Clinical trials: Injection Pain
- Condition Injection Pain
- Funder type Industry (pharma, biotech, devices)
- Accepts healthy volunteers yes
Healthy
Evaluation of Pain Reduction in the Administration of Saline Injections by the Usage of Pneumatic Skin Flattening
Each participant will be administered 2 injections of saline - the first in the right gluteal area and the second in the left gluteal area. Both injections will be administered intra-muscularly by the same clinician.
- Trial name
- NCT00503087
- Testing
- Saline Injection, Pneumatic Skin Flattening (PSF)
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- PalJect Ltd.
Musculoskeletal Pain
Study to Evaluate EB-001 in Reducing Musculoskeletal Pain
To determine the safety and efficacy of single intra-operative treatment of EB-001 IM injections into the Pectoralis Major (PM) in subjects undergoing breast augmentation with subpectoral implants
- Trial name
- NCT03193593
- Testing
- EB-001
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Bonti, Inc.
Pain, Postoperative
Pharmacokinetics of Nalbuphine Injection
A study to evaluate pharmacokinetics of nalbuphine hydrochloride (10 mg/mL) after a single intravenous administration in healthy volunteers under fasting conditions
- Trial name
- NCT03826316
- Testing
- Nalbuphine
- Where
- Taiwan
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Yung Shin Pharm. Ind. Co., Ltd.
Pain
A Phase I Clinical Study Trial of Felbinac Trometamol Injection in China
1. To evaluate the tolerances of healthy subjects treated with Felbinac Trometamol Injection on multiple dose and single dose 2.
- Trial name
- NCT03617510
- Testing
- Felbinac Trometamol Injection
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Shijiazhuang Yiling Pharmaceutical Co. Ltd
Post Operative Pain, Cesarean Section Pain
Application of Transversus Abdominus Plain Block, Local Subcutaneous Injection and IV Nalbuphine
Approximately 1 in 5 women who undergo CS will experience severe acute postoperative pain. The severity of pain in the acute postoperative period is a significant predictor for the development of chronic pain, which occurs in…
- Trial name
- NCT05276206
- Testing
- NSAID , NALUFIN , local anesthetic andTAP Block
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Egymedicalpedia
Healthy
Study of Ixekizumab in Healthy Participants
The purpose of this study is to compare the tolerability of injections of each of 3 formulations of ixekizumab using a prefilled syringe.
- Trial name
- NCT03848403
- Testing
- Ixekizumab
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Pain, Analgesia Disorder
A Bioavailability Study of Sebacoyl Dinalbuphine Ester IM Injection in Healthy Volunteers
This study is to evaluate the relative bioavailability of nalbuphine after single IM injection of Sebacoyl Dinalbuphine Ester (SDE) injection and Bain®, Nalbuphine HCl IM injection in healthy volunteers.
- Trial name
- NCT02446301
- Testing
- Bain®, SDE
- Where
- Taiwan
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Lumosa Therapeutics Co., Ltd.
Retinal Disease
SteRilizing Eye SoLution to ImprovE Patient ComFort (RELIEF)
This is a randomized, double-masked study to evaluate the tolerability and safety of IRX-101 versus 5% povidone-iodine (PI) in subjects receiving intravitreal anti-VEGF injections.
- Trial name
- RELIEF (NCT05747430)
- Testing
- IRX-101, Providone-Iodine
- Where
- 7 sites in United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- iRenix Medical, Inc.
Contraception
A Study to Evaluate Injection Pain and Local Tolerability Following Subcutaneous (SC) Administration of TV-46046
The purpose of this study is to evaluate the local tolerability associated with the SC administration of TV-46046, and inform next steps of the TV-46046 development program.
- Trial name
- NCT03700658
- Testing
- TV-46046, Depo-subQ 104
- Where
- Dominican Republic
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Dermal Filler, Hyaluronic Acid
Evaluate the Safety and Effectiveness of Sodium Hyaluronate When Used for the Correction of Nasolabial Folds
The aim of this study is to evaluate the safety and effectiveness of pain relief of modified sodium hyaluronate gel for injection when used for the correction of moderate or severe nasolabial folds.
- Conditions
- Dermal Filler, Hyaluronic Acid, Lidocaine, Nasolabial Fold
- Trial name
- NCT04569045
- Testing
- HA+Lidocaine, HA
- Where
- 2 sites in China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- SciVision Biotech Inc.
Postherpetic Neuralgia
Single-dose to Evaluate the Pharmacokinetics of GTX-101 and Subcutaneous Injectable Bupivacaine in Healthy Subjects
This is a single-center, randomized, single-dose, active-controlled study in healthy male and female subjects. The study will enroll subjects to evaluate the PK of 3 dose strengths (50 mg, 100 mg and 200 mg) of GTX-101 compared…
- Trial name
- NCT05517486
- Testing
- GTX-101, Bupivacaine HCl subcutaneous injection
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Grace Therapeutics Inc.
