Clinical trials: Injuries, Acute Brain
Acute Brain Injuries, TBI (Traumatic Brain Injury)
Dynamic and Static Autoregulation After Brain Injury
The aim of the study assesses static and dynamic cerebrovascular autoregulation daily over one week in patients with traumatic brain injury or intracranial hemorrhage to quantify the temporal profile of the autoregulatory status.
- Conditions
- Acute Brain Injuries, TBI (Traumatic Brain Injury), Intracranial Hemorrhages
- Trial name
- NCT01069250
- Testing
- There are no interventions in this study
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Johannes Gutenberg University Mainz
Coma, Emotional Distress
The COMA Family Program: A Skills-Based Resiliency Program for Caregivers of Patients With Severe Acute Brain Injuries
The purpose of this study is to pilot a psychosocial skills-based intervention for caregivers of patients with severe acute brain injuries.
- Trial name
- COMA-F (NCT05761925)
- Testing
- COMA-F
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Fibrinogen, Albumin
Fibrinogen-to-Albumin Ratio as a Predictor of Acute Respiratory Distress Syndrome in Traumatic Brain Injury
this study aims to assess the ability of fibrinogen-to-albumin ratio to predict the development of Acute respiratory distress syndrome in traumatic brain injury patients.
- Conditions
- Fibrinogen, Albumin, ARDS, TBI (Traumatic Brain Injury)
- Trial name
- FARDS (NCT07664358)
- Testing
- Fibrinogen-to-albumin ratio
- Where
- Egypt
- Volunteers
- 350 people
- Sponsor
- Tanta University
Acute Coronary Syndrome, Atrial Fibrillation
Short- and Long-term Health Effects of Air Pollution in Poland
The effects of air pollution on the frequency of hospital admissions and mortality due to acute coronary syndromes, atrial fibrillation, and renal disfunction are noted also in areas perceived as pollution-free (due to the lack…
- Conditions
- Acute Coronary Syndrome, Atrial Fibrillation, Kidney Diseases, Particulate Matter Inhalation Injury
- Trial name
- EP-PARTICLES (NCT05198492)
- Testing
- Impact of air pollution
- Where
- Poland
- Volunteers
- 8,300,000 people
- Sponsor
- Medical University of Bialystok
Delirium, Stroke
Impact of Neuromonitoring During Cardiac Procedures
Through a series of sequential analyses, retrospective database exploration looking for linkages and associations between the use of processed electroencephalogram (EEG) and/or cerebral saturation monitoring and patient outcomes…
- Conditions
- Delirium, Stroke, Acute Kidney Injury
- Trial name
- NCT02681731
- Where
- United States
- Volunteers
- 250,000 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Neuro-intensive Care Unit Patients, Subarachnoid Hemorrhage, Aneurysmal
Risk Factors and Outcomes in Patients Treated in Neurocritical Care
The overall purpose of this epidemiologic research project is to provide a comprehensive exploration and analysis of critical elements within the neuro-intensive care process in Sweden.
- Conditions
- Neuro-intensive Care Unit Patients, Subarachnoid Hemorrhage, Aneurysmal, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- EpiNIC (NCT07052656)
- Testing
- Observational study, participants are not assigned an intervention as part of the study., Transport modality
- Where
- Sweden
- Volunteers
- 70,000 people
- Sponsor
- Karolinska Institutet
Ischemic Stroke, Acute, Myocardial Injury
Safety and Efficacy of Remote Ischemic Conditioning in Patients With Acute Myocardial Injury Following Acute Ischemic Stroke
Introduction: The management of acute myocardial injury following acute ischemic stroke (AMI-AIS), a frequent complication that severely worsens prognosis, is challenging.
- Trial name
- NCT07531394
- Testing
- Remote Ischemic Conditioning
- Volunteers
- 580 people
- Sponsor
- Capital Medical University
TBI (Traumatic Brain Injury), Acute Brain Injuries
Study of Cerebral Tissue Oxygenation During Transfusion in Traumatic Brain Injury
This proposal aims to provide some objective, non-invasively achieved, physiologically relevant data in order to provide some rational basis for decision-making for transfusion in sTBI.
- Trial name
- NIRSTBI (NCT01728831)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Subarachnoid Hemorrhage, Aneurysmal, Intracerebral Hemorrhage
Systemic Nitrosative/Oxidative Stress in Patients With Acute Brain Injury
Acute brain injury due to traumatic brain injury (TBI), intracerebral haemorrhage (ICH), and aneurysmal subarachnoid haemorrhage (SAH) carries a high morbidity and mortality, in part due to the development of secondary brain…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Intracerebral Hemorrhage, Traumatic Brain Injury
- Trial name
- NOX (NCT04951453)
- Testing
- None (observational)
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Kidney Injury
Renal Oxygen Saturation During Off-pump Coronary Artery Bypass Graft Surgery
The purpose of this study is to evaluate changes in renal oxygen saturation (rrSO2) and its relationship with central venous oxygen saturation (cvSO2), cerebral cortical oxygen saturation (rcSO2), and hemodynamic parameters while…
- Trial name
- OPCAB (NCT04679337)
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Yeungnam University College of Medicine
Traumatic Brain Injury
Feasibility of a Motor-cognitive Training Program in Patients With Traumatic Brain Injury
The goal of this clinical study is to test feasibility of a motor-cognitive training program in patients after mild to severe traumatic brain injury in an acute hospitalization setting.
