Clinical trials: Inhalation
Cystic Fibrosis
Inhaled Bicarbonate Therapy in Cystic Fibrosis
The purpose of this study is to see if inhaled bicarbonate will increase the ability to cough up mucus in a person with cystic fibrosis.
- Trial name
- NCT00177645
- Testing
- sodium bicarbonate
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Pittsburgh
Head and Neck Cancer, Swallowing Disorder
İnvestigation of the Effect of Neck Endurance on Swallowing and Directional Coordination in Head and Neck Cancer Patients
In the study, it was aimed to evaluate the relationship between dysphagia, which is one of the treatment complications, and the variables of respiratory performance, intraoral pressure and neck endura, and to look at the future…
- Conditions
- Head and Neck Cancer, Swallowing Disorder, Respiratory Function, Neck Muscle Issue
- Trial name
- NCT07434245
- Testing
- Fiberoptic Endoscopic Evaluate Swallowing
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Istanbul Arel University
Cystic Fibrosis
A Safety and Efficacy Trial of Inhaled Mannitol in Adult Cystic Fibrosis Subjects
This trial aims to provide prospective evidence of the safety and efficacy of mannitol 400 mg b.i.d. in subjects aged 18 years and above. We hypothesize that inhaled mannitol 400 mg b.i.d.
- Trial name
- NCT02134353
- Testing
- Inhaled mannitol
- Where
- 100 sites in United States, Argentina and 16 more
- Volunteers
- 423 people
- Sponsor
- Syntara
Neonatal Respiratory Distress Syndrome
To Investigate the Effect of Pulmonary Surfactant With Different Inspired Oxygen Concentrations on the Clinical Outcomes of Very Preterm Infants Under Non-invasive Assisted Ventilation
A prospective multicenter randomized controlled study was conducted. Eligible very preterm infants with a gestational age of <32 weeks were enrolled.
- Trial name
- NCT07235345
- Testing
- According to the FiO2 threshold of PS application corresponding to randomization, PS treatment was given when FiO2 reached the threshold
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xu Falin
Healthy
Safety, Pharmacokinetics and Pharmacodynamics After Single and Multiple Dosing of AZD5423 in Japanese Healthy Male Subjects
The purpose of this study is to assess safety, tolerability, pharmacokinetics and pharmacodynamic effects (24-hours plasma cortisol area under curve, plasma cortisol pre and post ACTH stimulation, dehydroepiandrosterone sulphate…
- Trial name
- NCT01338350
- Testing
- AZD5423
- Where
- Japan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pulmonary Disease
A Single-center Study to Assess Peak Inspiratory Flow (PIF) in Different Stages' COPD Patients by Using the In-check Method.
Peak Inspiratory Flow Rate (PIFR) is defined by the fastest flow rate noted during the inspiratory cycle. Inhaled medication plays an important role in the treatment of chronic obstructive pulmonary disease (COPD), with dry…
- Trial name
- INSPIRE (NCT01855659)
- Where
- Greece
- Volunteers
- 210 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Acute Respiratory Failure, Airway Extubation
The Maximizing Extubation Outcomes Through Educational and Organizational Research (METEOR) Trial
The METEOR Trial will compare four implementation strategies-traditional online education, protocol-directed care, interprofessional education, and a combination of protocol-directed care and interprofessional education-to test…
- Trial name
- METEOR (NCT05523479)
- Testing
- Traditional online education, Interprofessional education, Clinical protocol
- Where
- 17 sites in United States
- Volunteers
- 12,857 people
- Sponsor
- University of Pittsburgh
Mechanical Ventilation, Respiratory Failure
Impact of PEEP on Respiratory Effort During Assisted Ventilation
Assisted mechanical ventilation is widely used to preserve diaphragmatic activity and improve lung aeration in patients with acute respiratory failure.
- Conditions
- Mechanical Ventilation, Respiratory Failure, Effort
- Trial name
- PEEP-EFFORT (NCT07437846)
- Testing
- PEEP Level Adjustment
- Where
- Chile
- Volunteers
- 12 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Hypertension
Effects of Slow Breathing on Blood Pressure and Autonomic Function
Hypertension is a chronic disease that affects about 23% of the brazilian population. The treatment of hypertension by pharmacological intervention is efficacious, but has side effects and significant costs.
- Trial name
- NCT01390727
- Testing
- Device-guided breathing (Resperate - InterCure, Israel), Listen music
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Fundação de Amparo à Pesquisa do Estado de São Paulo
Multiple Sclerosis
COld Exposure With Controlled BReathing And Meditation in Patients With Multiple Sclerosis (COBRAMS)
The goal of this interventional study is to test the effect of the anti-inflammatory and neuroprotective effects of this supplementary training program that includes breathing exercises, cold exposure, and meditation in patients…
- Trial name
- COBRAMS (NCT06280573)
- Testing
- Wim Hoff method
- Where
- Slovakia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Comenius University
Ozone, Exercise Intensity
Investigating Changes in Responses to Controlled Effective Doses of Ozone at Different Exercise Intensities
The project will look to investigate whether exercise during ozone exposure performed for a shorter duration at a higher intensity is more harmful than exercise performed for a longer duration at a lighter intensity.
