Clinical trials: Inhalation
Asthma
A Mechanistic Study to Evaluate the Efficacy of Montelukast on Airway Function in Asthma
The trial is an investigator-driven research study in subjects with intermittent asthma, the aim of which is to explore the likelihood of a functionally important separate leukotriene E4 (LTE4) receptor in airways and/or…
- Trial name
- E-Type (NCT01841164)
- Testing
- Montelukast, Inhaled leukotriene E4
- Where
- Sweden
- Volunteers
- 14 people
- Sponsor
- Karolinska University Hospital
Pneumonia, Ventilator-Associated
Removing Fluid Above Breathing Tubes in the Operating Room
In this study, subjects meeting criteria will be enrolled and randomized to one of two different suctioning schemes, either continuous or intermittent.
- Trial name
- NCT01110109
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Medtronic - MITG
Malignant Neoplasm
Nasal Inhalation of Isopropyl Alcohol for the Treatment of Nausea in Patients With Cancer
The goal of this research study is to understand the effect of inhalation approaches in reducing nausea in cancer patients.
- Trial name
- NCT04181463
- Testing
- Isopropyl Alcohol, Questionnaire Administration
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- M.D. Anderson Cancer Center
Cerebrovascular Disorders, Acute Cerebrovascular Disease
Inhaled Nitric Oxide in Acute Ischemic Stroke Patients Undergoing Mechanical Thrombectomy
The purpose of this study is to determine the safety and feasibility of using inhaled nitric oxide (iNO) in patients undergoing intra-arterial mechanical thrombectomy (blood clot extraction or IAMT) for treatment of acute…
- Trial name
- iNO (NCT05871606)
- Testing
- iNO
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Wake Forest University Health Sciences
Nasopharyngeal Carcinoma (NPC)
Sapylin Versus Dexamethasone Inhalation for CCRT-Induced Oral Mucositis in Nasopharyngeal Carcinoma
Radiation therapy is the main treatment for nasopharyngeal carcinoma (NPC), and standard care for advanced NPC often includes combination chemotherapy and radiation (CCRT).
- Trial name
- NCT07327216
- Testing
- Sapylin, Dexamethasone, CCRT with Cisplatin
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Affiliated Hospital of Guangdong Medical University
Coronary Artery Disease, Early-Onset
HIIT Versus IMT on Modulating Blood Rheology in CAD Risk Factors
Participants had randomly divided into two equal groups. Group (A) had received a program of high intensity interval training 30-40 minutes three times per week for one month.
- Trial name
- NCT03506984
- Testing
- Threshold Inspiration Muscle Training Device, Electronic Bicycle Ergometer
- Where
- Oman
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Asthma
Dose Finding Study on BI54903 (Inhaled Corticosteroid) Administered Twice Daily Via Respimat® Inhaler in Asthmatic Patients Inadequately Controlled on Short-acting-beta-agonist (SABA) Therapy
The aim of the study is to assess and compare efficacy and safety of BI 54903 at 3 doses twice daily (b.i.d.) and fluticasone propionate hydrofluoroalkane metered dose inhaler (HFA MDI) at a dose of 88 mcg b.i.d and placebo…
- Trial name
- NCT01397162
- Testing
- Fluticasone propionate, BI 54903
- Where
- 41 sites in United States
- Volunteers
- 29 people
- Sponsor
- Boehringer Ingelheim
Breathing Exercises
The Efficiency of Breathing Exercises
The purpose of this study is to evaluate the effectiveness of teaching breathing exercises to COVID-19 patients after intensive care.The research is a randomized controlled and pretest-posttest applied design.
- Trial name
- NCT05572827
- Testing
- Breathing exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ataturk University
Obstructive Sleep Apnea
Combined Upper-airway and Breathing Control Therapies for Obstructive Sleep Apnea
The current study combines two treatments for obstructive sleep apnea (OSA), oral appliances and supplemental inspired oxygen. The following aims will be tested: Aim 1.
- Trial name
- NCT03189173
- Testing
- Oral appliance, Oxygen, Oral appliance plus oxygen
- Where
- 2 sites in United States, Australia
- Volunteers
- 41 people
- Sponsor
- Brigham and Women's Hospital
Asthma
Breathing Counts: Evaluating Adherence in the Presence of Asthma Navigation Support
To determine if an asthma navigator is helpful in improving communication between care providers and improving patient adherence to asthma medications after an asthma exacerbation.
- Trial name
- NCT03065205
- Testing
- Propeller Health device + asthma navigator
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Colorado, Denver
COPD Exacerbation Acute
Tolerance and Acute Effects of a New HFNT Nasal Cannula
In the care of patients experiencing an acute exacerbation of COPD, supplemental oxygen therapy is often required. Oxygen is typically administered at flow rates between 1 and 4 liters per minute.