- Trial name
- NCT06149975
- Testing
- motor-cognitive training
- Where
- Switzerland
- Volunteers
- 7 people
- Sponsor
- Swiss Federal Institute of Technology
Traumatic Brain Injuries
Therapeutic Benefits of Pareidolia in Acute Traumatic Brain Injury Patients
This study will investigate whether viewing and identifying meaningful shapes or images hidden within nature pictures (pareidolia) can improve motivation and engagement in rehabilitation therapy for adults with mild to moderate…
- Trial name
- NCT07867119
- Testing
- Therapeutic Benefits of Pareidolia, Active Comparator #1
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Shirley Ryan AbilityLab
Acute Brain Injury, Paroxysmal Sympathetic Hyperactivity
Initial Volume Status in Patients With Acute Brain Injury is Associated With Neurological Prognosis
In this study, we investigated the clinical variability in paroxysmal sympathetic hyperactivity in patients with acute brain injury and examined the prognostic value of the Paroxysmal Sympathetic Hyperactivity Assessment Measure…
- Conditions
- Acute Brain Injury, Paroxysmal Sympathetic Hyperactivity, Volume Status, Right Heart Function
- Trial name
- NCT06090812
- Testing
- Ultrasound evaluation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital
Traumatic Brain Injury, TBI
TWILIGHT Study: Effect of Light Exposure During Acute Rehabilitation on Sleep After TBI
This study proposes to investigate how well Bright White Light Therapy will work in the acute inpatient rehabilitation units for people whom have experienced a traumatic brain injury for the purpose of treating sleep disruption.
- Conditions
- Traumatic Brain Injury, TBI, Sleep
- Trial name
- TWILIGHT (NCT02214212)
- Testing
- Bright White Light (BWL), Red Light (RL)
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- University of Washington
Post-Concussion Syndrome, Headache
Assessment of the Efficacy of Medrol Dose Pack for Acute Post-Concussive Headaches
This novel pilot project will assess the effectiveness of corticosteroids in treatment of acute post-concussion headache. The investigators hypothesize that the use of corticosteroids will cause significant headache reduction in…
- Trial name
- NCT04685772
- Testing
- Methylprednisolone
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Northwell Health
Traumatic Brain Injury, Intracerebral Hemorrhage
Clinical Decision Support System for Early Mobilization in the Neuro-ICU
This study aims to evaluate the feasibility, safety, and user acceptability of a tablet- and smartphone-based Clinical Decision Support System (CDSS) designed to guide early mobilization for patients with severe neurological…
- Conditions
- Traumatic Brain Injury, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Spontaneous, Acute Ischemic Stroke
- Trial name
- CDSS-EM-ICU (NCT07685145)
- Testing
- Clinical Decision Support System (CDSS) for Early Mobilization
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- National Taiwan University Hospital
Acute Brain Injury
Frontal Bone Window in ICUF (FBW-ICU)
Transcranial doppler (TCD) is an established tool for monitoring flows in intracranial cerebral arteries. Its use is recommanded in the last guidelines on traumatic brain injury.
- Trial name
- FBW-ICU (NCT02832895)
- Testing
- Transcranial doppler examination
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Montpellier
Mild Traumatic Brain Injury
Prescribed Light Exercise for ED Patients With MTBI
Introduction: Current guidelines for treating patients with mild traumatic brain injury (MTBI) recommend a period of cognitive rest and gradual return to usual activities with avoidance of any activity that exacerbates symptoms.
- Trial name
- NCT03084211
- Testing
- Light exercise discharge instructions
- Where
- Canada
- Volunteers
- 367 people
- Sponsor
- Mount Sinai Hospital, Canada
Stroke, Ischemic, Cardiac Complication
Cardiomyocyte Injury Following Acute Ischemic Stroke
The primary goal of the CORONA-IS study is to characterize stroke-associated acute myocardial injury (elevated hs-cardiac troponin) using different diagnostic examinations in order get a better understanding of it's underlying…
- Trial name
- CORONA-IS (NCT03892226)
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Acute Ischemic Stroke, Contrast-induced Nephropathy
Serum Electrolytes and Contrast-Induced Nephropathy in Acute Ischemic Stroke Patients Undergoing Endovascular Treatment
This study aims to evaluate the relationship between serum electrolyte levels and the development of contrast-induced acute kidney injury (CI-AKI) in patients with acute ischemic stroke undergoing endovascular therapy (EVT).
- Conditions
- Acute Ischemic Stroke, Contrast-induced Nephropathy, Acute Kidney Injury
- Trial name
- NCT07546448
- Testing
- No intervention (observational cohort study)
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital