Clinical trials: Injectables
General Anesthesia
Efficacy and Safety of HSK3486 Compared to Propofol for Adults Undergoing Elective Surgery With General Anesthesia
To demonstrate HSK3486 0.4/0.2 mg/kg (0.4 mg/kg intravenous [IV] slow injection over 30 [±5] seconds for the first dose, an additional 0.2 mg/kg if needed) is non-inferior to propofol 2.0/1.0 mg/kg (2.0 mg/kg IV slow injection…
- Trial name
- NCT05478174
- Testing
- HSK3486, Propofol
- Where
- 23 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Midface Volume Deficit
Safety and Effectiveness of Mosaic for the Treatment of Midface Volume Deficit
The goal of this clinical trial is to study whether the Mosaic Injectable Dermal Implant is a safe and effective treatment for age-related midface volume deficit in adults who are at least 22 years of age.
- Trial name
- PRIME (NCT07710443)
- Testing
- Injectable dermal implant
- Where
- 5 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Helios Aesthetics Inc.
Mid-facial Volume Deficit Related to Aging
Safety and Effectiveness of Juvéderm® VOLUMA XC Injectable Gel for Cheek Augmentation
Multicenter, single-blind, randomized, "no-treatment" control study to demonstrate the safety and effectiveness of VOLUMA XC for deep injection for cheek augmentation to correct age-related volume deficit in the mid-face.
- Trial name
- NCT00978042
- Testing
- Juvéderm® VOLUMA XC
- Where
- 2 sites in United States, Canada
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- Allergan
Face; Atrophy
DA-13-007 Versus Sculptra for the Treatment of Nasolabial Folds Wrinkles
Study DA-13-007 is a randomized, evaluator-blinded, within subject (split face) multicenter clinical study of DA-13-007l (Injectable poly-l-lactic acid) compared to SCULPTRA in the treatment of nasolabial fold wrinkles.
- Trial name
- NCT02310490
- Testing
- DA-13-007 right with left side Sculptra left side, DA-13-007 left with left side Sculptra right side
- Where
- 4 sites in United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- DermAvance
Monitored Anesthesia Care
A Study to Characterize Pharmacokinetics (PK) and Pharmacodynamics (PD) of LUSEDRA® Administered as Continuous Infusion or Bolus Compared With Continuous Infusion of Propofol Injectable Emulsion
The purpose of this study is to explore the pharmacokinetics (PK) and pharmacodynamics (PD) of LUSEDRA® administered as a continuous infusion or bolus compared with continuous infusion of propofol injectable emulsion.
- Trial name
- NCT01308541
- Testing
- arm 1, LUSEDRA, Propofol (arm 3)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Anesthesia, Sedation
A Study Evaluating Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of Single IV Dose of HSK3486 Injectable Emulsion in Healthy Subjects.
his single-center, open-label, uncontrolled, and dose-escalation study evaluated the safety, tolerability, and pharmacokinetics/pharmacodynamics of single IV dose of HSK3486 injectable emulsion in healthy subjects.
- Trial name
- NCT03773835
- Testing
- HSK3486
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Opioid Dependence, Alcohol Dependence
A Clinical Trial to Assess Pharmacokinetic Profiles, Safety and Tolerability of IVL3004 and IVL4002 in Healthy Male Subjects.
A Clinical Trial to Assess Pharmacokinetic Profiles, Safety and Tolerability of IVL3004 and IVL4002 in Healthy Male Subjects.
- Conditions
- Opioid Dependence, Alcohol Dependence, Multiple Sclerosis
- Trial name
- NCT05620940
- Testing
- Vivitrol Injectable Product, IVL3004, IVL4002
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Inventage Lab., Inc.
Aesthetic Dermatology
Safety and Effectiveness Clinical Evaluation of Injectable Medical Devices
The study aims to confirm the safety and effectiveness of FILLGEL devices
- Trial name
- NCT06142578
- Testing
- Dermal Filler Device
- Where
- Switzerland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Kylane Laboratoires
Contraception
Pharmacokinetic and Pharmacodynamic Study of Cyclofem
Cyclofem® is a monthly injectable contraceptive containing 25 mg of medroxyprogesterone acetate (MPA) and 5 mg of estradiol cypionate (E2C), a long-acting ester of estradiol.
- Trial name
- NCT01699022
- Testing
- Injection Cyclofem
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Sun Pharmaceutical Industries Limited
Wrinkles
Injectable Filler for Facial Soft Tissue Augmentation
The purpose of this study is to assess the safety and performance of Hydroxytite in all subjects who have received sub dermal or deep dermal injections.
