Clinical trials: Injection Pain, active
Herniated Disc
Comparison of Interlaminar CT Guided Epidural Platelet Rich Plasma Versus Steroid Injection in Patients With Lumbar Radicular Pain
The treatment of persistent lumbar radicular pain (LRP) using CT-guided epidural steroid injection (ESI) is widely used and associated with rare but serious complications.
- Trial name
- NCT07036445
- Testing
- Epidural Steroid Injection, Epidural platelet-rich plasma injection
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Clinique du Sport, Bordeaux Mérignac
Knee Osteoarthritis, Osteoarthritis, Knee
US-Guided Saphenous Block in Knee OA
The purpose of this prospective, randomized, open-label, active-controlled clinical trial is to evaluate the clinical and sonographic effects of ultrasound-guided (US-guided) high-volume saphenous nerve block combined with…
- Conditions
- Knee Osteoarthritis, Osteoarthritis, Knee, Gonarthrosis, Knee Pain
- Trial name
- SAPH-KNEE-OA (NCT07868770)
- Testing
- Intra-articular corticosteroid injection, Ultrasound-Guided High-Volume Saphenous Nerve Block, Home-Based Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Laparoscopic Appendectomy
Comparing Pain Relief Between Two Methods of Freezing Injections in Children Having Their Appendix Removed
Laparoscopic appendectomies are the most common emergency surgeries performed in children. Despite being considered minimally invasive surgeries, they can result in substantial postoperative pain and 2 of 3 patients require…
- Trial name
- NCT06945263
- Testing
- Rectus Sheath Block, Local Anesthetic at the Umbilical Port Site, Intravenous Dexamethasone
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Pain From onabotulinumtoxinA Injections
Topical Intranasal Anesthetic Block for Reducing the Pain of Botulinum Toxin Injections for Chronic Migraine
People find the injections used in onabotulinumtoxinA (Botox®) uncomfortable. This study will test whether putting a small piece of cotton soaked with 4% lidocaine (a numbing medicine) inside the front of each nostril for 5…
- Trial name
- NCT07571889
- Testing
- onabotulinumtoxinA prophylaxis with Lidocaine, OnabotulinumtoxinA prophylaxis with Saline
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Association of Migraine Disorders
Lumbar Disc Herniation, Lumbar Radiculopathy
PLDD With or Without Transforaminal Epidural Steroid Injection in Lumbar Disc Herniation
This prospective observational study aims to evaluate the clinical outcomes of patients with single-level lumbar disc herniation who undergo routine percutaneous laser disc decompression (PLDD).
- Trial name
- PLDD-TFESI (NCT07400068)
- Testing
- Percutaneous Laser Disc Decompression (PLDD), Transforaminal Anterior Epidural Steroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Mersin University
Myofascial Pain, Myofascial Trigger Point Pain
Investigating the Minimum Number of Needling Required to Optimize Trigger Point Injections Outcome
Myofascial pain is a common condition in which patients may experience severe chronic pain. The source of this pain is typically the soft tissue.
- Trial name
- NCT04732507
- Testing
- 1% plain lidocaine and 0.25% plain bupivacaine
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Arizona
Sacroiliac Joint Dysfunction, Multifidus
Does Injection Target Matter in Sacroiliac Joint Dysfunction?
This retrospective comparative cohort study aims to compare the short-term clinical outcomes of ultrasound-guided sacroiliac joint (SIJ) injection, combined SIJ and multifidus injection, and multifidus injection alone in patients…
- Conditions
- Sacroiliac Joint Dysfunction, Multifidus, Pain Management
- Trial name
- NCT07881718
- Testing
- Ultrasound-Guided Sacroiliac Joint Injection, Ultrasound-Guided Multifidus Injection
- Volunteers
- 30 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Tarsal Tunnel Syndrome, Tibial Neuropathy
Ultrasound-Guided Pulsed Radiofrequency Added to Perineural Steroid Injection Versus Perineural Steroid Injection Alone in the Treatment of Tarsal Tunnel Syndrome
Tarsal tunnel syndrome (TTS) is an entrapment neuropathy caused by compression of the posterior tibial nerve at the ankle, resulting in pain, numbness, and tingling sensations in the heel and sole of the foot.
- Trial name
- NCT07837557
- Testing
- Ultrasound-Guided Pulsed Radiofrequency and Perineural Steroid
- Volunteers
- 50 people
- Sponsor
- Assiut University
Degenerative Disc Disease
Efficacy and Safety of Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low Back Pain
The primary purpose of this study is to evaluate the efficacy of rexlemestrocel-L+HA compared to control in reducing low back pain at 12 months post-treatment and safety of a single injection of rexlemestrocel-L+HA injected into…
- Trial name
- HyaluronicAcid (NCT06325566)
- Testing
- Rexlemestrocel-L + HA mixture, Saline
- Where
- 40 sites in United States
- Volunteers
- 300 people
- Sponsor
- Mesoblast, Ltd.
Chronic Low Back Pain (CLBP)
A Superiority Trial of Radiofrequency Ablation for Low Back Pain
The purpose of the ASTRAL Study is to evaluate the effectiveness of LRFA (Lumbar radiofrequency ablation) against a control procedure.
