Clinical trials: Injuries, Acute Brain
Spontaneous Subarachnoid Hemorrhage
Baricitinib for the Lung Injury Following Spontaneous SAH
The present study is a randomized, parallel control, and double-blind trial designed to assess the efficacy of baricitinib in reducing the occurrence of pulmonary complications in patients with spontaneous subarachnoid hemorrhage…
- Trial name
- BLISS (NCT06439615)
- Testing
- Baricitinib 4 MG, Standard treatment
- Volunteers
- 100 people
- Sponsor
- Tang-Du Hospital
Acute Respiratory Failure, COVID-19
REmimazolam Infusion in the Context of Hypnotic Shortage in the Critical Care Unit During the Pandemic of COVID-19: REHSCU Study
The worldwide COVID-19 pandemic has led to a dramatic increase in the number of patients hospitalized in intensive care units for an acute respiratory failure in all countries.
- Conditions
- Acute Respiratory Failure, COVID-19, Trauma, Stroke
- Trial name
- REHSCU (NCT04611425)
- Testing
- Remimazolam
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Mechanical Ventilator Weaning, Acute Brain Injury
Brain-injured Patients Extubation Readiness Study
The BIPER study is a stepped wedge cluster randomised clinical trial aiming to decrease extubation failure in critically-ill brain-injured patients with residual impaired consciousness using a simple clinical score.
- Conditions
- Mechanical Ventilator Weaning, Acute Brain Injury, Altered Level of Consciousness, Mechanical Ventilation
- Trial name
- Biper (NCT04080440)
- Testing
- Extubation readiness clinical score, Usual Care
- Where
- 21 sites in France
- Volunteers
- 660 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Brain Injury
The NEUROlogically-impaired Extubation Timing Trial (NEURO-ETT)
This trial in brain-injured patients will test which of the following will lead to better patient outcomes: (1) an airway management pathway consisting of daily assessments and removal of the breathing tube as soon as patients…
- Trial name
- NCT04291235
- Testing
- Airway Management Pathway, Usual Care
- Where
- 14 sites in Canada
- Volunteers
- 332 people
- Sponsor
- Sunnybrook Health Sciences Centre
Traumatic Brain Injury
Participation and Executive Functions in Adults Following Traumatic Brain Injury In Sub-Acute Inpatient Rehabilitation
Aim: To examine the feasibility of a new treatment protocol in improving executive function deficits and participation in daily activities of adults with TBI at discharge and one month post-discharge.
- Trial name
- NCT04292925
- Testing
- New treatment protocol, Conventional therapy
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Loewenstein Hospital
Brain Injuries, Traumatic
Wellness and Quality of Life Perceptions of People With Traumatic Brain Injury
Telerehabilitation is a service delivery method that has grown substantially in recent years. It has both advantages and disadvantages in comparison to clinic-based services.
- Trial name
- NCT04794894
- Testing
- outpatient rehabilitation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Quality Living, Inc.
Cerebral Concussion
Acute Concussion Therapy Intervention Training in Healthy and Concussed Participants
Healthy (non-injured) and concussed college-aged participants will complete two testing sessions that include (1) clinical symptom, balance, and cognitive evaluations and (2) a progressive exercise session to establish symptom…
- Trial name
- ACTIVE (NCT02872480)
- Testing
- ACTIVE Training
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Dementia, Hip Fractures
Care Delivery in Acute Hospital Settings: an Observational Study
This small observational study is a contractual component of a 5-year (2013-18) NIHR funded programme called PERFECTED (Peri-operative Enhanced Recovery hip FracturE Care of paTiEnts with Dementia) whose overall aim is to develop…
- Trial name
- PERFECTED (NCT02212353)
- Testing
- Observational study, not interventional
- Volunteers
- 180 people
- Sponsor
- University of East Anglia
Concussion Post Syndrome
A Cohort Study Evaluating the Efficacy of PO Magnesium in the Treatment of Acute Traumatic Brain Injury in Adolescents
The objective of this study is to evaluate the efficacy of magnesium in symptomatic reduction of mild traumatic brain injury in the adolescent population in the acute setting of injury.
