Clinical trials: Inherited Movement Disorders
Dysarthria, Huntington Disease
Characterization of the Profile of Dysarthria in Huntington's Disease, Using the Clinical Evaluation Battery of Dysarthria
Huntington's disease is a hereditary disease of rare autosomal dominant transmission, both neurodegenerative and neuro-psychiatric.
- Trial name
- Huntington (NCT03142217)
- Testing
- Study of dysarthria in patients with Huntington's disease
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Parkinson Disease, Huntington Disease
Group Drum-Based Music Therapy Intervention for Parkinson's Disease/Huntington's Disease
Participants in this study (18-89 years) with Parkinson's disease or Huntington's disease receive drum classes twice a week for 12 weeks (24 lessons).
- Trial name
- NCT05157074
- Testing
- Group Drumming Music Therapy
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Tourette's Syndrome
Effects of Lactobacillus Plantarum PS128 in Patients With Tourette's Syndrome
To evaluate whether supplementing with PS128 can improve the symptoms and quality of life related to Tourette's disease in children.
- Trial name
- NCT04805385
- Testing
- PS128
- Where
- Taiwan
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Tourette Syndrome, Deep Brain Stimulation
Deep Brain Stimulation in Tourette Syndrome
Op-TICS is a clinical investigation of the use of Deep Brain Stimulation (DBS), with a CE marked implantable device, to reduce severe motor and vocal tics in patients who suffer from Tourette Syndrome (TS).
- Trial name
- Op-TICS (NCT06388291)
- Testing
- Deep Brain Stimulation
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University College, London
Tourette Disorder, Attention-Deficit/Hyperactivity Disorder
Neuropsychological Functioning Among Children With Tourret's Disorder and ADHD
Tourette's disorder (TD) is a childhood-onset neuropsychiatric disorder, manifesting motor and vocal tics with increased likelihood of comorbid with attention-deficit/hyperactivity disorder (ADHD) and other psychiatric disorders.
- Trial name
- NCT00416091
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Huntington's Disease (HD)
Biology-Driven Cognitive Profiling in Huntington's Disease
Huntington's disease (HD) is a genetic, progressive neurodegenerative disorder characterized by early and widespread brain changes that can begin more than a decade before the onset of unequivocal motor signs.
- Trial name
- NCT07503743
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Anorexia Nervosa, Obsessive Compulsive Disorder
Evaluation and Follow-up of Individuals With Obsessive-Compulsive Disorder and Related Conditions
The purpose of this study is to better understand the long-term progress of people with obsessive-compulsive disorder (OCD) and related conditions such as anorexia nervosa, Tourette syndrome, and trichotillomania.
- Conditions
- Anorexia Nervosa, Obsessive Compulsive Disorder, Tourette Syndrome, Trichotillomania
- Trial name
- NCT00004550
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Institute of Mental Health (NIMH)
Mild Cognitive Impairment, Dementia
COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE
This retrospective study is a more extensive, confirmatory analysis of the cognitive and functional outcomes initially seen in 2 groups of MCI/dementia patients in Springfield, MA and compares specialized dementia care and a…
- Conditions
- Mild Cognitive Impairment, Dementia, Hypoxia, Hyperhomocysteinemia
- Trial name
- NCT02860338
- Volunteers
- 900 people
- Sponsor
- Clionsky Neuro Systems Inc.
Bowel Incontinence
A Study to Evaluate the Safety, Tolerability and Effectiveness of the Renew Insert in Treating Accidental Bowel Leakage
The purpose of this study is to determine whether the use of the Renew Insert is effective, tolerable and safe in the treatment of accidental bowel leakage due to bowel incontinence.
- Trial name
- REST (NCT01475474)
- Testing
- Renew Insert
- Where
- 3 sites in United States
- Volunteers
- 97 people
- Sponsor
- Renew Medical
Tourette's Syndrome
Ecopipam Treatment of Tourette's Syndrome in Subjects 7-17 Years
Tourette's Syndrome is a neurological disease characterized by motor and vocal tics. It has been hypothesized that abnormal interactions of dopamine with its receptors may cause the tics.
- Trial name
- NCT02102698
- Testing
- Ecopipam
- Where
- 11 sites in United States
- Volunteers
- 40 people
- Sponsor
- Emalex Biosciences Inc.
Huntington Disease
TEsting METformin Against Cognitive Decline in HD
Multicenter, randomized, double-blind, placebo-controlled, parallel group study to assess the efficacy and safety of metformin treatment at a dose of 1700 mg / day in adults with Huntington's disease.
