Clinical trials: Inhibition, Psychological
Lung Cancer
An Open-Label Phase 1/2 Study of Itacitinib in Combination With Osimertinib in Subjects With Non-Small Cell Lung Cancer
The purpose of this study is to evaluate the safety and tolerability of itacitinib in combination with osimertinib in subjects with locally advanced or metastatic non-small cell lung cancer (NSCLC).
- Trial name
- NCT02917993
- Testing
- Itacitinib, Osimertinib
- Where
- 31 sites in United States, South Korea and 2 more
- Volunteers
- 59 people
- Sponsor
- Incyte Corporation
Executive Function
The Order Effect of Acute Concurrent Exercise on Executive Function: An Event-Related Potential Study
Executive function is a high-level cognition which plays an important role in our life. Meta-analysis study has demonstrated that acute exercise could improve executive function.
- Trial name
- NCT05314699
- Testing
- resistance-aerobic exercise, RA, aerobic-resistance exercise, AR
- Where
- Taiwan
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Cerebrovascular Accident
Preliminary Study of Transcranial Magnetic Stimulation for Stroke Rehabilitation
This is a preliminary study to evaluate the possible use of transcranial magnetic stimulation (TMS), together with exercise, for rehabilitation of chronic stroke patients.
- Trial name
- NCT00050128
- Testing
- rTMS, Magstim
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Alcohol Dependence
Learning to Resist the Urge: Inhibition Training in Abstinent Patients With Alcohol Use Disorders
The study aims to investigate the effects of a short computerized training as a therapeutic add-on to standard therapy in patients with alcohol-use disorder.
- Trial name
- INTRA (NCT02968537)
- Testing
- Alc-IT (50/50) (morning), Alc-IT (75/25) (morning), Control-training (morning)
- Where
- 3 sites in Switzerland
- Volunteers
- 242 people
- Sponsor
- University of Bern
Anaerobic Performance
Psychophysical Aspects of Maximal Anaerobic Performance
During anaerobic exercise, the metabolic pathway of glycolysis is used in order to produces high-energy compounds adenosine triphosphate (ATP).The level of lactic acid in the blood is a marker to the increased protons…
- Trial name
- NCT01770288
- Testing
- Anaerobic wingate test
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Cognitive Function and Well-Being
Acute Physical Exercise Intensity on Adolescents Cognitive Function
Cognitive function and psychological well-being are two variables related to academic performance. Several studies have shown that these variables are sensitive to acute physical exercise, but it is not known which doses of…
- Trial name
- APICA (NCT03441386)
- Testing
- Physical Exercise Session
- Where
- Spain
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Alcohol Use Disorder Cognitive Decline
NEUROPSYCHOLOGICAL REHABILITATION FOR ALCOHOL USE DISORDERS
This investigation will take place between September 2024 and June 2025, with the objective of analyzing executive deficits and the impact of Neuropsychological Rehabilitation on Alcohol Use Disorder, comparing different…
- Trial name
- AUD (NCT06933186)
- Testing
- Neuropsychological rehabilitation, Weekly therapeutic groups
- Where
- Portugal
- Volunteers
- 48 people
- Sponsor
- University of Lisbon
Focal Dystonia
EEG and EMG Studies of Hand Dystonia
This study will examine how the brain operates during execution and control of voluntary movement and what goes wrong with these processes in disease.
- Trial name
- NCT00025701
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Granuloma Annulare
Janus Kinase Inhibition in Granuloma Annulare
The primary objective is to determine if JAK1 specific inhibition is effective in treating granuloma annulare (GA), a problematic inflammatory skin disease without an FDA approved treatment.
- Trial name
- NCT05650736
- Testing
- Abrocitinib 200 mg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- William Damsky
Pediatric Obesity, Inhibition
Brain Mechanisms of Overeating in Children
The proposed research will follow healthy weight children who vary by family risk for obesity to identify the neurobiological and appetitive traits that are implicated in overeating and weight gain during the critical…
- Conditions
- Pediatric Obesity, Inhibition, Decision Making, fMRI
- Trial name
- RO1 (NCT03341247)
- Where
- United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cognitive Fatigue, Mental Fatigue
Effects of Natural Sounds on Attention Restoration Outdoors
This study aims to examine whether listening to natural sounds in a noisy outdoor environment compared to no natural sounds influences behavioural, cognitive, affective, and physiological markers.
