Clinical trials: Injuries, Knee
Knee Pain, Knee Injuries
Effect of PRP Injection After Arthroscopic Meniscal Repair in the Healing Process
The investigator's hypothesis was that intra-articular knee injection with PRP in patients underwent arthroscopic meniscal repair and didn't receive intra-surgical PRP, may add beneficial effect on post-meniscal repair outcomes…
- Trial name
- KneePRP (NCT03910036)
- Testing
- platelet rich plasma
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Knee Osteoarthritis
FAST and PSFS: Assessment and Validation of Two Functional Scales in Patients With Knee OA in Singapore
The new National One-Rehab framework mandates the use of the Patient-Specific Functional Scale (PSFS) as an outcome measure to track patients' rehabilitation progress.
- Trial name
- NCT05590663
- Testing
- Physiotherapy
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- SingHealth Polyclinics
ACL Injury, MRI
Evaluation of Anterior Cruciate Ligament Tears Using Diffusion Tractography
Knees injuries commonly affect the ACL. French current methodology is based on MRI focused on the knee with morphological sequences (T1, DP fat sat) allowing the study of ACL as follows: No lesion / Partial tear / Complete tear.
- Conditions
- ACL Injury, MRI, Tractography
- Trial name
- TRACTOLCA (NCT05806034)
- Testing
- tractography MRI sequence protocol
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Anterior Cruciate Ligament Injuries
Comparative Study of the Inclination Angle and Complications of Eccentric Grafts Position in ACL Reconstruction and Normal ACL: Retrospective Cohort
The anatomic ACL reconstruction aims at functional restoration of the ACL to its native dimensions, collagen orientation and insertion sites.
- Trial name
- NCT04188704
- Testing
- Interference screw
- Volunteers
- 108 people
- Sponsor
- Ramathibodi Hospital
Knee Injuries, Anterior Cruciate Ligament Injuries
Effects of Blood Flow Restriction (BFR) Therapy on ACL Graft Maturation
This is a study comparing the effects of blood flow restriction (BFR) therapy on the maturation of the Anterior Cruciate Ligament (ACL) graft after reconstruction surgery compared to physical therapy without the use of BFR.
- Trial name
- NCT04528992
- Testing
- Blood Flow Restriction Therapy, Standard Postoperative Physical Therapy
- Where
- United States
- Sponsor
- Stanford University
Knee Injuries, ACL Tear
ACL Reconstruction With Simple and Double Bundle Technique Using Two Different Implants for Graft Fixation
In this study our objective is to compare two tibial ACL graft fixation systems in patients undergoing two different reconstructions technique (with simple and double bundle) in terms of tendon graft osteointegration…
- Conditions
- Knee Injuries, ACL Tear, ACL Injury, Sports Injury
- Trial name
- NCT04550299
- Testing
- Surgical technique combined with a specific choice of the material for the ligament reconstruction
- Where
- Brazil
- Volunteers
- 112 people
- Sponsor
- Vita Care
Anterior Cruciate Ligament Rupture
Pain Relief Results After Anterior Cruciate Ligament (ACL) Reconstruction
Anterior cruciate ligament (ACL) reconstruction is surgery that is done to repair a damaged ligament in the knee. In this study we will look at whether the femoral nerve block, a commonly used method for pain relief after ACL…
- Trial name
- NCT00022854
- Testing
- Single-injection femoral nerve block, Femoral nerve block 60-hour continuous injection, Saline (control) injection into femoral nerve envelope
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- University of Pittsburgh
ACL, ACL Injury
Reduced Knee Flexion Strength 18 Years After ACL Reconstruction in Hamstring Group Compared to Patellar Tendon Group
Background: Bone-patellar tendon-bone (BPTB) and a double-looped semitendinosus gracilis (hamstring group) graft are commonly used for ACL reconstruction.
- Conditions
- ACL, ACL Injury, Cruciate Ligament Rupture, ACL Tear
- Trial name
- Studie ACL (NCT05876013)
- Testing
- ACL reconstruction
- Where
- Norway
- Volunteers
- 114 people
- Sponsor
- St. Olavs Hospital
ACL-injury
Comparison of Low-Level Laser Therapy Versus Infrared Therapy in Grade II ACL Injury Rehabilitation
This study is being conducted to compare two commonly used physical therapy treatments, low-level laser therapy (LLLT) and infrared therapy, for people with a Grade II anterior cruciate ligament (ACL) injury of the knee.
- Trial name
- NCT07829835
- Testing
- Low-Level Laser Therapy (LLLT), Infrared Therapy (IRT), Standard Physiotherapy
- Where
- 3 sites in Pakistan
- Volunteers
- 30 people
- Sponsor
- Superior University
Lower Limb Amputation Above Knee (Injury)
C-Leg 3 and C-Leg 4 Study in Transfemoral Amputees
The aim of this post-market study is to confirm that the microprocessor controlled prosthetic knee components (C-Leg 3 and C-Leg 4) in comparison to mechanical knee joints can bring additional benefit to the users primarily on…
- Trial name
- NCT02765035
- Testing
- C-Leg 4, C-Leg 3
- Where
- 2 sites in Austria, Belgium
- Volunteers
- 18 people
- Sponsor
- Otto Bock Healthcare Products GmbH
Anterior Cruciate Ligament Tear
IL-1RA Treatment in Patients With Acute ACL Tear and Painful Effusions
Injury to the knee during sports participation often involves partial or full detachment of the anterior cruciate ligament (abbreviated as ACL). ACL tears cause pain, swelling and inflammation.
