Clinical trials: Inhibition, Psychological
Osgood-Schlatter Disease
Rate of Torque Development in Adolescents With Osgood-Schlatter
Osgood-Schlatter is a growth-related condition involving multiple different types of tissue in the tendon-bone interface at the tibial tubercle.
- Trial name
- NCT05789095
- Testing
- Rate of torque development testing of knee flexors and knee extensors using a fixated handheld dynamometer (MicroFet 2, Hoggan, Scientific L.L.C., Salt Lake City, USA), sampling rate of 100hz)
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Subjects With Hyperlipidemia, Dyslipidemia and HIV Infection
Safety, Tolerability and Efficacy on Low Density Lipoprotein Cholesterol (LDL-C) of Evolocumab in Participants With Human Immunodeficiency Virus (HIV) and Hyperlipidemia/Mixed Dyslipidemia
The study is divided into 2 parts. The first part of the study will be double-blinded and will last for 24 weeks. During this time, participants will be randomized in a ratio of 2:1 to receive either evolocumab once monthly (QM)…
- Trial name
- NCT02833844
- Testing
- Evolocumab
- Where
- 78 sites in United States, Australia and 13 more
- Volunteers
- 467 people
- Sponsor
- Amgen
Diabetes
Effect of Chronic PDE5-Inhibition on Endothelial Function in Diabetics
chronic PDE5-Inhibition improves endothelial function in diabetics
- Trial name
- NCT00420901
- Testing
- sildenafil
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS San Raffaele
Atherosclerotic Cardiovascular Disease, Vascular Disease
The Effect of Anacetrapib on Vascular Function and Arterial Stiffness
There are currently no studies evaluating the effect of anacetrapib on blood vessel function and stiffness of the arteries. The REVEAL-Vasc trial will assess whether anacetrapib, in addition to atorvastatin (LDL-C lowering drug)…
- Trial name
- REVEAL-Vasc (NCT02931188)
- Testing
- Anacetrapib, Statin
- Where
- United Kingdom
- Volunteers
- 103 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Healthy Children, Preterm Birth
Executive Training and Brain in Children
The purpose of this study is to determine whether a daily executive training to cognitive inhibition, working memory or mindfulness as compared to an active control condition has a near- and far-transfer impact on brain and…
- Trial name
- APEX (NCT02989116)
- Testing
- Inhibition training, Working memory training, Mindfulness training
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Hypoactive Sexual Desire Disorder
Lybridos in Pre- and Postmenopausal Women With Hypoactive Sexual Desire Disorder Due to Maladaptive Activation of Sexual Inhibitory Systems
A double-blind, randomized, placebo-controlled, dose-finding study to investigate the safety and efficacy of Lybridos in the domestic setting in healthy female subjects with hypoactive sexual desire disorder and maladaptive…
- Trial name
- NCT01743235
- Testing
- Testosterone, Buspirone hydrochloride
- Where
- 12 sites in United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Emotional Brain NY Inc.
KINESIOTAPING
Effect of Kinesiotaping in Different Directions on Muscle
The study was conducted to investigate the effects of different Kinesio taping directions on dynamic muscle endurance. This randomized, double-blind, crossover study was implemented on 27 healthy male subjects.
- Trial name
- NCT04379674
- Testing
- FACILITATION TAPING, INHIBITION TAPING
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Prader-Willi Syndrome
Effects of Transcutaneous Vagus Nerve Stimulation on Emotion Regulation and Executive Functioning in Prader-Willi Syndrome
The STIM-PRADER study aims to assess the effectiveness of auricular vagal neuromodulation therapy (aVNT) on emotional, behavioral, and cognitive domains impaired in Prader-Willi Syndrome (PWS).
- Trial name
- STIM-PRADER (NCT06720571)
- Testing
- Auricular vagal neuromodulation therapy (aVNT)
- Where
- 4 sites in France
- Volunteers
- 24 people
- Sponsor
- University of Bordeaux
Musculoskeletal Pain, Cognitive Change
Health, Wellbeing and Performance in Law Enforcement Workers
This study aims to assess current health and fitness of law enforcement workers in various roles, and to evaluate the impact of an exercise intervention on markers on physical and mental wellbeing in this population.
- Conditions
- Musculoskeletal Pain, Cognitive Change, Occupational Stress, Inflammation
- Trial name
- NCT04204486
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University College, London
Impulsive Behavior, Mental Disorders
Cognitive Control Training for Urgency in a Naturalistic Clinical Setting
This study is designed to test whether computer-based cognitive exercises are helpful for reducing a specific type of impulsivity.
