Clinical trials: Inhalation
Insomnia
A Novel Inhaled Formulation of Melatonin to Treat Adults With Insomnia: Efficacy Study
The goal of this clinical trial is to explore the potential benefits of an inhaled version of melatonin compared to oral melatonin tablets on adults with insomnia.
- Trial name
- Mela-Nia (NCT06802913)
- Testing
- Inhaled Melatonin (100 μg), Oral Melatonin (4 mg)
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Woolcock Institute of Medical Research
COPD, Pulmonary Hypertension
Effect iNO on Functional Respiratory Imaging in Subjects With WHO Group 3 Pulmonary Hypertension With COPD on Oxygen
The objective of this exploratory study is to examine the utility of high resolution computed tomography (HRCT) to measure changes in functional pulmonary imaging parameters as a function of long term iNO administrationusing the…
- Conditions
- COPD, Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT03135860
- Testing
- Inhaled Nitric Oxide 30mcg/kg IBW/hr
- Where
- Belgium
- Volunteers
- 7 people
- Sponsor
- Bellerophon
Functional Neurological Disorder, Functional Movement Disorder
Additive Effects of Interoceptive Training to Physiotherapy in Functional Movement Disorders (interoPTfmd)
Functional movement disorder (FMD) is a common source of neurological disability that imposes a significant financial burden on healthcare systems.
- Trial name
- interoPTfmd (NCT06792760)
- Testing
- Physiotherapy, Specific Breathing Techniques
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- Charles University, Czech Republic
Cystic Fibrosis, Pseudomonas Aeruginosa Airway Infection
Aztreonam Lysine for Inhalation in Patients With Cystic Fibrosis and Pseudomonas Aeruginosa Airway Infection
The primary objective of this program is to provide expanded access to aztreonam lysine for inhalation (AZLI) 75 mg prior to its commercial availability to patients with cystic fibrosis (CF) and chronic P.
- Trial name
- NCT00499720
- Testing
- Aztreonam Lysine for Inhalation
- Where
- 65 sites in United States, Puerto Rico
- Sponsor
- Gilead Sciences
Emphysema, Alpha 1-Antitrypsin Deficiency
Efficacy/Safety of HA Inhalation Solution for Hereditary Emphysema in Patients With Alpha-1 Antitrypsin Deficiency
The purpose of the study is to evaluate the safety and efficacy of administering repeated doses of Hyaluronic Acid Inhalation Solution to subjects with Emphysema that have Alpha-1-Antitrypsin deficiency
- Trial name
- NCT03114020
- Testing
- Hyaluronic Acid Inhalation Solution
- Where
- 6 sites in United States, Canada
- Volunteers
- 27 people
- Sponsor
- Gerard Turino
All Adult Patients Undergoing an Otolaryngology Procedure With Inhaled Methoxyflurane as an Adjunct to Topical or Local Anesthesia
Penthrox in Otolaryngology
Our objective is to explore the use of methoxyflurane anesthesia as an adjunct analgesic to local anesthesia during in-office otolaryngology procedures in a prospective pilot study.
- Trial name
- PenthroxOTL (NCT07003880)
- Testing
- Methoxyflurane anesthesia
- Volunteers
- 50 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Critical Care, Inspiratory Effort
Use of Nasal Pressure to Assess Inspiratory Effort Under Different Oxygen Treatments
The aim of this study was to investigate the effects of different oxygen therapy modalities (including nasal cannula oxygen, mask oxygen and high-flow nasal cannula oxygen) on the correlation between Nasal Pressure and Esophageal…
- Trial name
- NCT06970990
- Testing
- HFNC:50L/min, HFNC:flow=40L/min, HFNC:flow=30L/min
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Jian-Xin Zhou
Cesarean Section Complications
Effects of Deep Breathing Excer. With & Without PMR on Post C Section LBP, QOS & PA
To find out the Effects of deep breathing exercises with and without Progressive Muscle Relaxation Technique on Post Cesarean Section low back Pain, Quality of Sleep and Physical Activity
- Trial name
- NCT05463146
- Testing
- Deep breathing excercises, Deep breathing exercises +and progressive muscle relaxation techniques, Deep breathing exercises
- Where
- Pakistan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Health, Health Adult Subjects
DBM-1152A Inhalation Solution in Chinese Healthy Subjects
This is a Phase Ia, single-center, randomized, double-blind, placebo-controlled, single ascending dose (SAD) study. The primary purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics (PK) of DBM-1152A…
- Trial name
- NCT07447141
- Testing
- DBM-1152A Inhalation Solution
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Joincare Pharmaceutical Group Industry Co., Ltd
Covid-19 Infection, Hospitalization in Respiratory Disease Department
Protective Role of Inhaled Steroids for Covid-19 Infection
We hypothesize that inhaled steroid therapy and long acting beta 2 adrenergic agonist, widely prescribed in asthma patients, may also have a local protective effect against coronavirus infection, even in patients without asthma.
