Clinical trials: Injection Site
Lupus Erythematosus Systemic Exacerbation
Open-label Trial of Acthar Gel in Subjects With Moderate to Severe Active Systemic Lupus Erythematosus
Systemic lupus erythematosus is a serious and potentially life-threatening condition with significant unmet medical need. The aim of this Investigator Initiated, single center, open-label study is to evaluate the efficacy and…
- Trial name
- ACTH (NCT01769937)
- Testing
- H.P. Acthar Gel
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Fiechtner, Justus J., M.D., P.C.
Hypercholesterolemia and Hyperlipidemia
Study of SHR-1209 Administered by Single-site or Multiple-site Subcutaneous Injections in Healthy Volunteers
In order to improve the medication convenience and compliance of patients and facilitates in the long-term control of disease condition, it is planned to reduced the number of injections to one per administration.
- Trial name
- NCT06837077
- Testing
- SHR-1209 single-site subcutaneous injection, SHR-1209 multiple-site subcutaneous injections
- Where
- China
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Recurrent Prostate Cancer
Clinical Study to Assess the Safety and Efficacy of the SpectraCure P18 System
The rationale for the study is to obtain safety and efficacy data as well as to establish dose parameters for the SpectraCure P18 System with IDOSE®, with verteporfin for injection (VFI) as photosensitizer for the treatment of…
- Trial name
- NCT03067051
- Testing
- Verteporfin, SpectraCure P18 System
- Where
- 4 sites in United States, Canada and 2 more
- Volunteers
- 66 people
- Sponsor
- SpectraCure AB
HIV Infections
RAL-eve Study: Raltegravir Substitution Study
The purpose of this study is to: Provide raltegravir to subjects with HIV and an undetectable viral load who are experiencing injection site reactions (ISR) to Enfuvirtide, Monitor the safety and efficacy of raltegravir, and…
- Trial name
- NCT00523237
- Testing
- Raltegravir
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Stanford University
Esophageal Stenosis, Deglutition Disorders
Endoscopic Injection of Mitomycin C for the Treatment of Pharyngoesophageal Stenosis
Management of pharyngoesophageal stenosis (PES) in patients after head and neck cancer (HNC) treatment remains a challenge. There are some cases of strictures refractory to dilation sessions.
- Conditions
- Esophageal Stenosis, Deglutition Disorders, Head and Neck Neoplasms, Esophageal Neoplasms
- Trial name
- NCT03540953
- Testing
- Endoscopic injection of Mitomycin C
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- Fauze Maluf Filho
Postoperative Pain
Bupivacaine for Postoperative Pain After Laparoscopic Hysterectomy
This prospective, randomized, single-blind controlled study aims to evaluate the effect of bupivacaine injection at trocar entry sites and the vaginal cuff on postoperative pain in patients undergoing total laparoscopic…
- Trial name
- bupivacaine (NCT07435909)
- Testing
- Bupivacaine %0.5 (hyperbaric)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Serkan Kumbasar
Non-Small Cell Lung Cancer
Efficacy/Safety of Imprime PGG® Injection With Bevacizumab and Paclitaxel/Carboplatin in Patients With Untreated Advanced Non-Small Cell Lung Cancer (NSCLC)
The Phase 2 study described in this protocol will serve to evaluate the antitumor activity, safety and pharmacokinetic profile of Imprime PGG when combined with bevacizumab and concomitant paclitaxel and carboplatin therapy in…
- Trial name
- NCT00874107
- Testing
- Imprime PGG® Injection, Bevacizumab, Paclitaxel
- Where
- 10 sites in United States, Germany
- Volunteers
- 90 people
- Sponsor
- HiberCell, Inc.
Head and Neck Cancer
Intratumoral Microdosing of TAK-981 in Head and Neck Cancer
This is a multi-center, single arm, open-label, multi-agent, localized pharmacodynamic biomarker Phase 0 trial designed to study the biological effects within the tumor microenvironment of TAK-981 and TAK-981 combined with…
- Trial name
- NCT04065555
- Testing
- TAK-981, Cetuximab, Avelumab
- Where
- 6 sites in United States
- Volunteers
- 12 people
- Sponsor
- Presage Biosciences
Efficacy and Safety
Evaluation of PLD Combined With Carboplatin Versus Paclitaxel Plus Carboplatin in the First-line Treatment of Epithelial Ovarian Cancer
This is a randomized, multicenter, open, controlled Post-Marketing Study. 396 patients who were histopathology or exfoliated cell pathology of pleural and ascites confirmed with epithelial ovarian cancer/fallopian tube/peritoneal…
- Trial name
- NCT03794778
- Testing
- pegylated liposomal doxorubicin, paclitaxel, Carboplatin
- Where
- China
- Volunteers
- 396 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Recurrent Squamous Cell Carcinoma of the Head and Neck, Metastatic Squamous Cell Carcinoma
A Clinical Trial of TQB2618 Injection Combined With Penpulimab Injection and Chemotherapy Versus Penpulimab Injection Combined With Chemotherapy in First-line Treatment of Relapsed/Metastatic Head and Neck Squamous Cell Carcinoma
To evaluate the efficacy and safety of TQB2618 injection combined with Penpulimab and chemotherapy in the first-line treatment of relapsed/metastatic head and neck squamous cell carcinoma compared to Penpulimab combined…
- Trial name
- NCT05783921
- Testing
- TQB2618 injection, Penpulimab injection, Paclitaxel, Cisplatin or Carboplatin, Penpulimab injection, Paclitaxel, Cisplatin or Carboplatin
- Where
- 12 sites in China
- Volunteers
- 60 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Ovarian Cancer
SHR - A1811 Injection in the Treatment of Platinum-sensitive Recurrent Ovarian Cancer
This study is a multi - center, single - arm, open - label, phase Ib/II clinical trial for dose exploration and efficacy expansion.
