Clinical trials: Injury, Spinal Cord
Spinal Cord Injuries
Umbilical Cord Blood Cell (MC001) Transplant Into Injured Spinal Cord Followed by the Locomotor Training
Umbilical cord blood mononuclear stem cells (UCBMSCs) transplant followed by the intensive locomotor training for up to 5±1 hours a day, 5±1 days a week, and for 3-6 months for treatment in patients with chronic, stable and…
- Trial name
- NCT03979742
- Testing
- Umbilical Cord Blood Mononuclear Cell, Locomotor Training
- Where
- 2 sites in Taiwan
- Volunteers
- 6 people
- Sponsor
- StemCyte, Inc.
Spinal Cord Injuries, Spine Disease
Temporary Inactivation of Strong Muscle Sensation to Improve Rehabilitation Interventions in SCI
The investigators are conducting a research study to try to improve rehabilitation interventions for individuals with spinal cord injury (SCI).
- Conditions
- Spinal Cord Injuries, Spine Disease, Stroke
- Trial name
- NCT05589402
- Testing
- Lidocaine Cream 5%, Rehabilitation Movement Training
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Texas Rio Grande Valley
Spinal Cord Injury, Spasticity
Shockwave for Elbow and Wrist Spasticity in People With Spinal Cord Injury
Approximately 305,000 people live with a spinal cord injury (SCI) in the United States. Sixty percent of these individuals have tetraplegia, which can cause significant dysfunction of the arms and hands.
- Conditions
- Spinal Cord Injury, Spasticity, Shockwave Therapy
- Trial name
- NCT07501429
- Testing
- Focused extracorporeal shockwave therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Kessler Foundation
Spinal Cord Injury
Robot-Assisted Intensive Physiotherapy in Individuals With Spinal Cord Injury
This randomized controlled trial aims to investigate the effects of robot-assisted intensive physiotherapy on trunk control, posture, and activities of daily living in individuals with spinal cord injury.
- Trial name
- NCT07849062
- Testing
- Robot-Assisted Physiotherapy, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Nuh Naci Yazgan University
Spinal Cord Injury
At-Home Genital Nerve Stimulation for SCI Bowel
The purpose of this study is to test whether electrical stimulation of the skin in the pelvic area (near the genitals) can reduce the reflexes that cause bowel accidents in people with spinal cord injuries.
- Trial name
- NCT06836739
- Testing
- Genital nerve stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- MetroHealth Medical Center
Incomplete Spinal Cord Injury, Exercise Training
Cardiorespiratory Fitness Training in Patients With Incomplete Spinal Cord Injury
The goal of this exploratory randomized controlled trial is to assess the effect of a personalized training intervention during primary rehabilitation of 6 weeks on cardiorespiratory fitness in individuals with subacute (<6…
- Trial name
- FIT@HOME (NCT06259227)
- Testing
- Cardiorespiratory fitness (CRF) training
- Where
- Netherlands
- Volunteers
- 19 people
- Sponsor
- Sint Maartenskliniek
Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders
Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration in Neurological Diseases and Healthy Aging
The MESO7 study is a prospective observational research project designed to investigate the mechanisms of resilience and neurodegeneration in neurological diseases and healthy aging.
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD), Alzheimer Disease
- Trial name
- MESO7 (NCT07202494)
- Testing
- Imaging Techniques (MRI 3T & 7T, Functional, Structural, and Metabolic Imaging)
- Where
- France
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Spinal Cord Injuries
Intrathecal Transplantation of UC-MSC in Patients With Early Stage of Chronic Spinal Cord Injury
This study aim to evaluate the safety and efficacy of intrathecal transplantation of allogeneic umbilical cord derived mesenchymal stem cells (UC-MSC) for treatment of different phrases of spinal cord injury.
- Trial name
- NCT03521323
- Testing
- Umbilical Cord Mesenchymal Stem Cells
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Spinal Cord Injuries (SCI)
Functional Electrical Stimulation Plus High Intensity Interval Training at Home
People living with SCI may experience loss of sensation, movement and regular body function. One way to address these impairments is activity-based therapy (ABT), which includes movement-based activities that promote the…
- Trial name
- NCT07773974
- Testing
- FES+HIIT@Home
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University Health Network, Toronto
Spinal Cord Injuries
A Multi-Centre Clinical Study in Spinal Cord Injury Patients in Mainland China and Hong Kong
To establish a solid foundation, e.g. a network and a coordinating centre for testing new SCI therapies in forthcoming randomised controlled multi-centre clinical trials following international standards and guidelines.
