Clinical trials: Injuries, Knee
Anterior Cruciate Ligament Injuries
Reverse Drilling Technique in Improving Outcomes After Arthroscopic Anterior Cruciate Ligament Reconstruction
Anterior cruciate ligament (ACL) injuries and bone tunnel enlargement (BTE) after ACL reconstruction (ACLR) remain frequent issues.
- Trial name
- NCT05994872
- Testing
- Reverse drilling technique, Traditional extraction drilling
- Where
- 6 sites in China
- Volunteers
- 216 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Thrombosis, Venous
A Study to Evaluate the Efficacy and Safety of Fondaparinux for the Prevention of Venous Blood Clots in Patients With a Plaster Cast or Other Type of Immobilization for a Below-knee Injury Not Needing Surgery
The purpose of this study is to evaluate the efficacy and safety of fondaparinux in comparison with a heparin (nadroparin) in preventing deep vein thrombosis (blood clots in the leg veins), whether symptomatic or detected by…
- Trial name
- FONDACAST (NCT00843492)
- Testing
- Fondaparinux sodium, Nadroparin
- Where
- 122 sites in France, Germany and 4 more
- Volunteers
- 1,351 people
- Sponsor
- GlaxoSmithKline
Cartilage Injury, OA Knee
Tissue Engineered Cartilage to Repairing Articular Cartilage Defects
The joint cartilage constructed by combining bone marrow mesenchymal stem cells with three-dimensional materials has achieved the goal of repairing joint cartilage.
- Trial name
- NCT07094100
- Testing
- Tissue engineered cartilage
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Iliotibial Band Syndrome
Clamshell and Frog Pump Exercises on Pain, Range of Motion, and Functional Disability
The study will be randomized clinical trial. This study will be conducted at the University of Lahore Teaching Hospital, Lahore, Pakistan.
- Trial name
- NCT07118371
- Testing
- Clamshell exercise, Frog pump exercises
- Where
- Pakistan
- Volunteers
- 92 people
- Sponsor
- University of Lahore
Knee Injury, Cartilage Injury
Norwegian Cartilage Project - Microfracture
114 patients between 18 and 50 years with an isolated focal cartilage defect in the knee will be randomized to either receive arthroscopic microfracture or arthroscopic debridement.
- Trial name
- NCT02637505
- Testing
- Arthroscopic microfracture (MF), Arthroscopic debridement (AD)
- Where
- Norway
- Volunteers
- 66 people
- Sponsor
- University Hospital, Akershus
Anterior Cruciate Ligament Injury, Knee Injury
Optimizing Plyometric Training for Functional Recovery Post-ACL Reconstruction
While surgical anterior cruciate ligament reconstruction (ACLR) of the knee restores passive stability, studies are showing consistently poor long-term outcomes.
- Trial name
- NCT02148172
- Testing
- Standard Plyometric Training, Plyometric Training with BWS
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Montana
ACL, ACL Injury
Comparison of Semitendinosus and Quadriceps Grafts for Anterior Cruciate Ligament Reconstruction
To investigate the differences between the two methods for reconstruction of the anterior cruciate ligament (ACL), to support the development of the best method for young federated male football players.
- Trial name
- NCT06167343
- Testing
- ACL reconstruction
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Universidad de Granada
Knee Injuries
Effect of Preoperative MRI Virtual Reality in Patients Undergoing Knee Arthroscope Surgery
Knee MRI is difficult for patients to understand as the image offers a single plane image. Accordingly,investigators sought to transfer the MRI image to 3-dimensional virtual reality system by Mesh rendering technique.
- Trial name
- NCT03426163
- Testing
- Virtual reality
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Hanyang University Seoul Hospital
Anterior Cruciate Ligament Rupture, Femoral Nerve Block
FNB in ACL Recon Under GA
The investigators will compare the results of sono-guided femoral nerve block in arthroscopic surgery for anterior cruciate ligament reconstruction under general anesthesia.
- Trial name
- NCT06048848
- Testing
- Sono-guided injection, Ropivacaine injection, Saline injection
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Chuncheon Sacred Heart Hospital
ACL Tears
Characterizing Clinical and Biomechanical Contributions to Function Following ACL Reconstruction
Quantify differences in quadriceps function and gait biomechanics in individuals within 2 years of ACL reconstruction compared to a healthy comparison group and establish the feasibility of conducting a progressive strengthening…
- Trial name
- NCT03132987
- Testing
- Progressive strengthening program
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Creighton University
Anterior Cruciate Ligament Injury, Postoperative Pain
Popliteal Plexus Block for Postoperative Pain After ACL Reconstruction
The study aims to investigate the effect of the popliteal plexus block (PPB) on postoperative pain in patients undergoing anterior cruciate ligament (ACL) reconstruction.