- Trial name
- TEMET (NCT04826692)
- Testing
- Metformin
- Where
- 9 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Tourette's Syndrome, Obsessive Compulsive Disorder
Evaluation of the HBDL Coil Transcranial Magnetic Stimulation (TMS) Device - Safety and Feasibility Study for the Treatment of Tourette Syndrome
This is an open study.approximately 20 patients diagnosed with tourette's syndrome and under pharmAcological or psychotherapy treatments will participate.patients will be recruited from Schneider hospital and all his extensions.
- Trial name
- NCT00965211
- Testing
- HBDL-coil Repetitive Deep Transcranial magnetic stimulation (rdTMS)
- Where
- 2 sites in Israel
- Volunteers
- 20 people
- Sponsor
- Shalvata Mental Health Center
Huntington Disease
Within Subject Crossover Study of Cognitive Effects of Neflamapimod in Early-Stage Huntington Disease
This is a double-blind, placebo-controlled 2-period 10-week treatment within-subject crossover study of neflamapimod in early-stage Huntington disease (HD).
- Trial name
- NCT03980938
- Testing
- neflamapimod
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- EIP Pharma Inc
Wilson Disease
An Exploratory Study to Evaluate the Tolerability and Safety of MWAV201 in Subjects With Wilson Disease
The primary objective of this study is to evaluate the tolerability and safety of MWAV201 in patients with Wilson disease.
- Trial name
- NCT06663878
- Testing
- MWAV201
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Tourette Syndrome
A Trial Evaluating the Efficacy, Safety, and Pharmacokinetics of SNC-102 in Subjects With Tourette Syndrome
This is an open-label study of SNC-102 (acamprosate calcium sustained release tablet) in adult subjects with Tourette Syndrome. Subjects will be treated with oral doses of SNC-102 800 mg on a BID basis - before breakfast and at…
- Trial name
- NCT02217007
- Testing
- SNC-102 sustained release tablet
- Where
- 2 sites in United States
- Sponsor
- Synchroneuron Inc.
Tourette Syndrome, Tourette's Disorder
Remote Delivery of a Mindfulness-based Intervention for Tics
This research study is being done to compare a mindfulness-based intervention for tics (MBIT) to psychoeducation with relaxation and supportive therapy (PRST) for individuals with Tourette's syndrome or Persistent Tic Disorders…
- Conditions
- Tourette Syndrome, Tourette's Disorder, Chronic Motor Tic Disorder, Chronic Vocal Tic Disorder
- Trial name
- MBIT (NCT06408662)
- Testing
- mindfulness-based intervention for tics (MBIT), psychoeducation with relaxation and supportive therapy (PRST)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Johns Hopkins University
Huntington's Disease
Safety Study of the Novel Drug Dimebon to Treat Patients With Huntington's Disease
This study is being conducted to determine the safety and tolerability of Dimebon in people with Huntington's disease after short-term exposure (one week) and after longer exposure (three months).
- Trial name
- NCT00387270
- Testing
- Dimebon
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Medivation, Inc.
Tic Disorder, Tourette Syndrome
Phase III Study of 5LGr to Treat Tic Disorder
The purpose of this study is to evaluate the effective and safety of 5LGr in pediatric patients with tic disorders.
- Conditions
- Tic Disorder, Tourette Syndrome, Chronic Tic Disorder
- Trial name
- 5LGr (NCT01501695)
- Testing
- 5LGr, tiapride
- Volunteers
- 603 people
- Sponsor
- Tasly Pharmaceuticals, Inc.
Primary Four Repeat Tauopathies (4RT), Corticobasal Syndrome (CBS)
Safety Study of TPI-287 to Treat CBS and PSP
The purpose of this study is to determine the safety and tolerability [maximum tolerated dose (MTD) within planned dosing range] of intravenous (IV) infusions of TPI 287 administered once every 3 weeks for 9 weeks (for a total of…
- Conditions
- Primary Four Repeat Tauopathies (4RT), Corticobasal Syndrome (CBS), Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD)
- Trial name
- TPI-287-4RT (NCT02133846)
- Testing
- TPI 287 2 mg/m2, TPI-287 20 mg/m2, TPI-287 6.3 mg/m2
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- University of California, San Francisco
Tourette Syndrome
Deep Brain Stimulation in Forel's H Field in Tourette's Syndrome
Tourette's Syndrome (TS) is a neurodevelopmental disease characterized tics that start before the age of 18 years. About 5% of cases do not respond to drug treatment and can be classified as refractory and in these cases surgical…
- Trial name
- NCT04342754
- Testing
- Deep Brain Stimulation (DBS)
- Where
- Brazil
- Volunteers
- 8 people
- Sponsor
- University of Sao Paulo General Hospital