- Trial name
- NCT00517374
- Where
- 17 sites in China
- Volunteers
- 600 people
- Sponsor
- China Spinal Cord Injury Network
Spinal Cord Injuries
Spinal Stimulation for Chronic Complete Tetraplegia
The purpose of this study is investigate the acceptability and effectiveness of transcutaneous spinal cord stimulation in people with complete high level spinal cord injury.
- Trial name
- Complete TESCS (NCT05522920)
- Testing
- Therapy with and without spinal cord stimulation
- Volunteers
- 12 people
- Sponsor
- NHS Greater Glasgow and Clyde
Spinal Cord Injuries
Tenodesis Grip Strength With Functional Hand Recovery in Cervical Spinal Cord Injury
Spinal cord injury (SCI) is devastating event, the individual become significant burden on their family and society SCI is impairments of sensory, motor and autonomic functions.
- Trial name
- NCT05356442
- Where
- Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Spinal Cord Injuries
Beta-alanine Supplementation and Its Effects on Performance, Muscle Carnosine Content and Safety in Athletes With Spinal-cord Injury
Paralympians competing in wheelchair sports may experience a very high glycolytic demand (and therefore acidotic environment) in their upper-body muscles, particularly in high-intensity disciplines.
- Trial name
- NCT02604927
- Testing
- Beta-alanine, Dextrose
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Spinal Cord Injury
Neural Stem Cell Transplantation in Traumatic Spinal Cord Injury
This research investigates the use of autologous neural stem cells in patients with complete traumatic spinal cord injury.
- Trial name
- NCT02326662
- Testing
- Autologous Stem Cell Transplantation
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Federal Research Clinical Center of Federal Medical & Biological Agency, Russia
Healthy
Nervous System Function in Normal Volunteers During Cycling Training
This study will identify changes that occur in the nervous system of healthy normal volunteers while they are learning a cycling task.
- Trial name
- NCT00055588
- Testing
- Locomotor training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Spinal Cord Injuries, Cardiometabolic Diseases
High Intensity Interval Exercise SCI
This study will determine if the implementation of a home-based telehealth high intensity interval exercise-training (HIIT)program can significantly improve cardiometabolic health and physical function in a cohort of individuals…
- Trial name
- NCT04940598
- Testing
- high intensity interval exercise, No-exercise control group
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Alabama at Birmingham
Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic
Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury
The study aims to explore how cardiovascular function changes in the first year after a spinal cord injury, and to see how different treatments, like spinal stimulation through the skin (transcutaneous spinal stimulation), affect…
- Conditions
- Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic, Cardiovascular, Transcutaneous Spinal Stimulation
- Trial name
- NCT06841198
- Testing
- spinal cord transcutaneous stimulation, Ice testing
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Spinal Cord Injuries
Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI
The purpose of this research is to learn about how the body is able to balance changes in blood pressure, how that changes over time, and how these changes impact a participant's risk of developing medical problems.
- Trial name
- NCT07210437
- Testing
- Tests of sympathetic inhibition, Tests of above level sympathetic activation, Testing of below level sympathetic activation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Spinal Cord Injury Cervical, Upper Extremity Dysfunction
Transcutaneous Electrical Spinal Stimulation to Restore Upper Extremity Functions in Spinal Cord Injury
Stimulation of the spinal cord may induce the growth and reorganization of neural pathways leading to the re-animation of paralyzed limbs.
- Trial name
- ADDRESS (NCT03184792)
- Testing
- Transcutaneous spinal stimulation, Physical therapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Washington
Spinal Cord Injuries
Evaluation of an eHealth System to Reduce Depression and Increase Resilience After SCI
The availability of symptom monitoring and self-management (SMSM) interventions is especially important for civilians and military populations with spinal cord injuries (SCI).
- Trial name
- SCIRP (NCT05095506)
- Testing
- eHealth Intervention, Active Control Condition
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Delaware