Clinical trials: Injuries, Knee
Anterior Cruciate Ligament Rupture
Safety and Efficacy of the Knee-T-nol Anterior Cruciate Ligament (ACL) Prosthesis
The study is designed to evaluate the safety and efficacy of implanting the Tavor ACL prosthesis in patients with a ruptured ACL by improvement of healing kinetics as well as major adverse treatment events (AEs).
- Trial name
- NCT01450332
- Testing
- Knee-T-Nol
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Tavor Ltd.
Anterior Cruciate Ligament Injuries, Quadriceps Muscle Atrophy
The Effects of Whole-body Vibration on Increasing Quadriceps Strength in Patients With ACL Ruptures
Introduction: Approximately 35% patients can not return to sports after anterior cruciate ligament reconstruction(ACLR). Persistent quadriceps weakness is a factor that prevents patients return to sports.
- Trial name
- NCT04988828
- Testing
- Whole body vibration
- Where
- Hong Kong
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Anterior Cruciate Ligament Rupture
Femoral Tunnel Position on Conventional MRI After Anterior Cruciate Ligament Reconstruction-Transtibial Technique Versus Transportal Technique
The position of the femoral tunnel in anterior cruciate ligament (ACL) reconstruction has been assessed on three dimensional CT (3D-CT) scan or in cadaveric study.
- Trial name
- NCT01513434
- Testing
- transtibial technique, Transportal technique, anterior cruciate ligament reconstruction
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- National Police Hospital
Patellofemoral Joint Dislocation, Bicep Tendon Rupture
BFR After Biceps Tendon Repair and MPFLR
The purpose of this study is to examine the effect of utilizing blood flow restriction (BFR) therapy after distal biceps tendon repair or medial patellofemoral ligament reconstruction (MPFLR) following a tear.
- Trial name
- NCT05375071
- Testing
- Blood Flow Restriction (BFR) Therapy, Physical Therapy
- Where
- United States
- Sponsor
- Mayo Clinic
Knee Injuries
Optimized Loading Response by JOURNEY II BCS Knee Increases Daily Physical Activity and Functions
Smith \& Nephew's first edition of the Journey posterior stabilizing total knee arthroplasty was analyzed by the Center for Musculoskeletal Research in a past research study, and it was determined that subjects experienced more…
- Trial name
- NCT02335710
- Testing
- Journey II BCS TKA
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Amputation, Lower Limb
Virtual Reality in the Rehabilitation in Patients With Lower Limb Amputation.
The goal of this clinical trial is to test the impact of virtual reality on rehabilitation for the patients after a major amputation.
- Conditions
- Amputation, Lower Limb, Rehabilitation, Activities of Daily Living
- Trial name
- NCT05773560
- Testing
- virtual reality rehabilitation
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Erlangen
Multi-ligament Knee Injury
Losartan to Improve Outcomes After Multi-ligament Knee Injury
Multi-ligament knee injuries (MLKIs) can occur during military training, sports injuries, or traumatic events such as motor vehicle accidents and can be devastating events.
- Trial name
- LION (NCT06933706)
- Testing
- losartan 25 mg
- Where
- 3 sites in United States
- Volunteers
- 90 people
- Sponsor
- Brigham and Women's Hospital
Anterior Cruciate Ligament Injury, Tunneling Technique
Evaluation of the Correlation Between Bone Tunnel Projection Placement and Clinical Outcomes in Anterior Cruciate Ligament Reconstruction Surgery
Anterior cruciate ligament (ACL) rupture is a common and clinically significant injury, particularly among young, active, and athletic adults, and may lead to knee instability and functional impairment.
- Conditions
- Anterior Cruciate Ligament Injury, Tunneling Technique, Tendon Graft; Complication, Mechanical
- Trial name
- NCT07876635
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sakarya University
Anterior Cruciate Ligament Rupture
A Clinical Trial of the Round-tunnel and Flat-tunnel Technique of ACL Reconstruction
This study intends to perform round-tunnel and flat-tunnel ACL reconstruction technique in 144 patients, and compare the clinical outcomes of the two surgical procedures through follow-up.
- Trial name
- NCT04953676
- Testing
- round tunnel technique, flat tunnel technique
- Volunteers
- 144 people
- Sponsor
- Peking University Third Hospital
Anterior Cruciate Ligament Injuries, Recovery Quality
Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Recovery Quality in Patients Undergoing Anterior Cruciate Ligament Reconstruction
Background: Arthroscopic anterior cruciate ligament reconstruction (ACLR) is a common orthopedic surgery. Postoperative pain, inflammatory response and opioid-related adverse events impair early recovery quality.
- Conditions
- Anterior Cruciate Ligament Injuries, Recovery Quality, Auricular Vagus Nerve Stimulation
- Trial name
- NCT07904949
- Testing
- Experimental-Active taVNS
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Peking University Third Hospital
Knee Injuries
Effects of Intraarticular IL1-Ra on Pain and Inflammatory Mediators After Knee Arhroscopy
This project investigates the relation between acute pain and local inflammation. Pain reported by the patients for knee arthroscopy are compared with local changes in inflammatory mediators by using microdialysis technique.