- Trial name
- NCT03130049
- Testing
- Popliteal plexus block
- Where
- 2 sites in Denmark
- Volunteers
- 15 people
- Sponsor
- University of Aarhus
Patellar Dislocation, ACL Injury
The Faroese Knee Cohort: Etiology and Long-term Implications of Trochlear Dysplasia and Patellar Dislocations.
The investigators intend to establish a national cohort including all persons in the ages from 15-20 years old with patellar instability (PI) or a prior knee injury (ACL-ruptur or meniscus damage) .
- Conditions
- Patellar Dislocation, ACL Injury, Meniscus Lesion, Trochlear Dysplasia
- Trial name
- FKC (NCT04607538)
- Testing
- No intervention is made
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Anterior Cruciate Ligament Rupture
Anterior Cruciate Ligament Radiology Follow-up Study
Following recent advances in the understanding of successful anterior cruciate ligament (ACL) reconstruction, three important factors have been identified: femoral tunnel positioning, femoral tunnel aperture shape, and native…
- Trial name
- NCT02816606
- Testing
- Flexible reamers, 70-degree arthroscope
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Muscle Atrophy, Proximal, Muscle Atrophy
Ultrasound for Rectus Femoris Measurement
Postoperative protocols for orthopedic procedures on the lower limb often require a period of immobilization to protect the surgical site.
- Conditions
- Muscle Atrophy, Proximal, Muscle Atrophy, ACL Tear, Quadriceps Muscle Atrophy
- Trial name
- NCT04105816
- Testing
- 892.1550 Ultrasonic pulsed doppler imaging system, Thigh circumference measurement
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Robert Westermann
Knee Injuries
Full Vs Partial Weightbearing During the First Six Weeks of Rehab. After Fibular Collateral Ligament Reconstruction
This is a prospective randomized controlled trial with the purpose to determine if patients undergoing fibular collateral ligament (FCL) reconstruction alone or combined FCL and anterior cruciate ligament (ACL) reconstructions…
- Trial name
- NCT05073263
- Testing
- Physical Therapy
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Twin Cities Orthopedics
Osteoarthritis (OA), Osteoarthritis (OA) of the Knee
Platelet Rich Plasma for Musculoskeletal Conditions
The primary purpose of this study is to follow patients with various musculoskeletal (MSK) conditions over a one-year follow-up period after receiving a platelet rich plasma (PRP) injection, assessing changes in their pain…
- Conditions
- Osteoarthritis (OA), Osteoarthritis (OA) of the Knee, Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Shoulder
- Trial name
- PRP for MSK (NCT07231471)
- Testing
- Platelet Rich Plasma Injection, Platelet Rich Plasma Preparation
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Utah
Defect of Articular Cartilage, Osteoarthritis
Comparison of Efficacy and Safety of Microfracture and Modified Microfracture
This study was designed to evaluate the efficacy and safety of a modified microfracture using collagen, and to compare them with those of a simple microfracture to prove the non-inferiority of the modified microfracture using…
- Conditions
- Defect of Articular Cartilage, Osteoarthritis, Traumatic Arthritis
- Trial name
- NCT02539030
- Testing
- Microfracture, CartiFill
- Where
- 12 sites in South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cellontech Co., Ltd.
Isolated Cartilage Injury of the Knee
Sprifermin (AS902330) in Cartilage Injury Repair (CIR)
Several people all over the world suffer from cartilage injuries in the knee. Symptoms include pain, joint swelling, and loss of function. Without repair, cartilage injury may ultimately lead to osteoarthritis (OA).
- Trial name
- NCT01066871
- Testing
- Sprifermin (AS902330) 10 mcg, Sprifermin (AS902330) 30 mcg, Sprifermin (AS902330) 100 mcg
- Where
- Germany
- Volunteers
- 74 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Patella-Dislocation
Functional Surface Electromyogram of Knee Extensors in Healthy Humans and Patients With Patella-dislocation.
The activation of the knee extensors in adults after patella dislocation. The kneecap can dislocate due to an accident or also only due to an interior turn in the stretched knee joint out of its sliding bearing. E.
- Trial name
- NCT00288847
- Where
- Switzerland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Orthopedic Surgery, Opioid Use
Post-op Crowd Sourcing Health Data Via Text-messaging
The Center for Disease Control has labeled the opioid prescription drug crisis an "epidemic" in the United States and recently this epidemic has been named a public health emergency.
- Conditions
- Orthopedic Surgery, Opioid Use, Acute Injuries Knee, Neurosurgery
- Trial name
- NCT03532256
- Testing
- Observation, Text to online survey, Bi-directional text script
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- University of Pennsylvania
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