- Trial name
- NCT06513754
- Testing
- Ozone, Heavy Intensity, Moderate Intensity
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Michael Koehle
Carcinomatous Disease
Establishment of an Artificial Larynx After Total Laryngectomy
This study aims to evaluate the effectiveness of an artificial larynx on the restoration of laryngeal functions, mainly breathing and swallowing.
- Trial name
- LA (NCT01474005)
- Testing
- PROTIP MEDICAL ( Artificial larynx prosthesis)
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Strasbourg, France
Pregnancy
Changes in Ventilation Inhomogeneity and Respiratory Function Following Elective Caesarean Section Under Regional Anaesthesia
Pregnancy is associated with physiological changes affecting the cardiorespiratory system as a consequence of an increase in both cardiac output and intra-abdominal pressure.
- Trial name
- VIRCA (NCT02714556)
- Testing
- Physiologic measures of lung function
- Where
- Switzerland
- Sponsor
- Walid HABRE
Ventilation Therapy; Complications
Ultrasound Measurements of Basilica Vein Diameter at Room Air Breathing and at Positive Pressure on Healthy Volunteers
Peripherally Inserted Central Catheters (PICC) and midline placement requires the catheter size to be one third of the venous diameter, or less.
- Trial name
- PEEPVEIN-2021 (NCT05201755)
- Testing
- CPAP
- Where
- Italy
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Chronic Obstructive Pulmonary Disease
Phase 4 COPD and Suboptimal Inspiratory Flow Rate
Study is a randomized, double-blind, double-dummy, parallel-group study evaluating efficacy and safety of revefenacin vs. tiotropium in adults with severe to very severe COPD and suboptimal PIFR.
- Trial name
- PIFR-2 (NCT05165485)
- Testing
- Revefenacin, Tiotropium
- Where
- 76 sites in United States
- Volunteers
- 404 people
- Sponsor
- Theravance Biopharma
GERD
Effectiveness of Diaphragmatic Breathing on Reflux Symptoms in Outpatients
Researchers are trying to determine if abdominal breathing exercises can reduce symptoms associated with GERD (Gastroesophageal reflux disease).
- Trial name
- NCT04120025
- Testing
- Diaphragm Training
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Mayo Clinic
Community-acquired Pneumonia, CAP
Inhaled Lexofloxacin vs Usual Care for Treatment of Community-Acquired Pneumonia
This trial aims to determine whether treatment with inhaled levofloxacin (an antibiotic) is equal to systemic antibiotic treatment (usual care) for patients admitted to a hospital with community-acquired pneumonia in regards to…
- Conditions
- Community-acquired Pneumonia, CAP, Community Acquired Pneumonia, Pneumonia
- Trial name
- LANDCAP 2 (NCT07843017)
- Testing
- Inhaled levofloxacin, Standard-of-care / Usual care
- Volunteers
- 460 people
- Sponsor
- Copenhagen Respiratory Research
Duchenne Muscular Dystrophy (DMD), Respiratory Function Decline
Respiratory Progression in Adults With Duchenne Muscular Dystrophy.
This is a multicenter, longitudinal observational study aimed at characterizing the natural history of respiratory progression in adults with genetically confirmed Duchenne muscular dystrophy (DMD).
- Conditions
- Duchenne Muscular Dystrophy (DMD), Respiratory Function Decline, Restrictive Lung Disease, Respiratory Failure
- Trial name
- GUP24005 (NCT07879989)
- Where
- 13 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Giannina Gaslini
Reperfusion Injury, Liver Injury
Study to Evaluate if Inhaled Nitric Oxide Improves Liver Function After Transplantation
This blinded, placebo-controlled study will administer inhaled nitric oxide to patients undergoing liver transplantation. The purpose of the study is to test if inhaled nitric oxide prevents liver injury associated with the…
- Trial name
- NCT00582010
- Testing
- inhaled nitric oxide, nitrogen gas
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Alabama at Birmingham
COVID-19, ARDS, Human
Inhaled Iloprost for Suspected COVID-19 Respiratory Failure
Acute respiratory distress syndrome (ARDS) is a type of respiratory failure characterized by the rapid onset of widespread inflammation in the lungs.
- Conditions
- COVID-19, ARDS, Human, Hypoxemic Respiratory Failure
- Trial name
- ILOCOVID (NCT04445246)
- Testing
- Inhaled ILOPROST
- Where
- Qatar
- Volunteers
- 40 people
- Sponsor
- Hamad Medical Corporation
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.