- Trial name
- NCT03475693
- Testing
- Magnesium Oxide, Acetaminophen, Zofran ODT 4 MG Disintegrating Oral Tablet
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Corewell Health South
Tetraplegia, Spinal Cord Injury
ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis
The purpose of this research study is to demonstrate that individuals with upper limb paralysis due to spinal cord injury, brachial plexus injury, amyotrophic lateral sclerosis and brain stem stroke can successfully achieve…
- Conditions
- Tetraplegia, Spinal Cord Injury, Brachial Plexus Injury, Muscular Dystrophy
- Trial name
- NCT01393444
- Testing
- Implantation of ECoG sensors on the brain surface
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Pittsburgh
Acute Ischemic Stroke, Acute Renal Injury
Recombinant Human C1 Esterase Inhibitor (Conestat Alfa) in the Prevention of Acute Ischemic Cerebral and Renal Events After Transcatheter Aortic Valve Implantation
The aim of this trial is to assess the safety and efficacy of conestat alfa (Ruconest®, Pharming Technologies B.V.) on renal and cerebral ischemic events in patients undergoing TAVI for severe symptomatic aortic stenosis (AS)…
- Trial name
- PAIR-TAVI (NCT05145283)
- Testing
- Conestat alfa (Ruconest®), NaCl 0.9%)
- Where
- 2 sites in Switzerland
- Volunteers
- 141 people
- Sponsor
- University Hospital, Basel, Switzerland
Biomarkers
Role of Concentration of Biomarkers S100B and NSE in Serum in Mild and Moderate Head Trauma
In pediatric age groups communication difficulties very sometimes may present further obstacles in obtaining a detailed injury history and early identification of TBI symptoms.
- Trial name
- NCT02988102
- Testing
- Following S100B and NSE in head trauma
- Where
- Albania
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Clinical Centre of Kosova
Concussion, Mild
Early Sub-threshold Exercise Treatment for Concussion
Each year millions of Americans suffer concussions as a result of accidents in sports, at work or through military service. Adolescents take the longest to recover from the effects of concussion yet no therapy exists to help…
- Trial name
- NCT03569709
- Testing
- Aerobic Exercise, Rest, Stretching
- Volunteers
- healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Traumatic Brain Injury
Early Digital, Analyte and Neurologic Biomarkers of Acute and Chronic Brain Injury and Recovery in CQT Instructors
Repetitive blast exposure has been shown to lead to more severe neurobehavioral impairments versus a single exposure. Blast-induced Traumatic Brain Injury (TBI) can lead to short- and long-term adverse outcomes Even mild brain…
- Trial name
- NCT05917665
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Ischemic Stroke
Differentiating Between Brain Hemorrhage and Contrast
The goal of this observational study is to use artificial intelligence to differentiate cerebral hemorrhage from contrast agent extravasation after mechanical revascularization in ischemic stroke.
- Trial name
- NCT06032819
- Volunteers
- 500 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Cardiac Arrest (CA), Extracorporeal Cardiopulmonary Resuscitation
Clinical Application of Low-Field Magnetic Resonance Imaging in Patients on Extracorporeal Cardiopulmonary Resuscitation
Timely identification of acute brain injury (ABI) patterns in patients with extracorporeal cardiopulmonary resuscitation (ECPR) is essential for prognostic assessment and optimization of clinical management, particularly…
- Conditions
- Cardiac Arrest (CA), Extracorporeal Cardiopulmonary Resuscitation, Acute Brain Injury
- Trial name
- NCT07526701
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Capital Medical University
Terminal Illness, End-of-Life Care
Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence
Background: Recent electroencephalography (EEG) data indicate that the transition from clinical death to cellular death is marked by highly organized neurophysiological events, including significant surges in gamma-band power…
- Conditions
- Terminal Illness, End-of-Life Care, Death, Brain Death
- Trial name
- NeuroCogPresv (NCT07477028)
- Volunteers
- 20 people
- Sponsor
- Noah Tech, Corp.
Post-Concussion Syndrome, COVID Long-Haul
Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS)
The purpose of this study is to test the effect of Auricular Percutaneous Electrical Nerve Field Stimulation (a Neurostim device) on children with pain and Post Concussion symptoms.
- Conditions
- Post-Concussion Syndrome, COVID Long-Haul, COVID-19
- Trial name
- NCT04978571
- Testing
- percutaneous electrical nerve-field stimulation, PENFS, percutaneous electrical nerve-field stimulation, PENFS (COVID active device)
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Children's Hospital of Orange County
Subdural Hematoma, Non-acute
Managing Non-acute Subdural Hematoma Using Liquid Materials：a Chinese Randomized Trial of MMA Treatment
MAGIC-MT study is multi-center, prospective, randomized (1:1) controlled trial designed to show that additional MMA embolization with Onyx in patients with non-acute symptomatic subdural hematoma(SDH) results in reduced hematoma…
- Trial name
- MAGIC-MT (NCT04700345)
- Testing
- Onyx, Burr-hole, Medical Management
- Where
- China
- Volunteers
- 722 people
- Sponsor
- Huashan Hospital
Brain Injuries, Traumatic
Determining the Incidence of Vestibular Dysfunction in Traumatic Brain Injury Patients
The purpose of this study is to determine the incidence of vestibular dysfunction in traumatic brain injury patients admitted to acute inpatient rehabilitation.
- Trial name
- NCT04592575
- Testing
- Vestibular Evaluation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Shirley Ryan AbilityLab