- Trial name
- ASTRAL (NCT07222462)
- Testing
- Lumbar radiofrequency ablation with conventional electrodes (LRFA-C), Lumbar radiofrequency ablation with multi-tined electrodes (LRFA-M), Simulated lumbar radiofrequency ablation
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Washington
Postoperative Acute Pain
Efficacy and Safety of Anrikefon Injection for Multimodal Postoperative Analgesia in Patients Undergoing Laparoscopic Hepatectomy
A single-center, randomized, double-blind, placebo-controlled trial design will be adopted to investigate whether Anruikefon can significantly reduce the consumption of sufentanil via PCIA pumps within 48 hours postoperatively…
- Trial name
- NCT07801183
- Testing
- Anruikefon 1 μg/kg per dose Group, Anruikefon 100 μg per dose Group, Control group
- Where
- China
- Volunteers
- 117 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis
Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis
The goal of this clinical trial is to learn if GNSC-001 works to treat knee osteoarthritis in adults. It will also learn about the safety of GNSC-001. The main questions it aims to answer are: 1.
- Conditions
- Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis, Knee Arthritis, Knee Arthritis Disease
- Trial name
- RAPHAEL (NCT07831577)
- Testing
- Gene Therapy GNSC-001
- Volunteers
- 240 people
- Sponsor
- Genascence Corporation
Patients with Jaw Muscles Myofascial Pain
A Comparative Study on the Impact of Trigger Points Injection of Platelet Rich Plasma Versus Botulinum Toxin on the Relief of Jaw Muscles Myofascial Pain
This study aims at comparing the effect of trigger points injection of platelet rich plasma and botulinum toxin a on the relief of jaw muscles Myofascial pain .
- Trial name
- NCT06814535
- Testing
- Botulinum Toxin A / Botulinum Toxin A, Platelet rich plasma
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Osteoarthritis, Knee
Treatment Effects of Subcutaneous Injections of Pentosan Polysulfate Sodium vs Placebo in Participants With Knee OA Pain
The purpose of this study is to measure the change in pain and function with subcutaneous injections of pentosan polysulfate sodium (PPS) compared with subcutaneous injections of placebo in participants with knee osteoarthritis…
- Trial name
- NCT04809376
- Testing
- Pentosan Polysulfate Sodium twice weekly, Pentosan Polysulfate Sodium Fixed Dose, Pentosan Polysulfate Sodium once weekly
- Where
- 33 sites in United States, Australia
- Volunteers
- 602 people
- Sponsor
- Paradigm Biopharmaceuticals USA (INC)
Anterior Cutaneous Nerve Entrapment Syndrome
Effect of Abdominal Wall Injections on Abdominal Pain
This is a prospective cohort study of outpatient adults with chronic abdominal wall pain receiving abdominal wall injections, as part of their usual care, with lidocaine.
- Trial name
- NCT06121466
- Testing
- Abdominal wall injections with lidocaine 2%
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Lumbar Radicular Pain, Spinal
Cutaneous Silent Period-Based Comparison of DRG-PRF and TFESI in Lumbar Radicular Pain
This prospective clinical study compares the effects of two interventional treatments, dorsal root ganglion pulsed radiofrequency (DRG-PRF) and transforaminal epidural steroid injection (TFESI), on patients with lumbar radicular…
- Conditions
- Lumbar Radicular Pain, Spinal, Inhibition
- Trial name
- CSP-LRP (NCT07097532)
- Testing
- Radiofrequency, Transforaminal Epidural Steroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- ahmet başarı
PAIN, ANXIETY, AND COMFORT
Impact of the Helfer Skin Tap Technique on Pain and Comfort Levels During Ventrogluteal Injection: A Randomized Controlled Trial
This randomized controlled study evaluates the effect of the Helfer Skin Tap Technique on pain and comfort during ventrogluteal intramuscular injections in adults.
- Trial name
- NCT07583472
- Testing
- Helfer Skin Tap Technique applied before IM Diclofenac injection
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Seyda Can
Cardiac Surgery, Postoperative Pain
Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block for Cardiac Surgery
This prospective, randomized, controlled study aims to evaluate the effects of ultrasound-guided bilateral single-shot serratus posterior superior intercostal plane (SPSIP) block on postoperative recovery and pain management in…
- Conditions
- Cardiac Surgery, Postoperative Pain, Postoperative Recovery After Cardiac Surgery
- Trial name
- NCT07785323
- Testing
- Serratus posterior superior intercostal plane block, Standard Perioperative Care
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Burak Çilingir
Pain, Acute Pain
Pain Induced by m-Cresol as Preservative
Preservatives such as m-Cresol are essential components in many subcutaneously injected medications, including insulin or human growth hormone, to prevent bacterial growth.
- Conditions
- Pain, Acute Pain, Healthy Volunteer Study
- Trial name
- NCT07600814
- Testing
- m-Cresol 0.1%, m-Cresol 0.25%, Control Solution
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Osteoarthritis, Knee, Osteo Arthritis Knee
Safety and Pharmacodynamics of GNSC-001 Intra-articular Injection for Knee Osteoarthritis
The goal of this clinical study is to determine if a single injection of 1 or more dose levels of adeno-associated virus (AAV) gene therapy (GNSC-001) is safe and tolerated compared to placebo in participants with painful…
- Conditions
- Osteoarthritis, Knee, Osteo Arthritis Knee, Knee Osteoarthritis
- Trial name
- DONATELLO (NCT05835895)
- Testing
- GNSC-001, transient immune-modulation
- Where
- 9 sites in United States
- Volunteers
- 67 people
- Sponsor
- Genascence Corporation