 mcg tiotropium administered once daily in the evening and 2.5 mcg tiotropium administered twice daily (morning and…
- Trial name
- NCT01696071
- Testing
- Tiotropium 5 mcg qd, Tiotropium 2.5 mcg bid
- Where
- 22 sites in Austria, Germany and 2 more
- Volunteers
- 98 people
- Sponsor
- Boehringer Ingelheim
Dyspnea
Inspiratory Muscle Training in Stroke Patients With Stable Congestive Heart Failure: a Prospective RCT.
Objectives: Little has been known the effectiveness of respiratory muscle training in patients with both stroke and heart failure.
- Trial name
- NCT02614001
- Testing
- Threshold® IMT HS730, RESPIRONICS Inc, Cedar Grove, NJ, USA, post-stroke rehabilitation program
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- Chang Gung Memorial Hospital
Asthma
Comparison of Combination Therapy: Montelukast and Inhaled Steroid on Exercise Induced Bronchoconstriction
The purpose of this study is to compare the effects of 2 weeks therapy of montelukast, budesonide, their combination on exercise induced bronchoconstriction (EIB) and airway inflammation in children and young adults, not on…
- Trial name
- NCT00462592
- Testing
- budesonide, montelukast
- Where
- 2 sites in Canada
- Volunteers
- 18 people
- Sponsor
- Hamilton Health Sciences Corporation
Respiratory Distress Syndrome, Adult
Early PReserved SPONtaneous Breathing Activity in Mechanically Ventilated Patients With ARDS (PReSPON)
The potential benefits of preserved early spontaneous breathing activity during mechanical ventilation are an increased aeration of dependent lung regions, less need for sedation, improved cardiac filling, and better matching of…
- Trial name
- PReSPON (NCT04228471)
- Testing
- spontaneous breathing activity during APRV, No spontaneous breathing activity
- Where
- Germany
- Volunteers
- 840 people
- Sponsor
- University Hospital, Bonn
Nursing Students
The Effect of 4-7-8 Breathing Exercise Training on Sleep Quality
Research; it will be carried out Kilis 7 Aralik University Yusuf Serefoglu Health Sciences Faculty, Department of Nursing. The training will take approximately 20 minutes in an empty classroom and will be planned when the…
- Trial name
- NCT06103344
- Testing
- 4-7-8 Breathing Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Uğur Doğan
Vascular Function in Healthy Volunteers
Diesel Exhaust Inhalation, Systemic Nitric Oxide Inhibition and Cardiac Output
Exposure to combustion-derived fine particulate air pollution is associated with cardiovascular mortality and morbidity. In previous studies, exposure to diesel exhaust (a major constituent of urban particulate air pollution) has…
- Trial name
- DISCO (NCT01060930)
- Testing
- Intravenous infusion of L-NMMA and Nor-epinephrine
- Where
- Sweden
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Chronic Obstructive Pulmonary Disease
Study in Subjects Greater Than 40 Years of Age With COPD
This is a multicenter, Phase IIIb, randomized, double-blind, active-controlled, parallel-group, comparative study. The objectives of this study are: 1.
- Trial name
- NCT00507234
- Testing
- formoterol fumarate inhalation solution
- Where
- 19 sites in United States
- Volunteers
- 128 people
- Sponsor
- Dey
Chronic Obstructive Pulmonary Disease
A Single Inhalation Dose Study to Assess Efficacy, Pharmacokinetics (PK), Safety and Tolerability of AZD8871 in Patients With Long-term Lung Diseases.
This study will evaluate the efficacy and safety data of AZD8871 in patients with moderate to severe chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT03645434
- Testing
- AZD8871, Anoro® Ellipta®
- Where
- 5 sites in Germany, United Kingdom
- Volunteers
- 73 people
- Sponsor
- AstraZeneca
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