Nasolabial Folds
Evaluation of Pain With Lidocaine-Mixed Radiesse® Injectable Dermal Filler
To assess pain during nasolabial fold treatment using Radiesse® Injectable Dermal Filler mixed with lidocaine.
- Trial name
- NCT01012661
- Testing
- Radiesse® Injectable Dermal Filler Mixed with Lidocaine, Radiesse® Injectable Dermal Filler without Lidocaine
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Merz North America, Inc.
Chondromalacia, Osteoarthritis
Efficacy of Intra-articular Collagen Injection in Patients With Knee Joint Pain Compared to Normal Saline Injection
The primary objective of this study is to confirm the superiority of intra-articular collagen injection in patients with knee joint pain compared to the control group.
- Conditions
- Chondromalacia, Osteoarthritis, Traumatic Arthritis
- Trial name
- NCT02539095
- Testing
- CartiZol, Normal saline
- Where
- 5 sites in South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cellontech Co., Ltd.
Assessing Injection Pain of Makena® (Hydroxyprogesterone Caproate Injection, 250 mg/mL) in Healthy Post-menopausal Women
Study Assessing Injection Pain of Makena® (Hydroxyprogesterone Caproate Injection, 250 mg/mL) When Administered Via Subcutaneous Auto-injector vs Intramuscular Injection Via Needle and Syringe in Healthy Post-menopausal Women
To demonstrate that Makena® (Hydroxyprogesterone Caproate Injection, 250 mg/mL) delivered subcutaneously via auto-injector is associated with less pain as compared to intramuscular injections of Makena®
- Trial name
- NCT02937766
- Testing
- Makena® (Hydroxyprogesterone Caproate Injection, 250 mg/mL)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- AMAG Pharmaceuticals, Inc.
Venomous Snakebites, Local Anesthesia
Subcutaneous Injection of Large Volumes of Tumescent Lidocaine and Epinephrine by Laypersons
This research is intended to show that it is safe and not difficult for nearly anyone to inject at least 125ml of a dilute solution of tumescent lidocaine and epinephrine (TLE), where a TLE solution consists of lidocaine (1gm/L)…
- Conditions
- Venomous Snakebites, Local Anesthesia, Painless Injection, Regional Anesthesia
- Trial name
- TLE-RCT (NCT04733781)
- Testing
- Tumescent Lidocaine and Epinephrine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Jeffrey Alan Klein, MD
Acute Pain
Single Ascending Dose Study of Two Liquidia Bupivacaine Formulations
This study is designed to assess and characterize the safety and tolerability profile of LIQ865A and LIQ865B formulations compared to diluent or aqueous bupivacaine hydrochloride when infiltrated into a defined area of the medial…
- Trial name
- NCT02982889
- Testing
- LIQ865A bupivacaine formulation, LIQ865B bupivacaine formulation, Diluent for LIQ865
- Where
- Denmark
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Liquidia Technologies, Inc.
Healthy
Safety and Efficacy of EZ-Ject Injector a Pain-Free Subcutaneous Automatic Injection in Healthy Volunteers
Subcutaneous injections are a widely used method for drug delivery. One of its major drawbacks is the pain inflicted during the process.
- Trial name
- NCT00684333
- Testing
- painless subcutaneous injection by EZ-Ject Injector
- Where
- Israel
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Sindolor
Healthy Participants
Study to Assess Tolerability of Injecting Larger Volumes (2-5 mL) Subcutaneously at Different Rates: Participant Experience and Acceptance
The purpose of the study is to investigate the tolerability of different injection/infusion volumes and speed compared to standard practise.
- Trial name
- RISE (NCT07769489)
- Testing
- Syringe Pump
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Neuropathic Pain
Safety, Tolerability, and Pharmacokinetics of ASCT-83 in Healthy Adults
The goal of this clinical trial is to learn if ASCT-83 is safe and well-tolerated and measure how ASCT-83 is absorbed, distributed, and eliminated from the body over time. The study will be conducted in healthy adults.
- Trial name
- NCT07363395
- Testing
- ASCT-83
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Alcamena Stem Cell Therapeutics
Retinal Disease
Safety and Tolerability of IRX-101 in Patients Receiving Intravitreal Injections
This is a randomized, double-masked study to evaluate the tolerability and safety of IRX-101 versus 5% povidone-iodine (PI) in subjects receiving intravitreal anti-VEGF injections.
- Trial name
- COMFORT (NCT05750589)
- Testing
- IRX-101, Providone-Iodine
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- iRenix Medical, Inc.