- Trial name
- INHASCO (NCT04331054)
- Testing
- 2: Usual practice + SYMBICORT RAPIHALER, 1: Usual practice
- Where
- France
- Volunteers
- 146 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Lung Injury (ALI) Associated With COVID-19, Lung Inflammation Associated With COVID-19
TD-0903 for ALI Associated With COVID-19
This Phase 2 study will evaluate the efficacy, safety, pharmacodynamics and pharmacokinetics of inhaled TD-0903 compared with a matching placebo in combination with standard of care (SOC) in hospitalized patients with confirmed…
- Trial name
- NCT04402866
- Testing
- TD-0903
- Where
- 24 sites in United States, Brazil and 5 more
- Volunteers
- 235 people
- Sponsor
- Theravance Biopharma
Covid19
Inhalation of Vapor With Medication (Diclofenac Sodium, Menthol, Methyl Salicylate and N-Acetyl Cysteine) Reduces Oxygen Need and Hospital Stay in COVID-19 Patients - A Case Control Study
Background: In the midst of the devastating COVID pandemic where there is no specific and effective treatment, traditional therapy may help to ease the patient's suffering.
- Trial name
- NCT04900129
- Testing
- Menthol 0.02%, Methyl salicylate 0.05%, N- Acetyl cysteine 1.2 gm%, and Diclofenac sodium 1gm%
- Where
- Bangladesh
- Volunteers
- 43 people
- Sponsor
- Sher-E-Bangla Medical College
OSA COPD Overlap Syndrome
Comparing Two Types of Breathing Support in People With COPD, High Carbon Dioxide Levels, and Sleep Apnea
This pilot study compares two positive airway pressure strategies for patients with both COPD and obstructive sleep apnea (overlap syndrome) who retain excess carbon dioxide.
- Trial name
- PAVE-OVS (NCT07891962)
- Testing
- high-intensity ventilation strategy, OSA-targeted ventilation strategy
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Healthy
Meditation and Yogic Breathing-driven Modulation of Neurofluid Coupling and Brain Clearance
This study will examine whether meditation and yogic breathing can alter brain fluid movement and waste clearance in healthy adults.
- Trial name
- SPANDHA (NCT07903688)
- Testing
- Nadi Shuddhi, Shoonya Meditation
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Ventilation Therapy; Complications
Diaphragmatic Mobility In Ventilated Assisted Patients
The study was a randomized controlled trial. A total of 24 patients who met the inclusion criteria were included in this study and randomly divided by sealed envelope method into Experimental and Control groups with 12 patients…
- Trial name
- NCT04733261
- Testing
- Diaphragmatic mobility, Chest Physiotherapy
- Where
- Pakistan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aqua Medical Services (Pvt) Ltd
Pulmonary Arterial Hypertension
Inhaled Imatinib Pulmonary Arterial Hypertension Clinical Trial - Follow Up Long Term Extension (IMPAHCT-FUL)
IMPAHCT-FUL: Inhaled Imatinib Pulmonary Arterial Hypertension Clinical Trial - Follow Up Long Term Extension (LTE) Trial was a follow up study to establish the long-term safety of AV-101.
- Trial name
- IMPAHCT-FUL (NCT05557942)
- Testing
- AV-101
- Where
- 72 sites in United States, Argentina and 18 more
- Volunteers
- 186 people
- Sponsor
- Aerovate Therapeutics
Chronic Obstructive Pulmonary Disease
An Investigation of the Mechanism of Action of Seretide in Chronic Obstructive Pulmonary Disease
This study is investigating the possible mechanisms of action of an inhaled treatment (Seretide), currently used worldwide in millions of patients with COPD (Chronic Obstructive Pulmonary Disease) and how it improves the symptoms…
- Trial name
- IMAS (NCT00974805)
- Testing
- Seretide 500 Accuhaler
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Acute Pharyngitis
Inhaled Steroids for Acute Pharyngitis.
Background: Acute pharyngitis (AP) is a common presentation to the Emergency Department (ED). Most AP patients' who present to the ED are interested in relief their sore throat (pain).
- Trial name
- ISAP (NCT04027322)
- Testing
- Budesonide 0.25 MG/ML Inhalant Solution, Dexamethasone, Normal saline
- Where
- 3 sites in Oman
- Volunteers
- 200 people
- Sponsor
- Oman Medical Speciality Board
IUGR, Gestational Diabetes
PED NEONAT 20-000599 Fetal Body Composition
Obesity is an ongoing public health problem that is difficult to treat. There is evidence that obesity has fetal origins. Body composition, including visceral, subcutaneous, brown, and hepatic fat have been found to be important…
- Conditions
- IUGR, Gestational Diabetes, Pregnancy Related
- Trial name
- NCT04508751
- Testing
- 3T "Free-Breathing" Fetal Magnetic Resonance Imaging
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Diastasis Recti And Weakness Of The Linea Alba, Diastasis, Muscle
Rehabilitation of Abdominal Diastasis After Childbirth: Trunk and Inspiratory Muscle Training
Diastasis Recti Abdominis (DRA) is the separation of the rectus muscles caused by stretching and thinning of the linea alba during pregnancy and childbirth.
- Trial name
- DR-TIME (NCT06286553)
- Testing
- Trunk exercise, Inspiratory Muscle Training (IMT), Control Group
- Where
- Greece
- Volunteers
- 48 people
- Sponsor
- University of Patras
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