Clinical trials: Inhaled Nitric Oxide
Sepsis
Studies of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome
Nitric oxide (NO) plays a pivotal role in maintenance of normal vascular tone. However, in sepsis the excessive production of NO results in myocardial depression, vasoplegia, and cytotoxic effects, thus promoting shock and…
- Trial name
- MB-NO (NCT00159510)
- Testing
- Methylene blue, Nitric oxide, Methylene blue & nitric oxide
- Where
- Russia
- Volunteers
- 28 people
- Sponsor
- Northern State Medical University
Asthma
Assessment of Utility of Exhaled Nitric Oxide Measurement for Treatment Monitoring in Children With Asthma
The aim of this study is to assess the utility of exhaled nitric oxide measurement (FeNO) in treatment monitoring in children with asthma. According to the aim of the study following assumptions are formulated: 1.
- Trial name
- NCT00500253
- Testing
- exhaled nitric oxide measurement, bronchial hyperresponsiveness with methacholine (PC20M), symptom score diary (according to 2007 GINA guidelines)
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Medical University of Lodz
Respiratory Distress Syndrome of Prematurity (Surfactant Dysfunction), Bronchopulmonary Dysplasia
Trial of Late Surfactant to Prevent BPD: A Pilot Study in Ventilated Preterm Neonates Receiving Inhaled Nitric Oxide
The purpose of this study is to determine if the combination of late doses of Infasurf with inhaled nitric oxide will interact to improve the surfactant function and thus the respiratory status and outcome of treated infants.
- Trial name
- TOLSURFPilot (NCT00569530)
- Testing
- Infasurf (ONY Inc.)
- Where
- 9 sites in United States
- Volunteers
- 85 people
- Sponsor
- Roberta Ballard
Bronchiolitis Acute
Evaluation of Two Doses of Nitric Oxide (NO) Given Intermittently Via Inhalation to Subjects With Bronchiolitis
Prospective, Double-Blinded, Randomized, Multi-Center Study for Evaluation of Two Doses of Nitric Oxide (NO) Given Intermittently Via Inhalation to Subjects With Bronchiolitis The proposed study judiciously expands these…
- Trial name
- NCT04060979
- Testing
- Nitric Oxide, Standard Supportive treatment
- Where
- 7 sites in Israel
- Volunteers
- 95 people
- Sponsor
- Beyond Air Inc.
Malaria, Cerebral
Evaluation of the Efficacy and Safety of Inhaled Nitric Oxide as Adjunctive Treatment for Cerebral Malaria in Children
The purpose of this study is to assess if adding inhaled Nitric Oxide to other malaria treatments can improve the outcome of cerebral malaria in children aged 2months to 12 years.
- Trial name
- NCT01388842
- Testing
- inhaled nitric oxide
- Where
- Uganda
- Volunteers
- 92 people
- Sponsor
- Epicentre
Type A Aortic Dissection
iNO as Salvage Treatment of Hypoxemia After TAAD Surgery
The purpose of this study was to clarify the possible mechanism of hypoxemia after surgical treatment of type A acute aortic dissection and the possible mechanism of the treatment role of inhaled nitric oxide in refractory…
- Trial name
- NCT04032366
- Testing
- inhaled nitric oxide, PEEP
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Zhongshan Hospital
COPD, IPF
Inhaled NO in IPF and COPD During 6 Minute Walk Test
Our objective is to evaluate the influence of inhaled NO on the saturation and exercise capacity of patients with COPD and IPF. each participant will undergo two six minute walk tests, one with inhaled NO and the other with…
- Conditions
- COPD, IPF, Inhaled Nitric Oxide, Six Minute Walk Test
- Trial name
- NCT03873298
- Testing
- Inhaled nitric oxide
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rabin Medical Center
Traumatic Brain Injury
Inhaled Nitric Oxide for Microvascular Dysfunction in Traumatic Brain Injury
Traumatic brain injury (TBI) causes acute deficits in cerebral perfusion which may lead to secondary injury and worse outcomes. Inhaled nitric oxide (iNO) is a vasodilator that increases cerebral blood flow and is clinically used…
- Trial name
- NCT05616910
- Testing
- inhaled nitric oxide
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Pennsylvania
Lung Disease, Hypoxemia
Inhaled Nitric Oxide in Neonates With Elevated A-a DO2 Gradients Not Requiring Mechanical Ventilation
The purpose of this pilot study is to evaluate whether administration of nitric oxide (NO)gas by oxygen hood at 20 ppm significantly increases PaO2, as compared to placebo gas (oxygen), within one hour of initiation and with no…
- Conditions
- Lung Disease, Hypoxemia, Respiratory Acidosis
- Trial name
- NCT00041548
- Testing
- nitric oxide for inhalation, Oxygen
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Mallinckrodt
Cystic Fibrosis
Efficacy and Safety of Inhaled Nitric Oxide (NO) in Cystic Fibrosis (CF) Patients
Prospective, randomized, placebo controlled, phase II clinical study of subjects crossing over from an approved inhaled antibiotic to inhaled nitric oxide as compared to a placebo control arm.