- Trial name
- NCT05182294
- Testing
- AIRVO 2, the new asymmetric nasal cannula
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Temple University
ARDS, COVID-19
Impact of Neck Inspiratory Muscle Activation During Sleep in ICU Patients After a COVID 19 ARDS
Most patients in intensive care units (ICUs) experience severe sleep disruption. Sleep disruption and sleep alteration may have an influence on the ability to breathe spontaneously.
- Trial name
- COVISLEEP (NCT04371029)
- Testing
- PSG
- Where
- France
- Volunteers
- 17 people
- Sponsor
- University Hospital, Bordeaux
Chronic Obstructive Pulmonary Disease
Inspiratory Muscle Training Combined With General Exercise Training in COPD
Chronic Obstructive Pulmonary Disease (COPD) is a frequent disease, with increasing prevalence. Pulmonary rehabilitation through general exercise training (GET) is a corner stone of COPD care.
- Trial name
- IMTGET (NCT02392715)
- Testing
- Inspiratory muscle training with Threshold by respironics
- Volunteers
- 80 people
- Sponsor
- Hôpital Riviera-Chablais, Vaud-Valais
Pulmonary Alveolar Proteinosis, Bronchiectasis
Inhaled Molgramostim (rhGM-CSF) in Healthy Adult Subjects
This is a randomized, double-blind, placebo-controlled, single ascending (SAD), and multiple ascending dose (MAD) study conducted at a single clinical site within the UK.
- Conditions
- Pulmonary Alveolar Proteinosis, Bronchiectasis, Cystic Fibrosis, Acute Respiratory Distress Syndrome
- Trial name
- NCT02468908
- Testing
- Molgramostim
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Savara Inc.
Pulmonary Alveolar Proteinosis, Autoimmune
SK-1401 (rhGM-CSF Agent for Inhalation) GM-CSF Inhalation Pharmacokinetic Study
Objective: Evaluate Pharmacokinetics and determine the safety of GM-CSF single dose inhalation. Study Design: Pharmacokinetic open study
- Trial name
- NCT02840708
- Testing
- Sargramostim
- Where
- Japan
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Niigata University Medical & Dental Hospital
Asthma
TRIple in asthMA With uncontRolled pAtient on Medium streNgth of ICS + LABA
Evaluate the superiority of CHF 5993 100/6/12.5 µg Pressurised Metered Dose Inhaler (pMDI) (fixed combination of extrafine beclometasone dipropionate (BDP) plus formoterol fumarate (FF) plus glycopyrronium bromide [GB]) versus…
- Trial name
- TRIMARAN (NCT02676076)
- Testing
- CHF 5993 100/6/12.5, CHF 1535 100/6 µg
- Where
- Germany
- Volunteers
- 1,155 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
COVID-19
Phase 1&2 Study to Evaluate the Safety & Efficacy of Inhaled IBIO123 in Severe COVID-19 Illness
This is a Phase 1 and phase 2, adaptive, placebo-controlled, double-blind, randomized single-dose study in participants with Severe COVID-19 illness.
- Trial name
- NCT05303376
- Testing
- IBIO123
- Where
- 5 sites in South Africa, Ukraine
- Volunteers
- 123 people
- Sponsor
- Immune Biosolutions Inc
Post-cardiac Surgery
Comb Effect of 4-7-8 Breathing Technique and Stationary Cycle on PP, QOL and Dyspnea in Post CABG Patients.
To determine the combined effects of 4-7-8 breathing technique and stationary cycle on physical performance, quality of life and dyspnea in post CABG patients.
- Trial name
- NCT06460740
- Testing
- 4-7-8 breathing technique, Stationary Cycling
- Where
- Pakistan
- Volunteers
- 58 people
- Sponsor
- Riphah International University
Gastric Emptying, Glucagon-Like Peptide-1 Receptor Agonists
Effect of Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RA) on Gastric Emptying
This study aims to assess the effect of using Glucagon-like peptide-1 receptor agonists (GLP-1) receptor agonists on gastric emptying on surgical patients and whether specific guidelines need to be established for these patients.
- Conditions
- Gastric Emptying, Glucagon-Like Peptide-1 Receptor Agonists, Intermittent Fasting, Intraoperative Complication Due to Anesthesia
- Trial name
- NCT07140289
- Testing
- Ultrasound of gastric contents
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wael Saasouh, MD
Asthma
Safety Study of the Effects of Inhaled Fluticasone Furoate/GW642444 on the Hypothalamic-Pituitary-Adrenal (HPA) Axis
The purpose of this study is to assess the effect of six weeks' treatment with two once-daily strengths of Fluticasone Furoate/GW642444 Inhalation Powder on the HPA axis system
- Trial name
- NCT01086410
- Testing
- Fluticasone Furoate/GW642444 Inhalation Powder, Prednisolone Oral Capsule
- Where
- 17 sites in United States, Germany and 1 more
- Volunteers
- 185 people
- Sponsor
- GlaxoSmithKline
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