Clinical trials: Inherited Cardiac Conduction Disorder
Long QT Syndrome, Hypoglycemia
The Physiological Effects of Human Ether-a-go-go-Related Gene (hERG)Blockade on Metabolism
The human ether-a-go-go-related gene HERG (encoding Kv11.1 potassium channels) is expressed in different parts of the body including the heart, pancreas and intestines.
- Trial name
- NCT03868657
- Testing
- Moxifloxacin
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Signe Torekov
Azithromycin Adverse Reaction, Covid19
The Effect of Azithromycin Use on Conduction System of Heart in COVID-19 Positive Children
Azithromycin (AZ) is used in the pediatric group in COVID-19 diseas. It has been reported to cause prolongation in the QT interval in adult age group.
- Conditions
- Azithromycin Adverse Reaction, Covid19, Long QT Syndrome
- Trial name
- NCT04699097
- Testing
- Azithromycin
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Kayseri City Hospital
Cardiac Death, Cardiac Death, Sudden
Longitudinal Evaluation of Active-Duty Personnel with Accessory Pathways (LEAD-AP)
The investigators propose a secondary chart review using EMR data to identify risk factors for sudden cardiac death in active-duty members diagnosed with an accessory pathway between the ages of 18-40.
- Conditions
- Cardiac Death, Cardiac Death, Sudden, Wolf Parkinson White Syndrome
- Trial name
- LEAD-AP (NCT06798961)
- Testing
- Ablation, Standard of care without ablation
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- United States Naval Medical Center, San Diego
Williams Syndrome
Motor Deficits and Signal Conduction in Individuals With Williams Syndrome
The current study aims to validate basic research findings of abnormal conductivity and motor abilities from a mouse model in humans.
- Trial name
- NCT05430763
- Where
- Israel
- Sponsor
- Sheba Medical Center
Inherited Cardiac Arrythmias, Long QT Syndrome (LQTS)
Derivation of Human Induced Pluripotent Stem (iPS) Cells to Heritable Cardiac Arrhythmias
Human induced pluripotent stem cells (hiPSCs) have driven a paradigm shift in the modeling of human disease; the ability to reprogram patient-specific cells holds the promise of an enhanced understanding of disease mechanisms and…
- Conditions
- Inherited Cardiac Arrythmias, Long QT Syndrome (LQTS), Brugada Syndrome (BrS), Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
- Trial name
- NCT02413450
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Long QT Syndrome
The Long QT Syndrome in Pregnancy
Long QT Syndrome (LQTS) is a disease of young adults and can affect women of child bearing age. Suffers of LQTS are at risk of ventricular dysrhythmias including torsades de pointes and ventricular fibrillation.
- Trial name
- NCT00488254
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of British Columbia
Pregnancy, Long QT Syndrome
Ventricular Repolarization During the Pregnancy-to-Postpartum Transition (QuTe)
Pregnancy and the postpartum period are accompanied by marked changes in heart rate, circulating hormones, and electrolyte balance that may influence ventricular repolarization.
- Trial name
- QuTe (NCT02931695)
- Testing
- Evaluation of QT interval duration, Circulating sex hormones levels sample
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- French Cardiology Society
Arrhythmia
The Effect of General Anesthesia on the Risk for Arrhythmia
Polymorphic ventricular tachycardia, known as Torsades de Pointes (TdP), is a specific form of ventricular arrhythmia with a characteristic twist of the QRS complex around the isoelectric baseline.
- Trial name
- 10-02725 (NCT01174251)
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of California, San Francisco
Sensorineural Hearing Loss, Long QT Syndrome
Determine the Incidence of Long QT Amongst a Large Cohort of Subjects Diagnosed With Unilateral or Bilateral Sensorineural Hearing Loss.
The purpose of this study is to determine the true incidence of long QT (LQT) amongst a large cohort of subjects diagnosed with unilateral (right/left) or bilateral sensorineural hearing loss.
- Trial name
- NCT02082431
- Where
- 12 sites in United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Pediatrix
High Risk Pregnancy, Congenital Heart Disease
Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise
Each year world-wide, 2.5 million fetuses die unexpectedly in the last half of pregnancy, 25,000 in the United States, making fetal demise ten-times more common than Sudden Infant Death Syndrome.
- Conditions
- High Risk Pregnancy, Congenital Heart Disease, Fetal Hydrops, Twin Monochorionic Monoamniotic Placenta
- Trial name
- NCT03775954
- Testing
- Fetal Magnetocardiogram and Neonatal Electrocardiogram, Substudy only: Maternal/Infant Pharmacogenomic assessment postnatally
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Medical College of Wisconsin
Brugada Syndrome
Echocardiography During Ajmaline Test
In this study the investigators analyse echocardiographic images before and during Ajmaline test. The purpose is to know if any echocardiographic modifications are present during either negative or positive Ajmaline testing.