- Trial name
- NCT02498535
- Testing
- Nitric Oxide 160 ppm
- Where
- 7 sites in United States, Canada
- Volunteers
- 49 people
- Sponsor
- Novoteris, LLC
Dyspnea
The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in Interstitial Lung Disease.
Interstitial Lung Disease (ILD) is a is a lung disorder which makes breathing more difficult. During exercise, patients with ILD are not efficient breathers and this leads to serious breathing difficulties, which often causes…
- Trial name
- iNO (NCT04181359)
- Testing
- Nitric Oxide
- Sponsor
- University of Alberta
Sepsis
Randomized Trial of Inhaled Nitric Oxide to Augment Tissue Perfusion in Sepsis
The purpose of this study is to determine whether inhaled nitric oxide is an effective treatment for microcirculatory dysfunction and acute organ system failure in the early stage of sepsis therapy.
- Trial name
- NCT00608322
- Testing
- Inhaled nitric oxide
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Viral Pneumonia, Nitric Oxide
Inhaled NO for the Treatment of Viral Pneumonia in Adults
The purpose of this multi center, open label, randomized, study is to obtain information on the safety and efficacy of 150 ppm Nitric Oxide given in addition to the standard of care of patients with viral pneumonia
- Conditions
- Viral Pneumonia, Nitric Oxide, Respiratory Disease, Pneumonia, Viral
- Trial name
- NCT04606407
- Testing
- LungFit™
- Where
- 3 sites in Israel
- Volunteers
- 40 people
- Sponsor
- Beyond Air Inc.
Asthma
Vivatmo proTM EU-study: FeNO Monitoring in Asthmatic Patients Responding to ICS Treatment
This is a multi-center study to evaluate fractional exhaled nitric oxide (FeNO) measured with the Vivatmo pro in adult and pediatric subjects.
- Trial name
- NCT05553379
- Testing
- FeNO measurement
- Where
- 5 sites in Czechia, Germany
- Volunteers
- 48 people
- Sponsor
- Bosch Healthcare Solutions GmbH
Critical Illness
Effect of Inhaled Nitric Oxide on Pulmonary Ventilation/Perfusion Ratio Assessed by EIT in Patients With ARDS
Electrical impedance tomography was used to monitor changes in pulmonary perfusion distribution and V/Q ratio before and after iNO in patients with acute respiratory distress syndrome to investigate the factors predicting iNO…
- Trial name
- NCT05873647
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Coronavirus Infections, Pneumonia, Viral
Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID19 Infection
The scientific community is in search for novel therapies that can help to face the ongoing epidemics of novel Coronavirus (COVID-19) originated in China in December 2019.
- Conditions
- Coronavirus Infections, Pneumonia, Viral, Dyspnea
- Trial name
- NoCovid (NCT04290858)
- Testing
- Nitric Oxide
- Sponsor
- Xijing Hospital
Obesity, Respiratory Insufficiency
Inhaled Nitric Oxide in Severe Obesity
The goal of this clinical trial is to learn about the effects of inhaled nitric oxide on oxygenation and lung perfusion in participants with severe obesity who have acute hypoxemic respiratory failure and are on mechanical…
- Conditions
- Obesity, Respiratory Insufficiency, Hypoxemic Respiratory Failure, Nitric Oxide
- Trial name
- NCT06675435
- Testing
- Nitric oxide
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Pulmonary Hypertension
Comparison of Vasodilator Response of Inhaled Epoprostenol and Inhaled Nitric Oxide
The overarching goal of this study is to examine the acute vasoreactive response to both inhaled nitric oxide and inhaled epoprostenol across both traditionally and non-traditionally interrogated phenotypes in PH, and to further…
- Trial name
- NCT04231084
- Testing
- Vasodilator testing (Inhaled Nitric Oxide), Vasodilator testing (Inhaled Epoprostenol)
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Brigham and Women's Hospital
SAH, Inhaled Nitric Oxide
Inhaled Nitric Oxide Treatment for Aneurysmal SAH Patients With Intractable Cerebral Vasospasm
Aneurysmal subarachnoid haemorrhage (aSAH) is a rare but severe subtype of stroke with high mortality and morbidity. Besides rebleeding, delayed cerebral ischaemia and cerebral vasospasm (CVS) are thought to be major reasons for…
- Conditions
- SAH, Inhaled Nitric Oxide, Cerebral Ischemia, Vasospasm
- Trial name
- NCT04988932
- Testing
- Inhaled nitric oxide
- Where
- Switzerland
- Volunteers
- 7 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Asthma
Exhaled Nitric Oxide in Asthma Management
This study will compare the absolute and relative effectiveness of managing real-life asthma with and without the use of NIOX MINO® and NIOX Flex® to measure exhaled nitric oxide (eNO) as a marker of underlying airway…
- Trial name
- NCT02140684
- Testing
- eNO monitoring
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- Research in Real-Life Ltd