- Conditions
- Cognitive Fatigue, Mental Fatigue, Behavioral Performance, Heart Rate Variability
- Trial name
- NEO (NCT05679882)
- Testing
- Masking Sounds, No Masking Sounds
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Attentional Control Switching, Task Switching Between Modalities
Yoga Practice, Stress and Cognitive Performance
It has been indicated in recent research that Mindfulness-based interventions may offer possibilities of promoting human stress processing and reducing anxiety or depression.
- Conditions
- Attentional Control Switching, Task Switching Between Modalities, Inhibition, Stress
- Trial name
- NCT05232422
- Testing
- Hatha yoga course
- Where
- Austria
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Overweight and Obesity, Inhibition, Psychological
Inhibitory Control Training for Excess Weight: Behavioural, Cognitive and Anthropometric Changes
People with excess weight (EW) are characterized by high impulsivity, high levels of craving for high-calorie foods, deficits in inhibitory control, and maladaptive decision-making.
- Trial name
- InhibeT (NCT06600100)
- Testing
- Inhibitory control training
- Where
- Spain
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Raquel Vilar López
Endotoxemia, Inflammation
Short-Chain Fatty Acids in Lypopolysaccharide-Induced Inflammation and Executive Function
Short-chain fatty acids (SCFAs) are substances produced by gut bacteria when they ferment dietary fiber. They can act as signals between the gut and the brain and may help regulate the body's immune and stress responses.
- Conditions
- Endotoxemia, Inflammation, Executive Function (Cognition)
- Trial name
- NCT07713641
- Testing
- Short-Chain Fatty Acid Colon-Delivery Capsules, Lipopolysaccharide (LPS)
- Where
- Belgium
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Premature Ejaculation, Sexual Dysfunction
Brain Networks Implicated in Lifelong Premature Ejaculation Patients
Using Brain Mapping and Cognitive ERPs, the investigatos have searched for a Brain Networks involved during Inhibitory Control in Lifelong Premature Ejaculation (LPE) participants.
- Trial name
- LPE (NCT04850703)
- Testing
- Transcranial Radom Noise Stimulation, Take Dapoxetine, Compare LPE EEG endophenotype between participants and healthy controls
- Where
- Spain
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Moises Domingo
Cognitive Fatigue, Mental Fatigue
Effects of Natural Sounds on Attention Restoration in Noisy Environment
This study aims to examine whether listening to natural sounds in a noisy (traffic) environment compared to traffic noise only impacts behavioural, cognitive, affective, and physiological markers associated with attention…
- Conditions
- Cognitive Fatigue, Mental Fatigue, Heart Rate Variability, Skin Conductance
- Trial name
- EARS (NCT05009784)
- Testing
- Baseline, Fatigue Manipulation, Traffic Sound
- Where
- Singapore
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Eye Movements, Attention
An Investigation of Attentional and Inhibitory Processes During Active Visual Search in Humans
The goal of this study is to investigate the finding that there are large individual differences in how participants move their eyes during active visual search.
- Conditions
- Eye Movements, Attention, Executive Function
- Trial name
- NCT06587113
- Testing
- Contour Search Task, Stop signal Task, Useful field of View
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Sickle Cell Disease
A Study to Evaluate Safety, Pharmacokinetic, and Biological Activity of INCB059872 in Subjects With Sickle Cell Disease
The purpose of this study was to evaluate the safety and tolerability, and the pharmacokinetic and biologic activity of INCB059872 in participants with sickle cell disease.
- Trial name
- NCT03132324
- Testing
- INCB059872
- Where
- 7 sites in United States
- Volunteers
- 12 people
- Sponsor
- Incyte Corporation
Pain Inhibition and Facilitation in Post Partum Women
Endogenous Pain Facilitation and Inhibition in Postpartum Women
This study seeks to further understand these three observations - (1) that the time period surrounding childbirth accelerates recovery from pain after injury (2) that this likely reflects dampened facilitating mechanisms and…
- Trial name
- NCT01843517
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Subjects With Hyperlipidemia, Dyslipidemia
Effects of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibition on Arterial Wall Inflammation in Patients With Elevated Lipoprotein(a) (Lp(a))
A study to assess the effects of proprotein convertase subtilisin/ kexin type 9 (PCSK9) inhibition on the arterial wall inflammation in patients with elevated lipoprotein(a).
- Trial name
- ANITSCHKOW (NCT02729025)
- Testing
- Evolocumab
- Where
- 15 sites in United States, Canada and 1 more
- Volunteers
- 129 people
- Sponsor
- Amgen