- Trial name
- NCT01997138
- Testing
- Anakinra 100 mg in 2 ml saline IA
- Where
- Norway
- Sponsor
- Oslo University Hospital
Postoperative Pain, Anterior Cruciate Ligament Injury
Combined Saphenous Nerve and IPACK Blocks Versus Infiltration Analgesia After Anterior Cruciate Ligament Reconstruction
A lot of patient have posterior knee pain after ACL reconstruction despite saphenous nerve block. Recently a new block has been described, know as IPACK block (interspace between the popliteal artery and the capsule of the…
- Conditions
- Postoperative Pain, Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
- Trial name
- NCT03680716
- Testing
- Ropivacaine injection
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Anterior Cruciate Ligament Tear, Posterior Cruciate Ligament Tear
Effect of Physical Therapy and/or Platelet Rich Plasma Injection in People With Knee Cruciate Ligament Injuries
Background: The anterior cruciate ligament(ACL) , one of the major ligaments in the knee joint which connects the posterior aspect of the lateral femoral condyle to the anterior intercondylar area of the tibia.
- Trial name
- NCT06233305
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taipei Hospital, Ministry of Health and Welfare
Rupture of Anterior Cruciate Ligament
Arthroscopic Primary Repair of the Anterior Cruciate Ligament (ACL)
A prospective cohort study that will be conducted at Sultan Qaboos University Hospital. It aims to determine the outcomes, in terms of, activity level, functional level, subjective knee function, range of motion, stability, and…
- Trial name
- NCT03510845
- Testing
- Arthroscopic ACL Primary Repair, Arthroscopic ACL Reconstruction
- Where
- Oman
- Volunteers
- 45 people
- Sponsor
- Sultan Qaboos University
ACL Tear
Quadriceps Strengthening ACL Reconstruction
The purpose of this study is to characterize quadriceps function and squat biomechanics during the early strengthening phase in adolescent patients undergoing a standardized combined neuromuscular electrical stimulation (NMES)…
- Trial name
- ACL (NCT07015541)
- Testing
- NMES and BFR, Standard physical therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Recurrent Patellar Dislocation, Patellar Instability
Evaluation of Adductor Magnus Tenodesis in Patients With Recurrent Patellar Dislocation.
Between 2010 and 2012, 33 children and adolescents (39 knees) with recurrent patellar dislocation were treated with MPFL reconstruction using the adductor magnus tendon.The aim of the study is to assess the effectiveness of this…
- Conditions
- Recurrent Patellar Dislocation, Patellar Instability, Patellofemoral Osteoarthritis
- Trial name
- NCT05184439
- Testing
- Adductor magnus tenodesis for recurrent patellar dislocation
- Where
- Poland
- Volunteers
- 22 people
- Sponsor
- Polish Mother Memorial Hospital Research Institute
Anterior Cruciate Ligament Injury
ACL SNNAP Trial: ACL Surgery Necessity in Non Acute Patients
The primary objective of this study is to determine in patients with non-acute Anterior Cruciate Ligament Deficiency (ACLD) whether a strategy of non-surgical management [Rehabilitation] (with option for later ACL reconstruction…
- Trial name
- ACL SNNAP (NCT02980367)
- Testing
- Non-Surgical Management (Rehabilitation), Surgical Management (Reconstruction)
- Where
- 32 sites in United Kingdom
- Volunteers
- 320 people
- Sponsor
- University of Oxford
Muscle Atrophy, Surgery
Use of Testosterone to Prevent Post-Surgical Muscle Loss - Pilot Study
The loss of muscle mass post-surgery confounds recovery efforts and leads to a delay in patient's ability to return to activities.
- Conditions
- Muscle Atrophy, Surgery, Knee Injuries and Disorders, Complication of Surgical Procedure
- Trial name
- NCT04456530
- Testing
- Aveed 750 MG in 3 ML IM Injection, Normal Saline 3 ML IM Injection
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- The Stone Research Foundation for Sports Medicine and Arthritis
Anterior Cruciate Ligament Injuries
Multiple Instrumentation for ACL Reconstruction Regarding Bacterial Contamination
To determine the Effect of multiple instrumentation regarding bacterial contamination in transportal and transtibial techniques in ACL reconstruction .A Randomized controlled study
- Trial name
- NCT04100837
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Anterior Cruciate Ligament Injuries, ACL
Blood Flow Restriction Following ACLR
The purpose of this study is to evaluate the the ability of BFR to reduce muscle loss and improve strength after ACL reconstruction.
- Conditions
- Anterior Cruciate Ligament Injuries, ACL, Physical Therapy
- Trial name
- NCT04086030
- Testing
- Blood Flow Restriction Training
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
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