- Trial name
- NCT02218788
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Panaxia Ltd
Drug Drug Interaction
Drug-drug Interaction Between Ciprofol and Mefanamic Acid or Valproate
study the effect of mefanamic acid or valproate on ciprofol
- Trial name
- NCT05181007
- Testing
- Mefanamic Acid, Valproate
- Where
- China
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Loss of Face Volume
Evaluation of the Efficacy and Safety of Three Injectable Hyaluronic Acid-based Fillers: Art Filler® Fine Lines, Art Filler® Universal and Art Filler® Lips
The function of injectable fillers for the treatment of dermal contour deformities is to smooth dermal depressions formed by the loss of volume and the aging process.
- Trial name
- AF4 (NCT04647513)
- Testing
- Intradermal injection (superficial dermis for Art Filler Fine Lines / moderately deep to deep dermis for Art Filler Universal and Art Filler Lips)
- Where
- France
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Laboratoires FILLMED
Lip Enhancement
Safety and Effectiveness of Juvéderm® Ultra Lip Injectable Gel for Lip Enhancement
The purpose of this study is to demonstrate the safety and effectiveness of Juvéderm® Ultra Lip Injectable Gel for lip enhancement.
- Trial name
- NCT01176773
- Testing
- hyaluronic acid gel
- Where
- 4 sites in United Kingdom
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Allergan Medical
Aging
Evaluation of the Efficacy and Safety of an Injectable Hyaluronic Acid-based Filler, Art Filler® Volume: Comparative Single-blind Study of the Non-inferiority Versus Juvéderm® Voluma on the Midface, Temple and Jaw-line and Non-comparative Study on the Chin. (AF3)
The function of injectable fillers for the treatment of dermal contour deformities is to smooth dermal depressions formed by the loss of volume.
- Trial name
- AF3 (NCT04645576)
- Testing
- Face correction with injectable fillers
- Where
- France
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Laboratoires FILLMED
Chronic Pain, Lower Back Pain Chronic
Lumbar Injectrode Feasibility Evaluation
The goal of this non-significant risk study is to determine whether stimulation with transcutaneous waveforms applied on the outside of the body and subcutaneously conducted to the lumbar medial branch nerve elicits visible (via…
- Trial name
- LIFE (NCT06206356)
- Testing
- PNS Injectrode F1
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Neuronoff, Inc
Parkinson's Disease (PD)
Relative Bioavailability Study of HNC364 Injectable Suspension
HNC364 is a new pro-drug of rasagiline as a long-acting injection for deep IM deltoid injection, for the treatment of Parkinson"s disease (PD).
- Trial name
- NCT06798519
- Testing
- HNC364 Injectable Suspension, Rasagiline Tablets
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Guangzhou Henovcom Bioscience Co. Ltd.
COVID-19 Patients
To Evaluate the Safety, Tolerability and Pharmacokinetic Properties of DWRX2003
This study is designed to assess the safety, tolerability and Pharmacokinetic Properties of Niclosamide Injectable (DWRX2003) in healthy volunteers.
- Trial name
- NCT04592835
- Testing
- DWRX2003
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Buttocks Volume Loss
Clinical Study for the Evaluation of the Effectiveness of Use of a Poly-L Lactic Acid Injectable Filler for the Aesthetic Treatment of Buttocks Volume Depression
The purpose of this study is to assess the effectiveness and safety of Gana X, a Poly L-lactic acid filler for the aesthetic treatment of buttocks.
- Trial name
- PLLA (NCT05363163)
- Testing
- Gana X
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- GCS Co., Ltd
General Anesthesia
Safety and Efficacy of HSK3486 Compared to Propofol for Induction of General Anesthesia in Adults With Elective Surgery
To demonstrate HSK3486 0.4/0.2 mg/kg (0.4 mg/kg intravenous [IV] slow injection over 30 [±5] seconds for the first dose, an additional 0.2 mg/kg if needed) is non-inferior to Propofol 2.0/1.0 mg/kg (2.0 mg/kg IV slow injection…
- Trial name
- NCT05486416
- Testing
- HSK3486, Propofol
- Where
- 28 sites in United States, Poland and 1 more
- Volunteers
- 465 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Obesity
An Efficacy, Safety and Pharmacokinetics Study of Beloranib (ZGN-440 for Injectable Suspension) in Obese Subjects
The purpose of this study is to evaluate weight reduction, safety and pharmacokinetics for certain doses of beloranib (ZGN-440 for injectable suspension) administered as twice-weekly subcutaneous injections for 12 weeks.
- Trial name
- NCT01666691
- Testing
- Beloranib
- Where
- 3 sites in Australia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Zafgen, Inc.