- Trial name
- NCT03527550
- Testing
- Cognitive Control Training
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Mclean Hospital
Recurrent Glioblastoma Multiforme, Primary Glioblastoma Multiforme
A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer
This study will test an investigational drug called AZD1390 in combination with radiation therapy for the treatment of brain tumors. This is the first time AZD1390 is being given to patients.
- Conditions
- Recurrent Glioblastoma Multiforme, Primary Glioblastoma Multiforme, Brain Neoplasms, Malignant, Leptomeningeal Disease (LMD)
- Trial name
- NCT03423628
- Testing
- Radiation Therapy, AZD1390
- Where
- 11 sites in United States, Japan and 1 more
- Volunteers
- 159 people
- Sponsor
- AstraZeneca
HDL, Drug Safety
Safety, Immunogenicity and Dose Response of ATH03, a New Vaccine Against the Cholesterol Ester Transfer Protein (CETP)
Phase 1 Study :Safety, Immunogenicity and Dose response of ATH03, a new vaccine against the cholesterol ester transfer protein (CETP), in healthy male subjects with high density lipoprotein cholesterol (HDLc) blood concentrations…
- Trial name
- NCT01284582
- Testing
- ATH03
- Where
- Austria
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Affiris AG
Inhibition
Exploring the Impact of Biofeedback on the Inhibitory Control of Healthy Older Adults
Inhibitory control refers to the conscious and voluntary suppression of predominant responses when they are automatic, inappropriate, or incorrect.
- Trial name
- I-BF (NCT04925830)
- Testing
- Heart rate variability biofeedback; haemoncephalography biofeedback
- Where
- Switzerland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Institutionalization
Life Skills-Based Intervention on Substance Use Intention in Adolescents in Social Care Institutions
Objective: evaluate the impact of a Life Skills Training (LST) intervention on substance use intention by analyzing changes in neuropsychological organization and psychological regulation processes in adolescents living in social…
- Trial name
- CASA-HpV (NCT07492069)
- Testing
- Life Skills Training (LST), Psicoeducation Traditional
- Where
- Mexico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Alcoholism
New Therapeutic Strategies for the Treatment of Alcohol Use Disorders
This is an experimental study in which the efficacy of three psychophysiological intervention modalities based on retrieval-extinction procedures is analyzed.
- Trial name
- NCT03028662
- Testing
- Retrieval-Extinction Learning
- Where
- Spain
- Volunteers
- 115 people
- Sponsor
- Gabriel Rubio Valladolid, MD
Drug-drug Interaction
Inhibition Metamizole 2020
This clinical phase I trial had 3 arms: inhibition by fluconazole, inhibition by ciprofloxacin and placebo. Subjects were treated for 3 days prior to the study day. The intervention was a single dose of 1 gram metamizole.
- Trial name
- NCT04621253
- Testing
- Novalgin
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Eating Behavior, Hunger
Effect of Consumption on Cognitive Processes
To get a better understanding of the interaction between metabolism, neural responses, cognitive processes and appetite the investigaters will examine the effect of food consumption on cognitive processes.
- Conditions
- Eating Behavior, Hunger, Inhibition, Functional Magnetic Resonance Imaging
- Trial name
- NCT03472703
- Testing
- Break-Lunch time
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Delayed Sleep Phase Syndrome
Experimental Manipulation of Sleep and Circadian Rhythms and the Role Played on Reward Function in Teens
Adolescence is a time of heightened reward sensitivity and greater impulsivity. On top of this, many teenagers experience chronic sleep deprivation and misalignment of their circadian rhythms due to biological shifts in their…
- Trial name
- CARRS-P2 (NCT04792697)
- Testing
- Increase morning bright light, Decrease evening blue light, Sleep Scheduling
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Healthy, Adolescent
Physical Activity on Motor Competence, Cognitive Function and Mood in Adolescents
The study aimed to determine the effect of coordinative-based physical activity practices on motor competence, cognitive function and mood levels of adolescent boys.
- Trial name
- NCT07111780
- Testing
- "Coordinative-Based Physical Activity Practices" training group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Namik Kemal University
Creativity, Executive Function (Cognition)
Active Breaks and Executive Function in Scholars
This study aims to examine whether short bouts of exercise (10 minutes) performed during the school day can improve thinking skills, creativity and emotional wellbeing in primary school children.
- Conditions
- Creativity, Executive Function (Cognition), Psychological Wellbeing
- Trial name
- ACTISTOP (NCT07538453)
- Testing
- Active Break
- Where
- Spain
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Universitat Jaume I