- Trial name
- NCT06990516
- Testing
- SHR-A1811, Carboplatin, Oxaliplatin
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Tongji Hospital
Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms
Anlotinib Hydrochloride Capsules Combined With TQB2450 Injection in Esophageal Squamous Cell Carcinoma Patients
This is an Open, Single Arm, Exploratory and Phase II Clinical Trial of Anlotinib Hydrochloride Capsules Combined With TQB2450 Injection in Esophageal Squamous Cell Carcinoma (ESCC) Patients as Postoperative Adjuvant Therapy.
- Conditions
- Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms, Esophageal Diseases, Gastrointestinal Neoplasms
- Trial name
- ALTER-E005 (NCT05252078)
- Testing
- Anlotinib hydrochloride, TQB2450
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jiangxi Provincial Cancer Hospital
Type 1 Diabetes Mellitus
Relative Bioavailability and Activity of Different Formulations of Insulin Glargine and Lixisenatide in Patients With Diabetes Mellitus Type 1
Primary Objective: to assess the relative bioavailability of a single dose of insulin glargine (Lantus) and lixisenatide given subcutaneously as on-site mix versus separate and simultaneous injections of each drug Secondary…
- Trial name
- NCT01146678
- Testing
- Insulin glargine HOE901, Lixisenatide AVE0010
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- Sanofi
Gastric Cancer, Metastatic
A Clinical Study of BioTTT001 in Combination With SOX and Toripalimab in Patients With Gastric Cancer
This is a phase I, single arm, open-label clinical study of BioTTT001 in combination with SOX and Toraplizumab in patients with peritoneal metastases from gastric cancer.
- Trial name
- NCT06283121
- Testing
- BioTTT001 intraperitoneal infusion, SOX regimen, toripalimab
- Volunteers
- 30 people
- Sponsor
- China Medical University, China
Urgency Urinary Incontinence
Reduction in Number of Botox Injections for Urgency Urinary Incontinence
The overall objective of this study is to determine if a reduced injection site protocol (5 injection sites) using an equivalent amount of Botox provides comparable relief of Urgency Urinary Incontinence (UUI) symptoms compared…
- Trial name
- NCT04731961
- Testing
- Standard of care (15 Botox injections), Experimental Arm (5 Botox injections)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Virginia
Breast Cancer, Ductal Carcinoma in Situ
The Ultrasound-guided Multiple-injection Costotransverse Block for Mastectomy and Primary Reconstructive Surgery.
The investigators have developed a novel ultrasound-guided nerve block indicated primarily for breast cancer surgery that mimic a thoracic paravertebral block (TPVB) - hitherto the internationally accepted regional anesthesia…
- Trial name
- NCT04248179
- Testing
- Ropivacaine injection, Saline 0.9%, Sufentanil and PONV prophylaxis
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Healthy
A Study of RAY1225 at Different Injection Sites in Participants With Different Body Sizes
The purpose of this study is to compare the amount of RAY1225 that gets into the blood stream and how long it takes the body to get rid of it, when injected under the skin of the upper arm and thigh compared to the abdomen.
- Trial name
- NCT06577428
- Testing
- RAY1225
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Guangdong Raynovent Biotech Co., Ltd
Hippel-Lindau Disease
EYE001 to Treat Retinal Tumors in Patients With Von Hippel-Lindau Syndrome
This study will test the ability of the experimental drug EYE001 to reduce retinal thickening and improve vision in patients with Von Hippel-Lindau syndrome (VHL).
- Trial name
- NCT00056199
- Testing
- EYE001
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Eye Institute (NEI)
Lung Diseases, Neoplasms
Apatinib Combined With SHR-1210 Injection in the Treatment of Patients With Removable IB-IIIA NSCLC
The aim of this study was to investigate the safety and efficacy of SHR-1210 in combination with the anti-vascular survival target drug apatinib in patients with resectable NSCLC, and to provide new treatment options for…
- Conditions
- Lung Diseases, Neoplasms, Respiratory Tract Diseases, Thoracic Neoplasms
- Trial name
- NCT04133337
- Testing
- Apatinib, SHR-1210
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Injection Site Discomfort
Intramuscular Benzathine Penicillin Injection Procedure
The aim of this study was the determination of the effect of applying VR and DC distraction methods on patients' pain and satisfaction levels during IM benzathine penicillin injection. The research hypothesis: 1.
- Trial name
- NCT04420559
- Testing
- Intramuscular Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 91 people
- Sponsor
- Saglik Bilimleri Universitesi