- Trial name
- EASI ACL (NCT02930122)
- Testing
- anakinra (150mg), Saline intraarticularly
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Cale Jacobs, PhD
Meniscal Tears
Effects of Pulsed Electromagnetic Field Therapy on Meniscal Healing, Symptom Relief, and Knee Function
The goal of this clinical trial is to learn if pulsed electromagnetic field (PEMF) combined with home exercise improves healing and function in adults with meniscus tears. The main questions it aims to answer are: 1.
- Trial name
- NCT07117929
- Testing
- Active PEMF, Exercise
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Anterior Cruciate Ligament Injury
Single Versus Double Hamstring Harvest for Anterior Cruciate Ligament Reconstruction
The aim of the study is to examine the influence of number of the harvested hamstring tendons on subjective and objective outcomes of primary anterior cruciate ligament reconstruction.
- Trial name
- 1vs2ham (NCT03626883)
- Testing
- single-bundle, single-hamstring ACL reconstruction, single-bundle, double-hamstring ACL reconstruction
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Rafał Kamiński
Orthopedic Surgery, Opioid Use
Post-op Crowd Sourcing Health Data Via Text-messaging
The Center for Disease Control has labeled the opioid prescription drug crisis an "epidemic" in the United States and recently this epidemic has been named a public health emergency.
- Conditions
- Orthopedic Surgery, Opioid Use, Acute Injuries Knee, Neurosurgery
- Trial name
- NCT03532256
- Testing
- Observation, Text to online survey, Bi-directional text script
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- University of Pennsylvania
Ligament Injury, Knee Injuries
Clinical-instrumental Evaluation and Assessment of Return to Sports Activity in Patients Surgically Treated for Isolated "Stener-like" Lesions of the Medial Collateral Ligament (MCL) or in the Context of Multiligament Injuries and Articular Fractures
The knee is a complex joint stabilized by four main ligaments: the anterior and posterior cruciate ligaments and the medial and lateral collateral ligaments.
- Trial name
- STENER_MCL (NCT07174219)
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- Stefano Zaffagnini
Surgical Wound, Knee Arthroplasty
Skin Closure in Prosthetic Joint Surgery: Comparative Evaluation of the "Barbed Sutures and Skin Glue" Technique (Cica-Pro)
The choice of skin closure (staples vs. monofilament sutures vs. barbed sutures/adhesive) is critical for wound healing quality in prosthetic surgery (hip and knee).
- Conditions
- Surgical Wound, Knee Arthroplasty, Hip Arthroplasty
- Trial name
- Cica-Pro (NCT07749495)
- Testing
- primary knee replacement, Primary hip replacement.
- Volunteers
- 400 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Knee Injuries, Pain Syndrome
The Effect of Kinesio Taping® on Motor Control in Patients With Patellofemoral Pain Syndrome
Background: Recently, several professionals are using the Kinesio Taping® in the treatment of pathologies related to the knee, aiming to improve the motor control, increase the response of muscle activation and promoting better…
- Trial name
- NCT03117205
- Testing
- Application of Kinesio Taping®
- Volunteers
- 40 people
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
Anterior Cruciate Ligament Injury
Effect of Dual Tasks on Gait Symmetry After Anterior Cruciate Ligament Reconstruction
Individuals who received anterior cruciate ligament (ACL) reconstruction demonstrated lower extremity movement asymmetries. The purpose of this study was to determine if psychological impairment was a contributor to lower…
- Trial name
- NCT04461145
- Testing
- command
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Peking University Third Hospital
Knee Joint Arthritis, Knee Joint Arthroplasty
Motor Sparing Block vs. Peri-Articular Catheters
This study is designed to determine if one anaesthetic modality, either motor sparing nerve block or peri-articular local infiltration anaesthesia with infusion, is superior in providing postoperative analgesia following total…
- Trial name
- NCT01503528
- Testing
- Motor Sparing Nerve Block, Peri-articular Catheters
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Tendinopathy, Epicondylitis
TENDOSHOCK-2010 Combination Therapy for Athletic Tendinopathies
Athletic tendinopathies of the upper and lower extremity are often therapeutically challenging. Colour and Power-Doppler-ultrasound visualizes pathological neovessels in painful tendons, which are associated with pain-mediating…
- Trial name
- TENDOSHOCK (NCT01185951)
- Testing
- Polidocanol, Focused extracorporeal shock wave therapy, Topical NO
- Where
- Germany
- Volunteers
- 114 people
- Sponsor
- Hannover Medical School
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