- Trial name
- NCT03491475
- Testing
- Ajmaline test
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
QT-prolongation
Drug Interactions With Risk of QT-prolongation in a General Hospital
In this epidemiological point prevalence study, medication profiles of patients with haloperidol treatment will be checked for drug interactions with risk of QT-prolongation.
- Trial name
- NCT02043912
- Testing
- Haloperidol
- Where
- Belgium
- Volunteers
- 222 people
- Sponsor
- KU Leuven
Brugada Syndrome, S-ICD System (Implantable Defibrillator)
Evaluation of Subcutaneous Implantable Cardiac Defibrillator in Brugada Patients
Brugada syndrome is an inherited arrhythmia syndrome with an increased risk of syncope and sudden death resulting from episodes of polymorphic ventricular tachychardia and fibrillation.
- Trial name
- S-ICD Brugada (NCT02344277)
- Testing
- S-ICD System (implantable defibrillator)
- Where
- 22 sites in Denmark, France and 3 more
- Volunteers
- 130 people
- Sponsor
- Nantes University Hospital
Long QT Syndrome
LQT and Smartphone/Smartwatch
Congenital long QT syndrome (LQTS) is a rare genetic disorder characterized by prolongation of the corrected QT interval (QTc) on the electrocardiogram.
- Trial name
- SMART-QT (NCT04728100)
- Testing
- LQT
- Where
- France
- Volunteers
- 111 people
- Sponsor
- Hospices Civils de Lyon
Jervell and Lange Nielsen Syndrome
Diltiazem in Jervell and Lange-Nielsen Syndrome
This study will test the effect of diltiazem, a calcium channel blocking drug, on the QT interval in patients with Jervell and Lange-Nielsen syndrome.
- Trial name
- NCT06534671
- Testing
- diltiazem
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Vanderbilt University Medical Center
Long QT Syndrome, Drug Toxicity
Genetics of QT Prolongation With Antiarrhythmics
To assess the ability of common genetic variants in aggregate to predict drug-induced QT prolongation in patients being loaded with dofetilide or sotalol.
- Trial name
- DOFEGEN (NCT02439658)
- Testing
- Dofetilide and/or sotalol
- Where
- 5 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Massachusetts General Hospital
Long QT Syndrome, Familial Hypercholesterolemia
Comparing Direct vs Indirect Methods for Cascade Screening
An important aspect of successful genomic medicine implementation is developing effective approaches for screening at-risk family members after probands are identified, also known as cascade screening.
- Conditions
- Long QT Syndrome, Familial Hypercholesterolemia, Ethics, Genetic Testing
- Trial name
- NCT05348564
- Testing
- Direct contact of family members for cascade screening of relevant variants
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Maryland, Baltimore
Fetal Arrhythmia, Abnormality in Fetal Heart Rate or Rhythm
Fetal and Neonatal Magnetophysiology
Fetal research and clinical practice has been hampered by a lack of suitable investigational techniques. Currently, ultrasound is the only widely used method of studying fetal anatomy and physiology, but it has significant…
- Conditions
- Fetal Arrhythmia, Abnormality in Fetal Heart Rate or Rhythm, Long QT Syndrome
- Trial name
- NCT01903564
- Testing
- magnetocardiography, postnatal ECG, fetal echocardiography
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Atrial Fibrillation, Atrial Flutter
Beta-blockers for Prevention of Supraventricular Arrhythmia Following PFO Closure
"The primary objective of the study is to evaluate whether the incidence of symptomatic or asymptomatic atrial fibrillation, atrial flutter, and atrial tachycardia within 30 days after percutaneous closure of idiopathic patent…
- Conditions
- Atrial Fibrillation, Atrial Flutter, Tachycardia, Supraventricular, Heart Septal Defects, Atrial
- Trial name
- BRAVE PFO (NCT07123506)
- Testing
- Beta-blocker treatment group, Non-treatment group
- Where
- South Korea
- Volunteers
- 350 people
- Sponsor
- Yonsei University
Atrial Fibrillation, Atrial Tachycardia
Cryotherapy Versus Radiofrequency Catheter Ablation Research Program
A program of research has been set up at St. George's Hospital, London studyng the practicalities of catheter ablation. The current practice of catheter ablation is being studied for a range of arrhythmias including PAF…
- Conditions
- Atrial Fibrillation, Atrial Tachycardia, Wpw, Ventricular Tachycardia
- Trial name
- NCT03816033
- Testing
- Cryotherapy, radiofrequency catheter ablation
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- St. George's Hospital, London